CN105287931A - Compound honeysuckle flower anti-cold dispersible tablets and preparation method thereof - Google Patents
Compound honeysuckle flower anti-cold dispersible tablets and preparation method thereof Download PDFInfo
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- CN105287931A CN105287931A CN201510882063.9A CN201510882063A CN105287931A CN 105287931 A CN105287931 A CN 105287931A CN 201510882063 A CN201510882063 A CN 201510882063A CN 105287931 A CN105287931 A CN 105287931A
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Abstract
The invention provides compound honeysuckle flower anti-cold dispersible tablets and a preparation method thereof. The dispersible tablets are prepared from the following raw materials by weight percent: 10-50% of traditional Chinese medicine extract, 10-80% of filling agent, 5-50% of internally added disintegrating agent, 5-15% of externally added disintegrating agent, 0.1-10% of flavoring agent, 0.1-20% of wetting agent and 0.05-20% of lubricating agent, wherein the traditional Chinese medicine extract comprises the following raw materials in parts by weight: 100-300 parts of honeysuckle flower, 100-400 parts of root of hempleaf negundo chastetree, 100-300 parts of cyrtomium rhizome, 100-300 parts of thin evodia twig and leaf, 100-300 parts of triquetrous tadehagi herb and 100-300 parts of twig and leaf of Buddha's lamp. The preparation method comprises the following specific steps: 1. raw material pretreatment; 2. extraction; 3. tablet preparation; and 4. packaging. The compound honeysuckle flower anti-cold dispersible tablets have the function of clearing away heat and toxic materials and are used for treating cold, fever with aversion to cold, headaches, coughs, swollen sore throats and other diseases.
Description
Technical field
the present invention relates to pharmaceutical technology sectors, particularly relate to anti-sense dispersible tablet of a kind of compound honeysuckle and preparation method thereof.
Background technology
common Cold is the common fever caused by exogenous pathogenic factors caused by ailment said due to cold or exposure invasion and attack human body.All can occur throughout the year.Especially be common with winter and spring.Clinical is main syndromes feature with headache, the cough of nasal obstruction, sneeze, watery nasal discharge, itching throat, fever with chills etc.If the state of an illness is heavier, and be widely current within a period of time, the similar person of syndrome, is called influenza.
Summary of the invention
the object of this invention is to provide anti-sense dispersible tablet of a kind of compound honeysuckle and preparation method thereof, there is effect of heat-clearing and toxic substances removing, for Common Cold, fever with aversion to cold, headache cough, the diseases such as laryngopharynx swelling and pain.
object of the present invention is achieved through the following technical solutions:
the anti-sense dispersible tablet of a kind of compound honeysuckle, be prepared from by following percentage by weight by raw material, Chinese medicine extract 10-50%, filler 10-80%, in disintegrating agent 5-50%, additional disintegrating agent 5-15%, correctives 0.1-10%, wetting agent 0.1-20%, lubricant 0.05-20%; In described Chinese medicine extract, raw materials by weight portion, Flos Lonicerae 100-300 part, Radix Viticis Cannabifoliae 100-400 part, Rhizoma Osmundae 100-300 part, Foliumet Ramulus Evodiae 100-300 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 100-300 part, Ramulus et Folium Mussaendae Pubescentis 100-300 part.
in described Chinese medicine extract, preferred weight number pressed by raw material, Flos Lonicerae 200-300 part, Radix Viticis Cannabifoliae 350-400 part, Rhizoma Osmundae 200-300 part, Foliumet Ramulus Evodiae 200-300 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 200-300 part, Ramulus et Folium Mussaendae Pubescentis 200-300 part.
in described Chinese medicine extract, optimum weight number pressed by raw material, Flos Lonicerae 234 parts, Radix Viticis Cannabifoliae 390 parts, Rhizoma Osmundae 234 parts, Foliumet Ramulus Evodiae 234 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 234 parts, Ramulus et Folium Mussaendae Pubescentis 234 parts.
described filler is the mixing of one or more in pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate; With the mixing of one or more that disintegrating agent or additional disintegrating agent are in low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone in described; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, orange flavor; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is the mixing of magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci wherein one or more.
the anti-sense dispersible tablet of described a kind of compound honeysuckle, the concrete steps of its preparation method are:
step 1, pretreatment of raw material: by weight, choose the Flos Lonicerae choosing high-quality of high-quality, Radix Viticis Cannabifoliae, Rhizoma Osmundae, Foliumet Ramulus Evodiae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Ramulus et Folium Mussaendae Pubescentis, cleans and remove impurity, for subsequent use;
step 2, extraction: by weight, extracting honeysuckle, Radix Viticis Cannabifoliae, Rhizoma Osmundae, Foliumet Ramulus Evodiae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Ramulus et Folium Mussaendae Pubescentis, secondary is decocted with water, for the first time 10 times amount soak by water 2 hours, second time 8 times amount soak by water 1 hour after mixing, merge twice decocting liquid, filtering medicinal residues and impurity, during filtrate reduced in volume to 70 DEG C, relative density is the clear paste of 1.24-1.28, finally drying under reduced pressure at 80 DEG C, obtains extract;
step 3, preparation: extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, after obtained granulate, add additional disintegrating agent, correctives, mix lubricant are even, with tabletting machine, make tablet;
step 4, packaging: according to tablet format, class wrapping, makes finished product.
in said medicine: Flos Lonicerae, dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, send out speckle, pyretic toxicity carbuncle sore, the diseases such as laryngopharynx swelling and pain, Radix Viticis Cannabifoliae, expelling pathogenic wind from the body surface, removing damp and stopping pain, for headache due to common cold, toothache, malaria, rheumatic arthralgia, Rhizoma Osmundae, parasite killing, heat clearing away, removing toxic substances, cooling blood for hemostasis, for anemopyretic cold, warm skin eruption, spits blood, hemoptysis, Foliumet Ramulus Evodiae, heat-clearing and toxic substances removing, expelling wind and removing dampness, controls laryngopharynx swelling and pain, rheumatic ostalgia, malaria, jaundice, eczema, dermatitis, the diseases such as traumatic injury and worm venom, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), has heat-clearing and toxic substances removing, dampness removing jaundice eliminating, effect of eliminating stagnated food and killing intestinal worms, is usually used in heatstroke excessive thirst, cold, fever, laryngopharynx swelling and pain, pneumonopathy hemoptysis, nephritis, infantile malnutrition, jaundice, have loose bowels, dysentery, rheumatic arthritis, ancylostomiasis, scabies, Ramulus et Folium Mussaendae Pubescentis, induce sweat, relieve summer heat, dampness removing, removing toxic substances, invigorates blood circulation, cure cold, heatstroke, heating, cough, laryngopharynx swelling and pain, diarrhea due to summer heat and dampness, dysentery, skin infection abscess, traumatic injury, snakebite.
beneficial effect of the present invention: anti-sense dispersible tablet of a kind of compound honeysuckle of the present invention and preparation method thereof, has effect of heat-clearing and toxic substances removing, for Common Cold, fever with aversion to cold, headache cough, the diseases such as laryngopharynx swelling and pain; Its dissolubility, favorable dispersibility, dissolution is high, and bioavailability is good, distribution in vivo is rapid, steady quality, and mouthfeel is good, taking convenience, can swallow, chew, containing sucking or taking with after aqueous dispersion, be more suitable for the patient of old people or children's, there is medicine stability good, packaging, transport, the advantages such as storage is convenient, its preparation method is simple, is applicable to commercial production.
be directed to cold patients, the present invention carries out two groups of clinical verifications, and wherein one group is treatment group, edible the present invention, eating the present invention every day once, 2 days is a course for the treatment of, another group matched group takes cold relief capsule, and taking every day once, 2 days is a course for the treatment of, every group selection outpatient 120 example, wherein male 60 example, women 60 example, max age 70 years old, minimal ages 25 years old, clinical manifestation is headache, dry cough, nasal obstruction, pharyngalgia, fever, fear of cold, and table 1 is for taking the contrasting data after the course for the treatment of:
table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of
the effective percentage for the treatment of group and matched group has notable difference, is not difficult to find out the significant curative effect in clinical practice of the present invention.
process characteristic of the present invention: 1, select raw material science, production technology is advanced, and its product is conveniently deposited and used; 2, product Chinese medicine composition is easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
Detailed description of the invention
embodiment 1
the anti-sense dispersible tablet of a kind of compound honeysuckle, be prepared from by following percentage by weight by raw material, Chinese medicine extract 10-50%, filler 10-80%, in disintegrating agent 5-50%, additional disintegrating agent 5-15%, correctives 0.1-10%, wetting agent 0.1-20%, lubricant 0.05-20%; In described Chinese medicine extract, raw materials by weight portion, Flos Lonicerae 100-300 part, Radix Viticis Cannabifoliae 100-400 part, Rhizoma Osmundae 100-300 part, Foliumet Ramulus Evodiae 100-300 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 100-300 part, Ramulus et Folium Mussaendae Pubescentis 100-300 part.
embodiment 2
in described Chinese medicine extract, preferred weight number pressed by raw material, Flos Lonicerae 200-300 part, Radix Viticis Cannabifoliae 350-400 part, Rhizoma Osmundae 200-300 part, Foliumet Ramulus Evodiae 200-300 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 200-300 part, Ramulus et Folium Mussaendae Pubescentis 200-300 part.
embodiment 3
in described Chinese medicine extract, optimum weight number pressed by raw material, Flos Lonicerae 234 parts, Radix Viticis Cannabifoliae 390 parts, Rhizoma Osmundae 234 parts, Foliumet Ramulus Evodiae 234 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 234 parts, Ramulus et Folium Mussaendae Pubescentis 234 parts.
embodiment 4
described filler is the mixing of one or more in pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate; With the mixing of one or more that disintegrating agent or additional disintegrating agent are in low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone in described; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, orange flavor; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is the mixing of magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci wherein one or more.
embodiment 5
the anti-sense dispersible tablet of described a kind of compound honeysuckle, the concrete steps of its preparation method are:
step 1, pretreatment of raw material: by weight, choose the Flos Lonicerae choosing high-quality of high-quality, Radix Viticis Cannabifoliae, Rhizoma Osmundae, Foliumet Ramulus Evodiae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Ramulus et Folium Mussaendae Pubescentis, cleans and remove impurity, for subsequent use;
step 2, extraction: by weight, extracting honeysuckle, Radix Viticis Cannabifoliae, Rhizoma Osmundae, Foliumet Ramulus Evodiae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Ramulus et Folium Mussaendae Pubescentis, secondary is decocted with water, for the first time 10 times amount soak by water 2 hours, second time 8 times amount soak by water 1 hour after mixing, merge twice decocting liquid, filtering medicinal residues and impurity, during filtrate reduced in volume to 70 DEG C, relative density is the clear paste of 1.24-1.28, finally drying under reduced pressure at 80 DEG C, obtains extract;
step 3, preparation: extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, after obtained granulate, add additional disintegrating agent, correctives, mix lubricant are even, with tabletting machine, make tablet;
step 4, packaging: according to tablet format, class wrapping, makes finished product.
Claims (5)
1. the anti-sense dispersible tablet of compound honeysuckle, it is characterized in that: be prepared from by following percentage by weight by raw material, Chinese medicine extract 10-50%, filler 10-80%, in disintegrating agent 5-50%, additional disintegrating agent 5-15%, correctives 0.1-10%, wetting agent 0.1-20%, lubricant 0.05-20%; In described Chinese medicine extract, raw materials by weight portion, Flos Lonicerae 100-300 part, Radix Viticis Cannabifoliae 100-400 part, Rhizoma Osmundae 100-300 part, Foliumet Ramulus Evodiae 100-300 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 100-300 part, Ramulus et Folium Mussaendae Pubescentis 100-300 part.
2. the anti-sense dispersible tablet of a kind of compound honeysuckle according to claim 1, it is characterized in that: in described Chinese crude drug fine powder, preferred weight number pressed by raw material, Flos Lonicerae 200-300 part, Radix Viticis Cannabifoliae 350-400 part, Rhizoma Osmundae 200-300 part, Foliumet Ramulus Evodiae 200-300 part, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 200-300 part, Ramulus et Folium Mussaendae Pubescentis 200-300 part.
3. the anti-sense dispersible tablet of a kind of compound honeysuckle according to claim 1, it is characterized in that: in described Chinese crude drug fine powder, optimum weight number pressed by raw material, Flos Lonicerae 234 parts, Radix Viticis Cannabifoliae 390 parts, Rhizoma Osmundae 234 parts, Foliumet Ramulus Evodiae 234 parts, Herba Desmodii Triquetri (Herba Tadehagi Triquetri) 234 parts, Ramulus et Folium Mussaendae Pubescentis 234 parts.
4. the anti-sense dispersible tablet of a kind of compound honeysuckle according to claim 1, is characterized in that: described filler is the mixing of one or more in pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate; With the mixing of one or more that disintegrating agent or additional disintegrating agent are in low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone in described; Described correctives is the mixing of one or more in aspartame, steviosin, citric acid, orange flavor; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is the mixing of magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci wherein one or more.
5. the anti-sense dispersible tablet of a kind of compound honeysuckle according to claim 1-3 any one, is characterized in that: the concrete steps of its preparation method are:
Step 1, pretreatment of raw material: by weight, choose the Flos Lonicerae choosing high-quality of high-quality, Radix Viticis Cannabifoliae, Rhizoma Osmundae, Foliumet Ramulus Evodiae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Ramulus et Folium Mussaendae Pubescentis, cleans and remove impurity, for subsequent use;
Step 2, extraction: by weight, extracting honeysuckle, Radix Viticis Cannabifoliae, Rhizoma Osmundae, Foliumet Ramulus Evodiae, Herba Desmodii Triquetri (Herba Tadehagi Triquetri), Ramulus et Folium Mussaendae Pubescentis, secondary is decocted with water, for the first time 10 times amount soak by water 2 hours, second time 8 times amount soak by water 1 hour after mixing, merge twice decocting liquid, filtering medicinal residues and impurity, during filtrate reduced in volume to 70 DEG C, relative density is the clear paste of 1.24-1.28, finally drying under reduced pressure at 80 DEG C, obtains extract;
Step 3, preparation: extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, after obtained granulate, add additional disintegrating agent, correctives, mix lubricant are even, with tabletting machine, make tablet;
Step 4, packaging: according to tablet format, class wrapping, makes finished product.
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Cited By (1)
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CN110051790A (en) * | 2018-03-08 | 2019-07-26 | 雷统生 | A kind of drug and its application method treated people and infect H7N9 bird flu and human influenza |
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CN101966244A (en) * | 2010-09-28 | 2011-02-09 | 广西健丰药业有限公司 | Preparation method of sugar-free type anti-cold and antidotal granule |
CN104352757A (en) * | 2014-11-26 | 2015-02-18 | 黑龙江省智诚医药科技有限公司 | Traditional Chinese medicine dispersible tablets with function of tonifying kidneys and spleen and preparation method thereof |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1468629A (en) * | 2003-07-01 | 2004-01-21 | 漳州片仔癀药业股份有限公司 | Chinese medicine composition for treating wind-heat type common cold |
CN101966244A (en) * | 2010-09-28 | 2011-02-09 | 广西健丰药业有限公司 | Preparation method of sugar-free type anti-cold and antidotal granule |
CN104352757A (en) * | 2014-11-26 | 2015-02-18 | 黑龙江省智诚医药科技有限公司 | Traditional Chinese medicine dispersible tablets with function of tonifying kidneys and spleen and preparation method thereof |
Non-Patent Citations (1)
Title |
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中华人民共和国卫生部药典委员会编: "《中华人民共和国卫生部 药品标准 中药成方制剂 第十二册》", 30 June 1997 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110051790A (en) * | 2018-03-08 | 2019-07-26 | 雷统生 | A kind of drug and its application method treated people and infect H7N9 bird flu and human influenza |
CN110051790B (en) * | 2018-03-08 | 2021-05-04 | 雷统生 | Medicine for treating human infection of H7N9 avian influenza and human influenza and preparation method thereof |
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