CN105168834A - Medicine for treating scrofula and preparation method thereof - Google Patents
Medicine for treating scrofula and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating scrofula and a preparation method thereof. The medicine is prepared from the following main raw materials according to a certain weight proportion: centipedes, scorpions, bulbus fritillariae cirrhosae, radix scrophulariae, bryozoatum, selfheal, dandelions, oysters, polygonum multiflorum and radix glehniae. The medicine has the functions of soothing liver, nourishing blood, regulating qi, reducing phlegm, nourishing yin and clearing away the lung heat and has the advantages of quick effect and good curative effect for treating scrofula and no relapse.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of scrofula and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Scrofula is also known as the tuberculosis of cervical lymph nodes, and be the infectious surgical diseases of one of being born in cervical region, the core block can laid one's hand on and differ in size between cervical region skin and flesh is contacted mutually, and its medium and small person claims scrofula, and large person claims scrofula, is mostly the specific infection caused by tubercule bacillus intrusion cervical region.The traditional Chinese medical science is then thought that scrofula to be pented up through wind heat gas poison by three Jiao, liver, gallbladder etc. and is formed, and Liver and kidney two, through deficiency of both QI and blood, caused by dynamic in asthenic fire, is divided into acute and chronic two classes.Acute many because of affection due to external wind and heat, in accumulate expectorant poison and send out; Because the stagnation of QI, void are hindered and sent out more than chronic.Because the side effect of western medicine scrofula is large, therefore there is great demand to the Chinese medicine of effectively treating scrofula in people, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally have found the medicine of effectively treatment scrofula, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment scrofula.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects Scolopendra, Scorpio, Bulbus Fritillariae Cirrhosae, Radix Scrophulariae, Pumex, Spica Prunellae, Herba Taraxaci, Concha Ostreae, Radix Polygoni Multiflori, Radix Glehniae, Radix Saposhnikoviae, Semen Sinapis Albae medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat scrofula.Wherein select Scolopendra to be because its nature and flavor are pungent, temperature, poisonous, enter Liver Channel, dispel the wind, arresting convulsion, counteracting toxic substances, the function of eliminating stagnation, controls apoplexy ， Jing Epilepsy, tetanus, pertussis, scrofula, tuberculosis ， mass in the abdomen tumor block, sore swollen toxin, and tinea corporis is bald in vain, anal fistula, scalds.Selects the scorpion because of their sexual taste salty, flat, toxic, with functions, antispasmodic, t2dm, the function of detoxification, epilepsy, epilepsy, stroke, hemiplegia, mouth askew, migraine, rheumatism bi pain, tetanus, lymph node tuberculosis, measles sore swollen.Bulbus Fritillariae Cirrhosae is selected to be because its property bitter but sweet flavor, cool, enter lung meridian, have lung moistening eliminating stagnation, the function that antitussive reduces phlegm, control cough due to consumptive disease, spitting of blood of spitting, ambition pent-up, consumptive lung disease, lung abscess, goiter, scrofula, sore throat, acute mastitis.Select Radix Scrophulariae to be because its nature and flavor are bitter, salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, control calentura excessive thirst, send out speckle, hectic fever due to YIN-deficiency consumptive fever, sleep night not peaceful, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.Select Pumex to be because its nature and flavor are salty-cold, enter lung, stomach warp, have lung heat clearing fire, change old expectorant, softening the hard mass, treating stranguria function, control expectorant dyspnea of heat type and cough, old accumulation of phlegm block, goiter, scrofula, hernia, skin ulcer swells, corneal nebula.Select Spica Prunellae to be because its nature and flavor toil, cold, enter liver, gallbladder meridian, have liver heat removing, the function of eliminating stagnation, controls scrofula, goiter, acute mastitis, breast carcinoma, order pearl nyctalgia, photophobia is shed tears, the vertigo, facial hemiparalysis, bones and muscles pain, pulmonary tuberculosis, acute icteric infectious hepatitis, metrorrhagia, leukorrhagia.Select Herba Taraxaci to be because its property bitter but sweet flavor, cold, enter liver, stomach warp, have heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, controls acute mastitis, lymphadenitis, scrofula, furuncle carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract infection.Select Concha Ostreae to be because its nature and flavor are salty and bitter, cool, enter liver, kidney channel, have yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduce phlegm, the function of softening the hard mass, Zhi Jing Epilepsy, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.Radix Polygoni Multiflori is selected to be that tepor, enters liver, kidney channel, have tonifying liver, kidney tonifying, nourish blood, the function of dispeling the wind because its property bitter but sweet flavor is puckery, control hepatic and renal YIN deficiency, sending out must be early white, and blood deficiency is dizzy, and waist knee joint is weak, and muscles and bones is ached, seminal emission, metrorrhagia and leukorrhagia, chronic malaria, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, haemorrhoids.Select Radix Glehniae to be that enter lung, spleen channel, have nourishing YIN and clearing away lung-heat, the function of expelling phlegm for arresting cough, controls lung-heat type cough, chronic consumptive disease chronic cough because its nature and flavor sweetness and bitterness is light, cool, the moon hinders dry pharynx, thirsty.Select Radix Saposhnikoviae to be because its property acrid-sweet flavor, temperature, enters bladder, lung, spleen channel, delivers, dispel the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, anemofrigid-damp arthralgia, and joint is ached, and extremity contraction is anxious, tetanus.Select Semen Sinapis Albae to be that temperature, enters lung, stomach warp, have promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, the function of removing obstruction in the collateral to relieve pain, control phlegm retention cough with asthma, fullness and distention in the chest and hypochondrium pain because its nature and flavor are pungent, regurgitation is vomitted, aphasia due to apoplexy, and limbs arthralgia pain is numb, beriberi, carbuncle of yin nature, toxic swelling, treating swelling and pain by traumatic injury.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:
Scolopendra 40-50 gram, Scorpio 40-50 gram, Bulbus Fritillariae Cirrhosae 95-110 gram, Radix Scrophulariae 100-150 gram, Pumex 120-160 gram, Spica Prunellae 120-180 gram, Herba Taraxaci 120-160 gram, Concha Ostreae 250-350 gram, Radix Polygoni Multiflori 120-180 gram, Radix Glehniae 120-160 gram, Radix Saposhnikoviae 120-180 gram, Semen Sinapis Albae 120-160 gram.
Be preferably:
Scolopendra 45 grams, Scorpio 45 grams, Bulbus Fritillariae Cirrhosae 100 grams, Radix Scrophulariae 120 grams, Pumex 150 grams, Spica Prunellae 150 grams, Herba Taraxaci 150 grams, Concha Ostreae 300 grams, Radix Polygoni Multiflori 150 grams, Radix Glehniae 150 grams, Radix Saposhnikoviae 150 grams, Semen Sinapis Albae 150 grams.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, Scolopendra: Scolopendra is removed cephalopodium, trisection, after spilling profit, low baking temperature dries;
2, Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;
3, Bulbus Fritillariae Cirrhosae: pick decontamination, slightly steeps with water, pulls out, and moistening peels off the heart, dries;
4, Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;
5, Pumex: clean and dry, smash;
6, Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
7, Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
8, Concha Ostreae: by the Concha Ostreae cleaned, put smokeless stove fire and get angry and be calcined to canescence, taking-up cools, and pulverizes;
9, Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;
10, Radix Glehniae: pick decontamination, removing stem foot, slightly washes with water, pulls out, slightly moisten, cutting, dry;
11, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
12, Semen Sinapis Albae: former medicine is winnowed with a dustpan most impurity, and fry to buff, micro-have fragrance and get final product.
Two, prepare
1, the preparation of medicament capsule of the present invention:
(1) Scolopendra cooked, Scorpio, Bulbus Fritillariae Cirrhosae, Radix Scrophulariae, Pumex, Spica Prunellae, Herba Taraxaci, Concha Ostreae, Radix Polygoni Multiflori, Radix Glehniae, Radix Saposhnikoviae, Semen Sinapis Albae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(3) dry extract is broken into powder, incapsulates, every 0.5g.
2, the preparation of medicinal granule of the present invention:
(1) Scolopendra cooked, Scorpio, Bulbus Fritillariae Cirrhosae, Radix Scrophulariae, Pumex, Spica Prunellae, Herba Taraxaci, Concha Ostreae, Radix Polygoni Multiflori, Radix Glehniae, Radix Saposhnikoviae, Semen Sinapis Albae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(3) dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule.
3, the preparation of medicinal tablet of the present invention:
(1) Scolopendra cooked, Scorpio, Bulbus Fritillariae Cirrhosae, Radix Scrophulariae, Pumex, Spica Prunellae, Herba Taraxaci, Concha Ostreae, Radix Polygoni Multiflori, Radix Glehniae, Radix Saposhnikoviae, Semen Sinapis Albae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(3) dry extract is broken into fine powder, adds adjuvant and make granule, tabletted, every sheet 0.5g.
4, the preparation of medicine honeyed pill of the present invention:
(1) Scolopendra cooked, Scorpio, Bulbus Fritillariae Cirrhosae, Radix Scrophulariae, Pumex, Spica Prunellae, Herba Taraxaci, Concha Ostreae, Radix Polygoni Multiflori, Radix Glehniae, Radix Saposhnikoviae, Semen Sinapis Albae are stirred, porphyrize powder crosses 200 order dusting covers;
(2) Mel is refined into the tender honey of 110-115 DEG C;
(3) by grind for fine powder spice by weight the ratio of 1:1 add mixing system in Mel and stick together, then rubbing pill, every ball, containing pure medicine 1.5 grams, obtains honeyed pill.
In prescription Scolopendra have dispel the wind, calm the frightened, the function of counteracting toxic substances, eliminating stagnation is monarch drug; Bulbus Fritillariae Cirrhosae lung moistening eliminating stagnation, antitussive reduces phlegm; Herba Taraxaci has heat-clearing and toxic substances removing, the function of diuresis eliminating stagnation, and the two is ministerial drug, three taste medicines jointly play heat-clearing and toxic substances removing, dispel the wind, calm the frightened, the effect of dispersing pathogen accumulation, and treatment scrofula effect is comprehensive, and with heat-clearing and toxic substances removing, dispelling wind-evil and transforming calculus is that master can be effected a permanent cure, and Semen Sinapis Albae has promoting the circulation of QI eliminating phlegm, warming spleen and stomach for dispelling cold, the function of removing obstruction in the collateral to relieve pain is adjuvant drug, Radix Polygoni Multiflori tonifying liver, kidney tonifying, nourishes blood, dispel the wind as making medicine, all medicines take stopgap measures with being left.
Medicine of the present invention has soothing the liver nourishing blood, heat-clearing and toxic substances removing, and the function of dispelling wind-evil and transforming calculus, is used for the treatment of scrofula, short treating period, instant effect, non-relapse after healing.
Detailed description of the invention:
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.
The animal toxicity test report of [test example 1] medicine of the present invention:
Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group oral capsule, a kind of dosage form in granule or tablet is 0.2g/kg, and normal amount is 0.1g/kg, administering mode is the administration of dilution administration by gavage, twice daily, serve on 7 days, observe administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept scrofula out-patient totally 36 examples for medical treatment.
2, diagnostic criteria
The scrofula symptom initial stage be cervical region core block as bean, single or severally concatenate, not hot color of the leather is constant not bitterly, and what push away is active; Mid-term is that core block is greatly cumulative, and with epidermis adhesion, several core block is fused into mutually large lump sometimes, feels pain gradually, and what push away does not move, or is liquefied as pus, the multiple finger pressed; Later stage is tuberculosis diabrosis, and pus is rare clearly, for a long time then fistulization, does not prolongedly heal, low grade fever night sweat, cough.
3, Therapeutic Method
Select above-mentioned medicament, take to patient, each serving with capsule or granule or 4 grams, tablet or honeyed pill 6 ball, every day is early, middle and late respectively takes 1 time, within 7 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: scrofula transference cure, body constitution recovers normal, recovery from illness;
Take a turn for the better: patient's neck region lump reduces, diabrosis place is healed gradually, and scrofula symptom is clearly better;
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form)
In above-mentioned treatment, by Drug therapy scrofula patient 36 example of the present invention, effective 32 examples of result, obvious effective rate is 88.89%, and take a turn for the better 3 examples, and improvement rate is 8.33%, and invalid 1 example, total effective rate is 97.22%.
Claims (3)
1. treat a medicine for scrofula, it is characterized in that: it is made up of the crude drug in following weight range:
Scolopendra 40-50 gram, Scorpio 40-50 gram, Bulbus Fritillariae Cirrhosae 95-110 gram, Radix Scrophulariae 100-150 gram, Pumex 120-160 gram, Spica Prunellae 120-180 gram, Herba Taraxaci 120-160 gram, Concha Ostreae 250-350 gram, Radix Polygoni Multiflori 120-180 gram, Radix Glehniae 120-160 gram, Radix Saposhnikoviae 120-180 gram, Semen Sinapis Albae 120-160 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
Scolopendra 45 grams, Scorpio 45 grams, Bulbus Fritillariae Cirrhosae 100 grams, Radix Scrophulariae 120 grams, Pumex 150 grams, Spica Prunellae 150 grams, Herba Taraxaci 150 grams, Concha Ostreae 300 grams, Radix Polygoni Multiflori 150 grams, Radix Glehniae 150 grams, Radix Saposhnikoviae 150 grams, Semen Sinapis Albae 150 grams.
3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:
(1) get the raw materials ready
(1) Scolopendra: Scolopendra is removed cephalopodium, trisection, after spilling profit, low baking temperature dries;
(2) Scorpio: clear water floats the matter that desalts, and dries, or low baking temperature roasting is used;
(3) Bulbus Fritillariae Cirrhosae: pick decontamination, slightly steeps with water, pulls out, and moistening peels off the heart, dries;
(4) Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;
(5) Pumex: clean and dry, smash;
(6) Spica Prunellae: get crude drug, except discarding stalk, blade and impurity, sieve dedust bits;
(7) Herba Taraxaci: pick decontamination, clean earth, cutting, dries;
(8) Concha Ostreae: by the Concha Ostreae cleaned, put smokeless stove fire and get angry and be calcined to canescence, taking-up cools, and pulverizes;
(9) Radix Polygoni Multiflori: pick decontamination, cleans, saturating with blister to eighty per cant, pulls out, and profit is even to inside and outside humidity, and section or dice, dry;
(10) Radix Glehniae: pick decontamination, removing stem foot, slightly washes with water, pulls out, slightly moisten, cutting, dry;
(11) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;
(12) Semen Sinapis Albae: former medicine is winnowed with a dustpan most impurity, and fry to buff, micro-have fragrance and get final product;
(2) prepare
(1) preparation of medicament capsule of the present invention:
1. the Scolopendra cooked, Scorpio, Bulbus Fritillariae Cirrhosae, Radix Scrophulariae, Pumex, Spica Prunellae, Herba Taraxaci, Concha Ostreae, Radix Polygoni Multiflori, Radix Glehniae, Radix Saposhnikoviae, Semen Sinapis Albae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
3. dry extract is broken into powder, incapsulates;
(2) preparation of medicinal granule of the present invention:
1. the Scolopendra cooked, Scorpio, Bulbus Fritillariae Cirrhosae, Radix Scrophulariae, Pumex, Spica Prunellae, Herba Taraxaci, Concha Ostreae, Radix Polygoni Multiflori, Radix Glehniae, Radix Saposhnikoviae, Semen Sinapis Albae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
3. dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule;
(3) preparation of medicinal tablet of the present invention:
1. the Scolopendra cooked, Scorpio, Bulbus Fritillariae Cirrhosae, Radix Scrophulariae, Pumex, Spica Prunellae, Herba Taraxaci, Concha Ostreae, Radix Polygoni Multiflori, Radix Glehniae, Radix Saposhnikoviae, Semen Sinapis Albae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
3. dry extract is broken into fine powder, adds adjuvant and make granule, tabletted;
(4) preparation of medicine honeyed pill of the present invention:
1. the Scolopendra cooked, Scorpio, Bulbus Fritillariae Cirrhosae, Radix Scrophulariae, Pumex, Spica Prunellae, Herba Taraxaci, Concha Ostreae, Radix Polygoni Multiflori, Radix Glehniae, Radix Saposhnikoviae, Semen Sinapis Albae are stirred, porphyrize powder crosses 200 order dusting covers;
2. Mel is refined into the tender honey of 110-115 DEG C;
3. by grind for fine powder spice by weight the ratio of 1:1 add mixing system in Mel and stick together, then rubbing pill, every ball, containing pure medicine 1.5 grams, obtains honeyed pill.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998487A (en) * | 2016-07-29 | 2016-10-12 | 安徽新盛中药饮片有限公司 | Traditional Chinese medicinal composition for treating scrofula |
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| CN102772634A (en) * | 2011-05-13 | 2012-11-14 | 冯章印 | Tablet for preventing and treating stagnation |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105998487A (en) * | 2016-07-29 | 2016-10-12 | 安徽新盛中药饮片有限公司 | Traditional Chinese medicinal composition for treating scrofula |
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