CN1762475A - Effervescence tablet for wind-cold type cold - Google Patents
Effervescence tablet for wind-cold type cold Download PDFInfo
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Abstract
The invention relates to an effervescence tablet for wind-cold type cold, wherein the raw materials include schizonepeta spike, mentha, ledebouriella root, Bupleurum root, purple perilla, kudzu vine root, root of ballon flower, bitter apricot seed, dahurian angelica root, Philippine violet herb and reed rhizome.
Description
Technical field
The present invention relates to the technical field of Chinese patent medicine effervescent tablet, relate in particular to effervescence tablet for treating wind-cold type cold.
Background technology
At present, the domestic main effervescent tablet of China is health product, as vitamin C, the effervescent tablet of replenishing the calcium, also has plenty of the effervescent tablet of gynecological external use medicine, as JIEERYIN PAOTENGPIAN, and metronidazole vagina effervescent tablet etc., but the oral Chinese medicine effervescent formulation is less.And the cold reducing-fever prescription is made the effervescent tablet of oral pure Chinese medicinal preparation, rarely found report.In addition, ring segment early has application in food industry, but less in the field of medicaments application, particularly in the effervescent tablet preparation field, and rarely found report.
The Chinese medicine effervescent tablet is a kind of new dosage form, have that drug release rate is fast, dosage is little, divided dose is accurate, take, advantage such as easy to carry, and the oral administration effervescing sheet is specially adapted to the patient of child, old people and the solid preparation of can not swallowing.
The effect of cold reducing-fever class Chinese patent medicine is expelling wind and cold, and the heat clearing away of inducing sweat is used for anemofrigid cold, have a headache and fever, and the aversion to cold general pain, rhinorrhea with clear discharge, the cough dry pharynx, former dosage form is a granule.Child, the old people inconvenience of swallowing.
The raw material of Chinese medicine of GANMAO QINGRE KELI is made up of Herba Schizonepetae, Herba Menthae, Radix Saposhnikoviae, Radix Bupleuri, Folium Perillae, Radix Puerariae, Radix Platycodonis, Semen Armeniacae Amarum, the Radix Angelicae Dahuricae, Herba Corydalis Bungeanae, Rhizoma Phragmitis.
Conventional Chinese medicine effervescent tablet adopts the form of conventional tablet, and disintegration rate is too slow, and the time that patient waits for is oversize, easily causes impatient emotion, influences Chinese medicine effervescent tablet commercial value.The administrative provisions of Chinese medicine effervescent tablet for example, the disintegration time of effervescent tablet is higher than 5 minutes, is judged to defective.This is because of slow excessively disintegration rate, inconvenient patient's treatment.
It is long partially that the health care products effervescent dosage form of Chinese medicine effervescent dosage form and other two big classes and Western medicine effervescent dosage form are compared on disintegration time, influenced the application of Chinese medicine effervescent dosage form.
Health product effervescent dosage form contains the material that easily is dissolved in water mostly, for example easily is dissolved in the small-molecule substance and the inorganic compound of water, and disintegrate is very fast; The common dose of Western medicine is little, and easily is dissolved in water, and Western medicine only accounts for below 3% of Western medicine effervescent formulation weight usually, and all the other all can adopt acid, alkali disintegrating agent, and sour, alkali disintegrating agent can be up to more than 90%, so the disintegrate of Western medicine effervescent chance water is also very fast; Health care products effervescent dosage form and Western medicine effervescent dosage form even are finished disintegrate usually in one minute in the several seconds, therefore do not have the technical problem of poor practicability on disintegration time.And Chinese medicine is when making the effervescent dosage form, usually water is carried with alcohol extraction and is obtained multiple blended macromolecular active substance, comprise multiple stickums such as pectin class, saccharide, polysaccharide, Chinese medicine effervescent dosage form is met the influence that the water disintegrate is subjected to stickum, disintegrate is slower, on the other hand for guaranteeing curative effect, the Chinese medicine effervescent dosage form dose of monolithic is bigger, this has also influenced disintegration rate, for guaranteeing disintegrate, have to increase the consumption of adjuvant, make some effervescent tablet will accomplish the 4-5g/ sheet, not only increased cost, also made troubles to producing, transport, carry, using.After the disintegration rate of Chinese medicine effervescent reached several minutes, compare advantage with Chinese medicine granules not outstanding, limited the application of Chinese medicine effervescent.
Summary of the invention
The purpose of this invention is to provide a kind of effervescence tablet for treating wind-cold type cold,, satisfy needs of medical treatment better to overcome the deficiency of present dosage form.
Particularly provide a kind of disintegration rate fast cold reducing-fever annular effervescent tablet.
Each constituent of effervescence tablet for treating wind-cold type cold of the present invention comprises cold reducing-fever extract, disintegrating agent and other adjuvant, and cold reducing-fever extract is wherein made by the following weight Chinese medicinal raw materials: Herba Schizonepetae 160-240, Herba Menthae 20-80, Radix Saposhnikoviae 60-140, Radix Bupleuri 60-140, Folium Perillae 20-80, Radix Puerariae 60-140, Radix Platycodonis 20-80, Semen Armeniacae Amarum 40-120, Radix Angelicae Dahuricae 20-100, Herba Corydalis Bungeanae 160-240, Rhizoma Phragmitis 120-200.
Each constituent of effervescence tablet for treating wind-cold type cold of the present invention comprises cold reducing-fever extract, disintegrating agent and other adjuvant, and cold reducing-fever extract is wherein made by the following weight Chinese medicinal raw materials: Herba Schizonepetae 200, Herba Menthae 60, Radix Saposhnikoviae 100, Radix Bupleuri 100, Folium Perillae 60, Radix Puerariae 100, Radix Platycodonis 60, Semen Armeniacae Amarum 80, the Radix Angelicae Dahuricae 60, Herba Corydalis Bungeanae 200, Rhizoma Phragmitis 160.
Effervescence tablet for treating wind-cold type cold, wherein each constituent proportioning is by weight: cold reducing-fever extract 1-50 part, disintegrating agent comprise sour agent 10-30 part, alkaline agent 10-30 part, other adjuvant comprises binding agent 0-15 part, lubricant 0-15 part, sweeting agent 0-10 part, aromatic 0-5 part.
Effervescence tablet for treating wind-cold type cold, wherein the effervescent tablet profile is an annular.
The annular of effervescence tablet for treating wind-cold type cold is made up of some bursts; Be provided with the connecting band of easy fracture between each burst.Disintegration rate can be further accelerated in the setting of connecting band between the burst.
An important feature of the present invention is that ring segment is incorporated into the effervescence tablet for treating wind-cold type cold preparation field, has invented cold reducing-fever annular effervescent tablet.Contain various saccharides, polysaccharide macromolecular material in the cold reducing-fever medical material, so the cold reducing-fever extract that makes after the drying has very strong viscosity.After being made into effervescence tablet for treating wind-cold type cold, these materials form one deck adhesive film in tablet surface easily when effervescent tablet is met the water disintegrate, influence the disintegration rate of effervescent tablet.After being made into ring segment, increased the contact surface of disintegrating agent and water, made disintegrating agent outer two aspects and water effect of ring in ring, increased the contact surface with water, made effervescent tablet complete disintegrate in the short time.
Because health care products effervescent dosage form and Western medicine effervescent dosage form are very fast because of self Material Characteristics disintegrate, health care products effervescent dosage form and Western medicine effervescent dosage form are made the technical meaning that ring segment further improves disintegration rate do not give prominence to.But to effervescence tablet for treating wind-cold type cold, be made into annular, but can improve disintegration rate greatly, significant, the annular effervescence tablet for treating wind-cold type cold of disintegrate had both met national standard in two minutes even in one minute, can satisfy patient's demand easy to use again; Need the disintegrate of 4-5 minute ability to compare with the common cold effervescence tablet for reducing fever, the commercial value of annular effervescence tablet for treating wind-cold type cold aspect the disintegrate convenience is higher.
The acid agent can be selected from one or more in tartaric acid, malic acid, fumaric acid, anhydrous citric acid, citric acid or the sodium dihydrogen citrate salt; Alkaline agent can be selected from one or more in potassium carbonate, potassium bicarbonate, sodium carbonate, sodium bicarbonate, calcium carbonate, the calcium bicarbonate; Binding agent can be selected from carboxymethylstach sodium, hyprolose, carmethose, low-substituted hydroxypropyl cellulose (L-HPC), microcrystalline Cellulose (MCC), crospolyvinylpyrrolidone (PVPP), polyvinylpyrrolidone (PVP), Polyethylene Glycol (PEG) 6000, Polyethylene Glycol (PEG) 4000.
Lubricant can be selected from one or more in sodium lauryl sulphate, magnesium stearate, Pulvis Talci, the silicon dioxide.
In the additive of tablet field, materials such as Polyethylene Glycol (PEG) 6000, Polyethylene Glycol (PEG) 4000 have the effect of binding agent, lubricant simultaneously concurrently.It is divided into binding agent or lubricant all belongs to normal.
In the additive of tablet field, have the effect that binding agent, speed collapse agent simultaneously concurrently as carboxymethylstach sodium, hyprolose, carmethose, low-substituted hydroxypropyl cellulose (L-HPC), microcrystalline Cellulose (MCC), crospolyvinylpyrrolidone (PVPP), the polyvinylpyrrolidone (PVP) of binding agent.It is divided into binding agent or speed collapses agent and all belongs to normal.
Sweeting agent can be selected from one or more in cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, the saccharin sodium (calcium) etc.
Aromatic can be selected from one or more among orange essence, flavoring orange essence, Herba Menthae essence or Fructus Citri Limoniae essence, the flavoring banana essence etc.
Effervescent tablet of the present invention was taken after every day, three times consumption was dissolved in water by each 1-3 sheet.
Being conventional substances because sour agent, alkaline agent, binding agent, lubricant, sweeting agent, aromatic, the speed in effervescent tablet field collapse the kind of agent, is not emphasis of the present invention.So the present invention does not do detailed expansion to this partial content.
Effervescence tablet for treating wind-cold type cold of the present invention can be by following three kinds of methods preparation, and concrete steps are:
Method one: the airtight preservation of cold reducing-fever extract that (1) drying obtains is standby; Sour agent, alkaline agent, binding agent pulverize separately are crossed the 80-100 mesh sieve, and airtight preservation is standby; Sweeting agent and aromatic were pulverized the 100-120 mesh sieve, and lubricant was pulverized the 140-200 mesh sieve; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; (2) press required proportioning with cold reducing-fever extract and sour agent mix homogeneously, or add sweeting agent again or/and the aromatic mix homogeneously gets powders A 1; (3), get powder B1 with the alkaline agent mix homogeneously; (4) powders A 1 is mixed with powder B1, add lubricant, fully mixing; (5) with the 4th step gained mixed-powder tabletting, obtain required effervescence tablet for treating wind-cold type cold.
Method two: the airtight preservation of cold reducing-fever extract that (1) drying obtains is standby; Sour agent, alkaline agent, binding agent pulverize separately are crossed the 80-100 mesh sieve, and airtight preservation is standby; Sweeting agent and aromatic were pulverized the 100-120 mesh sieve, and lubricant was pulverized the 140-200 mesh sieve; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; (2) press required proportioning with cold reducing-fever extract and sour agent mix homogeneously, or add sweeting agent again, get granule A2 or/and the aromatic mix homogeneously is granulated; (3), granulate with the alkaline agent mix homogeneously; Get granule B2; (4) granule A2 is mixed with granule B2, add lubricant, fully mixing; (5) with the 4th step gained hybrid particles tabletting, obtain required effervescence tablet for treating wind-cold type cold.
Method three: the airtight preservation of cold reducing-fever extract that (1) drying obtains is standby; Sour agent, alkaline agent, binding agent pulverize separately are crossed the 80-100 mesh sieve, and airtight preservation is standby; Sweeting agent and aromatic were pulverized the 100-120 mesh sieve, and lubricant was pulverized the 140-200 mesh sieve; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; (2) press required proportioning with cold reducing-fever extract and sour agent mix homogeneously, or add sweeting agent again or/and the aromatic mix homogeneously gets powders A 3; (3), get powder B3 with the alkaline agent mix homogeneously; (4) powders A 3 is mixed with powder B3, add lubricant, fully mixing; (5) the 4th step gained mixed-powder is added non-aqueous solution (as ethanol, isopropyl alcohol etc.) pelletizing press sheet, obtain required effervescence tablet for treating wind-cold type cold.
Experimental example:
The cold reducing-fever extract 80g that the drying of learning from else's experience respectively obtains, the citric acid 50g that pulverized 100 mesh sieves, sodium bicarbonate 55g, low-substituted hydroxypropyl cellulose (L-HPC) 10g, the PEG40005g that pulverized 120 mesh sieves make the effervescence tablet for treating wind-cold type cold of about 4g/ sheet by above-mentioned three kinds of preparation methoies, in the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%.Prepared effervescence tablet for treating wind-cold type cold is with reference to " 2000 editions one appendix XII A of Chinese pharmacopoeia inspection technique disintegration detects, and the result is up to specification.
Check result disintegration of three kinds of preparation method gained effervescence tablet for treating wind-cold type cold
| Method | Disintegration (min) |
| Method one (not adding the L-HPC solid sheet) method one (adding the L-HPC solid sheet) method one (adding the L-HPC ring segment) method two (not adding the L-HPC solid sheet) method two (adding the L-HPC solid sheet) method two (adding the L-HPC ring segment) method three (not adding the L-HPC solid sheet) method three (adding the L-HPC solid sheet) method three (adding the L-HPC ring segment) | 4.2±0.4 4.0±0.3 3.2±0.2 4.5±0.3 4.2±0.3 3.2±0.3 4.4±0.3 4.3±0.6 3.1±0.5 |
An important feature of the present invention is that the tablet speed commonly used that has added other in the pelletization collapses agent (also having the binding agent effect concurrently) as low-substituted hydroxypropyl cellulose (L-HPC), as can be seen from the table, prepare effervescence tablet for treating wind-cold type cold by above-mentioned three kinds of methods, the effervescent tablet that adds L-HPC is shorter than the effervescent tablet disintegration time that does not add L-HPC, and can significantly improve disintegration rate after making annular effervescent tablet.
Other gets above-mentioned raw materials, is pressed into the annular effervescence tablet for treating wind-cold type cold of being made up of connecting band between some bursts and the burst.Contrast disintegration with common annular effervescence tablet for treating wind-cold type cold:
| Method | Disintegration (min) |
| Method one (not adding the common ring segment of L-HPC) method one (not adding L-HPC with the ring segment of burst) method one (adding the common ring segment of L-HPC) method one (adding L-HPC with the ring segment of burst) | 3.5±0.3 1.8±0.2 3.2±0.2 1.8±0.3 |
| Method two (not adding the common ring segment of L-HPC) method two (not adding L-HPC with the ring segment of burst) method two (adding the common ring segment of L-HPC) method two (adding L-HPC with the ring segment of burst) | 3.3±0.4 1.8±0.3 3.2±0.3 1.5±0.3 |
In the above-mentioned preparation method, granulating process can adopt methods such as wet granulation, dry granulation, one-step palletizing when big production.
The effervescent tablet of preparation health:
(1) it is standby to get the airtight preservation of vitamin C 10g.Citric acid 150g, sodium bicarbonate 100g, sodium carbonate 10g pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Aspartame 8g and essence 1g pulverized 100 mesh sieves, and PEG 6000 21g pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With vitamin C and citric acid mix homogeneously, add steviosin and essence mix homogeneously by required proportioning again, granulate, get granule A; With sodium bicarbonate, sodium carbonate mix homogeneously, granulate, get granule B; Granule A is mixed with granule B, add PEG 6000, fully mixing; The gained hybrid particles is divided into identical two parts, and tabletting gets 50 of 50 of solid effervescent tablets of vitamin C and vitamin C annular effervescent tablets.
Adopt method for preparing other than ring type be that solid vitamin C effervescent tablet and vitamin C annular effervescent tablet is about the 3g/ sheet, the outer ring diameter of wherein annular effervescent dosage form is 20 millimeters, interior ring diameter is 8 millimeters.
(2) the airtight preservation of extracting lactic acid calcium 10g is standby.Citric acid 150g, sodium bicarbonate 100g, sodium carbonate 10g pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Aspartame 8g and essence 1g pulverized 100 mesh sieves, and PEG 6000 2lg pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With calcium lactate and citric acid mix homogeneously, add steviosin and essence mix homogeneously by required proportioning again, granulate, get granule A; With sodium bicarbonate, sodium carbonate mix homogeneously, granulate, get granule B; Granule A is mixed with granule B, add PEG 6000, fully mixing; The gained hybrid particles is divided into identical two parts, and tabletting gets 50 of 50 of solid effervescent tablets of calcium lactate and calcium lactate annular effervescent tablets.
Adopt method for preparing other than ring type be that solid calcium lactate effervescent tablet and calcium lactate annular effervescent tablet is about the 3g/ sheet, the outer ring diameter of wherein annular effervescent dosage form is 20 millimeters, interior ring diameter is 8 millimeters.
With reference to " 2000 editions one appendix XII A of Chinese pharmacopoeia inspection technique disintegration is checked, 25 ℃ of a slice effervescent tablet inputs are filled in the 250ml beaker of 200ml water, there are a large amount of bubbles to emit immediately, tablet dissolves, is scattered in the water rapidly, formed even or clear solution in 5 minutes, it is left not have accumulative granule.Check respectively 6 all qualified, the result is up to specification.
Check result disintegration of two kinds of vitamin C effervescent tablets
| Method | Disintegration (min) |
| Solid vitamin C effervescent tablet annular vitamin C effervescent tablet | 0.44±0.4 0.40±0.4 |
Check result disintegration of two kinds of calcium lactate effervescent tablets
| Method | Disintegration (min) |
| Solid calcium lactate effervescent tablet annular calcium lactate effervescent tablet | 0.72±0.4 0.67±0.4 |
As can be known from the results, the vitamin C effervescent tablet of health, calcium lactate effervescent tablet, do not relate to curative effect, every contained vitamin C or calcium lactate are less, and there is not the interference of the multiple stickum such as pectin class, saccharide, polysaccharide of Chinese medicine, so disintegration rate is fast, there is not the slow technical barrier of similar Chinese medicine effervescent tablet disintegration rate.The effervescent tablet of health is prepared into the effect that annular has only novelty attractive in appearance, adopts annular and other than ring type vitamin C or calcium lactate effervescent tablet, it is limited to compare the disintegration rate raising, does not have obvious technological progress.
The dose of Western medicine is less, and is similar with vitamin C, the calcium lactate effervescent tablet of health aspect the disintegration rate raising, and annular is compared the disintegration rate raising with other than ring type Western medicine effervescent tablet limited, do not have obvious technological progress.
The present invention uses the modern pharmaceutical technology, it is carried out the dosage form process modification, thereby obtain a kind of effervescence tablet for treating wind-cold type cold, many weak points of original dosage form have been remedied, and make it become a kind of production technology by optimization more to become fully rationally, quality is easy to control, and drug release rate is fast, the bioavailability height carries, the cold reducing-fever new formulation of taking convenience.
Each burst and connecting band can will be stamped to form after the medicated powder filling by the corresponding mould of design, and the realization of this technology can just can be finished by corresponding simple mould design.
The disintegration rate of solid Chinese medicine effervescent reaches several minutes, compare advantage with Chinese medicine granules not outstanding, its practicality is very poor, has limited the application of solid Chinese medicine effervescent, and Here it is does not see one of major reason of Chinese medicine being made oral annular effervescent dosage form report for a long time.When annular Chinese medicine effervescent dosage form was compared the obvious raising of disintegration rate with solid effervescent tablet after, its practicality improved greatly, can satisfy the demand of consumption market.Because health care products effervescent dosage form and Western medicine effervescent dosage form are very fast because of self Material Characteristics disintegrate, health care products effervescent dosage form and Western medicine effervescent dosage form are made the technical meaning that ring segment further improves disintegration rate do not give prominence to.But to the Chinese medicine effervescent tablet, be made into annular, but can improve disintegration rate greatly, significant, the annular Chinese medicine effervescent tablet of disintegrate had both met national standard in two minutes even in one minute, can satisfy patient's demand easy to use again; Need the disintegrate of 4-5 minute ability to compare with solid Chinese medicine effervescent tablet, the commercial value of annular Chinese medicine effervescent tablet aspect the disintegrate convenience is higher.
Specific embodiment
Embodiment 1
1, the preparation of cold reducing-fever extract: get 160 parts of 200 parts of Herba Schizonepetaes, 60 parts of Herba Menthaes, 100 parts of Radix Saposhnikoviaes, 100 parts of Radix Bupleuri, 60 parts of Folium Perillaes, 100 parts of Radix Puerariaes, 60 parts of Radix Platycodoniss, 80 parts of Semen Armeniacae Amarums, 60 parts of the Radixs Angelicae Dahuricae, 200 parts of Herba Corydalis Bungeanaes, Rhizoma Phragmitis totally ten simply.Get Herba Schizonepetae, Herba Menthae, Folium Perillae extraction volatile oil, the aqueous solution after distillation device is in addition collected; Eight flavors such as medicinal residues and all the other Radix Saposhnikoviaes decoct with water secondary, and each 1.5 hours, collecting decoction filtered, and filtrate and above-mentioned aqueous solution merge.Amalgamation liquid is evaporated to the medicinal liquid that relative density is 1.08～1.10 (55 ℃), and spray drying is made dry extract, gets dry extract, adds a small amount of dextrin again and wraps up above-mentioned volatile oil, behind the dry extract mixing, promptly gets 77 parts of cold reducing-fever extracts.To adopt be drying under reduced pressure or spray drying to the drying of extract in the technology.The drying under reduced pressure temperature is controlled at 50-80 ℃, and the best is 60 ℃.Obtain 77 parts of cold reducing-fever extracts altogether, yield 6.5%.
2, preparation cold reducing-fever effervescent solid sheet (100)
The prescription proportioning:
Cold reducing-fever extract 130g citric acid 115g
Steviosin 3g essence 1g
Sodium bicarbonate 95g sodium carbonate 10g
Sodium carboxymethyl cellulose 25g PEG 6000 21g
3, preparation method
The airtight preservation of cold reducing-fever extract that drying obtains is standby; Citric acid, sodium bicarbonate, sodium carbonate, low-substituted hydroxypropyl cellulose pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Steviosin and essence were pulverized 100 mesh sieves, and PEG 6000 pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With cold reducing-fever extract and citric acid mix homogeneously, add steviosin and essence mix homogeneously by required proportioning again, get powders A 1; With sodium bicarbonate, sodium carbonate mix homogeneously, get powder B1; Powders A 1 is mixed with powder B1, add low-substituted hydroxypropyl cellulose, PEG 6000, fully mixing; Be pressed into solid sheet, get 100 of effervescence tablet for treating wind-cold type cold.
The average sheet of gained effervescence tablet for treating wind-cold type cold heavily is 4.00 ± 0.04g, any surface finish, exquisiteness.With reference to " 2000 editions one appendix XII A of Chinese pharmacopoeia inspection technique disintegration is checked this product, 25 ℃ of a slice effervescent tablet inputs are filled in the 250ml beaker of 200ml water, there are a large amount of bubbles to emit immediately, tablet dissolves, is scattered in the water rapidly, formed light yellow transparent solution in 6 minutes, it is left not have accumulative granule.
Embodiment 2
1, the preparation of cold reducing-fever extract: with embodiment 1.
2, cold reducing-fever annular effervescent tablet (100)
The prescription proportioning:
Cold reducing-fever extract 95g tartaric acid 150g
Cyclamate 5g essence 2g
Sodium bicarbonate 80g PEG 4000 5g
Polyvinylpolypyrrolidone 30g PVP 33g
3, preparation method
The airtight preservation of cold reducing-fever extract that drying obtains is standby; Tartaric acid, sodium bicarbonate, microcrystalline Cellulose pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Cyclamate and essence were pulverized 100 mesh sieves, and PEG 4000 pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With cold reducing-fever extract and tartaric acid mix homogeneously, add cyclamate and essence mix homogeneously by required proportioning again, get powders A 2; With the sodium bicarbonate mix homogeneously, get powder B2; Powders A 2 is mixed with powder B2, add microcrystalline Cellulose, PEG 4000, fully mixing; The gained mixed-powder is granulated with the alcoholic solution of 3% PVP, tabletting, 100 of cold reducing-fever annular effervescent tablets.
The average sheet of gained cold reducing-fever annular effervescent tablet heavily is 4.02 ± 0.03g, any surface finish, exquisiteness.With reference to " 2000 editions one appendix XII A of Chinese pharmacopoeia inspection technique disintegration is checked this product, 25 ℃ of a slice effervescent tablet inputs are filled in the 250ml beaker of 200ml water, there are a large amount of bubbles to emit immediately, tablet dissolves, is scattered in the water rapidly, formed light yellow transparent solution in 5 minutes, it is left not have accumulative granule.Check 6 all qualified, the result is up to specification.
Embodiment 3
1, the preparation of cold reducing-fever extract: with embodiment 1.
2, preparation cold reducing-fever annular effervescent tablet (100)
The prescription proportioning:
Cold reducing-fever extract 65g malic acid 40g citric acid 115g
Aspartame 5g acesulfame potassium 3g essence 2g
Sodium bicarbonate 30g potassium carbonate 90g
Crospolyvinylpyrrolidone 35g magnesium stearate 15g
3, preparation method
The airtight preservation of cold reducing-fever extract that drying obtains is standby; Malic acid, citric acid, sodium bicarbonate, potassium carbonate, crospolyvinylpyrrolidone pulverize separately are crossed 100 mesh sieves, and airtight preservation is standby; Acesulfame potassium and essence were pulverized 100 mesh sieves, and magnesium stearate was pulverized 140 mesh sieves; In the preparation process control preparation ambient temperature at 25 ℃, humidity below 45%; With cold reducing-fever extract and malic acid mix homogeneously, add aspartame, acesulfame potassium and essence mix homogeneously by required proportioning again, granulate, get granule A3; With sodium bicarbonate, potassium carbonate mix homogeneously, granulate, get granule B3; Granule A3 is mixed with granule B3, add crospolyvinylpyrrolidone, magnesium stearate, fully mixing; Tabletting gets 100 of cold reducing-fever annular effervescent tablets.
The average sheet of gained effervescence tablet for treating wind-cold type cold heavily is 3.99 ± 0.04g, any surface finish, exquisiteness.With reference to " 2000 editions one appendix XII A of Chinese pharmacopoeia inspection technique disintegration is checked this product, 25 ℃ of a slice effervescent tablet inputs are filled in the 250ml beaker of 200ml water, there are a large amount of bubbles to emit immediately, tablet dissolves, is scattered in the water rapidly, formed light yellow transparent solution in 5 minutes, it is left not have accumulative granule.Check 6 all qualified, the result is up to specification.
Embodiment 4
Effervescence tablet for treating wind-cold type cold, the composition of this effervescent tablet comprise cold reducing-fever extract, disintegrating agent and other adjuvant.
(1) cold reducing-fever extract is wherein made by the following weight Chinese medicinal raw materials: Herba Schizonepetae 240, Herba Menthae 20, Radix Saposhnikoviae 140, Radix Bupleuri 60, Folium Perillae 80, Radix Puerariae 140, Radix Platycodonis 20, Semen Armeniacae Amarum 120, the Radix Angelicae Dahuricae 20, Herba Corydalis Bungeanae 240, Rhizoma Phragmitis 120.It is stand-by to obtain the cold reducing-fever extract by the method for embodiment 1, and wherein cold reducing-fever extract extraction ratio is 6.8%, and promptly 6.8g cold reducing-fever extract is equivalent to the 100g raw material of Chinese medicine.
(2) effervescence tablet for treating wind-cold type cold, each constituent proportioning is by weight:
Get 50 parts of cold reducing-fever extracts, disintegrating agent comprises 30 parts of sour agent, 30 parts of alkaline agents, 15 parts of lubricants, 10 parts of sweeting agents.
Sweeting agent is selected from 4 parts of steviosin, 2 parts of acesulfame potassiums, 4 parts of aspartames; The acid agent is selected from 14 parts of malic acids, 16 parts of anhydrous citric acids; Alkaline agent is selected from 15 parts of sodium bicarbonate, 15 parts of calcium bicarbonate; Lubricant is selected from 5 parts of sodium lauryl sulphates, 10 parts of magnesium stearate.All the other repeat embodiment 1,2,3 respectively.
Embodiment 5
(1) cold reducing-fever extract is wherein made by the following weight Chinese medicinal raw materials: Herba Schizonepetae 160, Herba Menthae 80, Radix Saposhnikoviae 60, Radix Bupleuri 140, Folium Perillae 20, Radix Puerariae 60, Radix Platycodonis 80, Semen Armeniacae Amarum 40, the Radix Angelicae Dahuricae 100, Herba Corydalis Bungeanae 160, Rhizoma Phragmitis 200.It is stand-by to obtain the cold reducing-fever extract by the method for embodiment 1, and wherein cold reducing-fever extract extraction ratio is 7.1%, and promptly 7.1g cold reducing-fever extract is equivalent to the 100g raw material of Chinese medicine.
(2) effervescence tablet for treating wind-cold type cold, each constituent proportioning is by weight:
Get 1 part of above-mentioned stand-by cold reducing-fever extract, disintegrating agent comprises 10 parts of sour agent, 10 parts of alkaline agents, 15 parts of binding agents, 5 parts of aromatic.
Aromatic wherein is selected from 2 parts of orange essences, 3 parts of flavoring orange essences.The acid agent is selected from 6 parts of citric acids, 4 parts in tartaric acid; Alkaline agent is selected from 2 parts of potassium carbonate, 1 part of potassium bicarbonate, 4 parts of sodium carbonate, 3 parts of sodium bicarbonate; Binding agent is selected from 10 parts of microcrystalline Cellulose, 5 parts of polyvinylpyrrolidones (PVP).All the other repeat embodiment 1,2,3 respectively.
Embodiment 6
Effervescence tablet for treating wind-cold type cold, each constituent proportioning is by weight: get 20 parts of cold reducing-fever extracts, disintegrating agent comprises 20 parts of sour agent, 20 parts of alkaline agents, 3 parts of binding agents, 4 parts of lubricants, 6 parts of sweeting agents, 3 parts of aromatic.
Sweeting agent is selected from 2 parts of steviosin, 2 parts of sucrose, 2 parts of Calcium o-benzolsulfimides; Aromatic is selected from respectively 1 part of Herba Menthae essence, Fructus Citri Limoniae essence, flavoring banana essence; The acid agent is selected from 10 parts in tartaric acid, 10 parts of malic acids; Alkaline agent is selected from 15 parts of sodium bicarbonate, 5 parts of sodium carbonate; Binding agent is selected from 1 part of microcrystalline Cellulose (MCC), 2 parts of crospolyvinylpyrrolidone (PVPP); Lubricant is selected from 3 parts of sodium lauryl sulphates, silica 1 part.All the other are with embodiment 3.
Embodiment 7
Get the effervescence tablet for treating wind-cold type cold of embodiment 1,2,3,4,5,6, it is prepared into outer ring diameter respectively is 30 millimeters, and interior ring diameter is 3 millimeters a ring segment.
Embodiment 8
Get the effervescence tablet for treating wind-cold type cold of embodiment 1,2,3,4,5,6, it is prepared into outer ring diameter respectively is 20 millimeters, and interior ring diameter is 8 millimeters a ring segment.
Embodiment 9
Get the effervescence tablet for treating wind-cold type cold of embodiment 1,2,3,4,5,6, it is prepared into outer ring diameter respectively is 25 millimeters, and interior ring diameter is 5 millimeters a ring segment.
Embodiment 10
Get the effervescence tablet for treating wind-cold type cold of embodiment 1,2,3,4,5,6, it is prepared into annular respectively forms, be provided with the ring segment of the connecting band of easy fracture between each burst by some bursts.
Claims (5)
1, a kind of effervescence tablet for treating wind-cold type cold, the composition that it is characterized in that this effervescent tablet comprises cold reducing-fever extract, disintegrating agent and other adjuvant, and cold reducing-fever extract is wherein made by the following weight Chinese medicinal raw materials: Herba Schizonepetae 160-240, Herba Menthae 20-80, Radix Saposhnikoviae 60-140, Radix Bupleuri 60-140, Folium Perillae 20-80, Radix Puerariae 60-140, Radix Platycodonis 20-80, Semen Armeniacae Amarum 40-120, Radix Angelicae Dahuricae 20-100, Herba Corydalis Bungeanae 160-240, Rhizoma Phragmitis 120-200.
2, effervescence tablet for treating wind-cold type cold as claimed in claim 1 is characterized in that the cold reducing-fever extract made by the following weight Chinese medicinal raw materials: Herba Schizonepetae 200, Herba Menthae 60, Radix Saposhnikoviae 100, Radix Bupleuri 100, Folium Perillae 60, Radix Puerariae 100, Radix Platycodonis 60, Semen Armeniacae Amarum 80, the Radix Angelicae Dahuricae 60, Herba Corydalis Bungeanae 200, Rhizoma Phragmitis 160.
3, effervescence tablet for treating wind-cold type cold as claimed in claim 1, it is characterized in that each constituent proportioning is by weight: cold reducing-fever extract 1-50 part, disintegrating agent comprises sour agent 10-30 part, alkaline agent 10-30 part, other adjuvant comprises binding agent 0-15 part, lubricant 0-15 part, sweeting agent 0-10 part, aromatic 0-5 part.
4,, it is characterized in that prepared effervescent tablet profile is annular as claim 1 or 2 or 3 described effervescence tablet for treating wind-cold type cold.
5, effervescence tablet for treating wind-cold type cold as claimed in claim 4 is characterized in that the annular of effervescence tablet for treating wind-cold type cold is made up of some bursts; Be provided with the connecting band of easy fracture between each burst.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100195231A CN100546570C (en) | 2005-09-30 | 2005-09-30 | Effervescence tablet for treating wind-cold type cold |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100195231A CN100546570C (en) | 2005-09-30 | 2005-09-30 | Effervescence tablet for treating wind-cold type cold |
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| Publication Number | Publication Date |
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| CN1762475A true CN1762475A (en) | 2006-04-26 |
| CN100546570C CN100546570C (en) | 2009-10-07 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101219193B (en) * | 2008-01-15 | 2012-05-23 | 陆小左 | Medicament for clearing heat, eliminating phlegm and relieving cough |
| JP2015156854A (en) * | 2014-01-21 | 2015-09-03 | 株式会社東洋新薬 | Bottled beverage |
-
2005
- 2005-09-30 CN CNB2005100195231A patent/CN100546570C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101219193B (en) * | 2008-01-15 | 2012-05-23 | 陆小左 | Medicament for clearing heat, eliminating phlegm and relieving cough |
| JP2015156854A (en) * | 2014-01-21 | 2015-09-03 | 株式会社東洋新薬 | Bottled beverage |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100546570C (en) | 2009-10-07 |
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Granted publication date: 20091007 Termination date: 20120930 |