CN1215861C - Xiasangju effervescent tablet and its preparing process - Google Patents
Xiasangju effervescent tablet and its preparing process Download PDFInfo
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- CN1215861C CN1215861C CN 02149751 CN02149751A CN1215861C CN 1215861 C CN1215861 C CN 1215861C CN 02149751 CN02149751 CN 02149751 CN 02149751 A CN02149751 A CN 02149751A CN 1215861 C CN1215861 C CN 1215861C
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Abstract
The present invention relates to a brunella vulgaris Llinne, mulberry leaf and wild chrysanthemum flower effervescent tablet comprising three traditional Chinese medicine ingredients of brunella vulgaris Llinne, mulberry leaf and wild chrysanthemum flower and a preparation method thereof. The brunella vulgaris Llinne, mulberry leaf and wild chrysanthemum flower effervescent tablet comprise ingredients of the following general proportion: 12 to 18 parts by weight of powdered extract of the brunella vulgaris Llinne, the mulberry leaf and the wild chrysanthemum flower, 0.03 to 0.1 part by weight of volatile oil of the wild chrysanthemum flower, disintegrant, 2 to 5 parts by weight of lubricant and 0 to 10 parts by weight of sweetener or / and 0 to 5 parts by weight of aromatizer, wherein the disintegrant comprises 15 to 30 parts by weight of acid agent and 40 to 60 parts by weight of alkali agent. The present invention adopts water extraction, alcohol deposition, spray drying and other processes to prepare the powdered extract of the brunella vulgaris Llinne, mulberry leaf and wild chrysanthemum flower and the volatile oil of the wild chrysanthemum flower, and then adopts a direct powder compression method to form the powdered extract of the brunella vulgaris Llinne, mulberry leaf and wild chrysanthemum flower, the volatile oil of the wild chrysanthemum flower and other auxiliary materials into the brunella vulgaris Llinne, mulberry leaf and wild chrysanthemum flower effervescent tablet. Dissolvability tests show that the whole brunella vulgaris Llinne, mulberry leaf and wild chrysanthemum flower effervescent tablet of the present invention can be dissolved into a homogeneous solution within 3 minutes by effervescence, and has the characteristics of easy swallows, high bioavailability, good tastes, sensory novelties of effervescence, high acceptability to various people, etc.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation summer Sang Ju Yin effervescent tablet and preparation technology thereof who contains Spica Prunellae, Folium Mori, Flos Chrysanthemi Indici three flavor Chinese medicine ingredients.
Technical background
Effervescent tablet is a kind of solid preparation that can produce bubble (being effervescent) rapidly behind the water and make for oral administration or external of the confession of the rapid disintegrate of tablet of putting into.Its maximum characteristics be disintegrating agent be with a kind of or several organic acid (sour agent) and a kind of or several meet acid and can produce CO
2Common composition of inorganic salt (alkaline agent), it is met waterishlogging and gives birth to the acid-base neutralization reaction and emits CO
2Make disintegration of tablet.Effervescent tablet has following characteristics as a kind of new formulation:
(1) its production, transportation, storage are solid forms, so have dosage of solid formulations accurately, characteristics such as steady quality, production automation degree height, cost be low, portable;
(2) effervescent tablet is taken facing with before being made into liquid, and liquid preparation is easy to swallow, the bioavailability height so have again, to characteristics such as GI irritation are little;
(3) its disintegrating agent is made of sour agent and alkaline agent, and disintegration is powerful, can make the rapid disintegrate of medicine become fine particle and dissolving rapidly;
(4) effervescent tablet chance water just produces bubble and seethes (being effervescent) up and down, and is interesting, satisfies people's curious psychology, is particularly useful for children taking;
(5) medicinal liquid is refrigerant good to eat, can make refreshment drink; Take medicine as the drink manna, patient Geng Yi accepts.
Spica Prunellae, Folium Mori, Flos Chrysanthemi are the traditional Chinese medicine of China.Three flavor medicines cure mainly from function that pharmacology is clinical all a lot of similar places.Modern pharmacological research shows that Spica Prunellae has effects such as blood pressure lowering, blood sugar lowering, anti-myocardial infarction and arrhythmia, antimicrobial antiphlogistic, lets out liver-fire clearly, and the effect of suppressing liver-YANG is stronger; It is stronger that Folium Mori, Flos Chrysanthemi are evacuated the effect of liver-heat, and the effect of stronger resisting pathogenic microbes is all arranged, and can enhance immunity body immunity.Three kinds of medicine compatibilities use, and are not only collaborative but also complementary, disease such as be used for the treatment of wind heat diseases caused by exogenous pathogenic factor, conjunctival congestion and swelling pain, excessive rising of liver-YANG, have a dizzy spell.
Be that the Chinese patent medicine preparation of main component mainly is the XIASANGJU KELI electuary at present, and Shang Weijian have summer Sang Ju Yin effervescent tablet and relevant report with Spica Prunellae, Folium Mori, Flos Chrysanthemi Indici three flavor Chinese medicines.
Summary of the invention
The purpose of this invention is to provide a kind of carrying and taking convenience, can be used as refreshment drink and drink, the Chinese medicine preparation of heat-clearing toxin-expelling functions is arranged---summer Sang Ju Yin effervescent tablet and preparation method thereof.
The composition of summer Sang Ju Yin effervescent tablet of the present invention comprises extract powder (being called for short summer Sang Ju Yin extract powder), Flos Chrysanthemi Indici volatile oil (abbreviation volatile oil) and disintegrating agent, the lubricant of Spica Prunellae, Folium Mori and Flos Chrysanthemi Indici; Can add sweeting agent again in the composition or/and aromatic, to improve taste and mouthfeel.
Each constituent proportioning (mass ratio) of summer Sang Ju Yin effervescent tablet of the present invention is generally: summer Sang Ju Yin extract powder 12-18, volatile oil 0.03-0.1, disintegrating agent comprise sour agent 15-30 and alkaline agent 40-60, lubricant 2-5, sweeting agent 0-10, aromatic 0-5.
Usually, every 100g summer Sang Ju Yin extract powder is equivalent to this three flavors Chinese medicine (mass ratio is: Spica Prunellae 20-70 part, Folium Mori 12-30 part, Flos Chrysanthemi Indici 5-20 part) 1100-1450g; Every 0.9g (1ml) volatile oil is equivalent to Flos Chrysanthemi Indici 400-450g.
Disintegrating agent is made of sour agent and alkaline agent; The acid agent can be selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid and the sodium dihydrogen citrate salt; Alkaline agent can be selected from sodium carbonate or/and sodium bicarbonate.
Lubricant is optional from Polyethylene Glycol 6000 or Macrogol 4000.
Sweeting agent can be selected from one or more in cyclamate, steviol glycosides, aspartame, protein sugar and the sucrose.
Aromatic can be selected from orange essence, flavoring orange essence, Herba Menthae essence or Fructus Citri Limoniae essence etc.
Summer Sang Ju Yin effervescent tablet of the present invention can prepare by the following method, and concrete steps are:
(1) the spray-dried airtight preservation of summer Sang Ju Yin extractum powder that obtains is standby; Sour agent, alkaline agent in 105-120 ℃ of dry 2-4 hour, were pulverized the 100--120 mesh sieve, and airtight preservation is standby; Sweeting agent and aromatic were pulverized the 100-120 mesh sieve, and lubricant was pulverized the 140-200 mesh sieve, preserved standby in the exsiccator; In the preparation process control preparation ambient temperature and humidity respectively 25 ℃, below 45%; Carry out according to the following steps then:
(2) by required proportioning summer Sang Ju Yin extract powder is mixed with sour agent, can add sweeting agent again or/and the aromatic mix homogeneously;
(3) Flos Chrysanthemi Indici volatile oil is dissolved with a spot of dehydrated alcohol (3-8 that is generally the volatile oil volume doubly measures), in the described mixed-powder of vaporific being sprayed on (2), mix homogeneously gets powders A;
(4), get powder B with the alkaline agent mix homogeneously;
(5) powders A is mixed with powder B, add lubricant, fully mixing;
(6), obtain required summer Sang Ju Yin effervescent tablet with (5) gained mixed-powder direct compression.
Used summer Sang Ju Yin extractum and the Flos Chrysanthemi Indici volatile oil of said method can prepare by the following method:
(1) three flavor Chinese medicine proportioning is: Spica Prunellae 20-70 part, Folium Mori 12-30 part, Flos Chrysanthemi Indici 5-20 part;
(2) get Flos Chrysanthemi Indici and add 12-15 times of water gaging with multi-functional extractor heating extraction (when Flos Chrysanthemi Indici consumption during) or with the attached volatile oil extractor reflux, extract, of round-bottomed flask (when the Flos Chrysanthemi Indici consumption is less than or equal to 300g) 4-6 hour greater than 300g, collect Flos Chrysanthemi Indici volatile oil, low temperature (4 ℃) is preserved standby; Water extract filtered while hot gets filtrate A;
(3) Spica Prunellae, Folium Mori are mixed, extract twice with multi-functional extractor with water as solvent; Add for the first time and be equivalent to medical material weight 18-20 water (being called for short 18-20 doubly measures) doubly, extract 1.5h; Add for the second time the water that 12-18 doubly measures, extract 1h; Filtered while hot, merging filtrate gets liquor B;
(4) the filtrate A and the B of the above-mentioned gained of merging; Being concentrated into medicine liquid volume is 1: 1.5~3 with total medical material weight ratio, and medicinal liquid is spent the night in 4 ℃ of cold preservations;
(5) (4) gained cold preservation liquid is centrifugal, get supernatant, under constantly stirring, add ethanol to containing the alcohol amount for 50-60%, spend the night in 4 ℃ of cold preservations;
(6) (5) gained cold preservation liquid is centrifugal, get supernatant, under constantly stirring, add ethanol to containing the alcohol amount for 70-75%, spend the night in 4 ℃ of cold preservations;
(7) (6) gained cold preservation liquid is centrifugal, get supernatant, reclaiming ethanol to medicine liquid volume and medical material weight ratio is 2-5: 1, use the spray dryer drying, get brown, bulk extract powder.
The effervescent effect of summer Sang Ju Yin effervescent tablet of the present invention:
Effervescent tablet is dropped under the room temperature in the 250ml drinking water, its suspension or fall within glass at the bottom of, and emit a large amount of bubbles immediately, tablet is dissolving rapidly thereupon, forms brown clear solution in 3 minutes.
Summer Sang Ju Yin effervescent tablet of the present invention have be convenient to swallow, bioavailability height, mouthfeel are good, the easy characteristics such as acceptance of effervescent sense organ novelty, all kinds of crowd.
Compare with commercially available XIASANGJU KELI (electuary), summer Sang Ju Yin effervescent tablet of the present invention has following characteristics:
After all need dissolving, (1) two kind of dosage form takes.Granule also is difficult to molten entirely in the water of room temperature through stirring, need just solubilized of boiled water or warm water.It is solubilized that effervescent tablet only needs the water of room temperature; Effervescent tablet is dropped in the water, and disintegrating agent is wherein met water acid-base reaction is taken place at once, produces CO
2Make the rapid disintegrate of medicine become microgranule and dissolve.Dissolving only needs 3 minutes from putting into fully, need not to stir.
(2) above characteristics make the more convenient daytime dress usefulness of effervescent tablet, and bottled mineral water or pure water can reach requirement.
(3) produce a large amount of CO during the effervescent tablet effervescent
2Tablet is seethed up and down, and surrounded by bubble group, have much interest, can satisfy people's curious psychology, the easier people of allowing accepts.
(4) delicious taste can be made refreshment drink, eliminates the notion of " medicine " when taking, and the easier people of allowing accepts.
(5) sweeting agent in the summer Sang Ju Yin effervescent tablet is the low-sugar type medicine not produce the sweeting agent of heat.And commercially available XIASANGJU KELI sugar content is higher, and this has infringement to tooth, and obesity and diabetes patient should not take.
The specific embodiment
Embodiment 1
1. the preparation of summer Sang Ju Yin extractum and Flos Chrysanthemi Indici volatile oil
Three flavor medical material consumptions are: Spica Prunellae 1500g, Folium Mori 525g, Flos Chrysanthemi Indici 240g;
Flos Chrysanthemi Indici 240g is added 12 times of water gagings, use the attached volatile oil extractor reflux, extract, of 5L round-bottomed flask 5 hours, collect Flos Chrysanthemi Indici volatile oil, low temperature (4 ℃) is preserved standby.With water extract filtered while hot, get filtrate A in addition.
With Spica Prunellae 1500g, Folium Mori 525g, put into multi-functional extractor, with twice of water extraction.The water that adds for the first time 24 times of amounts extracts 1.5h; The water that adds for the second time 18 times of amounts extracts 1h, filters while hot, and filtrate merges, and gets liquor B.Merging filtrate A and B.
Above-mentioned mixing filtrate is concentrated into medicine liquid volume and the medical material total mass ratio is 1: 2.5, i.e. 920ml.Then this concentrated medicament is put in the refrigerator, 4 ℃ of cold preservations are spent the night.Gained cold preservation liquid is centrifugal, get supernatant, adding ethanol under constantly stirring is that 55%, 4 ℃ of cold preservation is spent the night to containing the alcohol amount; It is that 75%, 4 ℃ of cold preservation is spent the night that cold preservation liquid is handled to containing the alcohol amount with method again.Cold preservation liquid is centrifugal, gets supernatant, and reclaiming ethanol is 3: 1 to medicine liquid volume and medical material weight ratio, and promptly about 7000ml uses the spray dryer drying, gets brown, bulk summer Sang Ju Yin extract powder.Obtain summer Sang Ju Yin extract powder 189g altogether, yield is 8.3%; Flos Chrysanthemi Indici volatile oil 0.63ml, yield are or 0.263%.
2. prepare summer Sang Ju Yin effervescent tablet
[set of dispense ratio]:
Tartaric acid 67.8g
Sodium bicarbonate 86.4g
Sodium carbonate 86.4g
Summer Sang Ju Yin extract powder 63.0g
PEG6000 9.0g
Aspartame 2.9g
Flavoring orange essence 4.8g
Flos Chrysanthemi Indici volatile oil 0.06ml
Make 100
[preparation method]: by the said components proportioning
(1) the spray-dried airtight preservation of summer Sang Ju Yin extractum powder that obtains; In respectively at 120 ℃ of dryings 2 hours, pulverize separately is crossed 100 mesh sieves to tartaric acid, airtight preservation in 105 ℃ of dryings 2 hours, sodium bicarbonate, sodium carbonate; Aspartame and flavoring orange essence were pulverized 100 mesh sieves, and PEG6000 pulverizes 140 mesh sieves, preserved standby in the exsiccator.In the preparation process control preparation ambient temperature and humidity respectively 25 ℃, below 45%;
(2) get summer Sang Ju Yin extract powder, tartaric acid mix homogeneously, add aspartame, flavoring orange essence mix homogeneously then:
(3) Flos Chrysanthemi Indici volatile oil 0.3ml anhydrous alcohol solution, in the described mixed-powder of vaporific being sprayed on (2), mix homogeneously gets powders A;
(4), get powder B with sodium bicarbonate and sodium carbonate mix homogeneously;
(5) powders A is mixed with powder B, add PEG6000, fully mixing;
(6) mixed-powder direct compression gets 100 of summer Sang Ju Yin effervescent tablets.
The average sheet of gained summer Sang Ju Yin effervescent tablet heavily is 3.05 ± 0.09g, any surface finish, exquisiteness, light brown.A slice effervescent tablet is dropped in 25 ℃ of 250ml drinking waters, at the bottom of it is sunken to glass very soon, and emit a large amount of bubbles immediately, tablet is dissolving rapidly thereupon, forms brown clear solution in 3 minutes.
Embodiment 2
1. the preparation of summer Sang Ju Yin extractum and Flos Chrysanthemi Indici volatile oil:
Three flavor medical material consumptions are: Spica Prunellae 1500g, Folium Mori 300g, Flos Chrysanthemi Indici 300g.
Flos Chrysanthemi Indici 300g is added 10 times of water gagings, use the attached volatile oil extractor reflux, extract, of 5L round-bottomed flask 6 hours, collect Flos Chrysanthemi Indici volatile oil, low temperature (4 ℃) is preserved standby.With water extract filtered while hot, get filtrate A in addition.
Spica Prunellae 1500g and Folium Mori 300g are put into multi-functional extractor, use twice of water extraction.The water that adds for the first time 222 times of amounts extracts 1.5h; The water that adds for the second time 18 times of amounts extracts 1h, filters while hot, and filtrate merges, and gets liquor B.Merging filtrate A and B.
Above-mentioned mixing filtrate is concentrated into medicine liquid volume and the medical material total mass ratio is 1: 2.5, i.e. 840ml; Then this concentrated medicament is put in the refrigerator, 4 ℃ of cold preservations are spent the night.Gained cold preservation liquid is centrifugal, get supernatant, adding an amount of ethanol under constantly stirring is that 55%, 4 ℃ of cold preservation is spent the night to containing the alcohol amount; It is that 75%, 4 ℃ of cold preservation is spent the night that cold preservation liquid is handled to containing the alcohol amount with method again.Cold preservation liquid is centrifugal, gets supernatant, and reclaiming ethanol is 3: 1 to medicine liquid volume and medical material weight ratio, and promptly about 6000ml uses the spray dryer drying, gets brown, bulk summer Sang Ju Yin extract powder.Obtain summer Sang Ju Yin extractum 180g altogether, yield is 8.6%.Flos Chrysanthemi Indici volatile oil 0.70ml yield is 0.233%.
2. prepare summer Sang Ju Yin effervescent tablet
[set of dispense ratio]:
Anhydrous citric acid 74.2g
Sodium bicarbonate 23.2g
Sodium carbonate 115.2g
Summer Sang Ju Yin extract powder 49.5g
PEG6000 8.6g
Icing Sugar 19.2g
Cyclamate 3.8g
Orange essence 4.8g
Flos Chrysanthemi Indici volatile oil 0.07ml
Make 100
[preparation method]: by the said components proportioning
(1) the spray-dried airtight preservation of summer Sang Ju Yin extractum powder that obtains; Anhydrous citric acid in respectively at 120 ℃ of dryings 2 hours, was pulverized 100 mesh sieves, airtight preservation in 105 ℃ of dryings 3 hours, sodium bicarbonate, sodium carbonate; Icing Sugar, cyclamate and orange essence were pulverized 100 mesh sieves, and PEG6000 pulverized 140 mesh sieves, preserved standby in the exsiccator.In the preparation process control preparation ambient temperature and humidity respectively 25 ℃, below 45%;
(2) get summer Sang Ju Yin extract powder, anhydrous citric acid, Icing Sugar mix homogeneously, add cyclamate, orange essence mix homogeneously then;
(3) Flos Chrysanthemi Indici volatile oil 0.5ml anhydrous alcohol solution, in the mixed-powder with vaporific being sprayed on (2) gained, mix homogeneously gets powders A;
(4) sodium bicarbonate and sodium carbonate are mixed, get powder B;
(5) powders A is mixed with powder B, add PEG6000, fully mixing;
(6) mixed-powder direct compression gets 100 of summer Sang Ju Yin effervescent tablets.
The average sheet of gained summer Sang Ju Yin effervescent tablet heavily is 2.95 ± 0.08g, any surface finish, exquisiteness, light brown.A slice effervescent tablet is dropped in 25 ℃ of 250ml drinking waters, at the bottom of it is sunken to glass very soon, and emit a large amount of bubbles immediately, tablet is dissolving rapidly thereupon, forms brown clear solution in 3 minutes.
Claims (7)
1. summer Sang Ju Yin effervescent tablet, it is characterized in that it mainly is made up of summer Sang Ju Yin extract powder, Flos Chrysanthemi Indici volatile oil, disintegrating agent and lubricant, its proportioning by mass ratio is: summer Sang Ju Yin extract powder 12-18, volatile oil 0.03-0.1, disintegrating agent comprises sour agent 15-30 and alkaline agent 40-60, lubricant 2-5; Wherein used summer Sang Ju Yin extract powder and Flos Chrysanthemi Indici volatile oil prepare by the following method:
(1) three flavor Chinese medicine proportioning is: Spica Prunellae 20-70 part, Folium Mori 12-30 part, Flos Chrysanthemi Indici 5-20 part;
(2) get Flos Chrysanthemi Indici and add 12-15 times of water gaging with the multi-functional extractor heating extraction or with the attached volatile oil extractor reflux, extract, of round-bottomed flask 4-6 hour, the collection Flos Chrysanthemi Indici volatile oil, cryopreservation is standby; Water extract filtered while hot gets filtrate A;
(3) Spica Prunellae, Folium Mori are mixed, with twice of multi-functional extractor heating extraction of water as solvent; Add for the first time and be equivalent to medical material weight 18-20 water doubly, extract 1.5h; Add for the second time the water that 12-18 doubly measures, extract 1h; Filtered while hot, merging filtrate gets liquor B;
(4) the filtrate A and the B of the above-mentioned gained of merging; Being concentrated into medicine liquid volume is 1: 1.5~3 with total medical material weight ratio, and medicinal liquid is spent the night in 4 ℃ of cold preservations;
(5) (4) gained cold preservation liquid is centrifugal, get supernatant, under constantly stirring, add ethanol to containing the alcohol amount for 50-60%, spend the night in 4 ℃ of cold preservations;
(6) (5) gained cold preservation liquid is centrifugal, get supernatant, under constantly stirring, add ethanol to containing the alcohol amount for 70-75%, spend the night in 4 ℃ of cold preservations;
(7) (6) gained cold preservation liquid is centrifugal, get supernatant, reclaiming ethanol to medicine liquid volume and medical material weight ratio is 2-5: 1, use the spray dryer drying, get brown, bulk extract powder.
2. according to the described effervescent tablet of claim 1, it is characterized in that wherein disintegrating agent acid agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid and the sodium dihydrogen citrate salt, alkaline agent is selected from sodium carbonate or/and sodium bicarbonate; Lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
3. according to the described effervescent tablet of claim 1, it is characterized in that also comprising sweeting agent or/and aromatic in its composition.
4. according to the described effervescent tablet of claim 3, it is characterized in that described sweeting agent: sweeting agent 10, aromatic 5 or/and the proportioning of aromatic by mass ratio is.
5. according to claim 3 or 4 described effervescent tablets, it is characterized in that wherein sweeting agent is selected from one or more in cyclamate, steviol glycosides, aspartame, protein sugar and the sucrose; Aromatic wherein is selected from orange essence, flavoring orange essence, Herba Menthae essence or Fructus Citri Limoniae essence.
6. the preparation method of claim 1 or 2 described summer Sang Ju Yin effervescent tablets, concrete steps comprise:
(1) the spray-dried airtight preservation of summer Sang Ju Yin extract powder that obtains is standby; Sour agent, alkaline agent in 105-120 ℃ of dry 2-4 hour, were pulverized the 100-120 mesh sieve, and airtight preservation is standby; Sweeting agent and aromatic were pulverized the 100-120 mesh sieve, and lubricant was pulverized the 140-200 mesh sieve, preserved standby in the exsiccator; In the preparation process control preparation ambient temperature and humidity respectively 25 ℃, below 45%;
(2) press required proportioning with summer Sang Ju Yin extract powder and sour agent mix homogeneously;
(3) with the Flos Chrysanthemi Indici volatile oil anhydrous alcohol solution, in the described mixed-powder of vaporific being sprayed on (2), mix homogeneously gets powders A;
(4), get powder B with the alkaline agent mix homogeneously;
(5) powders A is mixed with powder B, add lubricant, fully mixing;
(6), obtain required summer Sang Ju Yin effervescent tablet with (5) gained mixed-powder direct compression.
7. the preparation method of one of claim 3-5 Sang Ju Yin effervescent tablet of described summer, concrete steps comprise:
(1) the spray-dried airtight preservation of summer Sang Ju Yin extract powder that obtains is standby; Sour agent, alkaline agent in 105-120 ℃ of dry 2-4 hour, were pulverized the 100-120 mesh sieve, and airtight preservation is standby; Sweeting agent and aromatic were pulverized the 100-120 mesh sieve, and lubricant was pulverized the 140-200 mesh sieve, preserved standby in the exsiccator; In the preparation process control preparation ambient temperature and humidity respectively 25 ℃, below 45%;
(2) press required proportioning with summer Sang Ju Yin extract powder and sour agent mix homogeneously, add sweeting agent again or/and the aromatic mix homogeneously;
(3) with the Flos Chrysanthemi Indici volatile oil anhydrous alcohol solution, in the described mixed-powder of vaporific being sprayed on (2), mix homogeneously gets powders A;
(4), get powder B with the alkaline agent mix homogeneously;
(5) powders A is mixed with powder B, add lubricant, fully mixing;
(6), obtain required summer Sang Ju Yin effervescent tablet with (5) gained mixed-powder direct compression.
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CN105456312A (en) * | 2015-12-08 | 2016-04-06 | 肇庆医学高等专科学校 | Screwtree root tea effervescent tablet and preparation method thereof |
CN105519730A (en) * | 2015-12-08 | 2016-04-27 | 肇庆医学高等专科学校 | Lysimachia christinae herbal tea effervescent tablet and preparation method thereof |
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