CN106692715A - Hangover-alleviating effervescent tablets and preparation method thereof - Google Patents
Hangover-alleviating effervescent tablets and preparation method thereof Download PDFInfo
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- CN106692715A CN106692715A CN201510460015.0A CN201510460015A CN106692715A CN 106692715 A CN106692715 A CN 106692715A CN 201510460015 A CN201510460015 A CN 201510460015A CN 106692715 A CN106692715 A CN 106692715A
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Abstract
The invention discloses a hangover-alleviating effervescent tablet. The hangover-alleviating effervescent tablet comprises the following components in parts by weight: 10 to 20 parts of the root of kudzu vine, 10 to 20 parts of mulberry, 5 to 10 parts of lalang grass rhizome, 2 to 5 parts of hawthorn, 40 to 48 parts of an effervescing agent, 2 to 5 parts of a lubricating agent, namely polyethylene glycol-6000, a proper amount of an adhesive, namely absolute ethanol containing 1 percent of povidone, and a proper amount of a flavoring agent, namely mint oil. The invention also discloses a preparation method of the hangover-alleviating effervescent tablet. The preparation method of the hangover-alleviating effervescent tablet comprises the following steps: performing dry mixing on 10 to 20 parts of the root of kudzu vine, 10 to 20 parts of mulberry, 5 to 10 parts of lalang grass rhizome, 2 to 5 parts of hawthorn and 20 to 23 parts of sodium bicarbonate; adding the absolute ethanol containing 1 percent of povidone, performing wet mixing and pelleting; adding 20 to 25 parts of citric acid, adding a proper amount of absolute ethanol, performing wet mixing and pelleting; drying ethanol by cold air; after particle granulation, spraying the mint oil and mixing uniformly; adding 2 to 5 parts of polyethylene glycol-6000 and mixing uniformly; tabletting. Compared with the existing products, the product provided by the invention can be dissolved into water quickly, enables the active components to be absorbed quickly and completely, is convenient to carry and high in stability, and has hangover-alleviating and liver-protecting effects.
Description
Technical field
The present invention relates to drug compound preparation and preparation method thereof, more particularly to one kind is relieved the effect of alcohol effervescent tablet and preparation method thereof.
Background technology
The toxicity of alcohol can add up whole body main organs, and the influence to liver is maximum, and it will also result in insobriety, and the disturbance of consciousness is driven when intoxicated and even more severely compromises traffic safety, evil of biting off one's own head society.At present, the antialcoholic drugs of in the market are mostly beverage class, and effervescent tablet as a kind of relatively new formulation, have the advantages that drug release rate is fast, dosage is small, divided dose is accurate, take with it is easy to carry.
Some are the compound formulation of several kinds of Chinese medicinal materials to current disintoxicating product, can effectively using the active ingredient in several kinds of Chinese medicinal materials.The root of kudzu vine recovers normal liver function in the power of regeneration that can pharmacologically improve liver cell of Chinese medicine, promotes choleresis, prevents fat from being piled up in liver.Mulberries have improve body immunity, enriching yin of enriching blood, promote the production of body fluid to quench thirst, liver-kidney tonifying, dry ease constipation the effects such as.Rhizoma imperatae, the effect of with cooling blood and hemostasis, reducing fever and causing diuresis.The effects such as hawthorn has stagnant disperse accumulationsization, convergence and dysentery, activates blood circulation and disperses blood clots.Therefore, antialcoholic drugs are developed from Chinese medicine has huge potentiality.
The content of the invention
Fast, easy to carry, good stability, the medicine with effects of dispelling effects of alcohol and protecting liver are absorbed it is an object of the present invention to provide one kind.
To achieve the above object, the invention provides a kind of effervescent tablet, Ingredients Weight includes：Root of kudzu vine 10-20 parts, mulberries 10-20 parts, rhizoma imperatae 5-10 parts, hawthorn 2-5 parts, effervescent agent 40-48 parts, 2 ~ 5 parts of lubricant, adhesive and appropriate flavouring.
Further, effervescent agent includes citric acid 20-25 parts, and sodium acid carbonate 20-23 parts, lubricant is 2 ~ 5 parts of PEG-4000, and adhesive is that the absolute ethyl alcohol of 1% PVP is appropriate, and flavouring is that peppermint oil is appropriate.
Further, the Ingredients Weight of effervescent tablet includes：Root of kudzu vine 10-20 parts, mulberries 10-20 parts, rhizoma imperatae 5-10 parts, hawthorn 2-5 parts, citric acid 20-25 parts, sodium acid carbonate 20-23 parts, lubricant is 2 ~ 5 parts of PEG-4000, the absolute ethyl alcohol and appropriate peppermint oil of 1% PVP.
It is another object of the present invention to provide a kind of effervesce piece preparation method, for producing a kind of compound Chinese medicinal preparation for relieving the effect of alcohol, while be easy to carry, easily absorb again, belong to instant-drink type aerogenesis tablet.
To achieve the above object, relieved the effect of alcohol effervesce piece preparation method the invention provides one kind, comprised the following steps：
A. root of kudzu vine 10-20 parts, mulberries 10-20 parts, rhizoma imperatae 5-10 parts, hawthorn 2-5 parts is taken, concentrate is extracted with ethanol, medicinal extract is condensed into vacuum rotating concentrating instrument, beat powder, it is standby；
B. take above-mentioned medicinal extract extract carried out with sodium acid carbonate 20-23 parts it is dry-mixed；
C. the absolute ethyl alcohol wet mixing containing 1% PVP is added, and is pelletized；
D. 20-25 parts of citric acid is added, adds appropriate absolute ethyl alcohol to carry out wet mixing, and pelletize；
E. cold wind volatilizes ethanol；
F. peppermint oil is sprayed after particle whole grain and is added, mixed；
G. 2 ~ 5 parts of PEG-4000 is added, is mixed；
H. compressing tablet.
The effervescent tablet and preparation method thereof that relieves the effect of alcohol that the present invention is provided, it is i.e. rapidly dissolvable in cold water the characteristics of have solid pharmaceutical preparation and liquid preparation concurrently, it is evenly distributed, beneficial to absorption, and there is peppermint oil restoring consciouness to act on, and be a kind of compound Chinese medicinal preparation of good relieving alcoholism and protecting liver.
Specific embodiment
Following examples are further illustrated to of the invention, but are never limited the scope of the present invention.The present invention is further elaborated on referring to embodiment, it should be appreciated to those skilled in the art that the present invention is not limited to these embodiments and the preparation method for using.And, those skilled in the art's description of the invention can carry out equivalent, combination, improvement or modify to the present invention, but these are intended to be included in the scope of the present invention.
Embodiment 1：
Chinese medicine material medicine and its auxiliary material are pharmaceutical grade：
（1）10 parts of the root of kudzu vine, 20 parts of mulberries, 10 parts of rhizoma imperatae, 5 parts of hawthorn are taken, concentrate is extracted with ethanol, medicinal extract is condensed into vacuum rotating concentrating instrument, powder is beaten, 20 parts of sodium acid carbonate is added, the absolute ethyl alcohol softwood processed in right amount of 1% PVP is added, cross the granulation of 16 mesh sieves, 60-70 °C of drying, 16 mesh sieve whole grains；
（2）By 20 parts of mesh sieves of mistake 20 of citric acid, appropriate absolute ethyl alcohol is added to carry out wet mixing, and pelletize；
（3）After cold wind volatilizes ethanol, peppermint oil sprinkling is added to by step（1）And step（2）In the hybrid particles for obtaining, mix；
（4）5 parts of PEG-4000 is added, is mixed；
（5）Compressing tablet gets product.
The effervescent tablet as obtained in the above method, weight ratio of constituents is 10 parts of the root of kudzu vine, 20 parts of mulberries, 10 parts of rhizoma imperatae, 5 parts of hawthorn, 20 parts of sodium acid carbonate, 20 parts of citric acid, 5 parts of PEG-4000, the absolute ethyl alcohol and appropriate peppermint oil of 1% PVP.
Peppermint oil is flavouring, thus it is possible to vary the mouthfeel of effervescent tablet, can selectivity addition.
Embodiment 2：
Chinese medicine material medicine and its auxiliary material are pharmaceutical grade：
（1）20 parts of the root of kudzu vine, 10 parts of mulberries, 5 parts of rhizoma imperatae, 2 parts of hawthorn are taken, concentrate is extracted with ethanol, medicinal extract is condensed into vacuum rotating concentrating instrument, powder is beaten, 23 parts of sodium acid carbonate is added, the absolute ethyl alcohol softwood processed in right amount of 1% PVP is added, cross the granulation of 16 mesh sieves, 60-70 °C of drying, 16 mesh sieve whole grains；
（2）By 25 parts of mesh sieves of mistake 20 of citric acid, appropriate absolute ethyl alcohol is added to carry out wet mixing, and pelletize；
（3）After cold wind volatilizes ethanol, peppermint oil sprinkling is added to by step（1）And step（2）In the hybrid particles for obtaining, mix；
（4）Add PEG-4000
2 parts, mix；
（5）Compressing tablet gets product.
The effervescent tablet as obtained in the above method, weight ratio of constituents is 20 parts of the root of kudzu vine, 10 parts of mulberries, 5 parts of rhizoma imperatae, 2 parts of hawthorn, 23 parts of sodium acid carbonate, 25 parts of citric acid, 2 parts of PEG-4000, the absolute ethyl alcohol and appropriate peppermint oil of 1% PVP.
Peppermint oil is flavouring, thus it is possible to vary the mouthfeel of effervescent tablet, can selectivity addition.
Embodiment 3：
Chinese medicine material medicine and its auxiliary material are pharmaceutical grade：
（1）15 parts of the root of kudzu vine, 15 parts of mulberries, 8 parts of rhizoma imperatae, 3 parts of hawthorn are taken, concentrate is extracted with ethanol, medicinal extract is condensed into vacuum rotating concentrating instrument, powder is beaten, 21 parts of sodium acid carbonate is added, the absolute ethyl alcohol softwood processed in right amount of 1% PVP is added, cross the granulation of 16 mesh sieves, 60-70 °C of drying, 16 mesh sieve whole grains；
（2）By 23 parts of mesh sieves of mistake 20 of citric acid, appropriate absolute ethyl alcohol is added to carry out wet mixing, and pelletize；
（3）After cold wind volatilizes ethanol, peppermint oil sprinkling is added to by step（1）And step（2）In the hybrid particles for obtaining, mix；
（4）Add PEG-4000
3 parts, mix；
（5）Compressing tablet gets product.
The effervescent tablet as obtained in the above method, weight ratio of constituents is 15 parts of the root of kudzu vine, 15 parts of mulberries, 8 parts of rhizoma imperatae, 3 parts of hawthorn, 21 parts of sodium acid carbonate, 23 parts of citric acid, 3 parts of PEG-4000, the absolute ethyl alcohol and appropriate peppermint oil of 1% PVP.
Peppermint oil is flavouring, thus it is possible to vary the mouthfeel of effervescent tablet, can selectivity addition.
It should be understood that, although by above-mentioned implementation method, invention has been described, but the present invention also has other numerous embodiments.Without departing from the spirit and scope of the present invention; those of ordinary skill in the art obviously can make various corresponding changes and deformation to the present invention, but these change and deformation should all belong to appended claims of the present invention and its in the range of equivalent protects.
Claims (4)
1. one kind is relieved the effect of alcohol effervescent tablet, it is characterised in that, by the raw material including following weight portion is blended, dry, compressing tablet is made, Ingredients Weight includes for it：Root of kudzu vine 10-20 parts, mulberries 10-20 parts, rhizoma imperatae 5-10 parts, hawthorn 2-5 parts of extract.
2. effervescent tablet as claimed in claim 1, it is characterised in that the auxiliary material includes：Effervescent agent 40-48 parts, 2 ~ 5 parts of lubricant, adhesive and appropriate flavouring.
3. effervescent tablet as claimed in claim 2, it is characterised in that the effervescent agent includes citric acid and sodium acid carbonate,
The lubricant is PEG-4000, described adhesive is the absolute ethyl alcohol of 1% PVP, the flavouring is peppermint oil, the effervescent tablet weight ratio of constituents includes root of kudzu vine 10-20 parts, mulberries 10-20 parts, rhizoma imperatae 5-10 parts, hawthorn 2-5 parts of extract, citric acid 20-25 parts, sodium acid carbonate 20-23 parts, PEG-4000 2-5 parts, the absolute ethyl alcohol and appropriate peppermint oil of 1% PVP.
4. one kind is relieved the effect of alcohol effervesce piece preparation method, it is characterised in that comprised the following steps：
A takes root of kudzu vine 10-20 parts, mulberries 10-20 parts, rhizoma imperatae 5-10 parts, hawthorn 2-5 parts, and concentrate is extracted with ethanol, and medicinal extract is condensed into vacuum rotating concentrating instrument, beats powder, standby；
B take above-mentioned medicinal extract extract carried out with sodium acid carbonate 20-23 parts it is dry-mixed；
C adds the absolute ethyl alcohol wet mixing containing 1% PVP, and pelletizes；
D adds 20-25 parts of citric acid, adds appropriate absolute ethyl alcohol to carry out wet mixing, and pelletize；
E cold wind volatilizes ethanol；
Peppermint oil is sprayed after F particle whole grains is added, mixed；
G adds 2 ~ 5 parts of PEG-4000, mixes；Compressing tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510460015.0A CN106692715A (en) | 2015-07-31 | 2015-07-31 | Hangover-alleviating effervescent tablets and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510460015.0A CN106692715A (en) | 2015-07-31 | 2015-07-31 | Hangover-alleviating effervescent tablets and preparation method thereof |
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| CN106692715A true CN106692715A (en) | 2017-05-24 |
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| CN201510460015.0A Pending CN106692715A (en) | 2015-07-31 | 2015-07-31 | Hangover-alleviating effervescent tablets and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108740681A (en) * | 2018-04-03 | 2018-11-06 | 上海长欧生物科技有限公司 | A kind of chitosan oligosaccharide effervescent tablet and preparation method thereof |
| CN111109496A (en) * | 2019-12-30 | 2020-05-08 | 重庆宫妙生物科技有限公司 | Preparation method of radix puerariae effervescent tablets |
| CN115989843A (en) * | 2022-12-07 | 2023-04-21 | 山东安然纳米实业发展有限公司 | Energy micro-bubble tablet containing ginseng adventitious roots and capable of relieving physical fatigue and preparation method thereof |
| CN116983352A (en) * | 2023-08-18 | 2023-11-03 | 云南金叁柒产业发展有限公司 | Anti-alcohol effervescent tablet and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988523A (en) * | 2012-10-25 | 2013-03-27 | 罗瑞雪 | Hawthorn and powdered kudzuvine root effervescent tablet |
-
2015
- 2015-07-31 CN CN201510460015.0A patent/CN106692715A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988523A (en) * | 2012-10-25 | 2013-03-27 | 罗瑞雪 | Hawthorn and powdered kudzuvine root effervescent tablet |
Non-Patent Citations (1)
| Title |
|---|
| 顾奎琴等: "《解酒护肝饮食指导》", 30 September 2008, 青岛出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108740681A (en) * | 2018-04-03 | 2018-11-06 | 上海长欧生物科技有限公司 | A kind of chitosan oligosaccharide effervescent tablet and preparation method thereof |
| CN111109496A (en) * | 2019-12-30 | 2020-05-08 | 重庆宫妙生物科技有限公司 | Preparation method of radix puerariae effervescent tablets |
| CN115989843A (en) * | 2022-12-07 | 2023-04-21 | 山东安然纳米实业发展有限公司 | Energy micro-bubble tablet containing ginseng adventitious roots and capable of relieving physical fatigue and preparation method thereof |
| CN116983352A (en) * | 2023-08-18 | 2023-11-03 | 云南金叁柒产业发展有限公司 | Anti-alcohol effervescent tablet and preparation method thereof |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20170524 |