CN105519730A - Lysimachia christinae herbal tea effervescent tablet and preparation method thereof - Google Patents
Lysimachia christinae herbal tea effervescent tablet and preparation method thereof Download PDFInfo
- Publication number
- CN105519730A CN105519730A CN201510903295.8A CN201510903295A CN105519730A CN 105519730 A CN105519730 A CN 105519730A CN 201510903295 A CN201510903295 A CN 201510903295A CN 105519730 A CN105519730 A CN 105519730A
- Authority
- CN
- China
- Prior art keywords
- desmodium
- effervescent tablet
- cold tea
- acid
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a lysimachia christinae herbal tea effervescent tablet and a preparation method thereof. The effervescent tablet consists of the following components in parts by weight: 1-5 parts of lysimachia christinae extract powder, 1-10 parts of filler, 5-20 parts of disintegrant, and 0.2-1 part of lubricant. The filler is one or several kinds of the lactose, soluble starch or sucrose. The disintegrant is a combination of acid agent and alkali agent at a weight ratio of 2 : 1. The acid agent is selected from one or several kinds of tartaric acid, malic acid, anhydrous citric acid, citrus medica acid, citric acid or citric acid mono-sodium salt, and the alkaline agent is selected from one or several kinds of sodium carbonate or sodium bicarbonate. The lubricant is selected from polyethylene glycol 6000 or polyethylene glycol 4000. The effervescent tablet is obtained by mixing each of the components according to the prescription amount. The effervescent tablet is easy for use, greatly retains the pharmaceutical activity of the lysimachia christinae, and is more easily absorbed.
Description
Technical field
The invention belongs to food processing technology field, be specifically related to a kind of desmodium cold tea effervescent tablet and preparation method thereof.
Background technology
Desmodium is a kind of folks of china Chinese traditional herbs, one of cold tea that Cantonese often drinks.Herb contains the active ingredient that Quercetin, isoquercitin, Kaempferide, Hyperoside, trifolin, linarin, aurantiamarin etc. have certain pharmacological action.Modern pharmacological research shows, desmodium has invigorating gallbladder and removing gall-stone, diuresis and stone expeling, antibacterial, the pharmacological action such as anti-inflammatory and analgesia.There is heat-clearing, detoxify, relieve summer heat and dry, lower stomach thorn heat, diuresis, cool blood, drink during especially applicable summer.
At present, the use for desmodium generally still rests on traditional cold tea and decocts, and use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of desmodium is obviously reduced simultaneously, greatly hinders the promotion and application of desmodium.Therefore, at present in the urgent need to providing a kind of desmodium health drink of conveniently drinking, to adapt to the demand of consumers in general, the quality of life of people is significantly promoted.
Effervescent tablet is a kind of tablet containing gas-producing disintegrant.The mixture of so-called gas-producing disintegrant normally organic acid and sodium carbonate, sodium acid carbonate (sodium bicarbonate); The dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react; But after effervescent tablet puts into water, two kinds of material generation acid-base reactions, produce great amount of carbon dioxide, make the rapid disintegration of tablet and thawing, and the bubble that disintegration sometimes produces also can make tablet roll up and down in water, accelerates its disintegration and thawing.The carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, has the aesthetic feeling as carbonated drink when drinking-water is drunk in entrance.At present, effervescent tablet is at home and abroad widely used, and common are oral effervescent tablet, vagina effervescence; Have also appeared Traditional Chinese medicine foot-bath effervescent tablet etc. in recent years.
Cold tea is as Chinese tradition drink, and the cold tea paving big and small in In Guangdong Province is seen everywhere, and pouplarity has some idea of.But traditional herb tea decocts to waste time and energy, the rhythm of life of urbanite is but more and more faster now, and younger generation few people are ready to buy specially a watt pot and spend several hours and go decoction one to take cold tea.Therefore, effervescent tablet preparation formulation and traditional herb tea are organically combined, are convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of cold tea greatly.
Summary of the invention
Use habit for current cold tea of the present invention, proposes a kind of novel desmodium cold tea effervescent tablet, solves the technological deficiency that traditional desmodium cold tea is loaded down with trivial details, consuming time in use.
Another object of the present invention is to the preparation method that described desmodium cold tea effervescent tablet is provided.
The present invention realizes especially by following technical scheme:
A kind of desmodium cold tea effervescent tablet, comprises following component: Lysimachia tea extract powder 1 ~ 5 part, filler 1 ~ 10 part, disintegrant 5 ~ 20 parts, lubricant 0.2 ~ 1 part by weight.
Wherein said filler is selected from one or more in lactose, water soluble starch or sucrose.
Described disintegrant is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium acid carbonate.
Described lubricant is selected from Macrogol 6000 or Macrogol 4000.
Described Lysimachia tea extract powder is prepared by the following method:
After dry desmodium is pulverized after cold soaking 0.5h, add 10 ~ 15 times of water gagings and carry out refluxing extraction, refluxing extraction temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extract merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extract of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, proceed to vacuum drying chamber, at 70 DEG C, under 0.09MPa, vacuum drying is to dry, pulverized 40 ~ 100 mesh sieves, obtain desmodium medicinal extract fine powder.
In described refluxing extraction process, the solid-liquid ratio of refluxing extraction is 1:13 ~ 15 for the first time, and the solid-liquid ratio of second time refluxing extraction and for the third time refluxing extraction is 1:10.
Sweetener 1-2%, aromatic 0.5-0.8% also can be comprised by mass content in desmodium cold tea effervescent tablet of the present invention.Sweetener can be selected from honey element, Steviosin, acesulfame potassium, Aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or lemon extract, flavoring banana essence one or more.
Another object of the present invention is to the preparation method that a kind of desmodium cold tea effervescent tablet is provided, specifically comprise the following steps:
1) preparation of desmodium cold tea extract powder;
2) following component is taken by recipe quantity: desmodium cold tea extract powder 1 ~ 5 part, filler 1 ~ 10 part, sour agent and 5 ~ 20 parts, alkaline agent mixture, lubricant 0.2 ~ 1 part;
3) by sour agent and alkaline agent in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; 140 ~ 200 mesh sieves pulverized by lubricant, and 100 ~ 120 mesh sieves pulverized by filler, saved backup in drier;
4) desmodium cold tea extract powder is mixed with sour agent, sweetener can be added again or aromatic mixes to obtain powders A; Powder B is obtained by alkaline agent with filler Homogeneous phase mixing;
5) add lubricant by after powders A and powder B Homogeneous phase mixing, fully mix;
6) by gained mixed-powder direct tablet compressing, required desmodium cold tea effervescent tablet is obtained.
Further, described filler is selected from one or more in lactose, water soluble starch or sucrose.
Described sour agent and alkaline agent weight ratio are 2:1, and described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium acid carbonate.
Described lubricant is selected from Macrogol 6000 or Macrogol 4000.
The preparation of described desmodium cold tea extract powder is with the preparation process of above-mentioned Lysimachia tea extract powder.
Described sweetener and aromatic account for 1-2% and 0.5-0.8% of raw material gross weight, sweetener be selected from honey element, Steviosin, acesulfame potassium, Aspartame, protein sugar, sucrose, protein sugar, saccharin sodium one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or lemon extract, flavoring banana essence one or more.
Beneficial effect of the present invention is:
1, effectively remain the active component of desmodium cold tea, improve its utilization rate.
2, disintegration time limited of desmodium cold tea effervescent tablet that this formula and preparation method obtain can reach 105s, solve the slow difficult problem of Effervescent tablet disintegration, by the screening of the proportioning to desmodium cold tea effervescent tea tablet and the screening to gas-producing disintegrant and lubricant etc., desmodium cold tea effervescent tea tablet of the present invention is made to obtain best effervesce effect.
The present invention makes effervescent tablet traditional herb tea, be convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of cold tea greatly.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, only to preferred embodiment of the present invention, not do other forms of restriction to the present invention, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed to the Equivalent embodiments of equal change.Everyly do not depart from the present invention program's content, any simple modification done following examples according to technical spirit of the present invention or equivalent variations, all drop in protection scope of the present invention.
Desmodium is a kind of folks of china tradition drink, one of cold tea that Cantonese often drinks, use for desmodium generally still rests on traditional cold tea and decocts, use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of desmodium is obviously reduced simultaneously, greatly hinder the promotion and application of desmodium.Effervescent tablet preparation formulation and traditional herb tea are organically combined, are convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of cold tea greatly.
The invention provides desmodium cold tea effervescent tablet, comprise following component by weight: Lysimachia tea extract powder 1 ~ 5 part, filler 1 ~ 10 part, disintegrant 5 ~ 20 parts, lubricant 0.2 ~ 1 part.Wherein said filler is selected from one or more in lactose, water soluble starch or sucrose.Described disintegrant is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium acid carbonate.Described lubricant is selected from Macrogol 6000 or Macrogol 4000.
Lysimachia tea extract powder is prepared by the following method: after being pulverized by dry desmodium after cold soaking 0.5h, add 10 ~ 15 times of water gagings and carry out refluxing extraction, refluxing extraction temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, the solid-liquid ratio of refluxing extraction is 1:13 ~ 15 for the first time, the solid-liquid ratio of second time refluxing extraction and for the third time refluxing extraction is 1:10, each 0.5 ~ 2 hour, extract merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extract of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, proceed to vacuum drying chamber, at 70 DEG C, under 0.09MPa, vacuum drying is to dry, pulverized 40 ~ 100 mesh sieves, obtain desmodium medicinal extract fine powder.
Sweetener 1-2%, aromatic 0.5-0.8% also can be comprised by mass content in desmodium cold tea effervescent tablet of the present invention.Sweetener can be selected from honey element, Steviosin, acesulfame potassium, Aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or lemon extract, flavoring banana essence one or more.
Present invention also offers a kind of preparation method of desmodium cold tea effervescent tablet, specifically comprise the following steps:
1) preparation of desmodium cold tea extract powder
After dry desmodium is pulverized after cold soaking 0.5h, add 10 ~ 15 times of water gagings and carry out refluxing extraction, refluxing extraction temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, the solid-liquid ratio of refluxing extraction is 1:13 ~ 15 for the first time, the solid-liquid ratio of second time refluxing extraction and for the third time refluxing extraction is 1:10, each 0.5 ~ 2 hour, extract merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extract of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, proceed to vacuum drying chamber, at 70 DEG C, under 0.09MPa, vacuum drying is to dry, pulverized 40 ~ 100 mesh sieves, obtain desmodium medicinal extract fine powder.
2) following component is taken by recipe quantity: desmodium cold tea extract powder 1 ~ 5 part, filler 1 ~ 10 part, sour agent and 5 ~ 20 parts, alkaline agent mixture, lubricant 0.2 ~ 1 part.
3) by sour agent and alkaline agent in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; 140 ~ 200 mesh sieves pulverized by lubricant, and 100 ~ 120 mesh sieves pulverized by filler, saved backup in drier.
4) desmodium cold tea extract powder is mixed with sour agent, sweetener can be added again or aromatic mixes to obtain powders A; Powder B is obtained by alkaline agent with filler Homogeneous phase mixing.
5) add lubricant by after powders A and powder B Homogeneous phase mixing, fully mix, direct tablet compressing, obtain required desmodium cold tea effervescent tablet.
Embodiment 1
A kind of desmodium cold tea effervescent tablet, prepares especially by following steps:
After dry desmodium is pulverized after cold soaking 0.5h, add 10 ~ 15 times of water gagings and carry out refluxing extraction, refluxing extraction temperature is 80 DEG C, extraction time is 3 times, the solid-liquid ratio of refluxing extraction is 1:15 for the first time, the solid-liquid ratio of second time refluxing extraction and for the third time refluxing extraction is 1:10, each 0.5 ~ 2 hour, extract merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extract of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, proceed to vacuum drying chamber, at 70 DEG C, under 0.09MPa, vacuum drying is to dry, pulverized 40 ~ 100 mesh sieves, obtain desmodium medicinal extract fine powder.
Following component is taken: desmodium cold tea extract powder 2 parts, water soluble starch 5 parts, 10 parts, tartaric acid, sodium acid carbonate 5 parts, Macrogol 6000 0.5 part by recipe quantity; By tartaric acid and sodium acid carbonate in 90 ~ 100 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Macrogol 6000 pulverized 140 ~ 200 mesh sieves, and water soluble starch pulverized 100 ~ 120 mesh sieves, saved backup in drier; Desmodium cold tea extract powder is mixed to obtain powders A with tartaric acid, sodium acid carbonate and water soluble starch Homogeneous phase mixing are obtained powder B, adds Macrogol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct tablet compressing, obtains required desmodium cold tea effervescent tablet.
Embodiment 2
A kind of desmodium cold tea effervescent tablet, prepares especially by following steps:
After dry desmodium is pulverized after cold soaking 0.5h, add 10 ~ 13 times of water gagings and carry out refluxing extraction, refluxing extraction temperature is 85 DEG C, extraction time is 2 times, the solid-liquid ratio of refluxing extraction is 1:13 for the first time, the solid-liquid ratio of second time refluxing extraction is 1:10, each 0.5 ~ 2 hour, extract merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extract of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, proceed to vacuum drying chamber, at 70 DEG C, under 0.09MPa, vacuum drying is to dry, pulverized 40 ~ 100 mesh sieves, obtain desmodium medicinal extract fine powder.
Following component is taken: desmodium cold tea extract powder 1 part, lactose 1 part, citric acid 4 parts, sodium acid carbonate 2 parts, Macrogol 4000 0.2 part by recipe quantity; By citric acid and sodium acid carbonate in 90 ~ 100 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Macrogol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by lactose, saved backup in drier; Desmodium cold tea extract powder is mixed to obtain powders A with citric acid, sodium acid carbonate and lactose Homogeneous phase mixing are obtained powder B, adds Macrogol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct tablet compressing, obtains required desmodium cold tea effervescent tablet.
Embodiment 3
A kind of desmodium cold tea effervescent tablet, prepares especially by following steps:
After dry desmodium is pulverized after cold soaking 0.5h, add 10 ~ 14 times of water gagings and carry out refluxing extraction, refluxing extraction temperature is 75 DEG C, extraction time is 3 times, the solid-liquid ratio of refluxing extraction is 1:14 for the first time, the solid-liquid ratio of second time and for the third time refluxing extraction is 1:10, each 0.5 ~ 2 hour, extract merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extract of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, proceed to vacuum drying chamber, at 70 DEG C, under 0.09MPa, vacuum drying is to dry, pulverized 40 ~ 100 mesh sieves, obtain desmodium medicinal extract fine powder.
Following component is taken: desmodium cold tea extract powder 5 parts, sucrose 10 parts, citric acid 14 parts, 6 parts, sodium carbonate, Macrogol 6000 1 part by recipe quantity; By citric acid and sodium carbonate in 90 ~ 100 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Macrogol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by sucrose, saved backup in drier; Desmodium cold tea extract powder is mixed to obtain powders A with citric acid, sodium carbonate and sucrose Homogeneous phase mixing are obtained powder B, adds Macrogol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct tablet compressing, obtains required desmodium cold tea effervescent tablet.
Embodiment 4
A kind of desmodium cold tea effervescent tablet, prepares especially by following steps:
After dry desmodium is pulverized after cold soaking 0.5h, add 10 ~ 12 times of water gagings and carry out refluxing extraction, refluxing extraction temperature is 70 DEG C, extraction time is 2 times, the solid-liquid ratio of refluxing extraction is 1:12 for the first time, the solid-liquid ratio of second time refluxing extraction is 1:10, each 0.5 ~ 2 hour, extract merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extract of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, proceed to vacuum drying chamber, at 70 DEG C, under 0.09MPa, vacuum drying is to dry, pulverized 40 ~ 100 mesh sieves, obtain desmodium medicinal extract fine powder.
Following component is taken: desmodium cold tea extract powder 4 parts, lactose 8 parts, malic acid 8 parts, sodium acid carbonate 4 parts, Macrogol 4000 0.8 part by recipe quantity; By malic acid and sodium acid carbonate in 90 ~ 100 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Macrogol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by lactose, saved backup in drier; Desmodium cold tea extract powder is mixed to obtain powders A with malic acid, sodium acid carbonate and lactose Homogeneous phase mixing are obtained powder B, adds Macrogol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct tablet compressing, obtains required desmodium cold tea effervescent tablet.
Embodiment 5
A kind of desmodium cold tea effervescent tablet, prepares especially by following steps:
After dry desmodium is pulverized after cold soaking 0.5h, add 10 ~ 15 times of water gagings and carry out refluxing extraction, refluxing extraction temperature is 80 DEG C, extraction time is 3 times, the solid-liquid ratio of refluxing extraction is 1:15 for the first time, the solid-liquid ratio of second time and for the third time refluxing extraction is 1:10, each 0.5 ~ 2 hour, extract merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extract of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, proceed to vacuum drying chamber, at 70 DEG C, under 0.09MPa, vacuum drying is to dry, pulverized 40 ~ 100 mesh sieves, obtain desmodium medicinal extract fine powder.
Following component is taken: desmodium cold tea extract powder 2 parts, lactose 5 parts, 12 parts, tartaric acid, sodium acid carbonate 6 parts, Macrogol 6000 0.2 part by recipe quantity; By tartaric acid and sodium acid carbonate in 90 ~ 100 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Macrogol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by lactose, saved backup in drier; Desmodium cold tea extract powder is mixed to obtain powders A with tartaric acid, sodium acid carbonate and lactose Homogeneous phase mixing are obtained powder B, adds Macrogol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct tablet compressing, obtains required desmodium cold tea effervescent tablet.
Embodiment 6 quality evaluation
Below in conjunction with disintegration time limited, subjective appreciation, hardness, outward appearance evaluate beneficial effect of the present invention:
1, disintegration time detects
In 250mL beaker, add the water of 200mL and water temperature is controlled then add 1 effervescent tablet 15 ~ 25.When gas around tablet or fragment stops overflowing, tablet should be dissolved or dispersed in water, left without the particle assembled.No longer include gas to solution to overflow and time difference T (s) of dissolving is the disintegration time of effervescent tablet, experimental result part table 1 from adding effervescent tablet.
2, subjective appreciation
Scoring: thrown by effervescent tablet in people 300mL water, adopt " double-blind study " to carry out sour-sweet degree organoleptic examination scoring, scoring number is 20 people, averages, full marks 100 points.This accounts for 40% of total score value.Disintegration time is marked, and detects disintegration time by 1, and the shortest for disintegration time in test is decided to be full marks 100 points, and disintegration time often increases 5s and subtracts 1 point.This scoring accounts for total score value 60%, and outward appearance scoring accounts for 20%, mouthfeel 20%, experimental result part table 1.
3, hardness (Monsanto durometer method)
Be placed on by tablet between two pressing plates, diametrically pressurization slowly, the pressure just during fragmentation is the hardness of this effervescent tablet, and unit is N, experimental result part table 1.
The quality evaluation of table 1 desmodium cold tea of the present invention effervescent tablet
| Disintegration time limited (s) | Sensory evaluation scores (dividing) | Hardness (N) | |
| Embodiment 1 | 105s | 100 | 65N |
| Embodiment 2 | 105s | 100 | 64N |
| Embodiment 3 | 113s | 90 | 65N |
| Embodiment 4 | 108s | 93 | 63N |
| Embodiment 5 | 125s | 95 | 60N |
1., according to the inventive method, the application manually produces 150 batches of desmodium cold tea effervescent tablets altogether, product percent of pass 100%;
2. according to national standard, the desmodium cold tea effervescent tablet term of validity 24 months, the applicant's reserved sample observing to 36 month, every quality index has not yet to see obvious change;
3. embodiment 1-5 and comparative example illustrate and the invention solves the slow difficult problem of Effervescent tablet disintegration, screening by the proportioning to desmodium cold tea and the screening to gas-producing disintegrant and lubricant etc., make desmodium cold tea effervescent tablet of the present invention obtain best effervesce effect;
4. can be found out by above-mentioned result of the test, it is fast that desmodium cold tea effervescent tablet of the present invention has disintegration compared with prior art products, and good stability, the advantages such as weight differential is little, can provide more stable, effective, safe product.
5. the screwtree root effervescent tablet prepared 3 batches, smooth appearance, uniform color, sweet and sour taste, this stable process conditions of experiment results proved is feasible.
Embodiment 7 effect assessment
1, testing crew physical data
Select various lithiasis patients 290 example made a definite diagnosis through hospital, wherein: vesical calculus 40 example, urethral calculus 40 example, cholecystolithiasis 70 example, choledocholithiasis 60 example, calculus of hepatic duct 80 example; The male sex 160 example, women 130 example; 12 ~ 66 years old age, 49 years old mean age.
2, diagnosis basis
With national higher medical institute teaching material " clinical practice " and " surgery " for standard, with data such as clinical manifestation, hospital diagnosis conclusion, B ultrasonic reports for foundation, carry out reference, get rid of Other diseases.
3, experimental group desmodium effervescent tablet composition: desmodium cold tea extract powder 2 parts, water soluble starch 5 parts, 10 parts, tartaric acid, sodium acid carbonate 5 parts, Macrogol 6000 0.5 part.
Control group adopts common Lysimachia tea decoction.
4, curative effect determinate standard:
Cure: calculus is discharged, transference cure, x-ray is taken the photograph sheet calculus shade and is disappeared;
Take a turn for the better: symptom is improved, x-ray is taken the photograph sheet calculus and to be reduced or position moves down;
Do not heal: symptom and x-ray check that calculus is unchanged.
Cure and take a turn for the better and all count effective statistics.
The antilithic observation of curative effect of table 2 desmodium effervescent tablet
| Group | Total number of cases | Cure | Take a turn for the better | Do not heal | Total effective rate (%) | Control group efficient (%) |
| Vesical calculus | 40 | 30 | 8 | 2 | 95 | 45 |
| Urethral calculus | 40 | 28 | 9 | 3 | 92.5 | 48 |
| Cholecystolithiasis | 70 | 50 | 14 | 6 | 91 | 32 |
| Choledocholithiasis | 60 | 42 | 14 | 4 | 93 | 41 |
| Calculus of hepatic duct | 80 | 56 | 18 | 6 | 92.5 | 39 |
As shown in Table 2, illustrate that the effective component ratio in effervescent tablet of the present invention is easier to extract, effervescent tablet anti-calculus effect of the present invention is higher than existing Lysimachia tea, illustrate effervescent tablet of the present invention very degree remain the medical active of desmodium, more easily played absorption by people simultaneously, have the advantages that utilization rate is high.
Claims (8)
1. a desmodium cold tea effervescent tablet, is characterized in that, comprises following component by weight: Lysimachia tea extract powder 1 ~ 5 part, filler 1 ~ 10 part, disintegrant 5 ~ 20 parts, lubricant 0.2 ~ 1 part, described filler is selected from one or more in lactose, water soluble starch or sucrose; Described disintegrant is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium acid carbonate; Described lubricant is selected from Macrogol 6000 or Macrogol 4000.
2. a kind of desmodium cold tea effervescent tablet according to claim 1, it is characterized in that, described Lysimachia tea extract powder is prepared by the following method:
After dry desmodium is pulverized after cold soaking 0.5h, add 10 ~ 15 times of water gagings and carry out refluxing extraction, refluxing extraction temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extract merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extract of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, proceed to vacuum drying chamber, at 70 DEG C, under 0.09MPa, vacuum drying is to dry, pulverized 40 ~ 100 mesh sieves, obtain desmodium medicinal extract fine powder.
3. a kind of desmodium cold tea effervescent tablet according to claim 2, is characterized in that, in described refluxing extraction process, the solid-liquid ratio of refluxing extraction is 1:13 ~ 15 for the first time, and the solid-liquid ratio of second time refluxing extraction and for the third time refluxing extraction is 1:10.
4. a kind of desmodium cold tea effervescent tablet according to claim 1, is characterized in that, also comprises sweetener 1-2%, aromatic 0.5-0.8% in described desmodium cold tea effervescent tablet by mass content.
5. a kind of desmodium cold tea effervescent tablet according to claim 4, it is characterized in that, described sweetener be selected from honey element, Steviosin, acesulfame potassium, Aspartame, protein sugar, sucrose, protein sugar, saccharin sodium one or more, described aromatic be selected from orange essence, flavoring orange essence, Mint Essence or lemon extract, flavoring banana essence one or more.
6. a preparation method for desmodium cold tea effervescent tablet, is characterized in that, comprises the following steps:
1) preparation of desmodium cold tea extract powder;
2) following component is taken by recipe quantity: desmodium cold tea extract powder 1 ~ 5 part, filler 1 ~ 10 part, sour agent and 5 ~ 20 parts, alkaline agent mixture, lubricant 0.2 ~ 1 part;
3) by sour agent and alkaline agent in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; 140 ~ 200 mesh sieves pulverized by lubricant, and 100 ~ 120 mesh sieves pulverized by filler, saved backup in drier;
4) desmodium cold tea extract powder is mixed to obtain powders A with sour agent; Alkaline agent and filler Homogeneous phase mixing are obtained powder B;
5) add lubricant by after powders A and powder B Homogeneous phase mixing, fully mix;
6) by gained mixed-powder direct tablet compressing, required desmodium cold tea effervescent tablet is obtained.
7. preparation method according to claim 6, is characterized in that, the preparation process of described desmodium cold tea extract powder is with claim 2.
8. preparation method according to claim 6, is characterized in that, described filler is selected from one or more in lactose, water soluble starch or sucrose;
Described sour agent and alkaline agent weight ratio are 2:1, and described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium acid carbonate;
Described lubricant is selected from Macrogol 6000 or Macrogol 4000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510903295.8A CN105519730A (en) | 2015-12-08 | 2015-12-08 | Lysimachia christinae herbal tea effervescent tablet and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510903295.8A CN105519730A (en) | 2015-12-08 | 2015-12-08 | Lysimachia christinae herbal tea effervescent tablet and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105519730A true CN105519730A (en) | 2016-04-27 |
Family
ID=55762645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510903295.8A Pending CN105519730A (en) | 2015-12-08 | 2015-12-08 | Lysimachia christinae herbal tea effervescent tablet and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105519730A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425413A (en) * | 2002-12-27 | 2003-06-25 | 中山大学 | Xiasangju effervescent tablet and its preparing process |
| CN103300181A (en) * | 2013-06-27 | 2013-09-18 | 王振英 | Herbal tea |
| CN104543209A (en) * | 2014-12-18 | 2015-04-29 | 蓝春秀 | Herbal tea component capable of inducing diuresis and removing jaundice and preparation method of herbal tea component |
| CN104705763A (en) * | 2015-03-07 | 2015-06-17 | 湖北卫尔康现代中药有限公司 | Sangju effervescent tablet |
-
2015
- 2015-12-08 CN CN201510903295.8A patent/CN105519730A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425413A (en) * | 2002-12-27 | 2003-06-25 | 中山大学 | Xiasangju effervescent tablet and its preparing process |
| CN103300181A (en) * | 2013-06-27 | 2013-09-18 | 王振英 | Herbal tea |
| CN104543209A (en) * | 2014-12-18 | 2015-04-29 | 蓝春秀 | Herbal tea component capable of inducing diuresis and removing jaundice and preparation method of herbal tea component |
| CN104705763A (en) * | 2015-03-07 | 2015-06-17 | 湖北卫尔康现代中药有限公司 | Sangju effervescent tablet |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105533574A (en) | Toxin removing and body slimming green plum fruit and production technology thereof | |
| CN103828979A (en) | Dandelion internal heat clearing and stomach invigorating tea as well as preparation method thereof | |
| CN102113599A (en) | Eucommia bark and honeysuckle tea and preparation method thereof | |
| KR20140097961A (en) | Beverage for curing of hangover | |
| CN104256775A (en) | Snow pear juice health beverage | |
| CN111375049B (en) | Composition for relieving alcoholism and protecting liver as well as preparation method and application thereof | |
| CN104547515A (en) | Tangerine pear syrup and preparation method thereof | |
| CN105477467A (en) | Heat-clearing dampness-eliminating tea effervescent tablet and preparation method thereof | |
| CN106420656A (en) | Trollflower effervescent tablet and preparation method thereof | |
| CN103535468A (en) | Formula and production method of pine nut bowel relaxing tea | |
| CN103518878A (en) | Honey vinegar beverage with function of lubricating intestines and invigorating stomach and preparation method thereof | |
| CN110151851A (en) | Compound and its application based on a kind of Radix Glycyrrhizae medicine pair by honeysuckle | |
| CN105519731A (en) | Dried tangerine peel tea effervescent tablet and preparation method thereof | |
| CN109198352A (en) | A kind of propolis solid beverage powder and preparation method thereof | |
| CN104491359B (en) | It is a kind of to treat canker sore, Chinese medicine composition that pharyngitis swells and ache and preparation method thereof | |
| CN105519730A (en) | Lysimachia christinae herbal tea effervescent tablet and preparation method thereof | |
| CN106165815A (en) | A kind of dispersing lung-QI and dissipating phlegm antiasthmatic-antitussive beverage and preparation processing method | |
| CN110236067A (en) | A kind of sugarcane vinegar effervescent tablet and its application | |
| CN104186862B (en) | A kind of Chinese medicine tea-drinking for the treatment of canker sore and its production and use | |
| CN107812080A (en) | A kind of effervescent tablet for treating canker sore and preparation method thereof | |
| CN108669262A (en) | A kind of tea beverage and preparation method thereof | |
| CN103272017B (en) | Drug for treating burns and scalds | |
| CN106728669A (en) | A kind of aphtha preventing and treating ferment cream and preparation method thereof | |
| KR101866915B1 (en) | Manufacturing method for extracts granule of oriental herb medicine materials for improving constipation and extracts granule manufactured by the same | |
| CN105454577A (en) | Christina loosestrife herbal tea dropping pills and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20160427 |