CN105795462A - Preparation method of deer blood tablet polypeptide dry powder - Google Patents
Preparation method of deer blood tablet polypeptide dry powder Download PDFInfo
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- CN105795462A CN105795462A CN201610187439.9A CN201610187439A CN105795462A CN 105795462 A CN105795462 A CN 105795462A CN 201610187439 A CN201610187439 A CN 201610187439A CN 105795462 A CN105795462 A CN 105795462A
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- sanguis cervi
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- granule
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 36
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 32
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 32
- 239000000843 powder Substances 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000008280 blood Substances 0.000 title abstract description 6
- 241000282994 Cervidae Species 0.000 title abstract 5
- 210000004369 blood Anatomy 0.000 title abstract 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 11
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 11
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 11
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 6
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000001630 malic acid Substances 0.000 claims abstract description 6
- 235000011090 malic acid Nutrition 0.000 claims abstract description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract description 6
- 238000002156 mixing Methods 0.000 claims abstract description 4
- 239000008187 granular material Substances 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
- 239000006228 supernatant Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 238000000108 ultra-filtration Methods 0.000 claims description 9
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 5
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims description 5
- 150000004676 glycans Chemical class 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 238000009928 pasteurization Methods 0.000 claims description 5
- 229920001282 polysaccharide Polymers 0.000 claims description 5
- 239000005017 polysaccharide Substances 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 238000004659 sterilization and disinfection Methods 0.000 claims description 5
- 230000036039 immunity Effects 0.000 abstract description 4
- 230000036772 blood pressure Effects 0.000 abstract description 3
- 235000009508 confectionery Nutrition 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract description 2
- 238000004321 preservation Methods 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 208000016254 weariness Diseases 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 239000002131 composite material Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- -1 cross 20 mesh sieves Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a preparation method of deer blood tablet polypeptide dry powder. According to the preparation method disclosed by the invention, deer blood is used as a raw material, malic acid, sodium carbonate, polyethylene glycol, polyvinylpyrrolidone and the like are used as auxiliary materials, and the deer blood tablet polypeptide dry powder is prepared through the steps of mixing, blending and sterilizing. The deer blood tablet polypeptide dry powder has the characteristics of being capable of reducing blood pressure, improving immunity and resisting weariness, moderate in sour and sweet degrees, good in preservation and portability, high in biological availability and the like.
Description
Technical field
The preparation method that the present invention relates to a kind of Sanguis cervi sheet polypeptide dry powder.
Background technology
Sanguis cervi is always up famous and precious tonic since ancient times, and containing rich in protein, inorganic salt, glucose, hormone etc., the compound product based on it is referred to as celestial family and takes folk prescription.Protein is made up of peptide.Proteolysis produces the method for peptide and is mainly chemical method and enzyme process, and chemical method disconnects peptide bond with alkali or acid, and reaction environment is comparatively extreme, is unfavorable for the maintenance of activity, and enzyme process safety is higher, and reaction condition is gentle, and process is easily controllable.The selection of enzyme is the key of Production by Enzymes peptide.Sanguis cervi polypeptide is the pressed powder that Sanguis cervi obtains through enzymolysis purification process, has anti-blood pressure, strengthens immunity, promotes the effects such as mineral absorption.Do not damage nutritive value to increase the pot-life simultaneously, occur in that the deep processing of Sanguis cervi.By centrifugal method, plasma protein is separated from Sanguis cervi, and then prepare bioactive peptide, and separate purification superoxide dismutase and haemachrome.
Summary of the invention
Goal of the invention is in that the higher value application for Sanguis cervi resource and human nutrition material demand, it is provided that the preparation method of a kind of Sanguis cervi sheet polypeptide dry powder.
The technical solution used in the present invention is:
The preparation method of a kind of Sanguis cervi sheet polypeptide dry powder, it is characterised in that the method comprises the following steps:
A, take Sanguis cervi, add ethanol precipitate polysaccharides, take supernatant by the centrifugal 10～20min of the rotating speed of 5000～10000rpm；
B, supernatant ultrafiltration, collect the molecular cut off component less than 4500Da and dry making Sanguis cervi sheet polypeptide；
C, by finely ground for 70～80 parts of difference of 70～80 parts in Sanguis cervi sheet polypeptide 100 parts and malic acid become powder, cross 20～200 mesh sieves, mix homogeneously, add 6～7 parts in polyvinylpyrrolidone 9～10 parts and 7～8 parts of pelletizes of carboxymethylcellulose calcium, cross 60 mesh sieves, dried in 55～60 DEG C, obtain the first granule；
D, by finely ground for 50～60 parts of difference of remaining Sanguis cervi sheet polypeptide and sodium carbonate become powder, cross 20～200 mesh sieves, mix homogeneously, add remaining polyvinylpyrrolidone, cross 60 mesh sieves, dried in 55～60 DEG C, obtain the second granule；
E, by one or both in lactose and maltose alcohol 9～12 parts and Polyethylene Glycol 8～10 parts mixing, cross 60～80 mesh sieves, mix homogeneously, add above-mentioned first granule and the second granule, mix homogeneously, it is transferred in temperature 40～50 DEG C, humidity 55～60% operation room after pasteurization, flash-sterilization, grinds and prepare Sanguis cervi sheet polypeptide dry powder.
Preferably, it is 4500Da ultra-filtration centrifuge tube that described ultrafiltration is specially supernatant addition molecular cut off, centrifugal under 6000～8000rpm.
The invention has the beneficial effects as follows:
The Sanguis cervi sheet polypeptide dry powder of the present invention has blood pressure lowering, strengthens the function of immunity, and simultaneously taste is sour-sweet, bioavailability is high, be easily absorbed by the body.This Sanguis cervi sheet polypeptide dry powder has blood pressure lowering, strengthens immunity, resisting fatigue, sour and sweet palatability, preservation and good portability, bioavailability high.
Detailed description of the invention
Embodiment 1
A, take Sanguis cervi, add ethanol precipitate polysaccharides, take supernatant by the centrifugal 10min of the rotating speed of 5000rpm；
B, supernatant ultrafiltration, collect the molecular cut off component less than 4500Da and dry making Sanguis cervi sheet polypeptide；
C, by 70g and the malic acid 70g in Sanguis cervi sheet polypeptide 100g respectively finely ground become powder, cross 20 mesh sieves, mix homogeneously, add the 6g in polyvinylpyrrolidone 9g and carboxymethylcellulose calcium 7g part pelletize, cross 60 mesh sieves, dried in 55 DEG C, obtain the first granule；
D, by remaining Sanguis cervi sheet polypeptide and sodium carbonate 50g respectively finely ground become powder, cross 20 mesh sieves, mix homogeneously, add remaining polyvinylpyrrolidone, cross 60 mesh sieves, dried in 55 DEG C, obtain the second granule；
E, the composite 9g and Polyethylene Glycol 8g of lactose and maltose alcohol are mixed, cross 60 mesh sieves, mix homogeneously, add above-mentioned first granule and the second granule, mix homogeneously, it is transferred in temperature 40 DEG C, humidity 55% operation room after pasteurization, flash-sterilization, grinds and prepare Sanguis cervi sheet polypeptide dry powder.
Embodiment 2
A, take Sanguis cervi, add ethanol precipitate polysaccharides, take supernatant by the centrifugal 20min of the rotating speed of 10000rpm；
B, supernatant ultrafiltration, collect the molecular cut off component less than 4500Da and dry making Sanguis cervi sheet polypeptide；
C, by 80g and the malic acid 80g in Sanguis cervi sheet polypeptide 100g respectively finely ground become powder, cross 200 mesh sieves, mix homogeneously, add the 7g in polyvinylpyrrolidone 10g and carboxymethylcellulose calcium 8g pelletize, cross 60 mesh sieves, dried in 60 DEG C, obtain the first granule；
D, by remaining Sanguis cervi sheet polypeptide and sodium carbonate 60g respectively finely ground become powder, cross 200 mesh sieves, mix homogeneously, add remaining polyvinylpyrrolidone, cross 60 mesh sieves, dried in 60 DEG C, obtain the second granule；
E, the composite 12g and Polyethylene Glycol 10g of lactose and maltose alcohol are mixed, cross 80 mesh sieves, mix homogeneously, add above-mentioned first granule and the second granule, mix homogeneously, it is transferred in temperature 50 C, humidity 60% operation room after pasteurization, flash-sterilization, grinds and prepare Sanguis cervi sheet polypeptide dry powder.
Embodiment 3
A, take Sanguis cervi, add ethanol precipitate polysaccharides, take supernatant by the centrifugal 15min of the rotating speed of 6000rpm；
B, supernatant ultrafiltration, collect the molecular cut off component less than 4500Da and dry making Sanguis cervi sheet polypeptide；
C, by 75g and the malic acid 75g in Sanguis cervi sheet polypeptide 100g respectively finely ground become powder, cross 100 mesh sieves, mix homogeneously, add the 6.5g in polyvinylpyrrolidone 9.5g and carboxymethylcellulose calcium 7.5g pelletize, cross 60 mesh sieves, dried in 58 DEG C, obtain the first granule；
D, by remaining Sanguis cervi sheet polypeptide and sodium carbonate 58g respectively finely ground become powder, cross 100 mesh sieves, mix homogeneously, add remaining polyvinylpyrrolidone, cross 60 mesh sieves, dried in 58 DEG C, obtain the second granule；
E, the composite 10g and Polyethylene Glycol 9g of lactose and maltose alcohol are mixed, cross 70 mesh sieves, mix homogeneously, add above-mentioned first granule and the second granule, mix homogeneously, it is transferred in temperature 45 C, humidity 58% operation room after pasteurization, flash-sterilization, grinds and prepare Sanguis cervi sheet polypeptide dry powder.
Above-mentioned detailed description of the invention is used for illustrating the present invention, rather than limits the invention, in the spirit and scope of the claims of the present invention, and any amendment that the present invention is made and change, both fall within protection scope of the present invention.
Claims (2)
1. the preparation method of a Sanguis cervi sheet polypeptide dry powder, it is characterised in that the method comprises the following steps:
A, take Sanguis cervi, add ethanol precipitate polysaccharides, take supernatant by the centrifugal 10～20min of the rotating speed of 5000～10000rpm；
B, supernatant ultrafiltration, collect the molecular cut off component less than 4500Da and dry making Sanguis cervi sheet polypeptide；
C, by finely ground for 70～80 parts of difference of 70～80 parts in Sanguis cervi sheet polypeptide 100 parts and malic acid become powder, cross 20～200 mesh sieves, mix homogeneously, add 6～7 parts in polyvinylpyrrolidone 9～10 parts and 7～8 parts of pelletizes of carboxymethylcellulose calcium, cross 60 mesh sieves, dried in 55～60 DEG C, obtain the first granule；
D, by finely ground for 50～60 parts of difference of remaining Sanguis cervi sheet polypeptide and sodium carbonate become powder, cross 20～200 mesh sieves, mix homogeneously, add remaining polyvinylpyrrolidone, cross 60 mesh sieves, dried in 55～60 DEG C, obtain the second granule；
E, by one or both in lactose and maltose alcohol 9～12 parts and Polyethylene Glycol 8～10 parts mixing, cross 60～80 mesh sieves, mix homogeneously, add above-mentioned first granule and the second granule, mix homogeneously, it is transferred in temperature 40～50 DEG C, humidity 55～60% operation room after pasteurization, flash-sterilization, grinds and prepare Sanguis cervi sheet polypeptide dry powder.
2. preparation method as claimed in claim 1, it is 4500Da ultra-filtration centrifuge tube that described ultrafiltration is specially supernatant addition molecular cut off, centrifugal under 6000～8000rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610187439.9A CN105795462A (en) | 2016-03-29 | 2016-03-29 | Preparation method of deer blood tablet polypeptide dry powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610187439.9A CN105795462A (en) | 2016-03-29 | 2016-03-29 | Preparation method of deer blood tablet polypeptide dry powder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105795462A true CN105795462A (en) | 2016-07-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610187439.9A Pending CN105795462A (en) | 2016-03-29 | 2016-03-29 | Preparation method of deer blood tablet polypeptide dry powder |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553485A (en) * | 2018-06-08 | 2018-09-21 | 中国农业科学院特产研究所 | A kind of preparation method of deer Blood piece |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557341A (en) * | 2004-01-15 | 2004-12-29 | 高春平 | Preparing process of multiple biologically active substance containing formulation |
| CN101112390A (en) * | 2006-07-27 | 2008-01-30 | 上海汉德食品有限公司 | Joint production method for distilling immunopotentiator from waste blood |
| CN101461543A (en) * | 2007-12-19 | 2009-06-24 | 中国科学院大连化学物理研究所 | Deep-processing method of deer blood |
| CN101642470A (en) * | 2009-07-23 | 2010-02-10 | 大连理工大学 | Deer product effervescent tablets prepared by microshearing-additive interaction technology and preparation method thereof |
| CN101766251A (en) * | 2008-12-30 | 2010-07-07 | 天津市食品工业生产力促进中心 | Method for extracting modified plasma protein powder and bioactive peptide for enriching blood from pig blood |
| CN103007250A (en) * | 2011-09-23 | 2013-04-03 | 彰武福祥牛业有限责任公司 | Bovine blood polypeptide preparation and preparation method thereof |
| CN104147047A (en) * | 2014-07-30 | 2014-11-19 | 哈尔滨圣泰生物制药有限公司 | Deproteinized calf blood extract composition as well as injection and preparation method thereof |
| CN104628812A (en) * | 2013-11-07 | 2015-05-20 | 中国科学院兰州化学物理研究所 | Method for purifying deer blood oligopeptides by macroporous adsorption resin |
-
2016
- 2016-03-29 CN CN201610187439.9A patent/CN105795462A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557341A (en) * | 2004-01-15 | 2004-12-29 | 高春平 | Preparing process of multiple biologically active substance containing formulation |
| CN101112390A (en) * | 2006-07-27 | 2008-01-30 | 上海汉德食品有限公司 | Joint production method for distilling immunopotentiator from waste blood |
| CN101461543A (en) * | 2007-12-19 | 2009-06-24 | 中国科学院大连化学物理研究所 | Deep-processing method of deer blood |
| CN101766251A (en) * | 2008-12-30 | 2010-07-07 | 天津市食品工业生产力促进中心 | Method for extracting modified plasma protein powder and bioactive peptide for enriching blood from pig blood |
| CN101642470A (en) * | 2009-07-23 | 2010-02-10 | 大连理工大学 | Deer product effervescent tablets prepared by microshearing-additive interaction technology and preparation method thereof |
| CN103007250A (en) * | 2011-09-23 | 2013-04-03 | 彰武福祥牛业有限责任公司 | Bovine blood polypeptide preparation and preparation method thereof |
| CN104628812A (en) * | 2013-11-07 | 2015-05-20 | 中国科学院兰州化学物理研究所 | Method for purifying deer blood oligopeptides by macroporous adsorption resin |
| CN104147047A (en) * | 2014-07-30 | 2014-11-19 | 哈尔滨圣泰生物制药有限公司 | Deproteinized calf blood extract composition as well as injection and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553485A (en) * | 2018-06-08 | 2018-09-21 | 中国农业科学院特产研究所 | A kind of preparation method of deer Blood piece |
| CN108553485B (en) * | 2018-06-08 | 2020-08-18 | 中国农业科学院特产研究所 | Preparation method of deer blood tablets |
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Application publication date: 20160727 |
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