CN101190263B - Rhubarb chewable tablets and preparation method and application thereof - Google Patents
Rhubarb chewable tablets and preparation method and application thereof Download PDFInfo
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- CN101190263B CN101190263B CN2006100223823A CN200610022382A CN101190263B CN 101190263 B CN101190263 B CN 101190263B CN 2006100223823 A CN2006100223823 A CN 2006100223823A CN 200610022382 A CN200610022382 A CN 200610022382A CN 101190263 B CN101190263 B CN 101190263B
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- 238000002360 preparation method Methods 0.000 title abstract description 18
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 37
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical compound C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 claims description 32
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- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of traditional Chinese medicine. The invention mainly relates to a pieplant chewable tablet, the preparation method and the application thereof. The pieplant chewable tablet in the invention uses peiplant as crude material, and conventional excipients and adjuvant components are added to prepare the invention. The pieplant chewable tablet is characterized by small volume, convenient carrying, simple administration (no need to be taken with boiled water), good taste and compliance; the inventiono is suitable for being used at plateau and outside conditions. The experiment demonstrates that the pieplant chewable tablet has significant effect and good taste with promising market prospect.
Description
Technical field
The present invention relates to a kind of chewable tablet, particularly, it is to be the chewable tablet of effective ingredient preparation by Radix Et Rhizoma Rhei.
Background technology
Radix Et Rhizoma Rhei is used for a long time in China's traditional medicine, and the beginning is stated from the existing pharmacy monograph Shennong's Herbal the earliest of China, because of its yellow skin, so name.The successive dynasties book on Chinese herbal medicine all records: " prescriptions worth thousand gold " claims that Radix Et Rhizoma Rhei is bright and beautiful civilian Radix Et Rhizoma Rhei; " WU Pu Bencao " claim Radix Et Rhizoma Rhei be yellow good, fire is joined, skin as; Lee is called general when it " medicine record "; " the Chinese crude drug handbook then is referred to as Radix Et Rhizoma Rhei.Be the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L., Rheum tanguticum Rheum tanguticum Maxim.ex Balf. or Rheum officinale Rheum officinale Baill., except genuine rhubarb, also have other kinds of Rheum also to make Elsholtzia usefulness.Be perennial tall and big draft, the rhizome plumpness, stem is upright, achene 3 prismatics.Bitter in the mouth, cold in nature, return stomach, spleen, large intestine, liver, pericardium channel.Radix Et Rhizoma Rhei has heat and toxic materials clearing away, clearing away heat-fire, detoxifcation hemostasis, activating blood circulation to dissipate blood stasis, the function of eliminating damp-heat.Be widely used in control that constipation, carbuncle, furuncle, conjunctival congestion and swelling pain, mumps, sore throat, gingival swelling and pain, bleeding due to blood-heat cause various hemorrhage, congestion amenorrhea, puerperal abdonimal pain, traumatic injury, damp and hotly let out dysentery, jaundice, edema, middle wind-phlegm fan or the like, the gastrointestinal of cleansing is arranged, push away Chen Zhixin, the merit of peace and the five internal organs.
Existing is that the preparation made of raw material is mainly better with Radix Et Rhizoma Rhei granule (electuary) market sale with the Radix Et Rhizoma Rhei, but granule has the adjuvant of adding more, and active constituent content is few, need be with shortcomings such as hot water when taking.Compare with the granule dosage form, it is good that chewable tablet has mouthfeel, taking convenience (not needing boiled water to take), characteristics such as volume is little, delicately packed, and is easy to carry, and the compliance of use is better.But, how to optimize the mouthfeel of chewable tablet, strengthen it and take the difficult point that compliance is this area always, and Radix Et Rhizoma Rhei itself also has heavier bitterness, the therefore more difficult unification of accomplishing mouthfeel and drug effect.
Have not yet to see with the Radix Et Rhizoma Rhei is the relevant report of feedstock production chewable tablet.
Summary of the invention
Technical problem to be solved by this invention provides a kind of rhubarb chewable tablets.This chewable tablet of the present invention is prepared from by the following weight proportion raw material: 50～150 parts in extractum rhei powder, in sugar, xylitol or the hydroxyl isomaltulose one or more 21～63 parts, 21～63 parts in mannitol, 8～26 parts of instant starch, CaCO
38～26 parts, 8～26 parts of citric acid, 0.8～0.24 part of steviosin, 0.7～2.0 part of Mentholum, 0.13～0.39 part of flavoring orange essence, 3.8～11.6 parts of Pulvis Talci and percentage by weight are that 3～15% polyvidone alcoholic solution is an amount of.
Further, it is prepared from by the following weight proportion raw material: 80～120 parts in extractum rhei powder, 21～63 parts of one or more in lactose, xylitol or the hydroxyl isomaltulose, 21～63 parts in mannitol, 8～26 parts of instant starch, CaCO
38～26 parts, 8～26 parts of citric acid, 0.8～0.24 part of steviosin, 0.7～2.0 part of Mentholum, 0.13～0.39 part of flavoring orange essence, 3.8～11.6 parts of Pulvis Talci and percentage by weight are that 3～15% polyvidone alcoholic solution is an amount of.
Further, it is prepared from by the following weight proportion raw material: 100 parts in extractum rhei powder, 42 parts of one or more in lactose, xylitol or the hydroxyl isomaltulose, 42 parts in mannitol, 17 parts of instant starch, CaCO
317 parts, 17 parts of citric acid, 0.16 part of steviosin, 1.3 parts of Mentholums, 0.26 part of flavoring orange essence, 7.7 parts of Pulvis Talci and percentage by weight are that 3～15% polyvidone alcoholic solution is an amount of.
The total amount of aloe-emodin, chrysophanic acid, emodin, chrysophanol and Radix Et Rhizoma Rhei methyl ether is 2～8% in the above-mentioned extractum rhei powder.
The above-mentioned ethanol that is used to dissolve the polyvidone alcoholic solution of preparation 3～15% can use concentration commonly used at 30% to 100% ethanol, is preferably 60%～90% ethanol.
Another technical problem to be solved by this invention provides the preparation method of chewable tablet of the present invention, and it comprises the steps:
A, take by weighing in fresh Radix et Rhizoma Rhei rhizome, cane or the petiole one or more, through broken, squeeze the juice, after the filtration, juice is concentrated, be dried to dried cream or extract powder;
B, measure extractum rhei by prescription and be ground into extract powder, add in the lactose, xylitol, hydroxyl isomaltulose of formula ratio one or more, mixing therein; Add mannitol, mixing; Add instant starch, mixing; Add portion C aCO
3, mixing; Add citric acid, mixing; The reuse equivalent method of progressively increasing adds steviosin, mixing;
C, be that 3～15% polyvidone alcoholic solution is an amount of, granulate that 45～80 ℃ are dried to moisture less than 3～8%, 8～40 order granulate at 8～40 orders with percentage by weight; The Mentholum dissolve with ethanol is with Mentholum alcoholic solution residue CaCO
3Absorption joins in the above-mentioned granule mixing; Spray adds an amount of flavoring orange essence, mixing; Add Pulvis Talci, mixing; Tabletting, promptly.
It should be noted that CaCO in the said method
3Should add at twice, after adding instant starch for the first time, add the CaCO of part amount
3, reserve The addition of C aCO
3Be used for behind granulate, will using the Mentholum solution absorbs of dissolve with ethanol to granule.
Employed extractum rhei powder can be got one or more in fresh Radix et Rhizoma Rhei rhizome, cane or the petiole among the present invention, through broken, squeeze the juice, after the filtration, juice is concentrated into proportion 1.03～1.26, spray drying gets extract powder; Also can buy the extractum rhei powder product of market sale.But the total amount of noting wherein aloe-emodin, chrysophanic acid, emodin, chrysophanol and Radix Et Rhizoma Rhei methyl ether all should be 2～8%, is preferably 4～6%.
This product is a chewable tablet, and selected filler should be water solublity.In the adjuvant of this chewable tablet prescription, lactose, fructose, xylitol, hydroxyl isomaltulose, mannitol, instant starch is conventional adjuvant, plays filler and general correctives effect.CaCO
3, citric acid, steviosin, Mentholum though the amount of flavoring orange essence etc. is few, has but play a part very importantly, is the core adjuvant.CaCO wherein
3The fine hygroscopicity of improving this chewable tablet of energy is beneficial to preparations shaping; Citric acid can alleviate the bitterness of this product; Steviosin, Mentholum, flavoring orange essence can improve the mouthfeel of this product well.
Mannitol dissolves in the oral cavity gives cooling feeling, to relax a mouthful interior uncomfortable taste, can be used as the filler (diluent) of chewable tablet.Single mobility of particle, poor compressibility with mannitol system, mannitol and lactose can form eutectic mixture, and these mixture have good flowability and compressibility, and simultaneously, the sugariness of mannitol and lactose all is about 70% of sucrose, can make preparation that mouthfeel is preferably arranged.So, can select the filler of mannitol and lactose pairing use as this product.
Xylitol be a kind ofly from materials such as corn cob, bagasse, extract, the novel sweetener and the senior treatment food of pure natural.Its flavor is sweet, the outward appearance crystal powder powder that is white in color, and sugariness is equivalent to sucrose.Xylitol is the intermediate of human body carbohydate metabolism, also extensively exists at occurring in nature, and especially content is abundant in edible fungi such as vegetable, fruit, natural mushroom.Lacking insulin at human body influences under the glycometabolic situation, need not insulin and promotes, xylitol also can permeate through cell membranes be organized and absorbs, and can promote liver glycogen synthetic, improves liver function, is diabetes and hepatitis train wreck's desirable product of replacing sugar.Simultaneously, this product is not produced dental caries in the oral cavity antibacterial utilizes, and can prevent dental caries.So, can select the filler of xylitol as this product.
Hydroxyl isomaltulose claims Palatinitol again, claims isomalt abroad, is emerging in the world in recent years functional edible sugar alcohol, and sugariness is 42% of a sucrose, and sweet taste is pure, is a kind of ideal product of replacing sugar.Its unique physical and chemical properties, physiological function and edible safety have been tested abundant confirmation, are given food safety highest ranking " GRAS (generally recognized as safe) " by U.S. FDA, to its every day intake do not limit.Also can select the filler of hydroxyl isomaltulose as this product.
Chewable tablet of the present invention for different uses needs, can be selected different filleies in preparation process, such as being used for easy dental caries crowd, obese people, diabetes patient's group time, should mainly use xylitol and hydroxyl isomaltulose; As the health food of field usage the time, then can mainly use mannitol and lactose, can be user certain energy is provided.
For improving the chewable tablet mouthfeel, remove and also should add suitable correctives with filler.The citric acid sour in the mouth can be benumbed taste bud; Mentholum and flavoring orange essence belong to natural perfume material, can be used as correctives equally and use.Though lactose or xylitol or hydroxyl isomaltulose etc. are arranged in the adjuvant, through trial, its sweet taste is not enough, also need add sweeting agent.We the are preferred again affixing sweetening agent of steviosin as this product.Steviosin has been subjected to people's favor as a kind of new type natural sweeting agent, and is promoted and use.The sweet taste of steviosin is pure, after taking, is not absorbed by the body, and edible safety is reliable.For making mobility of particle better, and make tablet that outward appearance preferably be arranged, should suitably add Pulvis Talci.
It is little, easy to carry that rhubarb chewable tablets of the present invention has a volume, taking convenience (not needing boiled water to take), and characteristics such as mouthfeel is good, and compliance is good are adapted at using under plateau and the field condition.Take in the highlands, chew and ream weight to want the blood flow in brain district to significantly improve, improved the blood flow and the oxygen supply level in these brain districts, to improve anoxybiotic symptom.When containing mannitol and lactose in the adjuvant, on the plateau or open-air regional the use can also provide certain energy as user.And when using xylitol and hydroxyl isomaltulose, then more help the performance of chewable tablet effect for reducing blood fat of the present invention.Experiment shows that rhubarb chewable tablets effect of the present invention is remarkable, and mouthfeel is fine, is subjected to experimenter's consistent favorable comment; The inventive method is simple, practical, controlled, has good market prospect.
Below the invention will be further described by the specific embodiment, but this is not a limitation of the present invention, and those skilled in the art can make various modification or improvement according to basic thought of the present invention, only otherwise break away from basic thought of the present invention, all within the scope of the present invention.
The specific embodiment
The preparation of embodiment one chewable tablet of the present invention
Get in fresh Radix et Rhizoma Rhei rhizome, cane or the petiole one or more, through broken, squeeze the juice, after the filtration, juice is concentrated into proportion 1.03～1.26, it is 5 extractum rhei powder that spray drying gets the total amount of aloe-emodin, chrysophanic acid, emodin, chrysophanol and Radix Et Rhizoma Rhei methyl ether wherein.Get extractum rhei powder 50kg, add hydroxyl isomaltulose 21kg, mixing; Add mannitol 21kg, mixing; Add instant starch 8kg, mixing; Add CaCO
31kg, mixing; Add citric acid 8kg, mixing; The equivalent method of progressively increasing adds steviosin 0.08kg, mixing; An amount of with 15% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution (concentration of alcohol is 75%), 40 orders are granulated, and 45 ℃ are dried to moisture less than 8%, 40 order granulate; Mentholum 0.7kg dissolves with ethanol 3L, alcoholic solution CaCO
37kg absorption joins in the above-mentioned granule mixing; Spray adds flavoring orange essence 0.13kg, mixing; Add Pulvis Talci 3.8kg, mixing; Tabletting, the bag film-coat, promptly.
The preparation of embodiment two chewable tablet of the present invention
Get the total amount of aloe-emodin, chrysophanic acid, emodin, chrysophanol and Radix Et Rhizoma Rhei methyl ether wherein and be 5 extractum rhei powder 80kg, add hydroxyl isomaltulose 23kg, mixing; Add lactose 20kg, mixing; Add mannitol 43kg, mixing; Add instant starch 17kg, mixing; Add CaCO
32kg, mixing; Add citric acid 17kg, mixing; The equivalent method of progressively increasing adds steviosin 0.17kg, mixing; An amount of with 15% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution (concentration of alcohol is 75%), 40 orders are granulated, and 50 ℃ are dried to moisture less than 8%, 40 order granulate; Mentholum 1.5kg dissolves with ethanol 5L, alcoholic solution CaCO
314kg absorption joins in the above-mentioned granule mixing; Spray adds flavoring orange essence 0.27kg, mixing; Add Pulvis Talci 7.6kg, mixing; Tabletting, the bag film-coat, promptly.
The preparation of embodiment three chewable tablet of the present invention
Get the total amount of aloe-emodin, chrysophanic acid, emodin, chrysophanol and Radix Et Rhizoma Rhei methyl ether wherein and be 5 extractum rhei powder 120kg, add hydroxyl isomaltulose 20kg, mixing; Add xylitol 25kg, mixing; Add mannitol 41kg, mixing; Add instant starch 16kg, mixing; Add CaCO
33kg, mixing; Add citric acid 15kg, mixing; The equivalent method of progressively increasing adds steviosin 0.16kg, mixing; An amount of with 15% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution (concentration of alcohol is 75%), 40 orders are granulated, and 60 ℃ are dried to moisture less than 8%, 40 order granulate; Mentholum 1.3kg dissolves with ethanol 5L, alcoholic solution CaCO
312kg absorption joins in the above-mentioned granule mixing; Spray adds flavoring orange essence 0.25kg, mixing; Add Pulvis Talci 7.8kg, mixing; Tabletting, the bag film-coat, promptly.
The preparation of embodiment four chewable tablet of the present invention
Get the total amount of aloe-emodin, chrysophanic acid, emodin, chrysophanol and Radix Et Rhizoma Rhei methyl ether wherein and be 5 extractum rhei powder 150kg, add hydroxyl isomaltulose 15kg, mixing; Add lactose 20kg, mixing; Add xylitol 20kg, mixing; Add mannitol 51kg, mixing; Add instant starch 21kg, mixing; Add CaCO
33kg, mixing; Add citric acid 19kg, mixing; The equivalent method of progressively increasing adds steviosin 0.21kg, mixing; An amount of with 15% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution (concentration of alcohol is 75%), 40 orders are granulated, and 70 ℃ are dried to moisture less than 8%, 40 order granulate; Mentholum 1.7kg dissolves with ethanol 5L, alcoholic solution CaCO
316kg absorption joins in the above-mentioned granule mixing; Spray adds flavoring orange essence 0.32kg, mixing; Add Pulvis Talci 8.1kg, mixing; Tabletting, the bag film-coat, promptly.
The preparation of embodiment five chewable tablet of the present invention
Get the total amount of aloe-emodin, chrysophanic acid, emodin, chrysophanol and Radix Et Rhizoma Rhei methyl ether wherein and be 5 extractum rhei powder 100kg, add hydroxyl isomaltulose 21kg, mixing; Add lactose 21kg, mixing; Add mannitol 42kg, mixing; Add instant starch 17kg, mixing; Add CaCO
34kg, mixing; Add citric acid 17kg, mixing; The equivalent method of progressively increasing adds steviosin 0.16kg, mixing; An amount of with 15% 30 POVIDONE K 30 BP/USP, 30 alcoholic solution (concentration of alcohol is 75%), 40 orders are granulated, and 70 ℃ are dried to moisture less than 8%, 40 order granulate; Mentholum 1.3kg dissolves with ethanol 3L, this alcoholic solution CaCO
313kg absorption joins in the above-mentioned granule mixing; Spray adds flavoring orange essence 0.26kg, mixing; Add Pulvis Talci 7.7kg, mixing; Tabletting, the bag film-coat, promptly.
The screening test of test example one Radix Et Rhizoma Rhei consumption of the present invention
According to previous preparations shaping trial test, principal agent (leaching the weight of dry) can be taken into account the relative less demand with supplementary product consumption of preparations shaping when being about (1: 1～1.5) with the part by weight of adjuvant, thus the best proportion of principal agent and adjuvant is defined as 1: 1～1.5.
Use embodiment one to five identical prescription and method, but all do not add citric acid, Mentholum, flavoring orange essence and steviosin preparation chewable tablet A, B, C, D, E respectively, with the consumption of screening Radix Et Rhizoma Rhei.
1, the test of pesticide effectiveness
Sample preparation: get each 10g of chewable tablet that various embodiments of the present invention make, add water 10ml grinding and be made into suspension.
Test method: get 70 of healthy male SD rats, body weight 170 ± 10g adds the SD rat and is divided into 7 groups (each embodiment group, normal feedstuff group and high lipid food groups), 10 every group at random by basic blood lipid level.Before around, each embodiment group and the high lipid food matched group high lipid food of all feeding, the normal feedstuff group normal feedstuff of feeding.The 5th week rose to the 8th weekend, and each organizes the normal feedstuff of all feeding.The 5th week rose, and each embodiment group is irritated each embodiment sample of stomach 1 time every day, irritated the stomach amount and be 2ml/100g body weight (be equivalent to human body recommended dose 8～15 times); Normal feedstuff matched group and high lipid food matched group wait the capacity distilled water to irritate stomach.Respectively at getting tail hematometry T-CHOL and triacylglycerol (experimental result sees Table 1) the 8th weekend.When any one index is positive in T-CHOL and the triacylglycerol, can think that all this sample has the blood lipid regulation effect.
Table 1 mice lipid-lowering test result (x ± s, mmol/L)
| A | B | C | D | E | The high lipid food matched group | The normal feedstuff matched group | |
| T-CHOL | 1.75±0.26 * | ?1.96±0.31 * | 1.71±0.28 * | 1.71±0.32 * | 1.73±0.35 * | 2.86±0.36 ** | 1.61±0.22 |
| Triacylglycerol | 1.54±0.24 * | ?1.75±0.38 * | 1.51±0.27 * | 1.49±0.36 * | 1.51±0.25 * | 2.21±0.37 * | 1.07±0.34 |
*: compare p＜0.05 with the high lipid food group; *: compare p＜0.05 with the normal feedstuff group.
This experimental result shows that each embodiment sample all has tangible curative effect, and effect increases progressively with the increase of Radix Et Rhizoma Rhei consumption totally to come the effect of blood fat reducing.
2, mouthfeel experiment
Choose each 20 people of men and women totally 40 people participation.Everyone is difficult to stand (2 minutes) by standing (3 minutes) reluctantly, can't stand (1 minute) Three Estate really and respectively mouthfeel be marked, and calculates total points (the results are shown in Table 2) then.
Table 2 mouthfeel experimental result
| A | B | C | D | E | |
| The mouthfeel total points | 45 | 105 | 86 | 76 | 107 |
This experimental result shows that selected sample mouthfeel is all bad, and mouthfeel is poor more with the increase of Radix Et Rhizoma Rhei consumption.The curative effect of A, B, C, D, E then can be accepted, but takes all factors into consideration curative effect and mouthfeel, and the E effect is best.
The mouthfeel test of test example two rhubarb chewable tablets of the present invention
According to the experimental result of test example one, the prescription and the method for getting embodiment five only do not add citric acid, Mentholum, flavoring orange essence, steviosin or calcium carbonate respectively, make chewable tablet F, G, H, I, J, and the product for preparing with embodiment five carries out the mouthfeel experiment.Each 20 people of men and women totally 40 people participation is chosen in the mouthfeel experiment.Everyone presses bad (1 minute), and good (2 minutes), fine (3 minutes) Three Estate is marked with compliance to the mouthfeel kimonos respectively, calculates total points (the results are shown in Table 3) then.
Table 3 mouthfeel experimental result
| F | G | H | I | J | Embodiment five | |
| The mouthfeel total points | 54 | 61 | 68 | 48 | 87 | 103 |
| Take the compliance total points | 63 | 77 | 76 | 59 | 83 | 105 |
Score by this experimental result embodiment five contrasts group apparently higher than all the other.
By this above-mentioned example as can be known, rhubarb chewable tablets determined curative effect of the present invention, characteristics such as mouthfeel is good, and compliance is good are adapted at using under plateau and the field condition; The inventive method is simple, controlled, cost is low, has good market prospect.
Claims (4)
1. the rhubarb chewable tablets of tool blood lipid regulation effect, it is characterized in that, it is prepared from by the following weight proportion raw material: 50～150 parts in extractum rhei powder, in sugar, xylitol or the hydroxyl isomaltulose one or more 21～63 parts, 21～63 parts in mannitol, 8～26 parts of instant starch, CaCO
38～26 parts, 8～26 parts of citric acid, 0.8～0.24 part of steviosin, 0.7～2.0 part of Mentholum, 0.13～0.39 part of flavoring orange essence, 3.8～11.6 parts of Pulvis Talci and percentage by weight are that 3～15% polyvidone alcoholic solution is an amount of; The total amount of aloe-emodin, chrysophanic acid, emodin, chrysophanol and Radix Et Rhizoma Rhei methyl ether is 2～8% of an extractum rhei powder in the extractum rhei powder wherein, described extractum rhei powder is to get in fresh Radix et Rhizoma Rhei rhizome, cane or the petiole one or more, through broken, squeeze the juice, after the filtration, juice is concentrated into proportion 1.03～1.26, and spray drying makes.
2. the rhubarb chewable tablets of tool blood lipid regulation according to claim 1 effect, it is characterized in that, it is prepared from by the following weight proportion raw material: 80～120 parts in extractum rhei powder, 21～63 parts of in lactose, xylitol or the hydroxyl isomaltulose one or more, 21～63 parts in mannitol, 8～26 parts of instant starch, CaCO
38～26 parts, 8～26 parts of citric acid, 0.8～0.24 part of steviosin, 0.7～2.0 part of Mentholum, 0.13～0.39 part of flavoring orange essence, 3.8～11.6 parts of Pulvis Talci and percentage by weight are that 3～15% polyvidone alcoholic solution is an amount of.
3. the rhubarb chewable tablets of tool blood lipid regulation according to claim 2 effect, it is characterized in that, it is prepared from by the following weight proportion raw material: 100 parts in extractum rhei powder, 42 parts of in lactose, xylitol or the hydroxyl isomaltulose one or more, 42 parts in mannitol, 17 parts of instant starch, CaCO
317 parts, 17 parts of citric acid, 0.16 part of steviosin, 1.3 parts of Mentholums, 0.26 part of flavoring orange essence, 7.7 parts of Pulvis Talci and percentage by weight are that 3～15% polyvidone alcoholic solution is an amount of.
4. method for preparing the rhubarb chewable tablets of each described tool blood lipid regulation effect of claim 1～3, it comprises the steps:
A, take by weighing in fresh Radix et Rhizoma Rhei rhizome, cane or the petiole one or more, through broken, squeeze the juice, after the filtration, juice is concentrated, be dried to extractum;
B, measure extractum rhei by prescription and pulverize and to be extract powder, press in formula ratio adding lactose, xylitol, the hydroxyl isomaltulose one or more, mixing at extract powder; Add mannitol, mixing; Add instant starch, mixing; Add portion C aCO
3, mixing; Add citric acid, mixing; The reuse equivalent method of progressively increasing adds steviosin, mixing;
C, be that 3～15% polyvidone alcoholic solution is an amount of, granulate that 45～80 ℃ are dried to moisture less than 3～8%, 8～40 order granulate at 8～40 orders with percentage by weight; The Mentholum dissolve with ethanol is with the remaining CaCO of the alcoholic solution of Mentholum
3Absorption joins in the above-mentioned granule mixing; Spray adds an amount of flavoring orange essence, mixing; Add Pulvis Talci, mixing; Tabletting, promptly.
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| CN1170536A (en) * | 1996-07-14 | 1998-01-21 | 侯一超 | Rhubarb as food and drink material (rhubarb stalk juice and steamed rhubarb pulp) |
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| CN1055877A (en) * | 1990-04-20 | 1991-11-06 | 国家医药管理局上海医药工业研究院 | The preparation method of Chinese medicine chewable tablet |
| CN1170536A (en) * | 1996-07-14 | 1998-01-21 | 侯一超 | Rhubarb as food and drink material (rhubarb stalk juice and steamed rhubarb pulp) |
| CN1391924A (en) * | 2001-06-18 | 2003-01-22 | 中国科学院西北高原生物研究所 | Health care composition for rhubarb |
| CN1228299C (en) * | 2002-05-04 | 2005-11-23 | 中国科学院西北高原生物研究所 | Process of extracting anthraquinone matter from aerial powtion of rheum officinale plant |
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