CN101129292B - Vacuum puffing process technique for Chinese traditional medicine - Google Patents
Vacuum puffing process technique for Chinese traditional medicine Download PDFInfo
- Publication number
- CN101129292B CN101129292B CN2007101475402A CN200710147540A CN101129292B CN 101129292 B CN101129292 B CN 101129292B CN 2007101475402 A CN2007101475402 A CN 2007101475402A CN 200710147540 A CN200710147540 A CN 200710147540A CN 101129292 B CN101129292 B CN 101129292B
- Authority
- CN
- China
- Prior art keywords
- crude drug
- chinese crude
- vacuum
- tank
- bulking tank
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a vacuum bulking manufacturing technique of traditional Chinese medicine, which is characterized by the following: adopting vacuum bulking technique to control and select the shape, size and moisture content of the traditional Chinese medicine to generate many pores at the cell wall of the traditional Chinese medicine; lixiviating and distilling the cell content to improve the extracting quantity of effective component or ingredient; fitting for extracting volatile oil component in the traditional Chinese medicine; opening a new path for drug value.
Description
Technical field
The present invention relates to a kind of Chinese crude drug vacuum puffing process technique, belong to the Chinese crude drug manufacture field.
Background technology
The tradition natural drug; Not only can satisfied curative effect be provided like Chinese medicine for treatment viral disease, cardiovascular and cerebrovascular disease, metabolic disease and various senile disease; And very big advantage is being arranged aspect health care, the life lengthening, its side effect is little in addition, cost is low, and is easy to development and use; Global traditional medicine heat is constantly heated up, also make back to nature, advocate an important trend utilizing natural drug to become the development of current era medicine.
Had a strong impact on Chinese medicine quality and clinical efficacy but the Chinese crude drug extraction process is backward relatively, the Chinese crude drug quality is hard, and solvent needs penetrate plant cell wall; Rely on the effect of osmotic pressure to extract, effective ingredient is difficult for proposing, and extracts not exclusively; The medical material utilization rate is low, causes the waste of medical material.
In order to improve the Chinese crude drug utilization rate, avoid waste, alleviate the Chinese medicine imbalance between supply and demand, the protection natural resources of Chinese medicinal materials, people have proposed various improved technologies or method; For example
One Chinese patent application CN93100966.9 discloses serial Chinese medicine Dabu crisp medicine pieces and swollen system method, and that its swollen system method comprises is selected, box-packed case is adorned in cleaning, sheet slitting forming, crushing process, doping shaping, expanding processing, splitting sealing.Series Chinese medicine Dabu crisp medicine pieces comprises 30 kinds of single bag of packings of the swollen crisp decoction pieces of single medicinal material; 10 kinds of the swollen crisp decoction pieces class wrappings of kinds of traditional Chinese medicines.Wherein expanded is to adopt the anticyclonic bulking machine of high temperature, and described high temperature is 100 ℃.
In recent years, effective ingredient, effective site, the active component research and development Chinese medicine preparation by Chinese crude drug is the important directions of the modernization of Chinese medicine.And the first step that effective ingredient, effective site extract, as the water of routine carry, alcohol extraction process, the effective ingredient of extraction or the amount of active component are often not high, cost is also bigger, is difficult to reach the requirement of the modernization of Chinese medicine.For addressing this problem, Chinese medicine must walk to improve the road of the efficient of extraction and purification.The extraction of Chinese medicine comprises many unit operationss such as lixiviate, clarification, filtration, evaporation or distillation.Chinese crude drug lixiviate or distillation are wherein very important unit operationss, are the starting points that most of Chinese medicines are produced.Chinese crude drug lixiviate or the amount that distills out are directly connected to the utilization rate and the following process of Chinese crude drug.Chinese crude drug lixiviate or distil process can be regarded as the important step of Chinese medicine production modernization, therefore, the pretreatment of research Chinese crude drug, the lixiviate or the distillation amount that improve Chinese crude drug effective ingredient or active component etc. are very necessary.The lixiviate of Chinese medicine is that solvent gets into medical material; Effective ingredient, active component are transferred to the process of liquid phase from solid phase, as long as influence lixiviate or distillatory factor and have the flow regime etc. of the physicochemical property of former Chinese crude drug, solvent, temperature, pressure, solid phase medical material shape, size and liquid.Vacuum puffed technology is mainly used in puffed vegetable fruit crisp slice at present, also is applied to others, does not almost have but be applied in the expanded aspect of Chinese crude drug.Like Granted publication CN1230085 patent of invention; It discloses a kind of is dry product and the preparation technology thereof that raw material is made with the leaves of plants; Selecting Folium Mori for use is raw material; Through adding manufacturing procedures such as expanded and pressure variation, can open the cell wall of contained nutrient substance in the Folium Mori, intracellular nutrient substance is easily absorbed by the body.And for example publication number is that CN1483330A applies for a patent, and it relates to a kind of processing technique of fruit-vegetable food and with the fruit-vegetable food of this explained hereafter.Adopt this technology that the nutrition major part in the plant cell is absorbed by human consumption, the fruit and vegerable breaking cellular wall functional food of having developed at present has: Fructus Crataegi, Fructus Jujubae, Fructus Mali pumilae, Fructus Vitis viniferae, Fructus Lycopersici esculenti, Rhizoma Solani tuber osi, Radix Dauci Sativae, Thallus Laminariae (Thallus Eckloniae) etc.The inventor is according to the ultimate principle of vacuum puffed technology; Adopt vacuum puffed technology, select control Chinese crude drug shape, size and water content simultaneously, make the Chinese crude drug cell wall produce many micropores; Help the cellular content lixiviate or distill out; Improve the extracted amount of effective ingredient or active component etc., reduce cost, adapt to the requirement of the modernization of Chinese medicine.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese crude drug vacuum puffing process technique; Technology of the present invention is through using vacuum puffed technology; Shape, size and the water content of control Chinese crude drug; Regulate the cell wall structure that swelling temperature, pressure, instant decompression change Chinese crude drug, effective ingredient or the active component etc. of the Chinese crude drug except that mineral property medical material fully are extracted out.
In order to achieve the above object, the technical scheme of the present invention's employing is:
A kind of Chinese crude drug vacuum puffing process technique is characterized in that the Chinese crude drug except that mineral property medical material is carried out being put in the Bulking tank after the pretreatment, heating, and making the interior temperature of Bulking tank is 30-79 ℃, and pressure is increased to 0.1-0.9MPa, and the time kept 5-40 minute; Subsequently, open the air relief valve that connects Bulking tank and vacuum tank rapidly, moment is depressurized to-0.04 to-0.09MPa, cools off, and keeps 5-40 minute, and said vacuum tank is evacuation in advance.
Described pretreatment comprises purified treatment, shape and big or small processing, humidifying or dried.
Described shape is handled cutting, stripping and slicing, section or the cutting that comprises Chinese crude drug with size, and making the length of Chinese crude drug or thickness is 0.1-20 centimetre.
The Chinese crude drug moisture is the 5-30% of Chinese crude drug weight after described humidifying or the dried.
The length of described Chinese crude drug or thickness are 1-15 centimetre, and the length of preferred described Chinese crude drug or thickness are 2-8 centimetre.
Temperature is 40-60 ℃ in the described Bulking tank.
Described Bulking tank internal pressure rises to 0.4-0.6MPa, and the time kept 15-30 minute.
Described moment is depressurized to-0.04 to-0.06MPa, cooling, and kept 15-30 minute
A described Bulking tank and a volumes are than being connected through pipeline between the big 5-10 of the Bulking tank vacuum tank doubly.
The vacuum puffed technology of described a kind of Chinese crude drug utilizes the method for distilling of prior art to extract the volatile oil component in the Chinese crude drug after carrying out moment blood pressure lowering and cooling.
Specifically, method of the present invention may further comprise the steps:
(1) purified treatment: will carry out purified treatment except that the Chinese crude drug the mineral property medical material with methods such as dried brush, arrangement, cleanings, and remove impurity.
(2) shape is handled with size: the shape that different Chinese crude drugs requires is different with size, and with Chinese crude drug cutting, stripping and slicing, cutting or the section that purified treatment is crossed, length or thickness are 0.1-20 centimetre.
(3) humidifying or dried:, make its Chinese crude drug moisture be controlled at the 5-30% of Chinese crude drug weight through humidifying or dried.
(4) vacuum puffed: with water content is the Chinese crude drug of 5-30%, is put in the pressurized tank, and heating makes a jar interior temperature be controlled at 30-79 ℃, and a jar internal pressure is increased to 0.1-0.9MPa, and the time kept 5-40 minute.Subsequently, open the air relief valve that connects pressurized tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, moment is depressured to-0.04 to 0.09MPa, and the room temperature cooling perhaps is cooled to room temperature, and keeps 5-40 minute.
Vacuum puffed system among the present invention mainly is by Bulking tank and the volumes vacuum tank than the big several times of Bulking tank, and for example 5-10 vacuum tank is doubly formed.
Preferred manufacturing procedure of the present invention is: the length of Chinese crude drug or thickness are 1-15 centimetre, more preferably 2-8 centimetre.
The Chinese crude drug moisture is preferably 10-20%, and more preferably 15%
The vacuum puffed optimum condition of the present invention is: 40-60 ℃ of Bulking tank temperature, and Bulking tank internal pressure 0.4-0.6MPa, time 15-30 minute, room temperature or cooling back were taken out and are used for extracting.
Optimum condition among the present invention in the vacuum tank is: the pressure in the vacuum tank for-0.04MPa to-0.06MPa, the time is 15-30 minute.Be under such pressure, the hydrone instant vaporization that the Chinese crude drug after expanded is inner and blasting, the expanded power of huge blast can't be destroyed the active component in the Chinese crude drug in the cell wall structure that has changed Chinese crude drug.
Chinese crude drug of the present invention can be the root, stem, leaf, skin, flower, seed of various Chinese crude drugs (except the mineral property medical material), really, tissue, polypide etc.
In order to save time, improve extraction efficiency, reduce energy resource consumption and production cost, developing new Chinese crude drug puffing technique is to utilize the expanded principle of vacuum decompression, in conjunction with the characteristics of Chinese crude drug, it is carried out a kind of processing method that science is handled.Its principle is that Chinese crude drug is placed bulking machine; Carrying out along with warming and pressurizing; Instant decompression after reaching certain high pressure; The hydrone instant vaporization that Chinese crude drug is inner and blasting, the expanded power of huge blast has changed the cell wall structure of Chinese crude drug, more helps the extraction or the distillation of its effective ingredient or active component etc.
Chinese crude drug is vacuum puffed to be the deep processing of Chinese crude drug, can obviously improve the medical material utilization rate after Chinese crude drug is vacuum puffed, avoids waste the protection natural resources of Chinese medicinal materials; Save time, improve extraction efficiency, reduce energy resource consumption and production cost.Method of the present invention will thoroughly change the traditional Chinese medicines decoction and have a style of one's own, and form novel form---the swelling agent of Chinese medicine preparation.This dosage form need not decoct, and only needs can take with hot-water soak, and is simple, easy to carry.Adopt method of the present invention, can realize that technical specification is: parenchyma cell broken wall Shuai ≧ 95%; Prothenchyma (of wood) broken wall Shuai ≧ 90%; Extruded prod water (fat, volatile oil) dissolubility Cheng Fen ≧ non-expansion article water (fat, volatile oil) soluble components; Extruded prod Ti gets Shi Jian ≦ non-expansion article extraction time.Through the Chinese crude drug that method of the present invention is handled, its extraction ratio of effective constituents is than high more than 10% without the effective ingredient of expanded Chinese crude drug, and the extraction ratio of volatile oil is than high more than 10% without the extraction ratio of expanded Chinese crude drug.
The present invention adopts vacuum puffed technology; Be to utilize moment to reduce pressure significantly to be the vaporization of Chinese crude drug intracellular fluid attitude instant water; Inflatable thousands of times approximately of hydrone; The expanded power of huge blast makes the Chinese crude drug cell produce many micropores, more helps the extraction of Chinese crude drug effective ingredient or active component etc. or distills out.In the vacuum puffed technology of the present invention, selected suitable temperature and pressure for use, make Chinese crude drug effective ingredient after leaching process in can be easy to extract, and extraction ratio of effective constituents has also obtained big raising in the Chinese crude drug.Because the temperature of Chinese crude drug in vacuum puffed jar is lower, therefore avoid the loss of some thermal sensitivity active ingredient simultaneously, better kept the effective ingredient in the Chinese crude drug.In addition; Chinese crude drug bulking process provided by the present invention, the expanded time is short, and it is short that Bulking tank is in the highly compressed time; Prolonged the service life of Bulking tank; Effective ingredient under such condition in the Chinese crude drug has also obtained reservation as much as possible, and the parenchyma cell sporoderm-broken rate also can reach more than 95%, and the prothenchyma (of wood) sporoderm-broken rate also can reach more than 90%.
Compared with prior art; Vacuum puffed technology of the present invention makes Chinese crude drug under the condition of not adding any additives; Make Chinese crude drug content extraction rate or distillation amount showed increased than existing processes; Extraction ratio such as effective ingredient or active component greatly increases, and particularly the effective ingredient equal size is very low for some medical values are very high, and existing technology is difficult to the Chinese crude drug or the Chinese crude drug volatile oil component that extract; Highlight its special advantages, for the medical value that makes full use of Chinese crude drug has been opened up new approach.
The specific embodiment
Adopt the disclosed Bulking tank of Chinese patent ZL00206504.5; It comprises heat-insulation layer, vapor film, Bulking tank; The pipeline that is communicated with vacuum tank is arranged on the Bulking tank, and the thing that is positioned at Bulking tank is trembled and is placed on the heater, on heater, lays electrical heating pipeline and Steam Heating pipeline; Heater and Bulking tank shape adapt, and push swollen jar through guide wheel.
Embodiment 1
Get 20 kilograms of water content and be 20% the Radix Astragali and pack in the Bulking tank, be heated to a jar interior temperature and be controlled at 79 ℃, a jar internal pressure rises to 0.2MPa, and the time kept 10 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, moment is depressurized to .-0.09MPa, naturally cools to room temperature.Described vacuum tank is bigger 5 times than Bulking tank.
The expanded back of the 60% ethanol extraction Radix Astragali, the corresponding extraction ratio of the expanded Radix Astragali is not high by 17% than 60% ethanol extraction for the astragaloside extraction ratio.
The expanded back of the water extraction Radix Astragali, the corresponding extraction ratio of the expanded Radix Astragali is not high by 30% than water extraction for the astragaloside extraction ratio.
Embodiment 2
Get the Flos Magnoliae alabastrum, the treated water content that makes is 10%, gets in 20 kilograms of Bulking tanks of packing into, is heated to a jar interior temperature and is controlled at 60 ℃, and a jar internal pressure rises to 0.5MPa, and the time kept 30 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, moment is depressurized to-0.04MPa, is cooled to 25 ℃, and keeps 10 minutes.Described vacuum tank is bigger 8 times than Bulking tank.
Above-mentioned expanded back Flos Magnoliae alabastrum is added in the vapor distillation still, adds 40% water with the medical material part by weight and carry out moisteningly, and then feed steam, continuous still 20 hours promptly gets volatile oil after the oil-water separation.
Contrast: extract the Flos Magnoliae alabastrum according to the method for prior art, pulverize, cross 20 mesh, be added in the vapor distillation still, add 40% water with the medical material part by weight and carry out moisteningly, feed steam then, continuous still 20 hours.Promptly get volatile oil after the oil-water separation.
The extraction ratio that experiment showed, expanded back Flos Magnoliae alabastrum volatile oil is than the volatile oil that extracts according to the method for prior art, and corresponding extraction ratio improves 20%.
Embodiment 3
Get Radix Bupleuri and put into tap water for 20 kilograms and rinse well, then with its section, thickness is 3 centimetres, through drying; Moisture Control is put into Bulking tank 30% with the Radix Bupleuri after the dried, through heating; Temperature is controlled at 30 ℃ in jar, and a jar internal pressure rises to 0.9MPa, and the time kept 20 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.07MPa, is cooled to 30 ℃, and keeps 30 minutes.Under condition of negative pressure, continue to keep thermal dehydration after a period of time, be cooled to below 20 ℃ and get final product.Described vacuum tank is bigger 9 times than Bulking tank.
The expanded back of water extraction Radix Bupleuri, the Saikosaponin a extraction ratio is than the Saikosaponin a of expanded Radix Bupleuri is not high by 25% according to the prior art water extraction.
The expanded back of ethanol extraction Radix Bupleuri, the Saikosaponin a extraction ratio is higher by 22% than the saikoside a extraction ratio that extracts expanded Radix Bupleuri not according to prior art.
Embodiment 4
Get Radix Salviae Miltiorrhizae and be put in the tap water for 20 kilograms and rinse well, then with its section, thickness is 1-3 centimetre; Through drying, moisture is controlled at 5%, with the Radix Salviae Miltiorrhizae after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 50 ℃ in jar; The jar internal pressure rises to 0.9MPa, and the time kept 40 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.06MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 10 times than Bulking tank.
The expanded back of water extraction Radix Salviae Miltiorrhizae, the TANSHINONES extraction ratio is that the TANSHINONES extraction ratio is high by 25% than the not expanded Radix Salviae Miltiorrhizae of water extraction.
The expanded back of 6% ethanol extraction Radix Salviae Miltiorrhizae, the TANSHINONES extraction ratio is that the Radix Salviae Miltiorrhizae extraction ratio is high by 28% than the not expanded Radix Salviae Miltiorrhizae of 6% ethanol extraction.
Embodiment 5
Get Radix Aconiti Kusnezoffii and be put in the tap water for 20 kilograms and rinse well, then with its section, thickness is 1-3 centimetre; Through drying, moisture is controlled at 15%, with the Radix Aconiti Kusnezoffii after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 45 ℃ in jar; The jar internal pressure rises to 0.6MPa, and the time kept 20 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.07MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 7 times than Bulking tank.
Above-mentioned expanded back Radix Aconiti Kusnezoffii is added in the vapor distillation still, adds 35% water with the medical material part by weight and carry out moisteningly, and then feed steam, continuous still 20 hours promptly gets volatile oil after the oil-water separation.
Contrast: extract Radix Aconiti Kusnezoffii according to the method for prior art, pulverize, cross 20 mesh, be added in the vapor distillation still, add 35% water with the medical material part by weight and carry out moisteningly, feed steam then, continuous still 20 hours.Promptly get volatile oil after the oil-water separation.
The extraction ratio that experiment showed, expanded back Radix Aconiti Kusnezoffii volatile oil is than the volatile oil that extracts according to the method for prior art, and corresponding extraction ratio improves 18%.
Embodiment 6
Get Radix Paeoniae Rubra and be put in the tap water for 20 kilograms and rinse well, then with its section, thickness is 1-3 centimetre; Through drying, moisture is controlled at 12%, with the Radix Paeoniae Rubra after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 55 ℃ in jar; The jar internal pressure rises to 0.4MPa, and the time kept 15 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to 0.06MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 5 times than Bulking tank.
The expanded back of water extraction Radix Paeoniae Rubra, the Radix Paeoniae Rubra total glycosides extraction ratio is than the not expanded Radix Paeoniae Rubra of water extraction, and the Radix Paeoniae Rubra total glycosides extraction ratio is high by 15%.
The expanded back of 6% ethanol extraction Radix Paeoniae Rubra, the Radix Paeoniae Rubra total glycosides extraction ratio is than the not expanded Radix Paeoniae Rubra of 6% ethanol extraction, and the Radix Paeoniae Rubra total glycosides extraction ratio is high by 21%.
Embodiment 7
Extracting liquorice is put in the tap water for 20 kilograms and rinses well, and then with its cutting, thickness is 15-20 centimetre; Through drying, moisture is controlled at 25%, with the Radix Glycyrrhizae after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 79 ℃ in jar; The jar internal pressure rises to 0.7MPa, and the time kept 5 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.09MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 9 times than Bulking tank.
The expanded back of water extraction Radix Glycyrrhizae, the ammonium glycyrrhizinate extraction ratio is than the not expanded Radix Glycyrrhizae of water extraction, and the ammonium glycyrrhizinate extraction ratio is high by 22%.
The expanded back of 6% ethanol extraction Radix Glycyrrhizae, the ammonium glycyrrhizinate extraction ratio is than the not expanded Radix Glycyrrhizae of 6% ethanol extraction, and the ammonium glycyrrhizinate extraction ratio is high by 24%.
Embodiment 8
Get the Radix Paeoniae Alba and be put in the tap water for 20 kilograms and rinse well, then with its cutting, thickness is 3-5 centimetre; Through drying, moisture is controlled at 15%, with the Radix Paeoniae Alba after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 35 ℃ in jar; The jar internal pressure rises to 0.8MPa, and the time kept 35 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.05MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 7 times than Bulking tank.
Contrast: extract the Radix Paeoniae Alba according to the method for prior art, pulverize, cross 20 mesh, be added in the vapor distillation still, add 35% water with the medical material part by weight and carry out moisteningly, feed steam then, continuous still 20 hours.Promptly get volatile oil after the oil-water separation.
The extraction ratio that experiment showed, expanded back Radix Paeoniae Alba volatile oil is than the volatile oil that extracts according to the method for prior art, and corresponding extraction ratio improves 15%.
Embodiment 9
Get Radix Platycodonis and be put in the tap water for 20 kilograms and rinse well, then with its cutting, length is 10-15 centimetre; Through drying, moisture is controlled at 18%, with the Radix Platycodonis after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 38 ℃ in jar; The jar internal pressure rises to 0.5MPa, and the time kept 28 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to 0.06MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 10 times than Bulking tank.
The expanded back of water extraction Radix Platycodonis, the kikyosaponin extraction ratio is than the not expanded Radix Platycodonis of water extraction, and the kikyosaponin extraction ratio is high by 23%.
The expanded back of 6% ethanol extraction Radix Platycodonis, the kikyosaponin extraction ratio is than the not expanded Radix Platycodonis of 6% ethanol extraction, and the kikyosaponin extraction ratio is high by 27%.
Embodiment 10
Get Rhizoma Gastrodiae and be put in the tap water for 20 kilograms and rinse well, then with its section, thickness is 1-3 centimetre; Through drying, moisture is controlled at 10%, with the Rhizoma Gastrodiae after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 50 ℃ in jar; The jar internal pressure rises to 0.9MPa, and the time kept 30 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.04MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 8 times than Bulking tank.
The expanded back of water extraction Rhizoma Gastrodiae, the gastrodine extraction ratio is than the not expanded Rhizoma Gastrodiae of water extraction, and the gastrodine extraction ratio is high by 27%.
The expanded back of 6% ethanol extraction Rhizoma Gastrodiae, the gastrodine extraction ratio is than the not expanded Rhizoma Gastrodiae of 6% ethanol extraction, and the gastrodine extraction ratio is high by 30%.
Embodiment 11
Get the Radix Paeoniae Alba and be put in the tap water for 20 kilograms and rinse well, then with its section, thickness is 0.1-1 centimetre; Through drying, moisture is controlled at 8%, with the Radix Paeoniae Alba after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 40 ℃ in jar; The jar internal pressure rises to 0.8MPa, and the time kept 20 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.05MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 7 times than Bulking tank.
Contrast: extract the Radix Paeoniae Alba according to the method for prior art, pulverize, cross 20 mesh, be added in the vapor distillation still, add 45% water with the medical material part by weight and carry out moisteningly, feed steam then, continuous still 20 hours.Promptly get volatile oil after the oil-water separation.
The extraction ratio that experiment showed, expanded back Radix Paeoniae Alba volatile oil is than the volatile oil that extracts according to the method for prior art, and corresponding extraction ratio improves 18%.
Embodiment 12
Get Radix Notoginseng and be put in the tap water for 20 kilograms and rinse well, then with its section, thickness is 0.1-1 centimetre; Through drying, moisture is controlled at 14%, with the Radix Notoginseng after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 75 ℃ in jar; The jar internal pressure rises to 0.1MPa, and the time kept 35 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.05MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 10 times than Bulking tank.
The expanded back of water extraction Radix Notoginseng, the arasaponin extraction ratio is that the arasaponin extraction ratio is high by 16% than the not expanded Radix Notoginseng of water extraction.
The expanded back of 6% ethanol extraction Radix Notoginseng, the arasaponin extraction ratio is than the not expanded Radix Notoginseng of 6% ethanol extraction, and the arasaponin extraction ratio is high by 19%.
Embodiment 13
Get Folium Ginkgo and be put in the tap water for 20 kilograms and rinse well, then with its cutting, length is 1-3 centimetre; Through drying, moisture is controlled at 16%, with the Folium Ginkgo after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 35 ℃ in jar; The jar internal pressure rises to 0.9MPa, and the time kept 35 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.045MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 7.5 times than Bulking tank.
The expanded back of water extraction Folium Ginkgo, the flavone extraction ratio is that the flavone extraction ratio is high by 20% than the not expanded Folium Ginkgo of water extraction.
The expanded back of 6% ethanol extraction Folium Ginkgo, the flavone extraction ratio is that the flavone extraction ratio is high by 24% than the not expanded Folium Ginkgo of 6% ethanol extraction.
Embodiment 14
Get Rhizoma Coptidis and be put in the tap water for 20 kilograms and rinse well, then with its cutting, length is 4-5 centimetre; Through drying, moisture is controlled at 18%, with the Rhizoma Coptidis after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 40 ℃ in jar; The jar internal pressure rises to 0.8MPa, and the time kept 10 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.05MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 6.5 times than Bulking tank.
The expanded back of water extraction Rhizoma Coptidis, the berberine extraction ratio is than the not expanded Rhizoma Coptidis of water extraction, and the berberine extraction ratio is high by 22%.
The expanded back of 6% ethanol extraction Rhizoma Coptidis, the berberine extraction ratio is that the berberine extraction ratio is high by 25% than the not expanded Rhizoma Coptidis of 6% ethanol extraction.
Embodiment 15
Get Cortex Moutan and be put in the tap water for 20 kilograms and rinse well, then with its cutting, length is 8-10 centimetre; Through drying, moisture is controlled at 22%, with the Cortex Moutan after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 55 ℃ in jar; The jar internal pressure rises to 0.4MPa, and the time kept 15 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.07MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 8.5 times than Bulking tank.
The expanded back of water extraction Cortex Moutan, the paeonol extraction ratio is than the not expanded Cortex Moutan of water extraction, and the paeonol extraction ratio is high by 17%.
The expanded back of 6% ethanol extraction Cortex Moutan, the paeonol extraction ratio is than the not expanded Cortex Moutan of 6% ethanol extraction, and the paeonol extraction ratio is high by 21%.
Embodiment 16
Get the Rhizoma Atractylodis Macrocephalae and be put in the tap water for 20 kilograms and rinse well, then with its section, thickness is 3-5 centimetre; Through drying, moisture is controlled at 28%, with the Radix Salviae Miltiorrhizae after the dried; Be put in the Bulking tank, through heating, temperature is controlled at 60 ℃ in jar; The jar internal pressure rises to 0.6MPa, and the time kept 25 minutes.Subsequently, open the air relief valve that connects Bulking tank and vacuum tank (vacuum tank is evacuation in advance) rapidly, because moment blood pressure lowering in the Bulking tank makes the flash distillation of Chinese crude drug internal moisture, moment is depressurized to-0.06MPa, naturally cools to room temperature and gets final product.Described vacuum tank is bigger 6 times than Bulking tank.
The expanded back of the water extraction Rhizoma Atractylodis Macrocephalae, the not expanded Rhizoma Atractylodis Macrocephalae of atractylenolide extraction ratio water extraction, the extraction ratio of atractylenolide is high by 16%.
The expanded back of the 6% ethanol extraction Rhizoma Atractylodis Macrocephalae, the atractylenolide extraction ratio is than the not expanded Rhizoma Atractylodis Macrocephalae of 6% ethanol extraction, and the atractylenolide extraction ratio is high by 20%.
Claims (10)
1. a Chinese crude drug vacuum puffing process technique is characterized in that the Chinese crude drug except that mineral property medical material is carried out being put in the Bulking tank after the pretreatment, heating, and making the interior temperature of Bulking tank is 30-79 ℃, and pressure is increased to 0.1-0.9MPa, and the time kept 5-40 minute; Subsequently, open the air relief valve that connects Bulking tank and vacuum tank rapidly, moment is depressurized to-0.04 to-0.09MPa, cools off, and keeps 5-40 minute, and said vacuum tank is evacuation in advance.
2. the vacuum puffed technology of a kind of Chinese crude drug according to claim 1 is characterized in that described pretreatment comprises purified treatment, shape and big or small processing, humidifying or dried.
3. the vacuum puffed technology of a kind of Chinese crude drug according to claim 2 is characterized in that described shape and big or small cutting, stripping and slicing, section or the cutting that comprises Chinese crude drug of handling, and making the length of Chinese crude drug or thickness is 0.1-20 centimetre.
4. the vacuum puffed technology of a kind of Chinese crude drug according to claim 2 is characterized in that the Chinese crude drug moisture is the 5-30% of Chinese crude drug weight after described humidifying or the dried.
5. the vacuum puffed technology of a kind of Chinese crude drug according to claim 3 is characterized in that the length of described Chinese crude drug or thickness are 1-15 centimetre, and the length of preferred described Chinese crude drug or thickness are 2-8 centimetre.
6. the vacuum puffed technology of a kind of Chinese crude drug according to claim 1 is characterized in that temperature is 40-60 ℃ in the described Bulking tank.
7. the vacuum puffed technology of a kind of Chinese crude drug according to claim 1 is characterized in that described Bulking tank internal pressure rises to 0.4-0.6MPa, and the time kept 15-30 minute.
8. the vacuum puffed technology of a kind of Chinese crude drug according to claim 1 is characterized in that described moment is depressurized to-0.04 to-0.06MPa, cooling, and kept 15-30 minute
9. the vacuum puffed technology of a kind of Chinese crude drug according to claim 1 is characterized in that a described Bulking tank and a volumes than being connected through pipeline between the big 5-10 of the Bulking tank vacuum tank doubly.
10. according to any vacuum puffed technology of described a kind of Chinese crude drug among the claim 1-9, it is characterized in that after carrying out moment blood pressure lowering and cooling, also comprising that the method for distilling that utilizes prior art extracts the process of the volatile oil in the Chinese crude drug.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101475402A CN101129292B (en) | 2006-08-24 | 2007-08-24 | Vacuum puffing process technique for Chinese traditional medicine |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610111717 | 2006-08-24 | ||
| CN200610111717.9 | 2006-08-24 | ||
| CN2007101475402A CN101129292B (en) | 2006-08-24 | 2007-08-24 | Vacuum puffing process technique for Chinese traditional medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101129292A CN101129292A (en) | 2008-02-27 |
| CN101129292B true CN101129292B (en) | 2012-02-08 |
Family
ID=39126810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007101475402A Active CN101129292B (en) | 2006-08-24 | 2007-08-24 | Vacuum puffing process technique for Chinese traditional medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101129292B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111531610A (en) * | 2020-05-09 | 2020-08-14 | 亳州言合医药科技服务有限公司 | Production process of paeonia lactiflora pall capable of reducing paeoniflorin component loss |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104432011A (en) * | 2013-09-16 | 2015-03-25 | 江苏天润本草生命科技有限公司 | Method for processing puffed dendrobe |
| CN103610718B (en) * | 2013-10-18 | 2017-01-04 | 高尚先 | A kind of plant section containing total secondary ginseng glucoside and preparation thereof |
| CN104083698B (en) * | 2014-07-21 | 2017-12-15 | 广西仁普医院投资管理有限责任公司 | Chinese herbal medicine ecosystem nanosizing processing method |
| CN104222888B (en) * | 2014-08-27 | 2016-08-24 | 金湘范 | A kind of former dew of tuberous plant, preparation method and application |
| CN104189039B (en) * | 2014-08-27 | 2017-09-22 | 金湘范 | A kind of ginseng class plant former dew, preparation method and application |
| CN106269143A (en) * | 2016-08-31 | 2017-01-04 | 华南农业大学 | A kind of Chinese crude drug preprocess method |
| KR101833328B1 (en) * | 2016-10-05 | 2018-03-02 | 헬스밸런스 주식회사 | A preparing mehod of puffed ginseng with excellent taste and functionality by pre-treatment process |
| CN106578940A (en) * | 2016-11-09 | 2017-04-26 | 福建省农业科学院农业工程技术研究所 | Nutritive and convenient rice product and making method thereof |
| CN107927244B (en) * | 2018-01-11 | 2021-07-27 | 天中康元药业(山东)有限公司 | Health-care black tea containing pine and bamboo and preparation method of health-care black tea |
| CN108379405A (en) * | 2018-05-21 | 2018-08-10 | 浙江凯润药业股份有限公司 | A kind of blackberry lily coating medicine materical crude slice and preparation method thereof |
| CN108434306A (en) * | 2018-06-26 | 2018-08-24 | 张宗杰 | A kind of department of general surgery's burn and scald treatment Chinese medicine composition and preparation method thereof |
| CN111096903A (en) * | 2019-12-27 | 2020-05-05 | 湖南恒康农林科技有限公司 | Puffing processing device for Chinese herbal medicine raw materials |
| CN111436554A (en) * | 2020-04-14 | 2020-07-24 | 安徽斯普瑞生物科技有限公司 | Preparation method of edible and medicinal fungus solid beverage |
| CN111449957B (en) * | 2020-05-29 | 2022-04-08 | 浙江尖峰健康科技有限公司 | Preparation method of traditional Chinese medicine decoction pieces |
| CN111903938A (en) * | 2020-07-09 | 2020-11-10 | 西南林业大学 | Processing method of microwave puffed gastrodia elata crisp chips and gastrodia elata crisp chips |
| CN111789887A (en) * | 2020-07-29 | 2020-10-20 | 山东明仁福瑞达制药股份有限公司 | Chinese herbal medicine health foot bath powder for improving osteoarticular diseases and preparation method thereof |
| CN113244655B (en) * | 2021-05-21 | 2022-08-16 | 黄春荣 | Vacuum puffing rapid extraction equipment and extraction method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1060606A (en) * | 1990-10-10 | 1992-04-29 | 内蒙古自治区畜牧科学院 | Heat spray Chinese crude drug pretreating process |
| CN1072342A (en) * | 1991-11-15 | 1993-05-26 | 倪胜根 | The method of puffing Chinese crude drug |
| CN1231906A (en) * | 1998-04-15 | 1999-10-20 | 侯梦斌 | Method and special microwave apparatus for preparing instant traditional Chinese medicine in pieces |
| CN1994331A (en) * | 2006-12-30 | 2007-07-11 | 中国人民解放军第三军医大学第一附属医院 | Super micronization method for botanical medicinal, product obtained thereby and use thereof |
-
2007
- 2007-08-24 CN CN2007101475402A patent/CN101129292B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1060606A (en) * | 1990-10-10 | 1992-04-29 | 内蒙古自治区畜牧科学院 | Heat spray Chinese crude drug pretreating process |
| CN1072342A (en) * | 1991-11-15 | 1993-05-26 | 倪胜根 | The method of puffing Chinese crude drug |
| CN1231906A (en) * | 1998-04-15 | 1999-10-20 | 侯梦斌 | Method and special microwave apparatus for preparing instant traditional Chinese medicine in pieces |
| CN1994331A (en) * | 2006-12-30 | 2007-07-11 | 中国人民解放军第三军医大学第一附属医院 | Super micronization method for botanical medicinal, product obtained thereby and use thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111531610A (en) * | 2020-05-09 | 2020-08-14 | 亳州言合医药科技服务有限公司 | Production process of paeonia lactiflora pall capable of reducing paeoniflorin component loss |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101129292A (en) | 2008-02-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101129292B (en) | Vacuum puffing process technique for Chinese traditional medicine | |
| CN106433989B (en) | A kind of method of many fragrant fruit oil of subcritical normal butane fluid extraction | |
| CN1943619B (en) | Method for preparing Chinese medicine origanum volatile oil and its soft capsule | |
| CN103417612B (en) | Chinese herbal medicine processed radix puerariae decoction pieces and preparation method thereof | |
| CN104138442A (en) | Compound Chinese herbal medicine extracting solution preventing and treating sea eel bacterial enteritis and preparing method of compound Chinese herbal medicine extracting solution | |
| CN110151860A (en) | A kind of preparation method and its usage of black fruit fructus lycii extract | |
| CN105815703A (en) | Method for processing trichosanthes peel, cortex albiziae and hawthorn fruit healthcare powder | |
| CN108159344A (en) | A kind of method that heavy metal purifies in curcuma zedoary medicinal material based on means of supercritical extraction | |
| CN108192735A (en) | Plant extraction oil, the leach extraction method of plant extraction oil and application | |
| CN106987317A (en) | A kind of method of high efficiency extraction dendrobium candidum flower essential oil | |
| CN104547286A (en) | Method for preparing Chinese Eaglewood leaf extract | |
| CN101297952B (en) | Chinese medicine preparation for treating forestomach atony of milk cattle and preparing method thereof | |
| CN102552363A (en) | Preparation method for mother chrysanthemum extract | |
| KR101281060B1 (en) | Composition for accelerating hair groth and the manufacturing method thereof | |
| CN106188083B (en) | A method of extracting 1, 8-Cineole volatile oil from folium artemisiae argyi | |
| CN107982455A (en) | A kind of natural composite antioxidant | |
| JP7408203B1 (en) | Method for producing skin disease improving agent | |
| CN108159298A (en) | The preparation method of cold relief capsule | |
| CN108530432A (en) | A kind of preparation method of Puerarin | |
| CN105031481A (en) | Pharmaceutic preparation for treating neurasthenia | |
| CN104800497A (en) | Traditional Chinese medicine composition for treating irregular menstruation of gynecology | |
| CN105963448A (en) | Blood pressure lowering tea bags and making method thereof | |
| CN105125896A (en) | Pharmaceutical preparation for treating migraine | |
| CN114848669A (en) | Functional foot bath bag and preparation method thereof | |
| CN102627622A (en) | Method for extracting chrysoeriol from chrysanthemum nankingense |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: XIONG HUI |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20110211 Address after: 100068 Beijing city Fengtai District North Hospital No. 8 Building No. 3 room 402 Applicant after: Gao Shangxian Co-applicant after: Xiong Hui Address before: 100068 Beijing city Fengtai District North Hospital No. 8 Building No. 3 room 402 Applicant before: Gao Shangxian |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |