CN108159298A - The preparation method of cold relief capsule - Google Patents
The preparation method of cold relief capsule Download PDFInfo
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- CN108159298A CN108159298A CN201810060830.1A CN201810060830A CN108159298A CN 108159298 A CN108159298 A CN 108159298A CN 201810060830 A CN201810060830 A CN 201810060830A CN 108159298 A CN108159298 A CN 108159298A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/022—Refining
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/027—Recovery of volatiles by distillation or stripping
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention discloses a kind of preparation methods of cold relief capsule, it is decocted twice by the way that the residue after honeysuckle, lophatherum gracile, Fermented Soybean, great burdock achene, Radix Glycyrrhizae and schizonepeta and Fructus Forsythiae extraction volatile oil is mixed, and obtained filtrate is condensed into paste, particle is mixed and made into balloonflower powder, then Herba Schizonepetae volatile oil, Forsythia volatile oil and peppermint oil are mixed and made into inclusion compound, finally are uniformly mixed to be fitted into particle, inclusion compound and Cornu Saigae Tataricae powder in capsule shells the cold relief capsule is made;Preparation method is simple, and schizonepeta and Forsythia volatile oil stabilization be not easy to lose, and the performance of drug has been effectively ensured.
Description
Technical field
The present invention relates to technical field of Chinese medicine, more particularly to a kind of preparation method of cold relief capsule.
Background technology
Flu is divided into point of narrow sense and broad sense, refers to common cold in the narrow sense, is a kind of slight upper respiratory tract (nose and larynx
Portion) viral infection;Broadly further include influenza, it is generally more serious than common cold, additional symptom include fever,
Ague and DOMS, systemic symptoms are more apparent, and unbearably, and the course of disease seriously affects people to symptom generally at 7 days or so after flu
Normal studying and living.
At present, there are many drug that flu is treated in Western medicine, but general curative effect is not notable, and side effect is more, such as:
(1) Ipratropium Bromide (ipratropium bromide) spray:Placebo-controlled trial is proved to alleviating runny nose, sneezing
Effectively, particularly course of disease early stage begins to use on the 1st day, and main adverse reaction is the band trace of blood in 15%~20% patient's mucus tears.
(2) pseudoephedrine:Act on respiratory mucosa alpha-adrenergic receptor, it is congested to alleviate schneiderian membrance, to heart and
The effect of other peripheral blood vessel alpha-receptors is little, mitigates nasal obstruction, can improve sleep, but unsuitable prolonged application, be limited within 3-5 days.
(3) antihistamine:First generation antihistamine drug such as chlorphenamine maleate (chlorpheniramine) is to reducing sneezing and nose
It overflows effective, the elderly has hypertrophy of the prostate person to use with caution, and the antihistamine of non-sedating effect lacks anticholinergic effect, and effect be unwilling to
It is fixed.
(4) antipyretic-antalgic agent:It may be selected in fever and DOMS, headache, hot breath (flutterred with paracetamol
It is bitterly) the most frequently used, it should avoid determining to use simultaneously with the neat husband of inverase, and application can increase viral discharge to aspirin repeatedly more
Amount, and it is slight to improve symptom effect.
Chinese medicine also has much the drug for the treatment of flu, and wherein antelope's horn cold relief capsule is because of its moderate cost and curative effect is shown
The high praise for receiving people is write, but the drug quality of each producer is irregular, the quality of the wherein volatile oil in its formula is straight
Connecing influences its curative effect, and recovery rate directly affects the price of drug, thus be badly in need of one kind can improve volatile oil extracting quality and
The preparation method of recovery rate to ensure drug quality, and reduces drug price.
Invention content
It is an object of the invention to solve at least the above, and provide the advantages of at least will be described later.
It is a still further object of the present invention to provide a kind of preparation methods of cold relief capsule, and preparation method is simple, and schizonepeta and
Forsythia volatile oil stabilization is not easy to lose, and the performance of drug has been effectively ensured.
It is a still further object of the present invention to provide a kind of for extracting the extractor of schizonepeta and Forsythia volatile oil, tank structure
Simply, but recovery rate is high, and high to the DNA purity of volatile oil, and large-scale industrial production is suitble to use.
In order to realize these purposes and other advantages according to the present invention, a kind of preparation method of cold relief capsule is provided,
Include the following steps:
The Cornu Saigae Tataricae powder that parts by weight are 5-10 is broken to 100-150 mesh by step 1, obtains Cornu Saigae Tataricae powder;
The campanulaceae that parts by weight are 200-280 is crushed to 100-150 mesh by step 2, obtains balloonflower powder;
The schizonepeta that parts by weight are 150-200 is placed in extractor and extracts to obtain Herba Schizonepetae volatile oil by step 3;
Parts by weight are placed in institute by step 4, the extraction that Forsythia volatile oil is carried out using hydrodistillation for the Fructus Forsythiae of 300-400
It states extraction in extractor and obtains Forsythia volatile oil;
Step 5, the raw material by the dregs of a decoction generated in step 3 and step 4 and liquid and following parts by weight:Honeysuckle 300-
400th, lophatherum gracile 150-200, Fermented Soybean 100-200, great burdock achene 200-280 and Radix Glycyrrhizae 100-200 mixing, and add in 2-5 times
After the distilled water mixing of volume decocts 1.5-3h, first-time filtrate and filter residue is obtained by filtration;
Step 6 after the filter residue that step 5 obtains is mixed decoction 1.5-3h with the distilled water of 2-5 times of volume, is obtained by filtration two
Secondary filtrate;
Step 7 mixes first-time filtrate and secondary filtrate, is condensed into paste, after being mixed and stirred for uniformly with balloonflower powder, system
Into the first particle;
The Forsythia volatile oil and parts by weight that step 8, the Herba Schizonepetae volatile oil that step 3 is obtained, step 4 obtain are 10-20
Peppermint oil mixing, obtain Mixed chaotic sequences, the Mixed chaotic sequences with beta-cyclodextrin mixed, volatile oil clathrate compound is made;
First particle, volatile oil clathrate compound and Cornu Saigae Tataricae powder are uniformly mixed by step 9, are fitted into capsule shells to get to institute
State cold relief capsule.
Preferably, in the preparation method of the cold relief capsule, the Fructus Forsythiae in schizonepeta and step 4 in step 3 selects
With fresh schizonepeta and Fructus Forsythiae.
Preferably, in the preparation method of the cold relief capsule, in step 7, first particle also needs after being made
It dried at 45-55 DEG C, crush and be sieved.
Preferably, in the preparation method of the cold relief capsule, the peppermint oil in step 8 can also be replaced with menthol,
The parts by weight of wherein described menthol in the feed are 0.5-1.
Preferably, in the preparation method of the cold relief capsule, the detailed process of volatile oil clathrate compound is prepared in step 8
For:
After Mixed chaotic sequences are mixed with the absolute ethyl alcohol of 1-2 times of volume, it is slowly injected into 48-52 DEG C of beta-cyclodextrin saturation
In solution, at 45-48 DEG C it is closed concussion 4.5-5 hours after, place 15-20h at 0-5 DEG C, after filtering, wash and drying,
Up to the volatile oil clathrate compound.
A kind of extractor for being used to extract Herba Schizonepetae volatile oil and Forsythia volatile oil, including:
Extractor, including tank body, steam net and parcel shelf;The first venthole is provided at the top of the tank body, it is described
Gas vent is provided on the upper side wall of tank body, outage is provided in the lower wall of the tank body;The parcel shelf by sheet frame and
Be set to the grid composition of the hollow out in the sheet frame, and the parcel shelf is set as multiple, multiple parcel shelf by up to
Under laterally homogeneous be arranged in the tank body;Position corresponding with the parcel shelf offers opening on the side wall of the tank body,
The width of the opening is matched with the parcel shelf, and the inner wall of tank body position corresponding with the parcel shelf is provided with
Groove, the parcel shelf to be made to be flexibly connected in a manner of it can be slided along the groove with the inner wall of the tank body;And it described puts
Object plate can extract the tank body out by the opening;The steam net is symmetrically arranged in the lower section of the parcel shelf, in institute
It states and steam is passed through below parcel shelf;
Knockout drum, top are provided with inlet and the second venthole, liquid outlet are provided in lower wall, is set on upper side wall
It is equipped with oil outlet;Catheter is connected on the liquid outlet, one end of the catheter is connected to the liquid outlet, and the other end erects
It is straight upward, and ensure that height is identical with the oil outlet;A point oil film, the side for dividing oil film are horizontally arranged in the knockout drum
The inner wall of edge and the knockout drum is mutually supported, and positioned at the top of the oil outlet;
Condenser pipe, to have the helicoidal structure of bilayer with dissection, along the extending direction of the condenser pipe, in the folder
Laid out in parallel has a more coolant access tubes in layer, and in adjacent two coolant access tubes coolant flow direction it is opposite;It is described
One end of condenser pipe is connected to the gas vent, and the other end is connected to the inlet, and makes the condenser pipe described to connect
The relatively low mode in inlet one end is obliquely installed between the extractor and knockout drum;
Steam generator, outlet side are connected to the steam net, and steam is passed through the steam net;
In addition, the outage and liquid outlet are connect respectively with the liquid feeding end pipeline of the steam generator.
Preferably, in the extractor, the steam net has the hollow-core construction of cavity, the steam net for middle part
Upper surface on it is uniformly distributed have several steam holes, the steam hole is connect with the steam generator gas circuit.
Preferably, in the extractor, the angle of inclination of the condenser pipe is 35-50 °.
The present invention includes at least following advantageous effect:
The present invention is by carrying out each herbal medicine different processing, then through being rationally mixed and made into cold relief capsule, preparation method
It is simple and practicable, and can ensure the quality of drug, it is used suitable for large-scale promotion.
Wherein, by the way that the schizonepeta of volatile oil and the dregs of a decoction of Fructus Forsythiae and liquid and other bulk pharmaceutical chemicals will be extracted through hydrodistillation
It carries out rational proportion to be decocted twice so that the drug ingedient of schizonepeta and Fructus Forsythiae is extracted as far as possible, so as to avoid medicine
The waste of product, and the effect of ensure that drug.
By the way that volatile oil and beta-cyclodextrin are mixed volatile oil clathrate compound, the stabilization of volatile oil can effectively ensure that
Property, scattering and disappearing for volatile oil is avoided, so as to ensure the effect of being conducive to manufactured cold relief capsule.
The present invention chooses 240 patients with influenza and carries out medication experiment, finds the sense prepared using the method for the present invention
The effect of emitting high efficiency on the 3rd of capsule up to 97%, being significantly higher than other commercially available cold relief capsules.
Part is illustrated to embody by further advantage, target and the feature of the present invention by following, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Description of the drawings
Fig. 1 is the structure chart of extractor of the present invention.
Specific embodiment
The present invention is described in further detail below in conjunction with the accompanying drawings, to enable those skilled in the art with reference to specification text
Word can be implemented according to this.
It should be appreciated that such as " having ", "comprising" and " comprising " term used herein are not precluded one or more
The presence or addition of a other element or combinations.
The present invention provides a kind of preparation methods of cold relief capsule, include the following steps:
The Cornu Saigae Tataricae powder that parts by weight are 5-10 is broken to 100-150 mesh by step 1, obtains Cornu Saigae Tataricae powder;
The campanulaceae that parts by weight are 200-280 is crushed to 100-150 mesh by step 2, obtains balloonflower powder;
The schizonepeta that parts by weight are 150-200 is placed in extractor and extracts to obtain Herba Schizonepetae volatile oil by step 3;
Parts by weight are placed in institute by step 4, the extraction that Forsythia volatile oil is carried out using hydrodistillation for the Fructus Forsythiae of 300-400
It states extraction in extractor and obtains Forsythia volatile oil;
Step 5, the raw material by the dregs of a decoction generated in step 3 and step 4 and liquid and following parts by weight:Honeysuckle 300-
400th, lophatherum gracile 150-200, Fermented Soybean 100-200, great burdock achene 200-280 and Radix Glycyrrhizae 100-200 mixing, and add in 2-5 times
After the distilled water mixing of volume decocts 1.5-3h, first-time filtrate and filter residue is obtained by filtration;
Step 6 after the filter residue that step 5 obtains is mixed decoction 1.5-3h with the distilled water of 2-5 times of volume, is obtained by filtration two
Secondary filtrate;
Step 7 mixes first-time filtrate and secondary filtrate, is condensed into paste, after being mixed and stirred for uniformly with balloonflower powder, system
Into the first particle;
The Forsythia volatile oil and parts by weight that step 8, the Herba Schizonepetae volatile oil that step 3 is obtained, step 4 obtain are 10-20
Peppermint oil mixing, obtain Mixed chaotic sequences, the Mixed chaotic sequences with beta-cyclodextrin mixed, volatile oil clathrate compound is made;
First particle, volatile oil clathrate compound and Cornu Saigae Tataricae powder are uniformly mixed by step 9, are fitted into capsule shells to get to institute
State cold relief capsule.
In said program, by carrying out different processing to each herbal medicine, then through being rationally mixed and made into cold relief capsule, make
Preparation Method is simple and practicable, and can ensure the quality of drug, is used suitable for large-scale promotion;Wherein, by will be distilled through water
Method is extracted the schizonepeta of volatile oil and the dregs of a decoction of Fructus Forsythiae and liquid and is decocted twice with other bulk pharmaceutical chemicals progress rational proportion, makes
The drug ingedient of schizonepeta and Fructus Forsythiae is extracted as far as possible, so as to avoid the waste of drug, and the effect of ensure that drug;
By the way that volatile oil and beta-cyclodextrin are mixed volatile oil clathrate compound, it can effectively ensure that the stability of volatile oil, avoid
Volatile oil scatters and disappears, so as to ensure the effect of cold relief capsule made of being conducive to.
In addition, applicant thinks according to differential diagnosis in tcm theory, catch a cold to emit cold, stagnation of YANG QI in the interior because drenching with rain, in generation heat and
It does not obtain, therefore headache, pupil head are revolved, nausea is unhappy, are coughed, breathed heavily in shortness of breath rush, is utterly confused, fainted from fear, body weight such as mountain, thus
It is only frightened to treat appropriate to the occasion clearing heat and detoxicating, ventilating the lung and relieving cough, soothing the liver, wherein, the specific pharmacology of each taste medicine is:Antelope's horn, salty, the cold, thoughts of returning home
Liver Channel suppressing hyperactive liver for calming endogenous wind, clears liver and improve vision, is clearing heat and detoxicating;Great burdock achene, dispelling wind and heat from the body, facilitaing lung promoting eruption, subdhing swelling and detoxicating, relieving sore-throat;Light beans
Drum, taste bitter and cold, inducing diaphoresis relieving restlessness, Xuan Yu removing toxic substances;Honeysuckle, sweet in flavor, cold in nature, clearing heat and detoxicating, wind-heat dissipating, anticancer;Schizonepeta, solution
Table relieve heat, promoting eruption;Fructus Forsythiae, clearing heat and detoxicating, mass dissipating and swelling eliminating;Lophatherum gracile, clearing heat and relieving fidgetness, inducing diuresis for treating strangurtia;Campanulaceae, facilitaing lung relieving sore-throat are dispelled
Phlegm apocenosis;Peppermint oil, acrid flavour, cool in nature, dispelling wind and heat from the body, clearing throat, promoting eruption;Radix Glycyrrhizae, resolving sputum, are adjusted at clearing heat and detoxicating, emergency analgesic therapy
And pharmacological property.
The present invention chooses 240 patients with influenza and carries out medication experiment, finds the sense prepared using the method for the present invention
The total effective rates on the 3rd for emitting capsule are up to 64.3%, and quick, cure rate is high, in subsequent experimental, continuously takes 5 days, total effective
Rate can reach 96.2%, the effect of being significantly higher than other commercially available cold relief capsules.
In one preferred embodiment, the Fructus Forsythiae in schizonepeta and step 4 in step 3 selects fresh schizonepeta and Fructus Forsythiae.
In said program, but schizonepeta and Fructus Forsythiae are herbaceous stem medicinal material, and since soft texture is loose, medicinal material is being processed, done
Volatile oil is easy to lose during dry, storage, thus selects fresh schizonepeta and Fructus Forsythiae in the inventive solutions, can
Scattering and disappearing in transport, storage and dry etc. volatile oil is reduced, improves the recovery rate of volatile oil, and ensure that drug
Content.
In one preferred embodiment, in step 7, first particle need to also be dried at 45-55 DEG C after being made, be crushed simultaneously
Sieving.
In said program, by the low temperature drying, crushing and sieving to the first particle, can ensure made of capsule into
Product condition is preferable, and particle is tiny after crushing, is more easy to be decomposed and absorbed by human body.
In one preferred embodiment, the peppermint oil in step 8 can also be replaced with menthol, wherein the menthol is in the feed
Parts by weight be 0.5-1.
In said program, peppermint oil is substituted using menthol, is equally reached the effect for the treatment of flu.
In one preferred embodiment, the detailed process that volatile oil clathrate compound is prepared in step 8 is:By Mixed chaotic sequences and 1-2
After the absolute ethyl alcohol mixing of times volume, it is slowly injected into 48-52 DEG C of beta-cyclodextrin saturated solution, the closed shake at 45-48 DEG C
After swinging 4.5-5 hours, 15-20h is placed at 0-5 DEG C, to get the volatile oil clathrate compound after filtering, wash and drying.
In said program, Mixed chaotic sequences can increase the solubility of volatile oil and dissolution speed after β mono- is cyclodextrin encapsulated
Rate, improves the stability of Mixed chaotic sequences, and reduces the medicine irritation of finished capsule product, and can improve the bad gas of drug
Taste.
As shown in Figure 1, it is a kind of for extracting the extractor of Herba Schizonepetae volatile oil and Forsythia volatile oil, including:Extractor, packet
Include tank body 1, steam net 2 and parcel shelf 3;The top of the tank body 1 is provided with the first venthole 4, on the upper side wall of the tank body 1
Gas vent 5 is provided with, outage 6 is provided in the lower wall of the tank body 1;The parcel shelf 3 is by sheet frame and is set to described
The grid composition of hollow out in sheet frame, and the parcel shelf 3 is set as multiple, multiple parcel shelf 3 are laterally equal from top to bottom
It is even to be arranged in the tank body 1;Opening 7 is offered with the 3 corresponding position of parcel shelf on the side wall of the tank body 1, it is described
The width of opening 7 matches, and the inner wall of the tank body 1 is provided with the 3 corresponding position of parcel shelf with the parcel shelf 3
Groove, the parcel shelf 3 to be made to be flexibly connected in a manner of it can be slided along the groove with the inner wall of the tank body 1;It is and described
Parcel shelf 3 can be by the 7 extraction tank body 1 of opening;The steam net 2 is symmetrically arranged in the lower section of the parcel shelf 3,
To be passed through steam in the lower section of the parcel shelf 3.
Knockout drum 8, top are provided with 9 and second venthole 10 of inlet, liquid outlet 11, upside are provided in lower wall
Oil outlet 12 is provided on wall;It is connected with catheter 13 on the liquid outlet 11, one end of the catheter 13 is connected to described
Liquid outlet 11, the other end straight up, and ensure that height is identical with the oil outlet 12;It is horizontally arranged in the knockout drum 8
Point oil film 14, the inner wall at the edge and the knockout drum 8 for dividing oil film 14 are mutually supported, and be located at the upper of the oil outlet 12
Side.
Condenser pipe 15, to have the helicoidal structure of bilayer with dissection, along the extending direction of the condenser pipe 15, in institute
Stating laid out in parallel in interlayer has a more coolant access tubes, and in adjacent two coolant access tubes coolant flow direction it is opposite;
One end of the condenser pipe 15 is connected to the gas vent 5, and the other end is connected to the inlet 9, and makes the condenser pipe 15
By connect described 9 one end of inlet it is relatively low in a manner of be obliquely installed between the extractor and knockout drum 8.
Steam generator 16, outlet side are connected to the steam net 2, and steam is passed through the steam net 2.
In addition, the liquid feeding end pipeline of the outage 6 and liquid outlet 11 respectively with the steam generator 16 is connect.
In said program, the specifically used method of the extractor is:Parcel shelf is pulled out by the side mouth of extractor,
It will be placed on parcel shelf, then again put back to parcel shelf in extractor, from steam generator to steaming after schizonepeta or Fructus Forsythiae chopping
Vapour Netcom enters steam, and the schizonepeta or Fructus Forsythiae that the steam that steam net sprays is placed on parcel shelf from parcel shelf bottom are fumigated so that
Steam steams the volatile oil contained in schizonepeta or Fructus Forsythiae, is passed through later containing steam by the gas vent of upper side containing oil vapour
Spiral helicine condenser pipe is cooled, formed oil water mixture, then flow into knockout drum in, oil water mixture after excessive oil film,
Flow into knockout drum bottom, grease natural layering, lighter volatilization oil reservoir is located at the top of water, and when reaching fuel-displaced open height by
Oil outlet flows out, and then obtains the volatile oil by schizonepeta or Fructus Forsythiae extraction, and the flow condensed is flowed out by the liquid outlet of knockout drum.
Wherein, steam is sprayed upwards by parcel shelf bottom, and it is containing steam, and schizonepeta to enable to by the discharge of tank body upper side wall gas vent
It is herbaceous stem medicinal material with Fructus Forsythiae, carries out stifling extraction volatile oil using placing it on parcel shelf, can avoid directly using water
Cook the mode of volatilization steam extraction so that schizonepeta or Fructus Forsythiae boil erosion long, and result in blockage liquid pipeline, and it is tired to there is filtering
The phenomenon that difficult, occurs, while the aperture that gathers on parcel shelf, and steam net is corresponding so that and medicinal material is heated evenly on parcel shelf,
Convenient for improving DNA purity and recovery rate, certainly, the aperture of parcel shelf is less than the granularity of the cutting of schizonepeta or Fructus Forsythiae, and glove
Plate is provided with sealing ring with the side being in contact that is open, and to improve the compactness connected between parcel shelf and tank body, and then ensures tank
Internal air-tightness;Divide oil film by being set in knockout drum, be made wherein dividing oil film that hydrophilic and oleophobic material can be used, example
Such as superabsorbent fiber material, oil film will be divided to be positioned in knockout drum after being impregnated in the volatile oil with extraction, flowed by condenser pipe
Oil water mixture by dividing oil film when, moisture is divided oil film to take away part, and divide in oil film be bonded volatile oil can drive
There is the volatile oil in whose mixture quickly to be condensed with original volatile oil, and then reduce the generation of oil water mixture emulsion,
The effect of water-oil separating is improved, and improves the rate of water-oil separating;By setting helical form and being obliquely installed so that oil-containing
The path length of side of the steam in condenser pipe, and then ensure that condensation effect, the condenser pipe being obliquely installed can also be convenient for the oil of condensation
Aqueous mixtures are flowed into knockout drum, and the coolant by setting the coolant access tube in condenser pipe adjacent is flowed on the contrary, energy
Enough ensure that temperature is uniform in condenser pipe, convenient for improving condensation effect.
In one preferred embodiment, the steam net has the hollow-core construction of cavity, the upper surface of the steam net for middle part
Above uniformly distributed to have several steam holes, the steam hole is connect with the steam generator gas circuit.
In said program, by setting several steam holes on the net in steam so that steam is uniformly sprayed by steam hole
Water distillation is carried out to parcel shelf, and then to the drug on parcel shelf, so as to which the drug ensured on parcel shelf is heated evenly, conducive to waving
Hair oil sheds.
In one preferred embodiment, the angle of inclination of the condenser pipe is 35-50 °.
It,, can between the angle of inclination of condenser pipe is arranged on 35-50 ° by testing discovery repeatedly in said program
The vapor for carrying volatile oil is enabled almost all to be condensed into liquid, and then ensure that condensation effect.Angle of inclination simultaneously
When smaller so that the oil-water mixture of condensation has certain delay in inner wall of the pipe, and when angle of inclination is larger, and make condensation
Oil mixing with water flow velocity is excessive, and grease emulsifies, and is not easy to the separation of follow-up grease.
Embodiment 1
A kind of preparation method of cold relief capsule, includes the following steps:
The Cornu Saigae Tataricae powder that parts by weight are 7.5 is broken to 120 mesh by step 1, obtains Cornu Saigae Tataricae powder;
The campanulaceae that parts by weight are 240 is crushed to 120 mesh by step 2, obtains balloonflower powder;
The schizonepeta that parts by weight are 180 is placed in extractor and extracts to obtain Herba Schizonepetae volatile oil by step 3;
The Fructus Forsythiae that parts by weight are 360 is placed in described carry by step 4, the extraction that Forsythia volatile oil is carried out using hydrodistillation
Extraction in tank is taken to obtain Forsythia volatile oil;
Step 5, the raw material by the dregs of a decoction generated in step 3 and step 4 and liquid and following parts by weight:It is honeysuckle 360, light
The leaf of bamboo 180, Fermented Soybean 150, great burdock achene 240 and Radix Glycyrrhizae 150 mix, and the distilled water mixing for adding in 4 times of volumes decocts 2.5h
Afterwards, first-time filtrate and filter residue is obtained by filtration;
After the filter residue that step 5 obtains is mixed decoction 3h with the distilled water of 4 times of volumes, secondary filter is obtained by filtration in step 6
Liquid;
Step 7 mixes first-time filtrate and secondary filtrate, is condensed into paste, after being mixed and stirred for uniformly with balloonflower powder, system
Into the first particle;
The Forsythia volatile oil and parts by weight that step 8, the Herba Schizonepetae volatile oil that step 3 is obtained, step 4 obtain be 15 it is thin
Lotus oil mixes, and obtains Mixed chaotic sequences, the Mixed chaotic sequences with beta-cyclodextrin are mixed, volatile oil clathrate compound is made;
First particle, volatile oil clathrate compound and Cornu Saigae Tataricae powder are uniformly mixed by step 9, are fitted into capsule shells to get to institute
State cold relief capsule.
Embodiment 2
A kind of preparation method of cold relief capsule, includes the following steps:
The Cornu Saigae Tataricae powder that parts by weight are 7.5 is broken to 120 mesh by step 1, obtains Cornu Saigae Tataricae powder;
The campanulaceae that parts by weight are 240 is crushed to 120 mesh by step 2, obtains balloonflower powder;
The schizonepeta that parts by weight are 180 is placed in extractor as claimed in claim 6 and extracts to obtain schizonepeta volatilization by step 3
Oil;
Step 4, the extraction that Forsythia volatile oil is carried out using hydrodistillation, the Fructus Forsythiae that parts by weight are 360 is placed in such as right
It is required that extraction obtains Forsythia volatile oil in extractor described in 6;
Step 5, the raw material by the dregs of a decoction generated in step 3 and step 4 and liquid and following parts by weight:It is honeysuckle 360, light
The leaf of bamboo 180, Fermented Soybean 150, great burdock achene 240 and Radix Glycyrrhizae 150 mix, and the distilled water mixing for adding in 4 times of volumes decocts 2.5h
Afterwards, first-time filtrate and filter residue is obtained by filtration;
After the filter residue that step 5 obtains is mixed decoction 3h with the distilled water of 4 times of volumes, secondary filter is obtained by filtration in step 6
Liquid;
Step 7 mixes first-time filtrate and secondary filtrate, is condensed into paste, after being mixed and stirred for uniformly with balloonflower powder, system
Into the first particle;
The Forsythia volatile oil and parts by weight that step 8, the Herba Schizonepetae volatile oil that step 3 is obtained, step 4 obtain be 15 it is thin
Lotus oil mixes, and obtains Mixed chaotic sequences, the Mixed chaotic sequences with beta-cyclodextrin are mixed, volatile oil clathrate compound is made;
First particle, volatile oil clathrate compound and Cornu Saigae Tataricae powder are uniformly mixed by step 9, are fitted into capsule shells to get to institute
State cold relief capsule.
Embodiment 3
A kind of preparation method of cold relief capsule, includes the following steps:
The Cornu Saigae Tataricae powder that parts by weight are 7.5 is broken to 120 mesh by step 1, obtains Cornu Saigae Tataricae powder;
The campanulaceae that parts by weight are 240 is crushed to 120 mesh by step 2, obtains balloonflower powder;
The schizonepeta that parts by weight are 180 is placed in extractor as claimed in claim 6 and extracts to obtain schizonepeta volatilization by step 3
Oil;
Step 4, the extraction that Forsythia volatile oil is carried out using hydrodistillation, the Fructus Forsythiae that parts by weight are 360 is placed in such as right
It is required that extraction obtains Forsythia volatile oil in extractor described in 6;
Step 5, the raw material by the dregs of a decoction generated in step 3 and step 4 and liquid and following parts by weight:It is honeysuckle 360, light
The leaf of bamboo 180, Fermented Soybean 150, great burdock achene 240, Radix Glycyrrhizae 150, uncaria 100, stiff silkworm 60, sea-buckthorn 100, scouring rush 100 and duckweed 60
Mixing, and the distilled water for adding in 4 times of volumes is mixed after decocting 2.5h, and first-time filtrate and filter residue is obtained by filtration;
After the filter residue that step 5 obtains is mixed decoction 3h with the distilled water of 4 times of volumes, secondary filter is obtained by filtration in step 6
Liquid;
Step 7 mixes first-time filtrate and secondary filtrate, is condensed into paste, after being mixed and stirred for uniformly with balloonflower powder, system
Into the first particle;
The Forsythia volatile oil and parts by weight that step 8, the Herba Schizonepetae volatile oil that step 3 is obtained, step 4 obtain be 15 it is thin
Lotus oil mixes, and obtains Mixed chaotic sequences, the Mixed chaotic sequences with beta-cyclodextrin are mixed, volatile oil clathrate compound is made;
First particle, volatile oil clathrate compound and Cornu Saigae Tataricae powder are uniformly mixed by step 9, are fitted into capsule shells to get to institute
State cold relief capsule.
Experimental data
Choose 240 patients with influenza and carry out medication experiments, wherein 30 as a control group, in commercially available antelope's horn sense
Random selection one kind in capsule is emitted to take;Remaining 210 patient is divided into 3 groups, and flu glue made of embodiment 1-3 is respectively adopted
Capsule is taken.
240 patients unified diet during medication, and unified time medication, cold symptoms, which completely disappear to be considered as, to be had
Effect, symptom mitigation is considered as effective, continuously takes shown in the drug result of 3 days table 1 specific as follows.
Table 1 takes effect statistical form
By upper table statistical result as it can be seen that using cold granules prepared by the method for the present invention compared with commercially available antelope's horn flu glue
Effective percentage on the 3rd of capsule are higher by by about one time, and the effect of cold granules made of the extractor for using the present invention special is more prominent,
High efficiency is up to 74.3%, after adding uncaria, stiff silkworm, sea-buckthorn, scouring rush and a few taste medicines of duckweed again in original formula,
Effective percentage is further improved, and the efficient of popularity flu was all up to 90% on 3rd, wherein the tool of a few herbs added in
Body pharmacology is:Stiff silkworm, dispelling wind and relieving convulsion, reducing phlegm and resolving masses;Sea-buckthorn, promoting blood circulation to remove blood stasis reduce phlegm and widen breast, promote the production of body fluid to quench thirst, clearing away heat to stop diarrhea;Wood
Thief, wind-dispelling heat-dissipating move back screen hemostasis;Duckweed, acrid flavour, cold in nature, dispelling wind-heat, promoting eruption, detumescence.
Although the embodiments of the present invention have been disclosed as above, but its be not restricted in specification and embodiment it is listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, it is of the invention and unlimited
In specific details and legend shown and described herein.
Claims (8)
1. a kind of preparation method of cold relief capsule, wherein, include the following steps:
The Cornu Saigae Tataricae powder that parts by weight are 5-10 is broken to 100-150 mesh by step 1, obtains Cornu Saigae Tataricae powder;
The campanulaceae that parts by weight are 200-280 is crushed to 100-150 mesh by step 2, obtains balloonflower powder;
The schizonepeta that parts by weight are 150-200 is placed in extractor and extracts to obtain Herba Schizonepetae volatile oil by step 3;
The Fructus Forsythiae that parts by weight are 300-400 is placed in described carry by step 4, the extraction that Forsythia volatile oil is carried out using hydrodistillation
Extraction in tank is taken to obtain Forsythia volatile oil;
Step 5, the raw material by the dregs of a decoction generated in step 3 and step 4 and liquid and following parts by weight:It is honeysuckle 300-400, light
Leaf of bamboo 150-200, Fermented Soybean 100-200, great burdock achene 200-280 and Radix Glycyrrhizae 100-200 mixing, and add in 2-5 times of volume
After distilled water mixing decocts 1.5-3h, first-time filtrate and filter residue is obtained by filtration;
After the filter residue that step 5 obtains is mixed decoction 1.5-3h with the distilled water of 2-5 times of volume, secondary filter is obtained by filtration in step 6
Liquid;
Step 7 mixes first-time filtrate and secondary filtrate, is condensed into paste, after being mixed and stirred for uniformly with balloonflower powder, is made the
One particle;
The Forsythia volatile oil and parts by weight that step 8, the Herba Schizonepetae volatile oil that step 3 is obtained, step 4 obtain are the thin of 10-20
Lotus oil mixes, and obtains Mixed chaotic sequences, the Mixed chaotic sequences with beta-cyclodextrin are mixed, volatile oil clathrate compound is made;
First particle, volatile oil clathrate compound and Cornu Saigae Tataricae powder are uniformly mixed by step 9, are fitted into capsule shells to get to the sense
Emit capsule.
2. the preparation method of cold relief capsule as described in claim 1, wherein, the Fructus Forsythiae in schizonepeta and step 4 in step 3 is equal
Select fresh schizonepeta and Fructus Forsythiae.
3. the preparation method of cold relief capsule as described in claim 1, wherein, in step 7, first particle is gone back after being made
It need to be dried at 45-55 DEG C, crush and be sieved.
4. the preparation method of cold relief capsule as described in claim 1, wherein, the peppermint oil in step 8 can also use menthol generation
It replaces, wherein the parts by weight of the menthol in the feed are 0.5-1.
5. the preparation method of cold relief capsule as described in claim 1, wherein, the specific of volatile oil clathrate compound is prepared in step 8
Process is:
After Mixed chaotic sequences are mixed with the absolute ethyl alcohol of 1-2 times of volume, it is slowly injected into 48-52 DEG C of beta-cyclodextrin saturated solution
In, at 45-48 DEG C it is closed concussion 4.5-5 hours after, place 15-20h at 0-5 DEG C, after filtering, wash and drying to get
The volatile oil clathrate compound.
6. a kind of extractor being used for such as claim 1 extraction Herba Schizonepetae volatile oil and Forsythia volatile oil, wherein, including:
Extractor, including tank body, steam net and parcel shelf;The first venthole, the tank body are provided at the top of the tank body
Upper side wall on be provided with gas vent, be provided with outage in the lower wall of the tank body;The parcel shelf is by sheet frame and setting
It is formed, and the parcel shelf is set as multiple in the grid of the hollow out in the sheet frame, multiple parcel shelf are horizontal from top to bottom
To being evenly arranged in the tank body;Position corresponding with the parcel shelf offers opening on the side wall of the tank body, described
The width of opening is matched with the parcel shelf, and the inner wall of tank body position corresponding with the parcel shelf be provided with it is recessed
Slot, the parcel shelf to be made to be flexibly connected in a manner of it can be slided along the groove with the inner wall of the tank body;And the glove
Plate can extract the tank body out by the opening;The steam net is symmetrically arranged in the lower section of the parcel shelf, with described
Steam is passed through below parcel shelf;
Knockout drum, top are provided with inlet and the second venthole, liquid outlet are provided in lower wall, is provided on upper side wall
Oil outlet;Be connected with catheter on the liquid outlet, one end of the catheter is connected to the liquid outlet, the other end vertically to
On, and ensure that height is identical with the oil outlet;Be horizontally arranged with a point oil film in the knockout drum, the edge for dividing oil film with
The inner wall of the knockout drum is mutually supported, and positioned at the top of the oil outlet;
Condenser pipe, to have the helicoidal structure of bilayer with dissection, along the extending direction of the condenser pipe, in the interlayer
Laid out in parallel has a more coolant access tubes, and in adjacent two coolant access tubes coolant flow direction it is opposite;The condensation
One end of pipe is connected to the gas vent, and the other end is connected to the inlet, and makes the condenser pipe to connect the feed liquor
The relatively low mode in mouth one end is obliquely installed between the extractor and knockout drum;
Steam generator, outlet side are connected to the steam net, and steam is passed through the steam net;
In addition, the outage and liquid outlet are connect respectively with the liquid feeding end pipeline of the steam generator.
7. extractor as claimed in claim 6, wherein, the steam net has the hollow-core construction of cavity, the steaming for middle part
Uniformly distributed on the upper surface of vapour net to have several steam holes, the steam hole is connect with the steam generator gas circuit.
8. extractor as claimed in claim 6, wherein, the angle of inclination of the condenser pipe is 35-50 °.
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Cited By (1)
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CN114288361A (en) * | 2021-12-29 | 2022-04-08 | 江中药业股份有限公司 | Lonicera and Forsythia detoxifying mixture and preparation method thereof |
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Application publication date: 20180615 |