Summary of the invention
In order to overcome the problems referred to above, the present invention provides a kind of Chinese medicine preparation being used for the treatment of hundstaupe pyreticosis, thus improves the curative ratio of canine distemper disease, and with low cost, have no side effect.
The present invention provides a kind of Chinese medicine preparation being used for the treatment of hundstaupe pyreticosis, comprises the raw material of following components by weight percent:
Japanese Honeysuckle 5-10, capsule of weeping forsythia 5-10, root of large-flowered skullcap 5-10, Leaf of Indigowoad 5-10, radix bupleuri 5-10, coptis 5-10, lotus leaf 5-10, Radix Glycyrrhizae 5-10, root of herbaceous peony 5-10, cape jasmine 5-10, root of kudzu vine 5-10, rhizoma Gastrodiae 5-10, Radix Astragali 2-5.
Preferably, the described Chinese medicine preparation being used for the treatment of canine distemper disease comprises the raw material of following components by weight percent:
Japanese Honeysuckle 8, the capsule of weeping forsythia 8, the root of large-flowered skullcap 8, Leaf of Indigowoad 8, radix bupleuri 6, the coptis 7, lotus leaf 8, Radix Glycyrrhizae 8, the root of herbaceous peony 8, cape jasmine 8, the root of kudzu vine 8, rhizoma Gastrodiae 8, the Radix Astragali 3.
Preferably, it is used for the treatment of the Chinese medicine preparation of hundstaupe pyreticosis, obtains by following method:
Step one, cleaned clean by Japanese Honeysuckle, the capsule of weeping forsythia, the root of large-flowered skullcap, Leaf of Indigowoad, radix bupleuri, the coptis, lotus leaf, Radix Glycyrrhizae, the root of herbaceous peony, cape jasmine, the root of kudzu vine, rhizoma Gastrodiae, the Radix Astragali, with warm water soaking 10-30 minute; Again the raw material soaked is pulled out, smash to pieces, then continuation warm water soaking 1-3h;
Step 2, carries out the raw material soaked and soup juice intense fire and decocts and boil 10-30 minute, then slow fire boiling 0.5-2h; Then pour out decoction of medicinal ingredients, keep for subsequent use;
Step 3, continues to add warm water to carry out in raw material decocting for two times and boils, and intense fire is decocted and boiled 20-50 minute, then slow fire boiling 1-3h, pours out decoction of medicinal ingredients, keeps for subsequent use;
Step 4, decoction of medicinal ingredients step 2 and step 3 obtained mixes, and then filters, to obtain final product.
Wherein, being soaked by raw material, smash to pieces, repeatedly decoct and boil, be conducive to the extraction of pharmaceutically active ingredient in improving, pharmaceutically active ingredient in rapid extraction, rational decocting time, prevents from extracting non-active ingredients.
Preferably, warm water temperature described in step one is 50-80 DEG C. The too high or too low immersion being all unfavorable for raw material of soaking temperature, causes in decoction process losing or extracting too much non-active ingredients of material effective component.
Preferably, the warm water consumption described in step one is the 1/2 of raw material total amount, and with the warm Water spray raw material of same temperature in the process soaked, then will soak the container sealing of raw material. Be conducive to raw material to be soaked completely, accelerate raw tissue and absorb moisture, reduce decocting time, effectively prevent the loss of effective constituent in decoction process.
Preferably, described step 2 decocts 10 times that the water consumption boiling raw material is raw material total amount, and step 3 decocts 8 times that the water consumption boiling raw material is raw material total amount. Decocting the excess moisture boiled, in the soup juice obtained, the effective constituent concentration of formula is low, in addition it is also necessary to decoction of medicinal ingredients is carried out concentrated after gavage could to disease dog, a not only how step thus, also result in the waste of water resources.
According to the Chinese medicine preparation being used for the treatment of hundstaupe pyreticosis of the present invention, the nucite contained in Japanese Honeysuckle, flavonoid, inositol, soap glucoside and tannin etc. have broad-spectrum antibacterial action, the various pathogens such as streptococcus aureus, dysentery bacterium all there is is stronger restraining effect, the multiple pathogenic microorganisms such as Leptospira, influenza virus and pathogenic moulds are also had restraining effect. In addition, Japanese Honeysuckle also has obvious anti-inflammation and antipyretic, and booster immunization function etc. act on, to cool blood only dysentery have obvious curative effect.
The capsule of weeping forsythia can be clearing heat and detoxicating, dispersing swelling and dissipating binds, and dispelling wind and heat pathogens, cure mainly warm, erysipelas, macula etc., have good anti-microbial effect, and with the root of large-flowered skullcap, coptis composition compound, its anti-microbial effect is stronger than during the alone capsule of weeping forsythia.
The root of large-flowered skullcap has heat-clearing and damp-drying drug, eliminating fire and detoxication, hemostasis, antiabortive, falls effect of blood pressure, and for damp-warm syndrome, febrile diseases in summer evil of vomitting uncomfortable in chest, damp and hot ruffian rushes down the treatment of dysentery etc., the same use of medicine such as Chang Yuyin flower, the capsule of weeping forsythia, and the normal sore of heat poison is had significant curative effect.
Leaf of Indigowoad enters liver, the heart, stomach warp. Heat-clearing, removing toxic substances, cool blood, hemostasis. Control warm disease heat and contain polydipsia, influenza, acute infectious hepatitis, bacillary dysentery, acute gastroenteritis, acute pneumonia etc. Its pharmacology has resisting pathogenic microbes effect, multiple bacterial classification is had certain restraining effect, Leptospira is had kill activity.
Radix bupleuri, antipyretic, anti-inflammation, Promote immunity function, phagocytic function strengthens, and Natural killer activity strengthens, it is to increase special viral antibody degree of dripping, it is to increase lymphocyte turns core rate, it is to increase skin delayed type allergy; Anti-liver injury, reduces the probability of hepatocellular degeneration and necrosis.
The coptis is used for retention of damp-heat in the interior, and stomach is damp and hot, and vomiting, rushes down the diseases such as dysentery, have the pharmacologically actives such as antibacterial, antitumor and anti-arrhythmia, have effect of heat-clearing and damp-drying drug, eliminating fire and detoxication, also has antibacterial, hypoglycemic, antitumor, protection gastric mucosa isoreactivity.
Lotus leaf contains alkaloid, flavonoid glycoside, organic acid etc., for hot summer weather polydipsia, and insufficiency of the spleen few food, diarrhoea, the diseases such as haematemesis.
Radix Glycyrrhizae has similar adrenocortical hormone sample effect; the gastric acid secretion caused by histamine too much has restraining effect; and have antiacid and alleviate gastrointestinal smooth muscle spasm effect; Radix Glycyrrhizae also has anti-inflammation, anti-allergic effects simultaneously; protecting throat and the tunica mucosa tracheae of inflammation, the secondary acid wherein contained can block the effect of Induced by Carcinogen tumor growth.
The paeoniflorin contained in the root of herbaceous peony and the methyl alcohol mixture of Radix Glycyrrhizae share, and acetic acid twisting reaction is had synergic antalgic effect by the two, alleviates the analgesia of central nervous system; It directly acts on intestinal tube unstriated muscle, has good spasmolysis; Liver injury caused by D mono-GalN and SGP are raised by Radix Paeoniae Alba extract simultaneously obvious antagonistic action, SGPT can be made to reduce, and making the pathology of liver cell and downright bad recovery normal, the root of herbaceous peony also has significant anti-inflammatory action, and Promote immunity system is had positive effect.
Cape jasmine has purging intense heat relieving restlessness, clearing heat and promoting diuresis, effect of removing pattogenic heat from the blood and toxic material from the body, wherein cure mainly pyreticosis vexed, irascibility hot eyes, headache, jaundice due to damp-heat, bloody flux hematuria etc., Fructus Gardeniae extract is to liver cell free of toxic effects simultaneously, serum bilirubin level can be reduced, there is well profit courage effect, pancreatic secretion can also be promoted simultaneously, reduce the effect of pancreatic amylase, when pancreatitis, cape jasmine is improved body resistance against diseases, improve the pharmacological action such as function and alleviate pancreatitis of liver and gastro-intestinal system, the ursolic acid wherein contained has obvious restraining effect, Fructus Gardeniae extract is to streptococcus aureus simultaneously, meningococcus, the bacterium such as micrococcus catarrhalis have restraining effect, and myocardial contraction can be reduced, also has certain anastalsis.
The root of kudzu vine, the flavones contained in the root of kudzu vine can increase brain and crown vascular flow amount, reduce vascular resistance, action temperature and, also has spasmolysis simultaneously, and blood-sugar content can be reduced, also have refrigeration function, join and use with radix bupleuri, the root of large-flowered skullcap, quickening treatment is caught cold, the heating of stagnation of pathogen converted into heat is heavy, aversion to cold is light, the disease of headache nasal cavity dryness, having and play relieving superficies by cooling altogether, effect of dampness removing and diarrhea-relieving, is used for the treatment of damp-heat dysentery.
Rhizoma Gastrodiae breath wind is antipruritic; calming the liver, dispelling wind and removing obstruction in the collateral, has calmness, analgesia, anticonvulsant action; cerebral blood flow (CBF) can be increased; reduce cerebral vascular resistance, the light contraction cerebrovascular, increase coronary vasodilator flow; blood pressure can be reduced; reducing heart rate, has provide protection to myocardial ischemia, and gastrodia elata polysaccharide has immunocompetence simultaneously.
The Radix Astragali has invigorating QI to consolidate the body surface resistance, diuresis holder poison, apocenosis, effect of expelling pus and promoting granulation, weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO etc., the Radix Astragali can significantly increase blood middle leukocytes sum, promote phagocytic function and the sterilizing ability of neutrophil leucocyte and scavenger cell, and can obviously strengthen cellular immunization, increase RBC number, liver protecting, strengthen antifatigue effect, enhancing body immunologic function, strengthens hemopoietic function, improves substance metabolism, the Radix Astragali also has the strong heart, regulate blood pressure, antiviral property myocarditis, protect the effect such as liver, antiulcer agent.
Canine distemper initial stage disease and evil is being defended point, and based on nasal obstruction, sneeze, the conjunctival congestion of generating heat, controlling should be clearing heat and detoxicating, relieving the exterior syndrome with drugs of pungent in flavor and cool in nature. The hot Sheng phase, heresy is divided at gas, and thirsty with high heat, cough and asthma is main, controls suitable heat-clearing, promotes the production of body fluid, a surname's lung. Middle and later periods, heresy, in ying blood, is not moved back with Gao Re or low-heat, fash, is had blood in stool, spitting blood, and asoscope chaps, and tic is main, controls and should clearing heat and cooling blood strengthen the body resistance to consolidate the constitution.
In this prescription, Japanese Honeysuckle is clearing heat and detoxicating, and cool blood is dysentery only; The capsule of weeping forsythia is clearing heat and detoxicating, the carbuncle that disappears dissipating bind; Root of large-flowered skullcap heat-clearing and damp-drying drug, eliminating fire and detoxication; Leaf of Indigowoad is clearing heat and detoxicating, blood cooling and ecchymoses removing; Radix bupleuri induces sweat in conjunction, dispersing the stagnated live-QI to relieve the stagnation of QI; Coptis eliminating fire and detoxication, heat-clearing and damp-drying drug; Lotus leaf liter falls clearly turbid, separates thermal hemostasis; Radix Glycyrrhizae is clearing heat and detoxicating, moisten the lung and relieve the cough, and invigorating the spleen and replenishing QI, relaxes the property of medicine; The root of herbaceous peony is nourished blood and holds back the moon, flat liver pain relieving; Cape jasmine heat-clearing and fire-purging, removing pattogenic heat from the blood and toxic material from the body; Root of kudzu vine expelling pathogenic factors from muscles for reducing heat, rises sun antidiarrheal; The flat liver breath wind of rhizoma Gastrodiae, antispastic pain relieving; Radix Astragali tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration.
The present invention adopts Chinese medicine formula, raw material sources are extensive, with low cost, the formula simultaneously formed by Chinese medicine preparation, the property of medicine is gentle, evident in efficacy, by the synergy of recipe ingredient, substantially increase the drug effect of often kind of medicine, part composition has obvious antibacterial effect, while kill virus, liver protecting, increase the immunity function of body, from nervus centralis, the positions such as cardiovascular and liver are treated simultaneously, multi-pronged, thus accelerate the speed of kill virus, reduce the speed of virus diffusion, avoid the various good reaction that due to illness infected animal brings to greatest extent, corresponding hormone is produced by each gland body of medicine irritation while antibacterial, in time sick dog is supplemented corresponding nutritive ingredient, to maintain the resistance against diseases of disease dog. further, the Chinese medicine preparation that the present invention obtains is workable, and can make different preparations as required, and convenient sick dog is taken, and makes drug effect perform to maximum degree. Chinese medicine is gentle, and toxic side effect is little, virus can not be made to produce resistance, treat both principal and secondary aspect of disease.
Embodiment 5
In January, 2013-December, there is sick dog 25 example in certain community, and wherein 10 examples are respiratory symptom type canine distemper, and 5 examples are nervous symptoms type canine distemper, and 8 examples are comprehensive canine distemper, and 2 examples are digestion symptom type canine distemper, and collective shows as fever, sheds tears, refuses food; There is expiratory dyspnea in major part, the symptom such as have loose bowels, the sick dog purulence nose liquid of part, the present situations such as eye conjunctiva is rubescent, even instability of gait, frequent tic. Gavaging we's agent 7 days continuously, the 22 sick dog body temperature of example are normal, and eye, nasal discharge disappear, and spirit is normal, and appetite is recovered, and 3 example situations slightly take a turn for the better, and low fever, still has a nasal discharge, but liquid food of can searching for food. Continuing to gavage 3 days again, the 22 sick dog recoveries from illness of example, without recurrence symptom, have 2 example illnesss to take a turn for the better, body temperature is normal, and eye nasal discharge disappears, and can normally search for food. Curative ratio 99%.
According to the Chinese medicine preparation being used for the treatment of hundstaupe pyreticosis of the present invention, there is significant result for the treatment of, the present invention selects Japanese Honeysuckle, the capsule of weeping forsythia, the root of large-flowered skullcap, Leaf of Indigowoad, radix bupleuri, the formula that the coptis etc. are clearing heat and detoxicating, produce eliminating inflammation and expelling toxin effect, there is raising body resistance against diseases, improve the effects such as the function of liver and gastro-intestinal system and alleviate pancreatitis, Radix Glycyrrhizae can protect throat and the tunica mucosa tracheae of inflammation, the secondary acid wherein contained can block the effect of Induced by Carcinogen tumor growth, Radix Paeoniae Alba extract can make the pathology of liver cell and downright bad recovery normal, also there is significant anti-inflammatory action, Promote immunity system there is positive effect, cape jasmine reduces serum bilirubin level, there is well profit courage effect, pancreatic secretion can also be promoted simultaneously, reduce the effect of pancreatic amylase, the root of kudzu vine can increase brain and crown vascular flow amount, reduce vascular resistance, action temperature and, also has spasmolysis simultaneously, rhizoma Gastrodiae reduces cerebral vascular resistance, the light contraction cerebrovascular, the Radix Astragali can significantly increase blood middle leukocytes sum, promote phagocytic function and the sterilizing ability of neutrophil leucocyte and scavenger cell, and can obviously strengthen cellular immunization, increase RBC number, liver protecting. thus the synergy according to medicine, this Chinese medicine preparation is applicable to any one stage of hundstaupe pyreticosis, can not because of the mistaken diagnosis of certain one-phase delays treatment, there is well treatment and preventive effect, greatly improve the curative ratio of hundstaupe pyreticosis, and method is simple, easy and simple to handle.
Although embodiment of the present invention are open as above, but listed utilization that it is not restricted in specification sheets and enforcement mode, it can be applied to various applicable the field of the invention completely, for those skilled in the art, can easily realize other amendment, therefore claim is not being deviated from and under general concept that equivalency range limits, the present invention is not limited to specific details and illustrates and the embodiment described here.