CN108379405A - A kind of blackberry lily coating medicine materical crude slice and preparation method thereof - Google Patents

A kind of blackberry lily coating medicine materical crude slice and preparation method thereof Download PDF

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Publication number
CN108379405A
CN108379405A CN201810488026.3A CN201810488026A CN108379405A CN 108379405 A CN108379405 A CN 108379405A CN 201810488026 A CN201810488026 A CN 201810488026A CN 108379405 A CN108379405 A CN 108379405A
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Prior art keywords
blackberry lily
medicine materical
materical crude
crude slice
coating
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CN201810488026.3A
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Chinese (zh)
Inventor
刘利辉
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Zhejiang Kayun Pharmaceutical Ltd By Share Ltd
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Zhejiang Kayun Pharmaceutical Ltd By Share Ltd
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Priority to CN201810488026.3A priority Critical patent/CN108379405A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/10Expectorants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Otolaryngology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to the prepared slices of Chinese crude drugs, a kind of blackberry lily coating medicine materical crude slice and preparation method thereof is disclosed, the method includes the steps of:1)High-quality blackberry lily health product is selected, impurity elimination is cleaned;2)It picks up and is sliced after being filtered dry moisture content;3)Sheet blackberry lily is placed in pressure pan, 24 kgf/cm are first pressurized to2, and 15 25 min are kept, then so that pressure is down to 0 kgf/cm suddenly in 03 seconds2;4)By step 3)In obtained sheet blackberry lily be placed in be coated in seed-coating machine and be coated medicine materical crude slice to get blackberry lily.The present invention enables blackberry lily medicine materical crude slice be easy to decoct by decompression suddenly of pressurizeing again, improves drug effect, without additionally drying or drying of being exposed to the sun, product palatability is good, safe, by being coated in medicine materical crude slice outer wall, medicine materical crude slice oxidation and the moisture absorption are prevented, prevents isoflavones active ingredient from aoxidizing, extends the resting period;Preparation process is simple, and cost is relatively low, is suitable for industrial production.

Description

A kind of blackberry lily coating medicine materical crude slice and preparation method thereof
Technical field
The present invention relates to the prepared slices of Chinese crude drugs more particularly to a kind of blackberry lily to be coated medicine materical crude slice and preparation method thereof.
Background technology
Blackberry lily, Chinese medicine name.For the dry rhizome of irides blackberry lily.Its bitter, it is cold in nature.There is clearing heat and detoxicating, dissolving phlegm, profit The effect of pharynx, is usually used in heat toxin convulsive seizure due to phlegm-fire Tai knots, abscess of throat, accumulation and obstruction of sputum, cough and asthma.Currently, blackberry lily medicinal material is adopted from field After after receipts, typically arranging, drying, it is packaged storage and transport.After these blackberry lily medicinal materials are transported to prepared slices of Chinese crude drugs factory, need to tear open Packet, cleaning, bored profit, slice, and redry.Prior art time and effort consuming, process repeat, and increase the production cost of medicine materical crude slice. Not only result in the loss of aqueous soluble active constituent in the process, and if bored profit process high temperature season carry out, easily occur Medicinal material goes mouldy, so as to cause the decline of medical material quanlity and the reduction of clinical efficacy.Therefore, a kind of production of new blackberry lily medicinal material is developed Ground processing technology is imperative.
Application No. is 201510285803 Chinese patents to disclose a kind of production method of blackberry lily medicine materical crude slice, after enzymolysis It is processed with composite nutrient-fluid, not only enhancing has effects that clearing heat and detoxicating, dissolving phlegm, relieving sore-throat, and enhances blackberry lily medicine materical crude slice Nutrition and health care curative effect.But this method is added to a large amount of health cares or the substance with other additional therapeutic benefits, therefore be difficult directly to use In allotment or preparation, it is not suitable as one of the formula that Chinese medicine is made up the prescription.
Invention content
In order to solve the above technical problem, the present invention provides a kind of blackberry lilys to be coated medicine materical crude slice and preparation method thereof, by adding Pressure decompression suddenly again, enables blackberry lily medicine materical crude slice be easy to decoct, and by being coated in medicine materical crude slice outer wall, prevents medicine materical crude slice oxidation blackening and the moisture absorption, prolongs The long resting period.
The specific technical solution of the present invention is:The method includes the steps of:
1)High-quality blackberry lily health product is selected, impurity elimination is cleaned;
2)It picks up and is sliced after being filtered dry moisture content;
3)Sheet blackberry lily is placed in pressure pan, 2-4 kgf/cm are first pressurized to2, and 15-25 min are kept, then in 0-3 seconds Pressure is set to be down to 0 kgf/cm suddenly2
4)By step 3)In obtained sheet blackberry lily be placed in be coated in seed-coating machine and be coated medicine materical crude slice to get blackberry lily.
After blackberry lily slice, the mode first pressurizeed and be depressured suddenly again is used, using the abrupt transients of pressure difference, makes high pressure The boiling point of superheated water reduces rapidly in tank, flashes as water vapour, causes slice volume to surge, broken cellulose etc. in blackberry lily Strand can promote active ingredient to leach, improve drug effect in the decoction of follow-up blackberry lily medicine materical crude slice or soaking process;Dry effect simultaneously Fruit is good, without additionally drying or drying of being exposed to the sun.In addition, after formerly pressurization is depressured suddenly again, cause to generate bilgy odour in blackberry lily Some pernicious gases and sulfur dioxide etc. can be spread rapidly, keep product palatability good, safe, be also suitable for daily Baoshang to boil water With.
The principle active component of blackberry lily is isoflavones and flavonoid glycoside substance etc., is natural, after medicine materical crude slice coating Effectively and air exclusion medicine materical crude slice softening stickness can be prevented, while preventing active ingredient from aoxidizing, reduce drug effect, extend medicine materical crude slice Holding time.
Preferably, the step 3)Temperature is 115-150 DEG C in mesohigh tank.
Preferably, the step 4)Middle coating uses Slurry mixing.
Preferably, the step 4)Middle coating is the mixture of syrup and maltodextrin.
Preferably, the mass ratio of the syrup and maltodextrin is 3:1-2.
The water solubility of maltodextrin preferably, adds efficiency when maltodextrin can improve medicine materical crude slice decoction, no in syrup Decocting time can be caused to extend because of coating.
Preferably, the step 4)Middle coating temperature is 35-45 DEG C.
Preferably, the step 4)Middle coating thickness is 6-10 μm.
It is compared with the prior art, the beneficial effects of the invention are as follows:The present invention enables blackberry lily medicine materical crude slice by decompression suddenly of pressurizeing again It is easy to decoct, improves drug effect, without additionally drying or drying of being exposed to the sun, product palatability is good, safe, by medicine materical crude slice outer wall Coating prevents medicine materical crude slice oxidation and the moisture absorption, prevents isoflavones active ingredient from aoxidizing, extends the resting period;Preparation process is simple, cost It is relatively low, it is suitable for industrial production.
Specific implementation mode
With reference to embodiment, the invention will be further described.
Embodiment 1
High-quality blackberry lily health product is selected, impurity elimination is cleaned;It picks up and is sliced after being filtered dry moisture content;Sheet blackberry lily is placed in pressure pan, 115 At DEG C, it is first pressurized to 2kgf/cm2, and keep 15 min, then so that pressure is down to 0 kgf/cm2 suddenly in 0-3 seconds;By sheet Radix pseudostellariae is placed in seed-coating machine again, and Slurry mixing coating is coated the mixture for syrup and maltodextrin, mass ratio 3:1.5, packet After clothing multilayer to coating thickness is 6 μm, blows and be coated medicine materical crude slice up to radix pseudostellariae after heated drying.
Embodiment 2
High-quality blackberry lily health product is selected, impurity elimination is cleaned;It picks up and is sliced after being filtered dry moisture content;Sheet blackberry lily is placed in pressure pan, 150 At DEG C, it is first pressurized to 3kgf/cm2, and keep 20min, then so that pressure is down to 0 kgf/cm2 suddenly in 0-3 seconds;Too by sheet Son ginseng is placed in seed-coating machine again, and Slurry mixing coating is coated the mixture for syrup and maltodextrin, mass ratio 3:1, coating is more After layer to coating thickness is 8 μm, blows and be coated medicine materical crude slice up to radix pseudostellariae after heated drying.
Embodiment 3
High-quality blackberry lily health product is selected, impurity elimination is cleaned;It picks up and is sliced after being filtered dry moisture content;Sheet blackberry lily is placed in pressure pan, 135 At DEG C, it is first pressurized to 4kgf/cm2, and keep 25 min, then so that pressure is down to 0 kgf/cm2 suddenly in 0-3 seconds;By sheet Radix pseudostellariae is placed in seed-coating machine again, and Slurry mixing coating is coated the mixture for syrup and maltodextrin, mass ratio 3:2, coating After multilayer to coating thickness is 10 μm, blows and be coated medicine materical crude slice up to radix pseudostellariae after heated drying.
Total duration used in embodiment 1-3 preparation methods is 10-12h, and the technique used time is short.
The blackberry lily of the embodiment 1-3 of equivalent weight is taken to be coated the common blackberry lily medicine materical crude slice of medicine materical crude slice and market purchase respectively in water 20min is decocted, after filtering the dregs of a decoction, the content of Flavonoid substances is above market purchase in the liquid that the medicine materical crude slice of embodiment 1-3 obtains The common blackberry lily medicine materical crude slice bought.Illustrate that the method for the present invention can promote active ingredient to leach, improves drug effect.
Raw materials used in the present invention, equipment is unless otherwise noted the common raw material, equipment of this field;In the present invention Method therefor is unless otherwise noted the conventional method of this field.
The above is only presently preferred embodiments of the present invention, is not imposed any restrictions to the present invention, every according to the present invention Technical spirit still falls within the technology of the present invention side to any simple modification, change and equivalent transformation made by above example The protection domain of case.

Claims (8)

1. a kind of preparation method of blackberry lily coating medicine materical crude slice, it is characterised in that:The method includes the steps of:
1)High-quality blackberry lily health product is selected, impurity elimination is cleaned;
2)It picks up and is sliced after being filtered dry moisture content;
3)Sheet blackberry lily is placed in pressure pan, 2-4 kgf/cm are first pressurized to2, and 15-25 min are kept, then dash forward in 0-3 seconds So pressure is made to be down to 0 kgf/cm2
4)By step 3)In obtained sheet blackberry lily be placed in be coated in seed-coating machine and be coated medicine materical crude slice to get blackberry lily.
2. the preparation method of blackberry lily coating medicine materical crude slice as described in claim 1, which is characterized in that the step 3)In mesohigh tank Temperature is 115-150 DEG C.
3. the preparation method of blackberry lily coating medicine materical crude slice as described in claim 1, which is characterized in that the step 4)Middle coating uses Slurry mixing.
4. the preparation method of blackberry lily coating medicine materical crude slice as described in claim 1, which is characterized in that the step 4)Middle coating is sugar The mixture of slurry and maltodextrin.
5. the preparation method of blackberry lily as claimed in claim 4 coating medicine materical crude slice, which is characterized in that the syrup and maltodextrin Mass ratio is 3:1-2.
6. the preparation method of blackberry lily coating medicine materical crude slice as described in claim 1, which is characterized in that the step 4)Middle coating temperature It is 35-45 DEG C.
7. the preparation method of blackberry lily coating medicine materical crude slice as described in claim 1, which is characterized in that the step 4)Middle coating thickness It is 6-10 μm.
8. a kind of blackberry lily is coated medicine materical crude slice, which is characterized in that the medicine materical crude slice is that the method according to claim 1-7 is prepared 's.
CN201810488026.3A 2018-05-21 2018-05-21 A kind of blackberry lily coating medicine materical crude slice and preparation method thereof Pending CN108379405A (en)

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CN201810488026.3A CN108379405A (en) 2018-05-21 2018-05-21 A kind of blackberry lily coating medicine materical crude slice and preparation method thereof

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CN201810488026.3A CN108379405A (en) 2018-05-21 2018-05-21 A kind of blackberry lily coating medicine materical crude slice and preparation method thereof

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112807329A (en) * 2019-11-18 2021-05-18 亳州中强中药饮片有限公司 Antiseptic traditional Chinese medicine decoction pieces and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129292A (en) * 2006-08-24 2008-02-27 高尚先 Vacuum puffing process technique for Chinese traditional medicine
CN101972617A (en) * 2010-10-13 2011-02-16 周明千 High pressure processing method for Chinese medicinal materials
CN104873666A (en) * 2015-05-29 2015-09-02 曹红云 Preparation method for blackberry lily medicinal slices

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101129292A (en) * 2006-08-24 2008-02-27 高尚先 Vacuum puffing process technique for Chinese traditional medicine
CN101972617A (en) * 2010-10-13 2011-02-16 周明千 High pressure processing method for Chinese medicinal materials
CN104873666A (en) * 2015-05-29 2015-09-02 曹红云 Preparation method for blackberry lily medicinal slices

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112807329A (en) * 2019-11-18 2021-05-18 亳州中强中药饮片有限公司 Antiseptic traditional Chinese medicine decoction pieces and preparation method thereof

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Application publication date: 20180810

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