CN104127505A - Chalkbrood eliminating granule Chinese patent medicine for treating bee chalkbrood disease and production technology thereof - Google Patents
Chalkbrood eliminating granule Chinese patent medicine for treating bee chalkbrood disease and production technology thereof Download PDFInfo
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Abstract
The invention relates to the technical fields of Chinese patent medicine and veterinary drug, and discloses a chalkbrood eliminating granule Chinese patent medicine for treating bee chalkbrood disease and a production technology thereof. The Chinese patent medicine comprises the following main materials in parts by weight: 30 to 50 parts of isatis root, 15 to 30 parts of barbat skullcap, 15 to 30 parts of balloonflower root, and 10 to 20 parts of fructus forsythiae, and also comprises the following auxiliary materials in parts by weight: 2 to 5 parts of critic acid, and 2 to 5 parts of mint essence. The Chinese patent medicine can treat bee chalkbrood disease, and prevents left antibiotic or pesticide in bee products.
Description
Technical field
The present invention relates to Chinese patent medicine, veterinary drug technical field, more particularly, the particularly clean dissolved granule Chinese patent medicine of a kind of Chalk for the treatment of ascospherosis of bee for the treatment of ascospherosis of bee, Aspergillosis Huang and production technology.
Background technology
According to bee products quality safety, in bee products Mel, Lac regis apis, bee pollen, antibiotic must not be contained, pesticide is residual.A lot of bee farm of the prior art is often used the medicines such as tetracycline, oxytetracycline, streptomycin in the time that treatment Chalk is sick, causes in product because containing antibiotic remains or pesticide residues are defective.So, be necessary to study a kind of novel medicine.
Because Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and Fructus Forsythiae etc. have various effects, and citric acid and peppermint essence have the palatability of adjusting and increase immunization, their interaction effects are very outstanding, through inventor retrieval, the clean medicine powder of Chalk of the unexposed treatment honeybee disease about adopting the said goods to fill a prescription also in prior art.
1, Radix Isatidis Main Ingredients and Appearance and effect: (1) composition: Radix Isatidis is containing indigo (indigotin, indigo), indirubin (indirubin), Anthraquinones, cupreol (β-sitosterol), clionasterol (γ-sitosterol) and several amino acids: arginine (arginine), glutamic acid (glutamic acid), tyrosine (tyrosine), proline (proline), valine (valine), γ-aminobutyric acid (γ-aminobu-tyric acid).Also containing potassium myronate (sinigrin), indigo glycoside (indoxyl-β-hlucoside), couroupitine A (trptanthrin), 1-Hydrogen thiocyanate-2-hydroxyl fourth-3-alkene (l-thiocyano-2-hydroxy-3-butene), table is accused Yichun (epigoitrin), gland glycoside (adenosine), Palmic acid (palmitic acid), sucrose (sucrose) and contain 12% amino acid whose proteoglycan.Also contain antibacterial substance and the kinetin of resisting gram-positive and negative bacteria.(2) effect: antibiosis and antiviral functions; Anti-leptospira effect; Detoxication; Improve immunologic function; Antitumor action; Leukemia is had to therapeutical effect.
2, Herba Scutellariae Barbatae Main Ingredients and Appearance and effect: (1) composition: herb is containing carthamin (carthamidin), isocarthamidin (iso-carthamidin), high mountain baicalin (scutellarein), the yellow official seal glycoside of high mountain (scutel-larin), cupreol (β-sitosterol), stearic acid (steraricacid), alkaloid polysaccharide etc.According to another report, separate and obtain wogonin (wogo-nin) from aerial parts, rivularin (scutervulin), Herba Scutellariae Barbatae kind element (rivularin), naringenin (naringenin), apigenin (apigenin), dinatin (hispedulin), eriodictyol (eriodictyol), luteolin (suteolin), 5, 7, 4-trihydroxy-8-methoxyl group flavanone (5, 7,-trihydroxy-6-methoxyflavanone) 4-hydroxyl wogonin (4-hydroxywogonin), 7-gate of a lane base-5, 8-dimethoxy flavone (7-hy-droxy-5, 8-dimethoxyflavane), p-great base benzene first Tibet (p-hydroxyben-zaldehyde), p-great base benzylacetone (p-hydroxybenzylacetone), p-coumaric acid (p-coumaricaicd), protocatechuic acid (protocatechuicacid), energy fruit acid (ut-solicacid) plant sterol (phytosterol), plant sterol β-D-Glucose glycoside (phy-tosteryl-β-D-glucoside) etc.(2) effect: control haematemesis, epistaxis, stranguria with blood, bloody dysentery, jaundice, has sore throat, lung abscess, furuncle, scrofula, sore, cancerous protuberance, traumatic injury knife injury, venom.
3, the Main Ingredients and Appearance of Radix Platycodonis and effect: (1) composition: containing kikyosaponin (Platycodin), hydrolysis produces the mixture that ruscogenin is triterpenic acid, wherein one is Polygalacic acid (Polygalacic acid), another kind is platycodigenin (Platy-codigenin). still containing platycogenic acid A, B and C(Platycogenic acid A, B, C), inulin, platycodonin, glucose and plant sterol, as chondrillasterol (α-Spinasterol), hitodesterol-β-D-Glucose glycoside (α-Spinasteryl-β-D-glucoside) etc.(2) effect: antitussive, expectorant.
4, the Main Ingredients and Appearance of Fructus Forsythiae and effect: (1) composition: contain forsythol (Forsythol), forsythin (Phillyrin), phillygenin (Phillygenin), oleanolic acid (Oleanolic acid), betulic acid (Betulinic acid), ursolic acid (Ursolic acid), pinoresinol (Pinoresinol), sterol compound C49H70-80O6. horse tongue resinol glycoside (Matairesinoside), still contain multiple hydro carbons, aldoketones, alcohol ester ethers volatile ingredient: australene (α-Pinene), camphene (Camphene), nopinene (β-Pinene), p-ymene (p-Cymene), limonene (Limonene), γ-terpinene (γ-Terpinene), β-phellandrene (β-Phellandrene), myrcene (Myrcene), β-ocimene (β-Ocimene), Camphora (Camphor), geranial (Geranial), Borneolum Syntheticum (Borneol), α-terpinol (α-Terpineol), safrole (Safrole), linalool (Linalool), Terpinen-4-ol (Terpinen-4-ol), nor-lapachol (Norlapa-chol) and coumarin, rutin etc.(2) effect: resisting pathogenic microbes effect; Antiinflammatory action; Refrigeration function.
5, the nature and role of citric acid: (1) chemical property: be a kind of tricarboxylic acids compounds from structure citric acid, and therefore there is similar physics and chemistry character to other carboxylic acids, while being heated to 175 DEG C, it can decompose generation carbon dioxide and water, remains some white crystals.Citric acid is a kind of stronger organic acid, has 3 H+ to ionize; Heating can be resolved into multi-products, reacts with acid, alkali, glycerol etc.(2) effect: for food industry: because citric acid has gentle frank tart flavour, generally for the manufacture of the food such as various beverages, soda pop, wine, confection, dessert, cookies, canned fruit juice, milk product, in all organic acids market, citric acid market share more than 70%, does not also have a kind of acidic flavoring agent that can replace citric acid up till now.Citric acid is Wheat Protein also, also can be used as the antioxidant of edible oil.For sterilizing: citric acid and 80 DEG C of temperature synergy have the effect of good kill bacteria spore, and can effectively kill the bacterial spore polluting in haemodialysis control unit pipeline.
6, Main Ingredients and Appearance and effect of peppermint essence (powder): (1) composition: levorotatory menthol (menthol), content 62.3%～87.2%; Revolving menthone (menthone) etc.Again containing flavones ingredient: different Rui Fuling (isoraifolin), Herba Menthae isoflavone aglycone (mentho side); Determination of Organic Acids: rosmarinic acid (rosmarinicacid), caffeic acid (caffeic acid); Aminoacid ingredient: aspartic acid (asparticacid), glutamic acid (glutamic acid).Also containing dicarboxyl-1, the Multiple components that 2-dihydro bitter edible plant dicarboxylic acids is parent nucleus: 1-(3,4 dihydroxy phenyls)-6,7-dihydroxy-2 1, the 2-dihydro bitter edible plant-2,3-dicarboxylic acids (1-(3,4-dihydroxyp henyl)-6,7-dihydroxy-l, 2-dihydronaphthalene-2,3-dicarboxylic acid) etc.(2) effect: Herba Menthae has the double grading of " refrigerant when heat, warm body when cold ", therefore can effectively treat flu, and its most important contribution is the acute symptom aspect control digestive system.And have refrigerant, analgesic effect, can alleviate headache, migraine and toothache.
Summary of the invention
The object of the present invention is to provide a kind of clean dissolved granule Chinese patent medicine of Chalk and the production technology that can treat ascospherosis of bee disease and can avoid again the treatment ascospherosis of bee that has the residue such as antibiotic and pesticide in bee product.
In order to solve problem set forth above, the technical solution used in the present invention is: a kind of clean dissolved granule Chinese patent medicine of Chalk for the treatment of ascospherosis of bee, the formula of this Chinese patent medicine comprises the major ingredient with Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and Fructus Forsythiae composition, and the adjuvant forming with citric acid and peppermint essence, wherein, each component is respectively according to weight portion: 2 parts～5 parts of 30 parts～50 parts of Radix Isatidis, 15 parts～30 parts of Herba Scutellariae Barbataes, 15 parts～30 parts of Radix Platycodoniss, 10 parts～20 parts of Fructus Forsythiaes, 2 parts～5 parts of citric acids and peppermint essences.
According to a preferred embodiment of the invention: described Chinese patent medicine is graininess medicine powder.
It is a kind of according to the production technology of the clean dissolved granule Chinese patent medicine of Chalk of above-mentioned treatment ascospherosis of bee that the present invention also provides, and comprises the following steps:
The first step, by dry Radix Isatidis and Radix Platycodonis section, add and put pharmaceuticals industry with in reactor in 1:40 ratio respectively, carry out decocting and boil refinement 1.5 hours～2 hours, filter and obtain Radix Isatidis and Radix Platycodonis extract decocting liquid with 40 order sieves respectively again, separately Herba Scutellariae Barbatae, Fructus Forsythiae are pulverized respectively, after pulverizing, added respectively to put and in reactor, carry out decocting and boil 1 hour～1.5 hours, filter with 60 order sieves respectively and obtain Herba Scutellariae Barbatae, Fructus Forsythiae refines extract decocting liquid;
Second step, puts respectively in vacuum concentration pot obtaining four kinds of extract decocting liquid in the first step, carries out vacuum and low temperature and concentrates, obtain concentrated extract, put respectively again in freezer dryer, in low temperature-40 DEG C～-80 DEG C, carry out lyophilization, obtain respectively four kinds of pharmaceutical drying things;
The 3rd step, pulverizes four kinds of pharmaceutical drying things that obtain in second step respectively with cracker for medicine, after pulverizing, fully mix by formula proportion, then sieve with 80 order～100 mesh sieves, after sieving, pack hybrid medicine powder into dry clean equipment, preserve for subsequent use;
The 4th step, joins citric acid powder, Herba Menthae powder in the hybrid medicine powder in the 3rd step by formula proportion aequum, and fully mixes, and obtains hybrid medicine powder;
The 5th step, by the soft material of hybrid medicine powder process system in the 4th step, add therein suitable amount of adhesive, fully mix, make suitable flexible member, enter again granule operation processed and obtain hybrid medicine granule, finally hybrid medicine granule is put in 50 DEG C～60 DEG C drying machines and be dried and obtain the clean Chinese patent medicine of the Chalk of water content below 3%.
According to a preferred embodiment of the invention: before the described first step, also comprise Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and four kinds of cleaning with Chinese herbal of Fructus Forsythiae are arranged, put the step that dry in clean place.
According to a preferred embodiment of the invention: in the first step, the slice thickness of described Radix Isatidis and Radix Platycodonis is 2mm.
According to a preferred embodiment of the invention: the vacuum in the vacuum concentration pot in described second step is 0.8mpb.
According to a preferred embodiment of the invention: the binding agent in described the 5th step is starch slurry, and its addition is 8%～10%.
Compared with prior art, beneficial effect of the present invention is:
1, in Chinese patent medicine formula of the present invention, the refinement extract dry of Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis, Fructus Forsythiae accounts for 95%, play and kill and remove fungal disease in Apis oral cavity, respiratory tract and intestinal (Chalk disease) as Apis endo-medicine, stop fungus breeding, slow down the individual heat symptom-complex of bee colony Apis and swell and ache, and can increase the disease resistance of Apis, reducing the propagation between bee colony, auxiliary adjustment nervus centralis, fast effect of extensive wilful Apis body constitution;
2, in Chinese patent medicine formula of the present invention, refine extract dry as primary raw material taking Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and Fructus Forsythiae, add again citric acid and peppermint essence, can increase better medicine killing fungus and bacterial spore effect in Apis oral cavity, respiratory tract, digestive tract, Excretory system;
3, in Chinese patent medicine formula of the present invention, adopt be Chinese herbal medicine refine extract dry as primary raw material through being processed into the medicine for the treatment of ascospherosis of bee, in the time for the treatment of ascospherosis of bee, avoid bee colony to pollute and drug residue because dispenser causes bee product, ensured the quality safety of bee product.
Brief description of the drawings
Fig. 1. be the flow chart of the processing method of the clean dissolved granule Chinese patent medicine of Chalk for the treatment of ascospherosis of bee of the present invention.
Detailed description of the invention
Below in conjunction with embodiment and accompanying drawing, the present invention is described in further detail, but embodiments of the present invention are not limited to this.
The present embodiment provides a kind of clean dissolved granule Chinese patent medicine of Chalk for the treatment of ascospherosis of bee, it is granular medicament, use as electuary, the formula of this Chinese patent medicine comprises the major ingredient with Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and Fructus Forsythiae composition, and the adjuvant forming with citric acid and peppermint essence, wherein, each component is respectively according to weight portion: 2 parts～5 parts of 30 parts～50 parts of Radix Isatidis, 15 parts～30 parts of Herba Scutellariae Barbataes, 15 parts～30 parts of Radix Platycodoniss, 10 parts～20 parts of Fructus Forsythiaes, 2 parts～5 parts of citric acids and peppermint essences.
Consult shown in Fig. 1, what this enforcement provided is a kind of according to the production technology of the clean dissolved granule Chinese patent medicine of Chalk of above-mentioned treatment ascospherosis of bee, comprises the following steps:
The first step, arranges Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and four kinds of cleaning with Chinese herbal of Fructus Forsythiae, put clean place and dry; Then by dry Radix Isatidis and Radix Platycodonis section (thickness is about 2mm), add and put pharmaceuticals industry with in reactor in 1:40 ratio, carry out decocting and boil refinement 1.5 hours～2 hours, filter and obtain Radix Isatidis and Radix Platycodonis extract decocting liquid with 40 order sieves again, and Herba Scutellariae Barbatae, Fructus Forsythiae are pulverized respectively, after pulverizing, add respectively to put and in reactor, carry out decocting and boil 1 hour～1.5 hours, filter with 60 order sieves respectively and obtain Herba Scutellariae Barbatae, Fructus Forsythiae refines extract decocting liquid;
Second step, put respectively (vacuum is 0.8mpb) in vacuum concentration pot by obtaining four kinds of extract decocting liquid in the first step, carry out vacuum and low temperature concentrated, obtain respectively concentrated extract, put respectively again in freezer dryer, in low temperature-40 DEG C～-80 DEG C, carry out lyophilization, obtain respectively four kinds of pharmaceutical drying things;
The 3rd step, pulverizes four kinds of pharmaceutical drying things that obtain in second step respectively with cracker for medicine, after pulverizing, fully mix by formula proportion, then sieve with 80 order～100 mesh sieves, after sieving, pack hybrid medicine powder into dry clean equipment, preserve for subsequent use;
The 4th step, joins citric acid powder, Herba Menthae powder in the hybrid medicine powder in the 3rd step by formula proportion aequum, and fully mixes, and obtains hybrid medicine powder;
The 5th step, hybrid medicine powder in the 4th step, through the soft material of system, is added to appropriate 8% starch slurry binding agent therein, be fully mixed and made into soft material, enter again granule operation processed, finally granule is put in 50 DEG C～60 DEG C incubators and be dried and obtain the Chinese patent medicine particles of water content below 3%.
The dominant mechanism that Chinese patent medicine of the present invention is used for the treatment of honeybee disease is: 1, make full use of heat-clearing and toxic substances removing, the elimination effect of swelling and ache of Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and Fructus Forsythiae, due on Chinese medicine and pharmacy, by them for for oral administration, cure mainly that mycosis causes swell and ache, the disease such as intestinal infection and wind heat epidemic febrile disease, dysentery stomachache.So each ingredient interacts in the present invention's formula, stops fungus breeding, slow down the individual heat symptom-complex of bee colony Apis and swell and ache; 2, in the formula that is primary raw material at Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and Fructus Forsythiae, through refining, extract is mixed, add citric acid, peppermint essence each, make Apis Chinese patent medicine granule product more can play effects such as killing oral cavity, respiratory tract, upper digestive tract, lower digestive tract and Excretory system fungus, antibacterial; 3, in the present invention's formula, add citric acid, peppermint essence composition a small amount of, make that products taste is soft, palatability is strong, the bee colony Apis that makes to catch an illness initiatively sucks, absorb and accelerate, can also make product play certain resisting fatigue and strengthen immunologic function bee biological body, bee colony recovers to accelerate, and accelerates the treatment of Chalk disease simultaneously; What 4, the present invention adopted is Chinese herbal medicine refines extract dry as primary raw material through being processed into the medicine for the treatment of ascospherosis of bee, in the time for the treatment of ascospherosis of bee, avoid bee colony to pollute and drug residue because dispenser causes bee product, ensured the quality safety of bee product.
Following table 1 is one group and adopts the clean powder Chinese patent drugs for treatment of Chalk of the present invention honeybee disease and the contrast test data that adopt existing antibiotic therapy honeybee disease on cure rate.
Table 1
Above test data shows, uses the sick bee colony of antibiotic therapy Chalk, and after 7 days, cure rate is respectively 59%, 80%, average out to 69.5%.And use the sick bee colony of Chinese patent drugs for treatment Chalk of the present invention, and after 7 days, cure rate is respectively 90%, 94.7%, 91.7%, average out to 92.13%, and with respect to existing antibiotic therapy, cure rate is improved greatly.
2 one groups of following tables adopt Chinese patent drugs for treatment honeybee disease of the present invention and the contrast test data that adopt existing antibiotic therapy honeybee disease on antibiotic remains.
Table 2
Above test data shows, the Mel that uses the bee colony of oxytetracycline, tetracycline medication treatment ascospherosis of bee to produce, and after testing, antibiotic remains content is respectively: 1.2 μ g/kg, 1.8 μ g/kg are defective honey product.And the Mel that uses the bee colony of the clean powder Chinese patent drugs for treatment of Chalk of the present invention ascospherosis of bee to produce, consistent antibiotic-free is residual after testing, and Mel commodity is intact.
Above-described embodiment is preferably embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and principle, substitutes, combination, simplify; all should be equivalent substitute mode, within being included in protection scope of the present invention.
Claims (7)
1. treat the clean dissolved granule Chinese patent medicine of Chalk of ascospherosis of bee for one kind, it is characterized in that: the formula of this Chinese patent medicine comprises the major ingredient with Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and Fructus Forsythiae composition, and the adjuvant forming with citric acid and peppermint essence, wherein, each component is respectively according to weight portion: 2 parts～5 parts of 30 parts～50 parts of Radix Isatidis, 15 parts～30 parts of Herba Scutellariae Barbataes, 15 parts～30 parts of Radix Platycodoniss, 10 parts～20 parts of Fructus Forsythiaes, 2 parts～5 parts of citric acids and peppermint essences.
2. the clean dissolved granule Chinese patent medicine of the Chalk for the treatment of ascospherosis of bee according to claim 1, is characterized in that: described Chinese patent medicine is graininess medicine powder.
3. a production technology for the clean dissolved granule Chinese patent medicine of the Chalk for the treatment of ascospherosis of bee according to claim 1, is characterized in that, this technique comprises the following steps:
The first step, by the section of dry Radix Isatidis and Radix Platycodonis, add and put pharmaceuticals industry with in reactor in 1:40 ratio respectively, carry out decocting and boil refinement 1.5 hours～2 hours, filter and obtain Radix Isatidis and Radix Platycodonis extract decocting liquid with 40 order sieves respectively again, separately Herba Scutellariae Barbatae, Fructus Forsythiae are pulverized respectively, after pulverizing, add respectively to put and in reactor, carry out decocting and boil 1 hour～1.5 hours, filter with 60 order sieves respectively and obtain Herba Scutellariae Barbatae, Fructus Forsythiae refines extract decocting liquid;
Second step, put respectively in vacuum concentration pot obtaining four kinds of extract decocting liquid in the first step, carry out vacuum and low temperature concentrated, obtain concentrated extract, then put respectively in freezer dryer, in low temperature-40 DEG C～-80 DEG C, carry out lyophilization, obtain respectively four kinds of pharmaceutical drying things;
The 3rd step, four kinds of pharmaceutical drying things that obtain in second step are pulverized with cracker for medicine respectively, after pulverizing, fully mix by formula proportion, then sieve with 80 order～100 mesh sieves, after sieving, pack hybrid medicine powder into dry clean equipment, preserve for subsequent use;
The 4th step, citric acid powder, Herba Menthae powder are joined in the hybrid medicine powder in the 3rd step by formula proportion aequum, and fully mix, obtain hybrid medicine powder;
The 5th step, by hybrid medicine powder in the 4th step through the soft material of system, add therein suitable amount of adhesive, fully mix, make suitable flexible member, enter again granule operation processed and obtain hybrid medicine granule, finally hybrid medicine granule is put in 50 DEG C～60 DEG C drying machines and be dried and obtain the clean Chinese patent medicine of Chalk.
4. the production technology of the clean dissolved granule Chinese patent medicine of the Chalk for the treatment of ascospherosis of bee according to claim 3, is characterized in that: before the described first step, also comprise Radix Isatidis, Herba Scutellariae Barbatae, Radix Platycodonis and four kinds of cleaning with Chinese herbal of Fructus Forsythiae are arranged, put the step that dry in clean place.
5. the production technology of the clean dissolved granule Chinese patent medicine of the Chalk for the treatment of ascospherosis of bee according to claim 3, is characterized in that: in the first step, the slice thickness of described Radix Isatidis and Radix Platycodonis is 2mm.
6. the production technology of the clean dissolved granule Chinese patent medicine of the Chalk for the treatment of ascospherosis of bee according to claim 3, is characterized in that: the vacuum in the vacuum concentration pot in described second step is 0.8mpb.
7. the production technology of the clean dissolved granule Chinese patent medicine of the Chalk for the treatment of ascospherosis of bee according to claim 3, is characterized in that: the binding agent in described the 5th step is starch slurry, and its addition is 8%～10%.
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| CN107625955A (en) * | 2017-09-21 | 2018-01-26 | 广西吉朋投资有限公司 | A kind of honeybee prophylactic preparation and preparation method thereof |
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| CN104127505B (en) | 2016-08-31 |
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