CN102552363A - Preparation method for mother chrysanthemum extract - Google Patents
Preparation method for mother chrysanthemum extract Download PDFInfo
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- CN102552363A CN102552363A CN2010106063133A CN201010606313A CN102552363A CN 102552363 A CN102552363 A CN 102552363A CN 2010106063133 A CN2010106063133 A CN 2010106063133A CN 201010606313 A CN201010606313 A CN 201010606313A CN 102552363 A CN102552363 A CN 102552363A
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- flos chrysanthemi
- chrysanthemi indici
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Abstract
The invention relates to a preparation method for a mother chrysanthemum extract, which is characterized by comprising the following steps: (1) selecting and smashing the mother chrysanthemum raw material, adding ethanol solution, putting into a multifunctional extracting tank, and heating and pressurizing to extract for 1-3 times, wherein the step of heating and pressurizing to extract lasts for two hours each time; combining extracting solution, filtering and obtaining total extracting solution; (2) carrying out reduced pressure concentration to the total extracting solution to obtain mother chrysanthemum concentrated solution; and (3) carrying out high-speed centrifugation, spraying and drying the mother chrysanthemum concentrated solution to obtain the mother chrysanthemum extract. The preparation method for the mother chrysanthemum extract has the advantages that the extraction ratio of effective ingredients is obviously improved.
Description
Technical field
What the present invention relates to is a kind of Chinese herbal medicine extracting method, specifically, is a kind of method for preparing of Flos Chrysanthemi Indici extract
Background technology
Flos Chrysanthemi Indici is called and is Herba Dendranthematis indici, FLOS CHRYSANTHEMI INDICI, the bitter heart of a lotus seed, English FLOS CHRYSANTHEMIINDICI by name.Be the head inflorescence of Compositae herbaceos perennial Herba Dendranthematis indici, profile is similar with Flos Chrysanthemi, and is wild by meadow, hillside, field wing.With yellow skin do not have stalk, complete, gas is fragrant, flower not the standard-sized sheet person for good.Flos Chrysanthemi Indici is bitter, hot, is slightly cold, and returns liver, heart channel.Effect with heat-clearing and toxic substances removing can be widely used in diseases such as treatment furuncle carbuncle, laryngopharynx swelling and pain, wind-fire acute conjunctivitis, headache be dizzy.Simultaneously good hypotensive effect is arranged again, can be used for the auxiliary treatment of hypertension.
Research work to this medicine is a lot, generally all is that the different medical materials of using the various places of production carry out, because medical material content is with weather; Variations such as place, uncertain, crude drug is difficult for preserving; Instability, research work are carried out not smoothly, and we hope to prepare a kind of extract of Flos Chrysanthemi Indici; Make its steady quality, character is relatively stable, is beneficial to carrying out of preservation and further R&D work.Wild chrysanthemum preparation product in the market, main production are that the Flos Chrysanthemi Indici water is decocted, and decoction liquor merges, and concentrate precipitate with ethanol, the dry clear paste that gets.The problem that this technology exists is that the liposoluble constituent extraction ratio of medical material is extremely low.We are to the retrieval to the prior art document; People such as discovery Qian Yong are that the method for distilling to Flos Chrysanthemi Indici has carried out preliminary research in 200910057065.9 " linarin preparation method of extract in the Flos Chrysanthemi Indici " literary composition at application number; Discovery with linarin as index; With alcohol reflux 6 hours, or flood 8 hours as basic method for distilling.This method for distilling time is long, and efficient is low.We test method for distilling, to concentration of alcohol, and extraction time, extraction time is investigated, and confirms that alcoholic acid optimum extraction concentration is 70%, extracts 3 times, and each time 2h is the optimum extraction process of Flos Chrysanthemi Indici.This method has been taken into account the water soluble ingredient and the liposoluble constituent of Flos Chrysanthemi Indici; We test according to this method, and finding still has remaining effective ingredient such as linarin in the useless leaf of Flos Chrysanthemi Indici after extraction; We have attempted methods such as increase extraction time; More than 4 times, increased consumption with ethanol extraction, extraction ratio also obviously reduces.
Summary of the invention
The objective of the invention is to overcome the deficiency that exists in the prior art, a kind of method for preparing of Flos Chrysanthemi Indici extract is provided, make it increase the extraction efficiency of effective ingredient, reduce cost, prepare a kind of storage and transportation Flos Chrysanthemi Indici extract be convenient to.
The present invention includes following steps:
1. choose the Flos Chrysanthemi Indici raw material, add alcoholic solution, place multi-function extractor, heating and pressurizing is extracted 1-3 time, and extracting solution merges, and filters, and promptly gets total extracting solution;
2. with total extracting solution concentrating under reduced pressure, process the Flos Chrysanthemi Indici concentrated solution;
3. with the Flos Chrysanthemi Indici concentrated solution through high speed centrifugation, spray drying is processed Flos Chrysanthemi Indici extract.
Described step 1., its alcoholic solution, its concentration is 50-90%.
Described step 1., its Flos Chrysanthemi Indici raw material is 1 with the ratio of ethanol: 6-1: 12;
Described step 1., heating-up temperature is 60-130 ℃
Described step 1., moulding pressure is a 1.2-1.5 atmospheric pressure.
Described step 1., extraction time is 2.
The present invention is to the Flos Chrysanthemi Indici pulverizing medicinal materials, and the pressurization alcohol extraction can destroy the blade cell organizational structure, improves the dissolubility of effective ingredient, increases extraction efficiency, has reduced extraction time, lowers energy consumption, can to greatest extent the effective ingredient in the Flos Chrysanthemi Indici be proposed.Flos Chrysanthemi Indici extract gross mass through the preparation of this method improves nearly 10% and improves nearly 25% with the content of linarin.
Choose the Flos Chrysanthemi Indici medical material, clean, oven dry is pulverized the back and is crossed 50 orders.Take by weighing the 2kg plant powder and place multi-function extractor respectively for 2 parts; Adding 10 times of amount concentration is 70% alcoholic solution; Be heated to 80 ℃, a setting pressure is that 1.5 atmospheric pressure extract 4 times, and a normal pressure extracts 4 times; Calculate the extraction ratio (with the weight ratio of medical material) and the linarin rate of transform (according to " Chinese Pharmacopoeia 2005 editions " first one, liquid phase process is measured under the Flos Chrysanthemi Indici item) of every part of extracting solution respectively.
The different extraction processes of table 1 are to the influence of the extraction ratio and the linarin rate of transform
The specific embodiment
Embodiment 1
Choose Flos Chrysanthemi Indici, clean, oven dry is pulverized the back and is crossed 50 orders.Take by weighing the 5kg plant powder and place multi-function extractor, adding 10 times of amount concentration is 70% alcoholic solution, is heated to 80 ℃, and setting pressure is that 1.5 atmospheric pressure extract 2 times, and extracting solution merges, and filters, and concentrating under reduced pressure is processed the Flos Chrysanthemi Indici concentrated solution; With its high speed centrifugation, spray drying is processed Flos Chrysanthemi Indici extract 1.38kg.
Embodiment 2
Choose Flos Chrysanthemi Indici, clean, oven dry is pulverized the back and is crossed 100 orders.Take by weighing the 5kg plant powder and place multi-function extractor, adding 12 times of amount concentration is 50% alcoholic solution, is heated to 130 ℃, and a setting pressure is that 1.5 atmospheric pressure extract 2 times, and extracting solution merges, and filters, and concentrating under reduced pressure is processed the Flos Chrysanthemi Indici concentrated solution; With its high speed centrifugation, spray drying is processed Flos Chrysanthemi Indici extract 1.79kg.
Embodiment 3
Choose Flos Chrysanthemi Indici, clean, oven dry.Take by weighing the 5kg medical material and place multi-function extractor, adding 6 times of amount concentration is 85% alcoholic solution, is heated to 80 ℃, and a setting pressure is that 1.5 atmospheric pressure extract 2 times, and extracting solution merges, and filters, and concentrating under reduced pressure is processed the Flos Chrysanthemi Indici concentrated solution; With its high speed centrifugation, spray drying is processed Flos Chrysanthemi Indici extract 1.19kg.
Embodiment 4
Choose Flos Chrysanthemi Indici, clean, oven dry.Take by weighing the 5kg medical material and place multi-function extractor, adding 8 times of amount concentration is 80% alcoholic solution, is heated to 90 ℃, and a setting pressure is that 1.2 atmospheric pressure extract 3 times, and extracting solution merges, and filters, and concentrating under reduced pressure is processed the Flos Chrysanthemi Indici concentrated solution; With its high speed centrifugation, spray drying is processed Flos Chrysanthemi Indici extract 1.58kg.
Claims (8)
1.-plant the method for preparing of Flos Chrysanthemi Indici extract, it is characterized in that, may further comprise the steps:
1. choose the Flos Chrysanthemi Indici raw material pulverizing, add alcoholic solution, place multi-function extractor, heating and pressurizing is extracted 1-3 time, each 2h, and extracting solution merges, and filters, and promptly gets total extracting solution;
2. with total extracting solution concentrating under reduced pressure, process the Flos Chrysanthemi Indici concentrated solution;
3. with the Flos Chrysanthemi Indici concentrated solution through high speed centrifugation, spray drying is processed Flos Chrysanthemi Indici extract.
2. the method for preparing of Flos Chrysanthemi Indici extract according to claim 1 is characterized in that, described step 1., its alcoholic solution, its concentration is 50-90%.
3. the method for preparing of Flos Chrysanthemi Indici extract according to claim 1 is characterized in that, described step 1., its Flos Chrysanthemi Indici raw material is 1 with the ratio of ethanol: 6-1: 12;
4. the method for preparing of Flos Chrysanthemi Indici extract according to claim 1 is characterized in that, described step 1., heating-up temperature is 60-130 ℃.
5. the method for preparing of Flos Chrysanthemi Indici extract according to claim 1 is characterized in that, described step 1., moulding pressure is a 1.2-1.5 atmospheric pressure.
6. the method for preparing of Flos Chrysanthemi Indici extract according to claim 1 is characterized in that, described step 1., extraction time is 2.
7. the method for preparing of Flos Chrysanthemi Indici extract according to claim 1; It is characterized in that, described step 2., described concentrating under reduced pressure is meant extracting solution evacuation-0.1 atmospheric pressure that reduces pressure; And extracting solution placed 60-90 ℃ of heating, extracting solution is concentrated.
8. the method for preparing of Flos Chrysanthemi Indici extract according to claim 1; It is characterized in that, described step 2., described concentrating under reduced pressure is meant extracting solution evacuation-0.1 atmospheric pressure that reduces pressure; And extracting solution placed 60-90 ℃ of heating, extracting solution is concentrated.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010106063133A CN102552363A (en) | 2010-12-15 | 2010-12-15 | Preparation method for mother chrysanthemum extract |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961427A (en) * | 2012-12-14 | 2013-03-13 | 安徽老炊食品有限公司 | Wild chrysanthemum extraction process and measuring method for total flavonoids in wild chrysanthemums |
| CN103173285A (en) * | 2013-02-21 | 2013-06-26 | 天津商业大学 | Method and device for extracting active ingredients from orange peels through utilizing high-pressure solvent |
| CN106389501A (en) * | 2016-08-28 | 2017-02-15 | 成都宝科生物科技有限公司 | Chrysanthemum indicum extract for treatment of high blood pressure |
-
2010
- 2010-12-15 CN CN2010106063133A patent/CN102552363A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102961427A (en) * | 2012-12-14 | 2013-03-13 | 安徽老炊食品有限公司 | Wild chrysanthemum extraction process and measuring method for total flavonoids in wild chrysanthemums |
| CN103173285A (en) * | 2013-02-21 | 2013-06-26 | 天津商业大学 | Method and device for extracting active ingredients from orange peels through utilizing high-pressure solvent |
| CN106389501A (en) * | 2016-08-28 | 2017-02-15 | 成都宝科生物科技有限公司 | Chrysanthemum indicum extract for treatment of high blood pressure |
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Application publication date: 20120711 |