CN101035563B - 包括聚合物部分的多价vla-4拮抗剂 - Google Patents
包括聚合物部分的多价vla-4拮抗剂 Download PDFInfo
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- CN101035563B CN101035563B CN2005800298537A CN200580029853A CN101035563B CN 101035563 B CN101035563 B CN 101035563B CN 2005800298537 A CN2005800298537 A CN 2005800298537A CN 200580029853 A CN200580029853 A CN 200580029853A CN 101035563 B CN101035563 B CN 101035563B
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- Prior art keywords
- substituted
- alkyl
- conjugate
- chemical compound
- polymer moieties
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- 0 CC(C*CC1C(S(C)C)=O)N1S(C1[Al]C1)(=O)=O Chemical compound CC(C*CC1C(S(C)C)=O)N1S(C1[Al]C1)(=O)=O 0.000 description 12
- CVQHSXPTARJNDG-UHFFFAOYSA-N CCC(C)(COC)OCCOC(C)CCNC(NCCC(C)(C)OCCC(C)(C)N)=O Chemical compound CCC(C)(COC)OCCOC(C)CCNC(NCCC(C)(C)OCCC(C)(C)N)=O CVQHSXPTARJNDG-UHFFFAOYSA-N 0.000 description 1
- JYNOZRWOLNYVCN-UHFFFAOYSA-N CCC(CCOC(C)CCNC(OC(COCCOC(C)CCOC)=N)=O)N Chemical compound CCC(CCOC(C)CCNC(OC(COCCOC(C)CCOC)=N)=O)N JYNOZRWOLNYVCN-UHFFFAOYSA-N 0.000 description 1
- FPEPRRGVRQSZEF-MHZLTWQESA-N CCN(CC)c(nc1N[C@@H](Cc(cc2)ccc2N(c(nccc2)c2N2)C2=O)C(OC(C)(C)C)=O)ncc1N(CC)C(c1ccncc1)=O Chemical compound CCN(CC)c(nc1N[C@@H](Cc(cc2)ccc2N(c(nccc2)c2N2)C2=O)C(OC(C)(C)C)=O)ncc1N(CC)C(c1ccncc1)=O FPEPRRGVRQSZEF-MHZLTWQESA-N 0.000 description 1
- LHGMCUVJFRBVBH-UHFFFAOYSA-N Nc(cncn1)c1Cl Chemical compound Nc(cncn1)c1Cl LHGMCUVJFRBVBH-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58697504P | 2004-07-08 | 2004-07-08 | |
US60/586,975 | 2004-07-08 | ||
PCT/US2005/024369 WO2006010054A2 (en) | 2004-07-08 | 2005-07-08 | Multivalent vla-4 antagonists comprising polyethylene glycol moieties |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101035563A CN101035563A (zh) | 2007-09-12 |
CN101035563B true CN101035563B (zh) | 2012-03-28 |
Family
ID=35501261
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800298537A Expired - Fee Related CN101035563B (zh) | 2004-07-08 | 2005-07-08 | 包括聚合物部分的多价vla-4拮抗剂 |
Country Status (20)
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU773538B2 (en) * | 1999-01-22 | 2004-05-27 | Elan Pharmaceuticals, Inc. | Acyl derivatives which treat VLA-4 related disorders |
EP1706399A1 (en) * | 2004-01-23 | 2006-10-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
CN101035563B (zh) * | 2004-07-08 | 2012-03-28 | 艾伦药物公司 | 包括聚合物部分的多价vla-4拮抗剂 |
CN101300255A (zh) * | 2005-05-20 | 2008-11-05 | 艾伦药物公司 | 咪唑啉酮苯丙氨酸衍生物vla-4拮抗剂 |
MX2008000291A (es) * | 2005-07-08 | 2008-04-04 | Elan Pharm Inc | Preparacion de conjugados polimericos de compuestos de aditivos terapeuticos, agricolas y alimentarios. |
WO2007041324A1 (en) * | 2005-09-29 | 2007-04-12 | Elan Pharmaceuticals, Inc. | Carbamate compounds which inhibit leukocyte adhesion mediated by vla-4 |
JP5101512B2 (ja) * | 2005-09-29 | 2012-12-19 | エラン ファーマシューティカルズ,インコーポレイテッド | Vla−4によって媒介される白血球接着を阻害するピリミジニルアミド化合物 |
CN101360736A (zh) * | 2005-11-23 | 2009-02-04 | 阿斯利康(瑞典)有限公司 | L-丙氨酸衍生物 |
CN101389611B (zh) * | 2006-02-27 | 2012-07-18 | 伊兰制药公司 | 抑制由vla-4所介导的白血球粘附的嘧啶磺酰胺化合物 |
CA3127202A1 (en) | 2006-02-28 | 2007-09-07 | Biogen Ma Inc. | Methods of treating inflammatory and autoimmune diseases with natalizumab |
JP2009531304A (ja) * | 2006-02-28 | 2009-09-03 | エラン ファーマシューティカルズ,インコーポレイテッド | α−4阻害剤化合物を用いて炎症性疾患および自己免疫疾患を治療する方法 |
CN101437541A (zh) | 2006-03-03 | 2009-05-20 | 伊兰药品公司 | 用那他珠单抗治疗炎性疾病和自身免疫病的方法 |
SG172604A1 (en) | 2006-05-22 | 2011-07-28 | Elan Pharm Inc | Preparation of polymer conjugates of therapeutic, agricultural, and food additive compounds |
WO2007141473A1 (en) * | 2006-06-09 | 2007-12-13 | Astrazeneca Ab | N-(benzoyl)-o- [2- (pyridin- 2 -ylamino) ethyl] -l-tyrosine derivatives and related compounds as a5b1 antagonists for the treatment of solid tumors |
WO2008093065A1 (en) * | 2007-01-29 | 2008-08-07 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS α5βL ANTAGONISTS |
CA2714335A1 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
WO2008153967A1 (en) * | 2007-06-08 | 2008-12-18 | Contec Therapeutics, Inc. | Bk1 antagonist conjugates |
JP2011506322A (ja) * | 2007-12-07 | 2011-03-03 | エラン ファーマシューティカルズ,インコーポレイテッド | 液性腫瘍を治療するための方法および組成物 |
EP2085407A1 (en) | 2008-02-04 | 2009-08-05 | Sahltech I Göteborg AB | Treatment of idiopathic thrombocytopenic purpura |
US8367836B2 (en) * | 2009-04-27 | 2013-02-05 | Elan Pharmaceuticals, Inc. | Pyridinone antagonists of alpha-4 integrins |
US20120258093A1 (en) * | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
DK3339865T5 (da) | 2010-01-11 | 2023-03-20 | Biogen Ma Inc | Assay for jc-virus-antistoffer |
US11287423B2 (en) | 2010-01-11 | 2022-03-29 | Biogen Ma Inc. | Assay for JC virus antibodies |
WO2011089214A1 (en) * | 2010-01-22 | 2011-07-28 | Ascendis Pharma As | Carrier-linked carbamate prodrug linkers |
JP2013525435A (ja) | 2010-04-30 | 2013-06-20 | エラン ファーマシューティカルズ,インコーポレイテッド | 選択的インテグリン阻害剤 |
WO2013019326A2 (en) * | 2011-08-03 | 2013-02-07 | Henkel Corporation | Electrically conductive structural adhesive |
US9487485B2 (en) | 2013-02-28 | 2016-11-08 | Takeda Pharmaceutical Company Limited | Method for producing sulfonyl chloride compound |
EP3004334A4 (en) | 2013-05-28 | 2016-12-21 | Biogen Ma Inc | METHODS OF EVALUATION RISK OF DEVELOPMENT OF PML |
AU2014285086A1 (en) * | 2013-07-05 | 2016-01-21 | Biogen Ma Inc. | Compositions and methods for treatment of stroke |
EP3104867B1 (en) * | 2014-02-12 | 2022-01-19 | 7 Hills Pharma LLC | Compositions and methods to improve the homing and grafting of hematopoetic stem cells |
WO2017015544A1 (en) * | 2015-07-23 | 2017-01-26 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
WO2020092383A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
EP3873605A1 (en) | 2018-10-30 | 2021-09-08 | Gilead Sciences, Inc. | Compounds for inhibition of alpha4beta7 integrin |
US11174256B2 (en) | 2018-10-30 | 2021-11-16 | Gilead Sciences, Inc. | Imidazopyridine derivatives |
KR20240015737A (ko) | 2018-10-30 | 2024-02-05 | 길리애드 사이언시즈, 인코포레이티드 | 알파4베타7 인테그린 억제제로서의 퀴놀린 유도체 |
US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
US5177059A (en) | 1989-11-15 | 1993-01-05 | Sandoz Ltd. | Polymyxin B conjugates |
DE4107857A1 (de) | 1991-03-12 | 1992-09-17 | Thomae Gmbh Dr K | Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
WO1992016555A1 (en) | 1991-03-18 | 1992-10-01 | Enzon, Inc. | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
US5824701A (en) | 1993-10-20 | 1998-10-20 | Enzon, Inc. | Taxane-based prodrugs |
US5880131A (en) | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
DE69833654T2 (de) | 1997-05-29 | 2006-12-14 | Merck & Co., Inc. (A New Jersey Corp.) | Biarylalkansäuren in der verwendung als zelladhäsionsinhibitoren |
EP1001764A4 (en) * | 1997-05-29 | 2005-08-24 | Merck & Co Inc | Heterocyclic amides as cell adhesion inhibitors |
US6939855B2 (en) * | 1997-07-31 | 2005-09-06 | Elan Pharmaceuticals, Inc. | Anti-inflammatory compositions and method |
US6489300B1 (en) * | 1997-07-31 | 2002-12-03 | Eugene D. Thorsett | Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4 |
AR016133A1 (es) | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
ATE268609T1 (de) | 1998-03-12 | 2004-06-15 | Nektar Therapeutics Al Corp | Polyethylenglycolderivate mit benachbarten reaktiven gruppen |
GB9821061D0 (en) * | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
AU2623900A (en) | 1999-01-22 | 2000-08-07 | American Home Products Corporation | Compounds which inhibit leukocyte adhesion mediated by vla-4 |
AU773538B2 (en) * | 1999-01-22 | 2004-05-27 | Elan Pharmaceuticals, Inc. | Acyl derivatives which treat VLA-4 related disorders |
US6436904B1 (en) | 1999-01-25 | 2002-08-20 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
PT1265606E (pt) * | 1999-08-13 | 2007-01-31 | Biogen Idec Inc | Inibidores da adesão celular |
EP1253923A1 (en) * | 2000-01-28 | 2002-11-06 | Biogen, Inc. | Pharmaceutical compositions containing anti-beta 1 integrin compounds and uses |
AU2001282938A1 (en) | 2000-07-21 | 2002-02-05 | Elan Pharmaceuticals, Inc. | Alpha amino acid derivatives--inhibitors of leukocyte adhesion mediated by vla-4 |
US20040043030A1 (en) | 2001-07-31 | 2004-03-04 | Immunomedics, Inc. | Polymeric delivery systems |
US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
ES2197003B1 (es) | 2002-04-08 | 2005-03-16 | J. URIACH & CIA S.A. | Nuevos compuestos antagonistas de integrinas alfa. |
TWI281470B (en) * | 2002-05-24 | 2007-05-21 | Elan Pharm Inc | Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins |
TW200307671A (en) * | 2002-05-24 | 2003-12-16 | Elan Pharm Inc | Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins |
KR101260497B1 (ko) | 2003-01-24 | 2013-09-12 | 엘란 파마슈티칼스, 인크. | 수초재생제의 투여에 의한 탈수초성 질환 및 마비의 치료 및 조성물 |
AU2004251754A1 (en) | 2003-06-25 | 2005-01-06 | Elan Pharmaceuticals, Inc. | Methods and compositions for treating rheumatoid arthritis |
EP1706399A1 (en) * | 2004-01-23 | 2006-10-04 | Elan Pharmaceuticals, Inc. | Polyethylene glycol conjugates of heterocycloalkyl carboxamido propanoic acids |
AU2005231467A1 (en) | 2004-04-01 | 2005-10-20 | Elan Pharmaceuticals, Inc. | Steroid sparing agents and methods of using same |
US7205310B2 (en) * | 2004-04-30 | 2007-04-17 | Elan Pharmaceuticals, Inc. | Pyrimidine hydantoin analogues which inhibit leukocyte adhesion mediated by VLA-4 |
CN101035563B (zh) | 2004-07-08 | 2012-03-28 | 艾伦药物公司 | 包括聚合物部分的多价vla-4拮抗剂 |
CN101300255A (zh) | 2005-05-20 | 2008-11-05 | 艾伦药物公司 | 咪唑啉酮苯丙氨酸衍生物vla-4拮抗剂 |
MX2008000291A (es) * | 2005-07-08 | 2008-04-04 | Elan Pharm Inc | Preparacion de conjugados polimericos de compuestos de aditivos terapeuticos, agricolas y alimentarios. |
JP2011506322A (ja) | 2007-12-07 | 2011-03-03 | エラン ファーマシューティカルズ,インコーポレイテッド | 液性腫瘍を治療するための方法および組成物 |
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