CN101027982A - Phenolic disinfectant neutralizer - Google Patents
Phenolic disinfectant neutralizer Download PDFInfo
- Publication number
- CN101027982A CN101027982A CN 200610042513 CN200610042513A CN101027982A CN 101027982 A CN101027982 A CN 101027982A CN 200610042513 CN200610042513 CN 200610042513 CN 200610042513 A CN200610042513 A CN 200610042513A CN 101027982 A CN101027982 A CN 101027982A
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- China
- Prior art keywords
- lecithin
- histidine
- polysorbate
- neutralizer
- disinfectant
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A neutralizer for the liquid disinfectant made of phenol is prepared from lecithin, polysorbitol-80, and histidine through proportional mixing. Its advantages are high and reliable neutralizing action, and no damage and suppression to experimental microbes.
Description
Technical field the present invention relates to a kind of phenolic disinfectant neutralizer, and its main component is that polysorbate-80, lecithin, histidine are mixed into mixture in proportion.The key problem of disinfection experiment is to estimate the sterilization and the bacteriostasis of disinfection factor.The effect of evaluating chemical disinfectant must strictly be grasped action time.Disinfectant and microorganism touch after the preset time, must remove its effect immediately, so just can accurately obtain the data of disinfectant action effect; Simultaneously must not contain remaining disinfectant in the sample after taking to sterilize.To prevent that in recover cultivating microorganism from continuing to be subjected to the effect of disinfectant.Therefore, the experiment of any one evaluating chemical disinfectant all must have the reliable method of removing remaining disinfectant.Do not adopt the experiment of removing remaining disinfectant measure, should think serious mistake in design, the result who draws according to such experiment is insecure.The chemistry neutralisation is the disinfectant method of at present the most frequently used removal remnants, and its advantage is that method is simple, and is easy to use, reliable for effect.The phenolic disinfectant neutralizer can be used for estimating the disinfective action of phenolic disinfectant.Existing thimerosal neutralizer kind is a lot, and common have acid, alkali, absorption, dilution, centrifugal a, filtration etc.The above-mentioned screening of all passing through strictness also can't not determined its working concentration; Corresponding disinfectant do not had solid neutralization; Neutralizer itself or with the product of disinfectant reaction the experiment microorganism is had killing or suppress the effect of its growth; To cultivating composition destruction is arranged, also influence its physical behavior.Along with the sterilization progress of research, both at home and abroad to the research of neutralizer also in continuous development.The disinfection person wishes to have a kind of neutralizer that can overcome above-mentioned neutralizer deficiency always.
Background technology the object of the present invention is to provide a kind of phenols liquid neutralizer that can overcome existing sterilization neutralizer deficiency, compares with other class neutralizer to possess following characteristics: the corresponding phenolic disinfectant is had solid neutralization; Neutralizer itself or with the product of phenols disinfectant reaction the experiment microorganism is not had killing or suppress the effect of its growth; Do not have destruction to cultivating composition, also do not influence its physical behavior.
Summary of the invention main points of the present invention are to select suitable component, and rationally are mixed, through heat, dissolve, technology such as mixing, cooling, packing, high-temperature sterilization forms a kind of phenolic disinfectant neutralizer.
The prescription following (component and percentage by weight % thereof) that the present invention selects: polysorbate-80 (1.0-10.0); Lecithin (0.1-0.3); Histidine (0.1-0.3); Purified water adds to 100.
Polysorbate-80, lecithin, histidine can with the phenolic disinfectant generation chemical reaction of remnants, generate to the experiment microorganism do not kill or suppress its growth effect, do not have destruction to cultivating composition, physical behavior not have the neutralized reaction product that influences.The corresponding phenolic disinfectant had solid neutralization.
The preparation method of product of the present invention is:
1), polysorbate-80, lecithin are heated in proportion, dissolved.
2), histidine is dissolved in the pure water 54 ℃ of heating in proportion, cooling.
3), the polysorbate-80, lecithin of dissolving joined in the histidine solution of cooling back by proportioning, mix, carry out packing after the cooling, 105 ℃ of sterilizations 15 minutes.Check, warehousing after passing.
The present invention has the following advantages: the corresponding phenolic disinfectant is had solid neutralization; Neutralizer itself or with the product of phenols disinfectant reaction the experiment microorganism is not had killing or suppress the effect of its growth; Do not have destruction to cultivating composition, also do not influence its physical behavior.
The present invention is described in further detail below in conjunction with embodiment for embodiment:
Be configured according to listed data of following table (percentage by weight %) and described step thereof:
Prescription one:
Polysorbate-80 1.0-10.0
Lecithin 0.1-0.3
Histidine 0.1-0.3
Purified water adds to 100
Prescription two:
Polysorbate-80 4.0-10.0
Lecithin 0.15-0.3
Histidine 0.15-0.3
Purified water adds to 100
Prescription three:
Polysorbate-80 1.0-8.0
Lecithin 0.1-0.2
Histidine 0.1-0.2
Purified water adds to 100
Prescription four:
Polysorbate-80 5.0-8.0
Lecithin 0.15-0.25
Histidine 0.15-0.25
Purified water adds to 100
Claims (2)
1, a kind of is the phenolic disinfectant neutralizer of key component with polysorbate-80, lecithin, histidine.Mainly be that polysorbate-80, lecithin, histidine mix in proportion.It is characterized in that having following prescription (component and percentage by weight % thereof): polysorbate-80 (1.0-10.0); Lecithin (0.1-0.3); Histidine (0.1-0.3); Purified water adds to 100.
2, the preparation method of the described phenolic disinfectant neutralizer of a kind of claim 1 is characterized in that having following step:
1), polysorbate-80, lecithin are heated in proportion, dissolved.
2), histidine is dissolved in the pure water 54 ℃ of heating in proportion, cooling.
3), the polysorbate-80, lecithin of dissolving joined in the histidine solution of cooling back by proportioning, mix, carry out packing after the cooling, 105 ℃ of sterilizations 15 minutes.Check, warehousing after passing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610042513 CN101027982A (en) | 2006-02-27 | 2006-02-27 | Phenolic disinfectant neutralizer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610042513 CN101027982A (en) | 2006-02-27 | 2006-02-27 | Phenolic disinfectant neutralizer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101027982A true CN101027982A (en) | 2007-09-05 |
Family
ID=38713666
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610042513 Pending CN101027982A (en) | 2006-02-27 | 2006-02-27 | Phenolic disinfectant neutralizer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101027982A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115253144A (en) * | 2022-08-09 | 2022-11-01 | 青岛嘉智生物技术有限公司 | Neutralizing agent for glutaraldehyde disinfectant and preparation method thereof |
-
2006
- 2006-02-27 CN CN 200610042513 patent/CN101027982A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115253144A (en) * | 2022-08-09 | 2022-11-01 | 青岛嘉智生物技术有限公司 | Neutralizing agent for glutaraldehyde disinfectant and preparation method thereof |
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