CN100577136C - 水凝胶、水凝胶的制备方法及其用途 - Google Patents
水凝胶、水凝胶的制备方法及其用途 Download PDFInfo
- Publication number
- CN100577136C CN100577136C CN200610171440A CN200610171440A CN100577136C CN 100577136 C CN100577136 C CN 100577136C CN 200610171440 A CN200610171440 A CN 200610171440A CN 200610171440 A CN200610171440 A CN 200610171440A CN 100577136 C CN100577136 C CN 100577136C
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- China
- Prior art keywords
- hydrogel
- acid
- ascorbic acid
- aluminum
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000017 hydrogel Substances 0.000 title claims description 100
- 238000002360 preparation method Methods 0.000 title claims description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 78
- -1 aluminum compound Chemical class 0.000 claims abstract description 68
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 40
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 40
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 38
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 26
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims abstract description 22
- 229920000058 polyacrylate Polymers 0.000 claims abstract description 22
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims abstract description 22
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 20
- 229920000642 polymer Polymers 0.000 claims abstract description 20
- 239000004584 polyacrylic acid Substances 0.000 claims abstract description 18
- 239000008213 purified water Substances 0.000 claims abstract description 14
- 239000000499 gel Substances 0.000 claims description 39
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N L-ascorbic acid 2-phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 15
- 229940070721 polyacrylate Drugs 0.000 claims description 15
- 150000003839 salts Chemical group 0.000 claims description 12
- OCYUQKSNQVZPED-UHFFFAOYSA-L aluminum;magnesium;dihydroxide Chemical compound [OH-].[OH-].[Mg+2].[Al+3] OCYUQKSNQVZPED-UHFFFAOYSA-L 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 9
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 8
- 239000002537 cosmetic Substances 0.000 claims description 8
- 238000010998 test method Methods 0.000 claims description 8
- 150000000996 L-ascorbic acids Chemical class 0.000 claims description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- HZVVJJIYJKGMFL-UHFFFAOYSA-N almasilate Chemical compound O.[Mg+2].[Al+3].[Al+3].O[Si](O)=O.O[Si](O)=O HZVVJJIYJKGMFL-UHFFFAOYSA-N 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 229910052751 metal Inorganic materials 0.000 claims description 5
- 239000002184 metal Substances 0.000 claims description 5
- HDVDLQFPDLTOSI-UHFFFAOYSA-L O[AlH]O Chemical compound O[AlH]O HDVDLQFPDLTOSI-UHFFFAOYSA-L 0.000 claims description 4
- PCRDIRUKXOTDNN-UHFFFAOYSA-K aluminum;sodium;carbonate;hydroxide Chemical compound [OH-].[Na+].[Al+3].[O-]C([O-])=O PCRDIRUKXOTDNN-UHFFFAOYSA-K 0.000 claims description 4
- 150000003863 ammonium salts Chemical group 0.000 claims description 4
- 239000001177 diphosphate Substances 0.000 claims description 4
- 229920005862 polyol Polymers 0.000 claims description 4
- GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical compound [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 claims description 4
- 239000004471 Glycine Substances 0.000 claims description 3
- 235000011180 diphosphates Nutrition 0.000 claims description 3
- 150000003077 polyols Chemical class 0.000 claims description 3
- VXYADVIJALMOEQ-UHFFFAOYSA-K tris(lactato)aluminium Chemical compound CC(O)C(=O)O[Al](OC(=O)C(C)O)OC(=O)C(C)O VXYADVIJALMOEQ-UHFFFAOYSA-K 0.000 claims description 3
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 2
- 229920000388 Polyphosphate Polymers 0.000 claims description 2
- 239000001205 polyphosphate Substances 0.000 claims description 2
- 239000010409 thin film Substances 0.000 claims description 2
- 239000001226 triphosphate Substances 0.000 claims description 2
- 229940072107 ascorbate Drugs 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 238000012360 testing method Methods 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 30
- 229920001577 copolymer Polymers 0.000 description 28
- 239000000126 substance Substances 0.000 description 23
- 239000000284 extract Substances 0.000 description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 20
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 18
- 229940047670 sodium acrylate Drugs 0.000 description 16
- PQUXFUBNSYCQAL-UHFFFAOYSA-N 1-(2,3-difluorophenyl)ethanone Chemical compound CC(=O)C1=CC=CC(F)=C1F PQUXFUBNSYCQAL-UHFFFAOYSA-N 0.000 description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 14
- 239000003814 drug Substances 0.000 description 14
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 14
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 13
- 239000003205 fragrance Substances 0.000 description 13
- 239000002994 raw material Substances 0.000 description 13
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 12
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
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- 239000011505 plaster Substances 0.000 description 11
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 10
- 235000011187 glycerol Nutrition 0.000 description 10
- 229960005150 glycerol Drugs 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 10
- 229960002920 sorbitol Drugs 0.000 description 10
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 235000014113 dietary fatty acids Nutrition 0.000 description 9
- LVTYICIALWPMFW-UHFFFAOYSA-N diisopropanolamine Chemical compound CC(O)CNCC(C)O LVTYICIALWPMFW-UHFFFAOYSA-N 0.000 description 9
- 229940043276 diisopropanolamine Drugs 0.000 description 9
- 239000000194 fatty acid Substances 0.000 description 9
- 229930195729 fatty acid Natural products 0.000 description 9
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- 239000002253 acid Substances 0.000 description 8
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 8
- 229910052749 magnesium Inorganic materials 0.000 description 8
- 239000011777 magnesium Substances 0.000 description 8
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 7
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 7
- 239000004743 Polypropylene Substances 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 239000006185 dispersion Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 7
- 229920001155 polypropylene Polymers 0.000 description 7
- 229960004889 salicylic acid Drugs 0.000 description 7
- KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 6
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 6
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 6
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 6
- 239000004480 active ingredient Substances 0.000 description 6
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 6
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 description 6
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 6
- 229940024545 aluminum hydroxide Drugs 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- 235000019437 butane-1,3-diol Nutrition 0.000 description 6
- 238000004132 cross linking Methods 0.000 description 6
- 239000003431 cross linking reagent Substances 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 229960004063 propylene glycol Drugs 0.000 description 6
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 6
- 239000000600 sorbitol Substances 0.000 description 6
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- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 6
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0212—Face masks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
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| CN103623457A (zh) * | 2013-12-09 | 2014-03-12 | 长春吉原生物科技有限公司 | 一种异形水凝胶功能敷料及其制备方法 |
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| KR100511202B1 (ko) * | 2002-11-26 | 2005-08-31 | 한국과학기술원 | 케이블 메카니즘을 이용한 로봇 그리퍼 |
| CN1329022C (zh) * | 2004-08-31 | 2007-08-01 | 贵州太和制药有限公司 | 亲水性生物粘附凝胶贴剂及其制备工艺 |
| EP1828750A1 (de) * | 2004-12-22 | 2007-09-05 | Süd-Chemie Ag | Vorrichtung zur detektion mindestens einer chemischen komponente |
| GB0517840D0 (en) * | 2005-09-02 | 2005-10-12 | Henderson Morley Plc | Topical anti viral formulations |
| CN100450480C (zh) * | 2006-03-30 | 2009-01-14 | 华中科技大学 | 水凝胶型甲巯咪唑贴剂 |
| KR100846141B1 (ko) * | 2007-02-07 | 2008-07-14 | 권수안 | 의료용 폴리우레탄하이드로겔 제조용 조성물 및 이조성물로 폴리우레탄하이드로겔 필름을 연속적으로제조하는 방법 |
| ES2431366T3 (es) * | 2008-08-19 | 2013-11-26 | Kyowa Chemical Industry Co., Ltd. | Partículas de gel de hidróxido de aluminio y proceso para la producción de las mismas |
| CN104258408B (zh) * | 2010-03-31 | 2017-10-03 | 持田制药株式会社 | 易服用性固体制剂 |
| GB2479198B (en) * | 2010-04-01 | 2012-05-09 | H & R Chempharm Uk Ltd | Method of forming a crosslinked superabsorbent polymer on a nonwoven or woven substrate |
| US9603805B2 (en) | 2011-09-30 | 2017-03-28 | Mochida Pharmaceutical Co., Ltd. | Easily dosable solid preparation |
| CN102441185B (zh) * | 2011-12-08 | 2014-12-03 | 李舜丽 | 固体香薰 |
| US9549891B2 (en) | 2012-03-19 | 2017-01-24 | The Procter & Gamble Company | Superabsorbent polymers and sunscreen actives for use in skin care compositions |
| IN2012DE02302A (OSRAM) * | 2012-07-31 | 2015-10-16 | Council Scient Ind Res | |
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| CN112521627B (zh) * | 2020-10-14 | 2022-05-03 | 浙江树人学院(浙江树人大学) | 一种具有缓释型净化杀菌功能的绿色复合水凝胶的制备方法 |
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| CN112842678B (zh) * | 2021-02-03 | 2022-02-22 | 天津市肿瘤医院(天津医科大学肿瘤医院) | 一种用于预防手足综合征的贴片 |
| CN113173728B (zh) * | 2021-05-08 | 2023-08-22 | 四川铁科新型建材有限公司 | 抗骨料碱活性反应的无碱速凝剂及其制备方法 |
| US20250120889A1 (en) * | 2022-01-27 | 2025-04-17 | Dead Sea Bromine Company Ltd. | Magnesium hydroxide facial mask and methods of making and using same |
| CN115089767B (zh) * | 2022-05-25 | 2023-06-20 | 中山大学 | 一种大豆创伤修复材料及其制备方法与应用 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103623457A (zh) * | 2013-12-09 | 2014-03-12 | 长春吉原生物科技有限公司 | 一种异形水凝胶功能敷料及其制备方法 |
Also Published As
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| KR20050013217A (ko) | 2005-02-03 |
| CN1662586A (zh) | 2005-08-31 |
| ATE391744T1 (de) | 2008-04-15 |
| WO2004000918A1 (en) | 2003-12-31 |
| CN1301285C (zh) | 2007-02-21 |
| US20060165801A1 (en) | 2006-07-27 |
| US8580849B2 (en) | 2013-11-12 |
| DE60320251D1 (de) | 2008-05-21 |
| TWI349558B (OSRAM) | 2011-10-01 |
| AU2003243001A1 (en) | 2004-01-06 |
| DE60320251T2 (de) | 2009-05-14 |
| CN101002722A (zh) | 2007-07-25 |
| HK1072062A1 (en) | 2005-08-12 |
| EP1513889A1 (en) | 2005-03-16 |
| US20100099636A1 (en) | 2010-04-22 |
| TW200400048A (en) | 2004-01-01 |
| EP1513889B1 (en) | 2008-04-09 |
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