CN100558903C - 将分子输递进胞质溶胶的光化学内化法 - Google Patents

将分子输递进胞质溶胶的光化学内化法 Download PDF

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Publication number
CN100558903C
CN100558903C CNB018223575A CN01822357A CN100558903C CN 100558903 C CN100558903 C CN 100558903C CN B018223575 A CNB018223575 A CN B018223575A CN 01822357 A CN01822357 A CN 01822357A CN 100558903 C CN100558903 C CN 100558903C
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cells
molecule
photosensitizer
light
cell
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Expired - Fee Related
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CNB018223575A
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English (en)
Chinese (zh)
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CN1553958A (zh
Inventor
K·伯格
L·普拉斯密凯特
A·霍格西特
P·K·塞尔博
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PCI Biotech AS
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PCI Biotech AS
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Priority claimed from GB0029134A external-priority patent/GB0029134D0/en
Priority claimed from GB0029404A external-priority patent/GB0029404D0/en
Priority claimed from GB0114695A external-priority patent/GB0114695D0/en
Application filed by PCI Biotech AS filed Critical PCI Biotech AS
Publication of CN1553958A publication Critical patent/CN1553958A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB018223575A 2000-11-29 2001-11-29 将分子输递进胞质溶胶的光化学内化法 Expired - Fee Related CN100558903C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0029134A GB0029134D0 (en) 2000-11-29 2000-11-29 Method
GB0029134.4 2000-11-29
GB0029404.1 2000-12-01
GB0029404A GB0029404D0 (en) 2000-12-01 2000-12-01 Method
GB0114695A GB0114695D0 (en) 2001-06-15 2001-06-15 Method
GB0114695.0 2001-06-15

Publications (2)

Publication Number Publication Date
CN1553958A CN1553958A (zh) 2004-12-08
CN100558903C true CN100558903C (zh) 2009-11-11

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CNB018223575A Expired - Fee Related CN100558903C (zh) 2000-11-29 2001-11-29 将分子输递进胞质溶胶的光化学内化法

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Country Link
US (2) US7223600B2 (https=)
EP (1) EP1346059B1 (https=)
JP (1) JP4578770B2 (https=)
KR (2) KR20080080685A (https=)
CN (1) CN100558903C (https=)
AU (2) AU2002220853B2 (https=)
BR (1) BR0115795A (https=)
CA (1) CA2430087C (https=)
CZ (1) CZ301427B6 (https=)
ES (1) ES2383516T3 (https=)
HU (1) HU229805B1 (https=)
PL (1) PL213560B1 (https=)
PT (1) PT1346059E (https=)
WO (1) WO2002044396A1 (https=)

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US8411669B2 (en) * 2008-04-18 2013-04-02 Cisco Technology, Inc. Distributed transcoding on IP phones with idle DSP channels
GB0811955D0 (en) 2008-06-30 2008-07-30 Pci Biotech As Method
US8808733B2 (en) 2009-03-31 2014-08-19 The Board Of Trustees Of The University Of Arkansas Method of controlled drug release from a liposome carrier
GB0914287D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Compositions
GB0914286D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Method
US9872833B2 (en) * 2011-10-07 2018-01-23 National University Corporation Tottori University Liposome composite body
US9849087B2 (en) 2011-11-08 2017-12-26 The Board Of Trustees Of The University Of Arkansas Methods and compositions for X-ray induced release from pH sensitive liposomes
DK2911650T3 (da) * 2012-10-29 2019-11-18 Agency Science Tech & Res Hidtil ukendt reagens til gen-lægemiddel-terapeutika
US20160040128A1 (en) * 2013-03-15 2016-02-11 Pci Biotech As Method
EP3035969B1 (en) 2013-08-19 2022-08-03 S.M. Discovery Holdings Inc. Peptidic nanodelivery composition targeting two receptors
AU2014314149B2 (en) * 2013-08-28 2019-12-19 Pci Biotech As Compound and method for vaccination and immunisation
WO2015028575A1 (en) * 2013-08-28 2015-03-05 Pci Biotech As Immunisation method by photochemical internalisation
US10973896B2 (en) 2014-04-11 2021-04-13 Pci Biotech As Treatment or prevention of melanoma using photochemical internalization of a melanoma antigen
WO2016030529A1 (en) 2014-08-28 2016-03-03 Pci Biotech As Compound and method
GB201415250D0 (en) * 2014-08-28 2014-10-15 Pci Biotech As Compound and method
GB201503776D0 (en) 2015-03-05 2015-04-22 Pci Biotech As Compound and method
WO2018017954A1 (en) * 2016-07-21 2018-01-25 Rutgers, The State University Of New Jersey Antimicrobial cationic systems and methods of use
ES2841941T3 (es) 2016-10-14 2021-07-12 Pci Biotech As Tratamiento del colangiocarcinoma a través de la internalización fotoquímica de gemcitabina inducida por TPCS2a
KR101911725B1 (ko) * 2017-01-16 2018-12-28 주식회사 코어파마 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법
CN107029236B (zh) * 2017-04-18 2020-04-10 中国医学科学院生物医学工程研究所 一种吲哚菁绿自组装纳米疫苗及制备方法
GB201718631D0 (en) 2017-11-10 2017-12-27 Pci Biotech As Method
GB201801169D0 (en) 2018-01-24 2018-03-07 Pci Biotech As Method
WO2020017962A1 (en) 2018-07-16 2020-01-23 Dcprime B.V. A combination product for use in tumor vaccination.
CA3109804A1 (en) 2018-08-16 2020-02-20 The Regents Of The University Of California Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof
CA3133410A1 (en) 2019-04-25 2020-10-29 Dcprime B.V. Methods of tumor vaccination
CN115916963A (zh) 2020-03-27 2023-04-04 门德斯有限公司 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途
US20210322471A1 (en) 2020-03-27 2021-10-21 Dcprime B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
EP4171617A1 (en) 2020-06-30 2023-05-03 Mendus B.V. Use of leukemia-derived cells in ovarian cancer vaccines
CA3196677A1 (en) 2020-11-05 2022-05-12 Erik Hans MANTING Use of tumor-independent antigens in immunotherapies
JP2024506249A (ja) 2021-01-22 2024-02-13 メンドゥス・ベスローテン・フェンノートシャップ 腫瘍ワクチン接種の方法
CA3212351A1 (en) 2021-03-12 2022-09-15 Mendus B.V. Methods of vaccination and use of cd47 blockade
GB202115451D0 (en) 2021-10-27 2021-12-08 Pci Biotech As Method

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Also Published As

Publication number Publication date
CA2430087C (en) 2016-06-28
CN1553958A (zh) 2004-12-08
US20050075268A1 (en) 2005-04-07
US7223600B2 (en) 2007-05-29
CA2430087A1 (en) 2002-06-06
JP4578770B2 (ja) 2010-11-10
HUP0402260A2 (hu) 2005-02-28
PT1346059E (pt) 2012-06-01
CZ301427B6 (cs) 2010-02-24
EP1346059B1 (en) 2012-05-23
AU2085302A (en) 2002-06-11
KR100980153B1 (ko) 2010-09-03
AU2002220853B2 (en) 2007-06-28
CZ20031791A3 (cs) 2003-10-15
BR0115795A (pt) 2003-08-12
HUP0402260A3 (en) 2005-06-28
KR20080080685A (ko) 2008-09-04
HU229805B1 (en) 2014-07-28
WO2002044396A1 (en) 2002-06-06
PL213560B1 (pl) 2013-03-29
KR20030074632A (ko) 2003-09-19
HK1056573A1 (en) 2004-02-20
EP1346059A1 (en) 2003-09-24
JP2004520021A (ja) 2004-07-08
PL365006A1 (en) 2004-12-27
US8008077B2 (en) 2011-08-30
US20070274953A1 (en) 2007-11-29
ES2383516T3 (es) 2012-06-21

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