ES2383516T3 - Internalización fotoquímica para suministrar moléculas en el citosol - Google Patents

Internalización fotoquímica para suministrar moléculas en el citosol Download PDF

Info

Publication number
ES2383516T3
ES2383516T3 ES01998646T ES01998646T ES2383516T3 ES 2383516 T3 ES2383516 T3 ES 2383516T3 ES 01998646 T ES01998646 T ES 01998646T ES 01998646 T ES01998646 T ES 01998646T ES 2383516 T3 ES2383516 T3 ES 2383516T3
Authority
ES
Spain
Prior art keywords
cells
molecule
cell
light
transfer molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01998646T
Other languages
English (en)
Spanish (es)
Inventor
Kristian Berg
Lina Prasmickaite
Anders Hoegset
Pal Kristian Selbo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PCI Biotech AS
Original Assignee
PCI Biotech AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0029134A external-priority patent/GB0029134D0/en
Priority claimed from GB0029404A external-priority patent/GB0029404D0/en
Priority claimed from GB0114695A external-priority patent/GB0114695D0/en
Application filed by PCI Biotech AS filed Critical PCI Biotech AS
Application granted granted Critical
Publication of ES2383516T3 publication Critical patent/ES2383516T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES01998646T 2000-11-29 2001-11-29 Internalización fotoquímica para suministrar moléculas en el citosol Expired - Lifetime ES2383516T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0029134 2000-11-29
GB0029134A GB0029134D0 (en) 2000-11-29 2000-11-29 Method
GB0029404 2000-12-01
GB0029404A GB0029404D0 (en) 2000-12-01 2000-12-01 Method
GB0114695A GB0114695D0 (en) 2001-06-15 2001-06-15 Method
GB0114695 2001-06-15
PCT/GB2001/005299 WO2002044396A1 (en) 2000-11-29 2001-11-29 Photochemical internalization for delivery of molecules into the cytosol

Publications (1)

Publication Number Publication Date
ES2383516T3 true ES2383516T3 (es) 2012-06-21

Family

ID=27255991

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01998646T Expired - Lifetime ES2383516T3 (es) 2000-11-29 2001-11-29 Internalización fotoquímica para suministrar moléculas en el citosol

Country Status (14)

Country Link
US (2) US7223600B2 (https=)
EP (1) EP1346059B1 (https=)
JP (1) JP4578770B2 (https=)
KR (2) KR100980153B1 (https=)
CN (1) CN100558903C (https=)
AU (2) AU2085302A (https=)
BR (1) BR0115795A (https=)
CA (1) CA2430087C (https=)
CZ (1) CZ301427B6 (https=)
ES (1) ES2383516T3 (https=)
HU (1) HU229805B1 (https=)
PL (1) PL213560B1 (https=)
PT (1) PT1346059E (https=)
WO (1) WO2002044396A1 (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905911D0 (en) 1999-03-15 1999-05-05 Photocure As Method
KR100980153B1 (ko) * 2000-11-29 2010-09-03 피씨아이 바이오테크 에이에스 사이토졸 내로의 분자 전달을 위한 광화학적 내부이행
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
GB0613753D0 (en) 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
EP2099496A2 (en) * 2006-12-08 2009-09-16 Massachusetts Institute of Technology Delivery of nanoparticles and/or agents to cells
RU2339414C1 (ru) * 2007-03-27 2008-11-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Способ подавления роста опухолей
US8411669B2 (en) * 2008-04-18 2013-04-02 Cisco Technology, Inc. Distributed transcoding on IP phones with idle DSP channels
GB0811955D0 (en) 2008-06-30 2008-07-30 Pci Biotech As Method
US8808733B2 (en) 2009-03-31 2014-08-19 The Board Of Trustees Of The University Of Arkansas Method of controlled drug release from a liposome carrier
GB0914287D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Compositions
GB0914286D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Method
JP5979385B2 (ja) * 2011-10-07 2016-08-24 国立大学法人鳥取大学 リポソーム複合体
WO2013070872A1 (en) 2011-11-08 2013-05-16 The Board Of Trustees Of The University Of Arkansas Methods and compositions for x-ray induced release from ph sensitive liposomes
CN105101951B (zh) * 2012-10-29 2021-08-03 新加坡科技研究局 一种用于基因-药物治疗的新型试剂
CA2906279A1 (en) * 2013-03-15 2014-09-18 Pci Biotech As A method of generating antigen presenting cells using photochemical internalisation
WO2015024931A1 (en) 2013-08-19 2015-02-26 Moghimi Seyed Moien Peptidic nanodelivery composition targeting two receptors
JP6684215B2 (ja) * 2013-08-28 2020-04-22 ピーシーアイ バイオテック エイエス 予防接種用化合物および免疫化用化合物、ならびに予防接種方法および免疫化方法
WO2015028575A1 (en) * 2013-08-28 2015-03-05 Pci Biotech As Immunisation method by photochemical internalisation
AU2014390262B2 (en) 2014-04-11 2020-11-26 Pci Biotech As Method of treating melanoma
GB201415250D0 (en) * 2014-08-28 2014-10-15 Pci Biotech As Compound and method
EP3185901B1 (en) 2014-08-28 2023-10-04 PCI Biotech AS Compound and method
GB201503776D0 (en) 2015-03-05 2015-04-22 Pci Biotech As Compound and method
WO2018017954A1 (en) * 2016-07-21 2018-01-25 Rutgers, The State University Of New Jersey Antimicrobial cationic systems and methods of use
AU2017342086A1 (en) 2016-10-14 2019-05-09 Pci Biotech As Treatment of cholangiocarcinoma with TPCS-2a induced photochemical internalisation of gemcitabine
KR101911725B1 (ko) * 2017-01-16 2018-12-28 주식회사 코어파마 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법
CN107029236B (zh) * 2017-04-18 2020-04-10 中国医学科学院生物医学工程研究所 一种吲哚菁绿自组装纳米疫苗及制备方法
GB201718631D0 (en) * 2017-11-10 2017-12-27 Pci Biotech As Method
GB201801169D0 (en) 2018-01-24 2018-03-07 Pci Biotech As Method
EP3823668A1 (en) 2018-07-16 2021-05-26 DCPrime B.V. A combination product for use in tumor vaccination
CA3109804A1 (en) 2018-08-16 2020-02-20 The Regents Of The University Of California Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof
AU2020264083A1 (en) 2019-04-25 2021-12-02 Mendus B.V. Methods of tumor vaccination
US20210322471A1 (en) 2020-03-27 2021-10-21 Dcprime B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
US12091681B2 (en) 2020-03-27 2024-09-17 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
CN116133679A (zh) 2020-06-30 2023-05-16 门德斯有限公司 白血病衍生细胞在卵巢癌疫苗中的用途
WO2022097068A1 (en) 2020-11-05 2022-05-12 Dcprime B.V. Use of tumor-independent antigens in immunotherapies
AU2022211682A1 (en) 2021-01-22 2023-08-03 Mendus B.V. Methods of tumor vaccination
KR20230157388A (ko) 2021-03-12 2023-11-16 멘두스 비.브이. 백신접종의 방법 및 cd47 차단의 용도
GB202115451D0 (en) 2021-10-27 2021-12-08 Pci Biotech As Method

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649151A (en) 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
JPH0764728B2 (ja) 1985-04-30 1995-07-12 日本石油化学株式会社 新規なテトラピロ−ル医薬用組成物
NO891491L (no) 1987-08-12 1989-04-11 Peter Nemeth Prosedyre for befrielse av celleblandinger og vev for uoenskede populasjoner.
GB8721108D0 (en) 1987-09-08 1987-10-14 Salford University Of Liposomes
NO176947C (no) 1988-07-06 1995-06-28 Long Island Jewish Medical Ct Fremgangsmåte for fremstilling av et topisk preparat for fotodynamisk terapi
US5059619A (en) 1989-06-14 1991-10-22 Quadra Logic Technologies, Inc. Stable freeze-dried polyhematoporphyrin ether/ester
NO179410C (no) 1989-07-17 1996-10-02 Univ British Columbia Analogifremgangsmåte for fremstilling av terapeutisk aktive monobenzofyriner og anvendelse av disse
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5179120A (en) 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
PL165249B1 (pl) 1991-10-29 1994-11-30 Wojskowa Akad Tech Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL
US5258453A (en) 1992-01-21 1993-11-02 University Of Utah Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
GB9318841D0 (en) 1993-09-10 1993-10-27 Res Foundation Of The Norwegia Composition
NO180167C (no) 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
ATE202076T1 (de) 1995-03-10 2001-06-15 Photocure Asa Ester der 5-aminolevulinsäure als mittel zur photosensibilisierung in der chemotherapie
GB9700396D0 (en) 1997-01-10 1997-02-26 Photocure As Photochemotherapeutic compositions
DK0983273T3 (da) * 1997-05-07 2002-04-22 Univ British Columbia Ethylenglycolestere af monohydrobenzoporphyrinderivater som fotoaktive midler
DE60040274D1 (de) 1999-03-10 2008-10-30 Phogen Ltd Verabreichung von nukleinsäuren und proteinen an zellen
GB9905911D0 (en) 1999-03-15 1999-05-05 Photocure As Method
GB0018527D0 (en) 2000-07-27 2000-09-13 Photocure Asa Composition
KR100980153B1 (ko) * 2000-11-29 2010-09-03 피씨아이 바이오테크 에이에스 사이토졸 내로의 분자 전달을 위한 광화학적 내부이행

Also Published As

Publication number Publication date
CN1553958A (zh) 2004-12-08
CZ301427B6 (cs) 2010-02-24
WO2002044396A1 (en) 2002-06-06
HU229805B1 (en) 2014-07-28
HUP0402260A2 (hu) 2005-02-28
US7223600B2 (en) 2007-05-29
HK1056573A1 (en) 2004-02-20
AU2002220853B2 (en) 2007-06-28
PL213560B1 (pl) 2013-03-29
CA2430087C (en) 2016-06-28
CA2430087A1 (en) 2002-06-06
JP4578770B2 (ja) 2010-11-10
CZ20031791A3 (cs) 2003-10-15
AU2085302A (en) 2002-06-11
KR20030074632A (ko) 2003-09-19
JP2004520021A (ja) 2004-07-08
HUP0402260A3 (en) 2005-06-28
US20070274953A1 (en) 2007-11-29
KR20080080685A (ko) 2008-09-04
CN100558903C (zh) 2009-11-11
US20050075268A1 (en) 2005-04-07
PL365006A1 (en) 2004-12-27
KR100980153B1 (ko) 2010-09-03
PT1346059E (pt) 2012-06-01
BR0115795A (pt) 2003-08-12
EP1346059A1 (en) 2003-09-24
US8008077B2 (en) 2011-08-30
EP1346059B1 (en) 2012-05-23

Similar Documents

Publication Publication Date Title
ES2383516T3 (es) Internalización fotoquímica para suministrar moléculas en el citosol
AU2002220853A1 (en) Photochemical internalization for delivery of molecules into the cytosol
CA2430334C (en) Photochemical internalization for virus-mediated molecule delivery into the cytosol
AU2002222104A1 (en) Photochemical internalization for virus-mediated molecule delivery into the cyosol
RS55530B1 (sr) So fotosenzitivnog agensa za upotrebu u fotohemijskoj internalizaciji
Chen et al. Manganese Ions Chelated Tumosomes as Autologous Cancer Nanovaccines for Effective Suppression of Postsurgical Tumor Relapse
ES2968843T3 (es) Molécula de ARNm y agente fotosensibilizador para uso médico
RU2333246C2 (ru) Фотохимическая интернализация для доставки молекул в цитозоль
HK1056573B (en) Photochemical internalization for delivery of molecules into the cytosol
HK40041750A (en) Mrna molecule and photosensitizing agent for medical use