HUP0402260A2 - Citoszolba irányuló molekula-bevitelre szolgáló fotokémiai internalizáció és eljárás - Google Patents

Citoszolba irányuló molekula-bevitelre szolgáló fotokémiai internalizáció és eljárás

Info

Publication number
HUP0402260A2
HUP0402260A2 HU0402260A HUP0402260A HUP0402260A2 HU P0402260 A2 HUP0402260 A2 HU P0402260A2 HU 0402260 A HU0402260 A HU 0402260A HU P0402260 A HUP0402260 A HU P0402260A HU P0402260 A2 HUP0402260 A2 HU P0402260A2
Authority
HU
Hungary
Prior art keywords
cytosol
molecules
delivery
cell
photochemical internalization
Prior art date
Application number
HU0402260A
Other languages
English (en)
Inventor
Kristian Berg
Lina Prasmickaite
Anders Hogset
Pal Kristian Selbo
Original Assignee
Pci Biotech As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0029134A external-priority patent/GB0029134D0/en
Priority claimed from GB0029404A external-priority patent/GB0029404D0/en
Priority claimed from GB0114695A external-priority patent/GB0114695D0/en
Application filed by Pci Biotech As filed Critical Pci Biotech As
Publication of HUP0402260A2 publication Critical patent/HUP0402260A2/hu
Publication of HUP0402260A3 publication Critical patent/HUP0402260A3/hu
Publication of HU229805B1 publication Critical patent/HU229805B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A találmány tárgya eljárás molekulák bevitelére sejtek citoszoljába,amely eljárásban a sejtet fotoszenzitizáló ágenssel érintkeztetik, asejtet a fotoszenzitizáló ágens aktiválására alkalmas hullámhosszúfénnyel sugározzák be és - lényegében ugyanekkor vagy a besugárzásután - a sejtet előnyösen, rákkezelési, génterápiás és vakcinakénttörténő alkalmazás céljából a bevinni kívánt molekulávalérintkeztetik. Ó
HU0402260A 2000-11-29 2001-11-29 Photochemical internalization for delivery of molecules into the cytosol HU229805B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0029134A GB0029134D0 (en) 2000-11-29 2000-11-29 Method
GB0029404A GB0029404D0 (en) 2000-12-01 2000-12-01 Method
GB0114695A GB0114695D0 (en) 2001-06-15 2001-06-15 Method
PCT/GB2001/005299 WO2002044396A1 (en) 2000-11-29 2001-11-29 Photochemical internalization for delivery of molecules into the cytosol

Publications (3)

Publication Number Publication Date
HUP0402260A2 true HUP0402260A2 (hu) 2005-02-28
HUP0402260A3 HUP0402260A3 (en) 2005-06-28
HU229805B1 HU229805B1 (en) 2014-07-28

Family

ID=27255991

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402260A HU229805B1 (en) 2000-11-29 2001-11-29 Photochemical internalization for delivery of molecules into the cytosol

Country Status (15)

Country Link
US (2) US7223600B2 (hu)
EP (1) EP1346059B1 (hu)
JP (1) JP4578770B2 (hu)
KR (2) KR20080080685A (hu)
CN (1) CN100558903C (hu)
AU (2) AU2085302A (hu)
BR (1) BR0115795A (hu)
CA (1) CA2430087C (hu)
CZ (1) CZ301427B6 (hu)
ES (1) ES2383516T3 (hu)
HK (1) HK1056573A1 (hu)
HU (1) HU229805B1 (hu)
PL (1) PL213560B1 (hu)
PT (1) PT1346059E (hu)
WO (1) WO2002044396A1 (hu)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9905911D0 (en) 1999-03-15 1999-05-05 Photocure As Method
CZ301427B6 (cs) * 2000-11-29 2010-02-24 Pci Biotech As Zpusob zavedení molekuly do cytosolu bunky
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
GB0613753D0 (en) 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
CA2671850A1 (en) * 2006-12-08 2008-06-19 Massachusetts Institute Of Technology Delivery of nanoparticles and/or agents to cells
US8411669B2 (en) * 2008-04-18 2013-04-02 Cisco Technology, Inc. Distributed transcoding on IP phones with idle DSP channels
GB0811955D0 (en) * 2008-06-30 2008-07-30 Pci Biotech As Method
US8808733B2 (en) 2009-03-31 2014-08-19 The Board Of Trustees Of The University Of Arkansas Method of controlled drug release from a liposome carrier
GB0914286D0 (en) * 2009-08-14 2009-09-30 Pci Biotech As Method
GB0914287D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Compositions
JP5979385B2 (ja) * 2011-10-07 2016-08-24 国立大学法人鳥取大学 リポソーム複合体
WO2013070872A1 (en) 2011-11-08 2013-05-16 The Board Of Trustees Of The University Of Arkansas Methods and compositions for x-ray induced release from ph sensitive liposomes
EP2911650B1 (en) * 2012-10-29 2019-09-04 Agency For Science, Technology And Research A novel reagent for gene-drug therapeutics
US20160040128A1 (en) * 2013-03-15 2016-02-11 Pci Biotech As Method
US9981047B2 (en) 2013-08-19 2018-05-29 Thomas Lars Andresen Peptidic nanodelivery composition targeting two receptors
CN105873585A (zh) 2013-08-28 2016-08-17 Pci生物技术公司 用于疫苗接种或免疫的化合物和方法
WO2015028575A1 (en) * 2013-08-28 2015-03-05 Pci Biotech As Immunisation method by photochemical internalisation
US10973896B2 (en) 2014-04-11 2021-04-13 Pci Biotech As Treatment or prevention of melanoma using photochemical internalization of a melanoma antigen
GB201415250D0 (en) * 2014-08-28 2014-10-15 Pci Biotech As Compound and method
NZ729408A (en) 2014-08-28 2021-12-24 Pci Biotech As A method of photochemical internalization (pci) utilizing a antigenic molecule, a photosensitizing agent, and a cytokine
GB201503776D0 (en) 2015-03-05 2015-04-22 Pci Biotech As Compound and method
WO2018017954A1 (en) * 2016-07-21 2018-01-25 Rutgers, The State University Of New Jersey Antimicrobial cationic systems and methods of use
DK3525783T3 (da) 2016-10-14 2021-01-18 Pci Biotech As Behandling af cholangiocarcinom med tpcs-2a-induceret fotokemisk internalisering af gemcitabin
KR101911725B1 (ko) * 2017-01-16 2018-12-28 주식회사 코어파마 적색형광단백질을 발현하는 유전자 및 틴 에틸 에티오푸르푸린을 이용한 광역학 치료용 조성물 및 이를 이용한 광역학 치료방법
CN107029236B (zh) * 2017-04-18 2020-04-10 中国医学科学院生物医学工程研究所 一种吲哚菁绿自组装纳米疫苗及制备方法
GB201718631D0 (en) 2017-11-10 2017-12-27 Pci Biotech As Method
GB201801169D0 (en) * 2018-01-24 2018-03-07 Pci Biotech As Method
JP2021531345A (ja) 2018-07-16 2021-11-18 ディーシープライム・ベスローテン・フェンノートシャップDcprime B.V. 腫瘍ワクチン接種に用いるための組合せ製品
CA3109804A1 (en) * 2018-08-16 2020-02-20 The Regents Of The University Of California Chemically and photochemically initiated cell membrane blebbing to induce cell vesicle production, modifications thereof, and uses thereof
WO2020217226A1 (en) 2019-04-25 2020-10-29 Dcprime B.V. Methods of tumor vaccination
CN115916963A (zh) 2020-03-27 2023-04-04 门德斯有限公司 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途
WO2021191871A1 (en) 2020-03-27 2021-09-30 Dcprime B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
JP2023547520A (ja) 2020-11-05 2023-11-10 メンドゥス・ベスローテン・フェンノートシャップ 免疫療法における腫瘍非依存性抗原の使用
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
GB202115451D0 (en) 2021-10-27 2021-12-08 Pci Biotech As Method

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649151A (en) 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
DK168690B1 (da) 1985-04-30 1994-05-24 Nippon Petrochemicals Co Ltd Farmaceutiske præparater til detektion og/eller behandling af pattedyrtumorer
NO891491D0 (no) 1987-08-12 1989-04-11 Peter Nemeth Prosedyre for befrielse av celleblandinger og vev for uoenskede populasjoner.
GB8721108D0 (en) 1987-09-08 1987-10-14 Salford University Of Liposomes
NO176947C (no) 1988-07-06 1995-06-28 Long Island Jewish Medical Ct Fremgangsmåte for fremstilling av et topisk preparat for fotodynamisk terapi
US5059619A (en) 1989-06-14 1991-10-22 Quadra Logic Technologies, Inc. Stable freeze-dried polyhematoporphyrin ether/ester
NO179410C (no) 1989-07-17 1996-10-02 Univ British Columbia Analogifremgangsmåte for fremstilling av terapeutisk aktive monobenzofyriner og anvendelse av disse
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5179120A (en) 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
PL165249B1 (pl) 1991-10-29 1994-11-30 Wojskowa Akad Tech Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL
US5258453A (en) 1992-01-21 1993-11-02 University Of Utah Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
GB9318841D0 (en) 1993-09-10 1993-10-27 Res Foundation Of The Norwegia Composition
NO180167C (no) * 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
CA2215069C (en) * 1995-03-10 2006-09-12 Photocure As Esters of 5-aminolevulinic acid as photosensitizing agents in photochemotherapy
GB9700396D0 (en) 1997-01-10 1997-02-26 Photocure As Photochemotherapeutic compositions
JP3378889B2 (ja) * 1997-05-07 2003-02-17 キューエルティー インコーポレイテッド 光活性薬剤としてのモノヒドロベンゾポルフィリン誘導体のエチレングリコールエステル
EP1159441B8 (en) 1999-03-10 2008-10-29 Marie Curie Cancer Care Delivery of nucleic acids and proteins to cells
GB9905911D0 (en) * 1999-03-15 1999-05-05 Photocure As Method
GB0018527D0 (en) 2000-07-27 2000-09-13 Photocure Asa Composition
CZ301427B6 (cs) * 2000-11-29 2010-02-24 Pci Biotech As Zpusob zavedení molekuly do cytosolu bunky

Also Published As

Publication number Publication date
WO2002044396A1 (en) 2002-06-06
CZ301427B6 (cs) 2010-02-24
US20050075268A1 (en) 2005-04-07
CA2430087C (en) 2016-06-28
JP2004520021A (ja) 2004-07-08
US7223600B2 (en) 2007-05-29
PT1346059E (pt) 2012-06-01
ES2383516T3 (es) 2012-06-21
HU229805B1 (en) 2014-07-28
PL365006A1 (en) 2004-12-27
HK1056573A1 (en) 2004-02-20
KR20030074632A (ko) 2003-09-19
AU2002220853B2 (en) 2007-06-28
BR0115795A (pt) 2003-08-12
KR20080080685A (ko) 2008-09-04
EP1346059A1 (en) 2003-09-24
KR100980153B1 (ko) 2010-09-03
CZ20031791A3 (cs) 2003-10-15
AU2085302A (en) 2002-06-11
US8008077B2 (en) 2011-08-30
JP4578770B2 (ja) 2010-11-10
HUP0402260A3 (en) 2005-06-28
EP1346059B1 (en) 2012-05-23
US20070274953A1 (en) 2007-11-29
CA2430087A1 (en) 2002-06-06
CN1553958A (zh) 2004-12-08
CN100558903C (zh) 2009-11-11
PL213560B1 (pl) 2013-03-29

Similar Documents

Publication Publication Date Title
HUP0402260A2 (hu) Citoszolba irányuló molekula-bevitelre szolgáló fotokémiai internalizáció és eljárás
HUP0402626A2 (hu) Vírus közreműködésével történő, a citoszolba irányuló molekulabevitelre szolgáló fotokémiai internalizáció és eljárás
CY1119951T1 (el) Συνθεσεις για αυξηση δραστηριοτητας τελομερασης και αγωγη λοιμωξης hiv
Kharkwal et al. Photodynamic therapy for infections: clinical applications
ID22689A (id) Metode untuk mengaktifkan sel-sel yang menunjukan-sifat antigen manusia, sel-sel teraktifkan yang menunjukan sifat antigen manusia, dan penggunaannya
da Silva et al. Fast elimination of onychomycosis by hematoporphyrin derivative-photodynamic therapy
DK0906758T3 (da) Zink-phthalocyaniner og tilsvarende konjugater, deres frembingelse og anvendelse i fotodynamisk terapi og som diagnostiske midler
HUP0400231A2 (hu) Rákos megbetegedések kezelésében különösen hasznos, immundecepcióra szolgáló eljárások és gyógyszerkészítmények
UY26456A1 (es) Compuestos que fijan la estructura g-cuadruplex de los telomeros, triazinas de aplicación de dichos compuestos, la utilización de dichos compuestos como productos farmacéuticos y las asociaciones terapéuticas que los incluyen.
DK1427403T3 (da) Valproinsyre til behandling af brystkræft, kolonkræft, hoved- og halskræft, lillecelle-lungecarcinom og kræft i blodceller i kombination med bestråling
MXPA01010393A (es) Tratamiento de neoplasmas con virus.
ATE209507T1 (de) Transfer von molekülen in das zytosol von zellen durch photosensibilisierende substanzen
HK1088242A1 (en) Ceramic based nanoparticles for entrapping therapeutic agents for photodynamic therapy and method of using same
AR032912A1 (es) Formulacion farmaceutica
de Albuquerque et al. Photodynamic therapy in superficial basal cell carcinoma treatment
HK1040993B (zh) 多元胺及其在治療中的用途
ATE415962T1 (de) Verwendung von asiatsäure oder asiaticosid zur behandlung von krebs
BRPI0418157A (pt) terapêutica de tumores alogênicos
EP1605847A4 (en) PHOTODYNAMIC THERAPY PROVIDED AGAINST ANTIBODIES
Aires-Fernandes et al. Tissue engineering and photodynamic therapy: A new frontier of science for clinical application-an up-to-date review
NO20064753L (no) Kombinasjonsterapi
MXPA04007443A (es) Nuevos compuestos de porfirina-platino solubles en agua con alta selectividad tumoral y su uso para el tratamiento de enfermedades tumorales benignas y malignas.
PT1276501E (pt) Metodo para o tratamento de tumores utilizando terapia fotodinamica
HK1088926A1 (en) Autologous self-tolerance inducing cells of monocytic origin and their use in pharmaceutical proparations
Yen et al. Comparative studies in vivo of free and liposomal forms of photosensitizer on a base of hydrophilic derivative of chlorin e6

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees