HUP0400231A2 - Rákos megbetegedések kezelésében különösen hasznos, immundecepcióra szolgáló eljárások és gyógyszerkészítmények - Google Patents

Rákos megbetegedések kezelésében különösen hasznos, immundecepcióra szolgáló eljárások és gyógyszerkészítmények

Info

Publication number
HUP0400231A2
HUP0400231A2 HU0400231A HUP0400231A HUP0400231A2 HU P0400231 A2 HUP0400231 A2 HU P0400231A2 HU 0400231 A HU0400231 A HU 0400231A HU P0400231 A HUP0400231 A HU P0400231A HU P0400231 A2 HUP0400231 A2 HU P0400231A2
Authority
HU
Hungary
Prior art keywords
immune
deception
cancer
treatment
methods
Prior art date
Application number
HU0400231A
Other languages
English (en)
Inventor
Yoram Reiter
Avital Lev
Original Assignee
Technion Research And Development Foundation Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technion Research And Development Foundation Ltd. filed Critical Technion Research And Development Foundation Ltd.
Publication of HUP0400231A2 publication Critical patent/HUP0400231A2/hu
Publication of HUP0400231A3 publication Critical patent/HUP0400231A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A találmány tárgyát egy olyan immunmolekula képezi, mely tartalmaz egyoldható humán I. osztályú MHC effektordomént és az említett oldhatóhumán I. osztályú MHC effektordoménhez kapcsolt célzódomént. Atalálmány továbbá az immunmolekulát kódoló nukleinsavszerkezetekre, azimmunmolekula előállítási eljárására és a molekulát tartalmazókészítményekre vonatkozik. A találmány további tárgya az immunmolekulaalkalmazása egy adott célsejt, különősen rákos sejtek elpusztítására. Ó
HU0400231A 2001-06-19 2002-06-18 Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer HUP0400231A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29891501P 2001-06-19 2001-06-19
US10/108,511 US20030017134A1 (en) 2001-06-19 2002-03-29 Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer
PCT/IL2002/000478 WO2002102299A2 (en) 2001-06-19 2002-06-18 Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer

Publications (2)

Publication Number Publication Date
HUP0400231A2 true HUP0400231A2 (hu) 2005-05-30
HUP0400231A3 HUP0400231A3 (en) 2010-11-29

Family

ID=26805971

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0400231A HUP0400231A3 (en) 2001-06-19 2002-06-18 Methods and pharmaceutical compositions for immune deception, particularly useful in the treatment of cancer

Country Status (11)

Country Link
US (1) US20030017134A1 (hu)
EP (1) EP1409547B1 (hu)
JP (1) JP5148804B2 (hu)
CA (1) CA2451353C (hu)
CZ (1) CZ200479A3 (hu)
DK (1) DK1409547T3 (hu)
ES (1) ES2652017T3 (hu)
HU (1) HUP0400231A3 (hu)
NZ (2) NZ530656A (hu)
PL (1) PL373302A1 (hu)
WO (1) WO2002102299A2 (hu)

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US20040191260A1 (en) 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
WO2001072768A2 (en) * 2000-03-27 2001-10-04 Technion Research And Development Foundation Ltd. Single chain class i major histo-compatibility complexes, constructs encoding same and methods of generating same
US8022190B2 (en) 2001-06-19 2011-09-20 Technion Research & Development Foundation Ltd. Immuno-molecules containing viral proteins, compositions thereof and methods of using
GB2408507B (en) * 2003-10-06 2005-12-14 Proimmune Ltd Chimeric MHC protein and oligomer thereof for specific targeting
CA2571168A1 (en) * 2004-06-17 2006-01-26 Mannkind Corporation Mhc i-binding ssx-241-49 variants
EP1896498B1 (en) 2005-06-17 2014-12-24 MannKind Corporation Epitope analogues
US8846393B2 (en) 2005-11-29 2014-09-30 Gamida-Cell Ltd. Methods of improving stem cell homing and engraftment
US7977457B2 (en) * 2006-05-19 2011-07-12 Teva Pharmaceutical Industries Ltd. Fusion proteins, uses thereof and processes for producing same
US8604184B2 (en) * 2009-05-05 2013-12-10 The United States Of America As Represented By The Secretary Of The Air Force Chemically programmable immunity
GB0908613D0 (en) * 2009-05-20 2009-06-24 Immunocore Ltd T Cell Reseptors
US20130011394A1 (en) * 2011-06-22 2013-01-10 Hoffmann-La Roche Inc. Complexes comprising mhc class i fusion polypeptides and antigen-specific antibodies and methods of use
US10047345B2 (en) 2012-02-13 2018-08-14 Gamida-Cell Ltd. Culturing of mesenchymal stem cells with FGF4 and nicotinamide
US9175266B2 (en) 2012-07-23 2015-11-03 Gamida Cell Ltd. Enhancement of natural killer (NK) cell proliferation and activity
US9567569B2 (en) 2012-07-23 2017-02-14 Gamida Cell Ltd. Methods of culturing and expanding mesenchymal stem cells
CA2887486A1 (en) * 2012-11-30 2014-06-05 Roche Glycart Ag Removal of cancer cells by circulating virus-specific cytotoxic t-cells using cancer cell targeted mhc class i comprising multi-function proteins
CN109324190A (zh) 2012-12-11 2019-02-12 艾伯特叶史瓦大学爱因斯坦医学院 高通量受体:配体鉴定方法
CA2889788A1 (en) * 2012-12-21 2014-06-26 F. Hoffmann-La Roche Ag Disulfide-linked multivalent mhc class i comprising multi-function proteins
WO2014127220A1 (en) * 2013-02-15 2014-08-21 The Johns Hopkins University Antigen-specific t cell redirectors
KR102488477B1 (ko) * 2014-01-21 2023-01-13 앨버트 아인슈타인 컬리지 오브 메디신 신속하고 포괄적인 t-세포 면역 모니터링을 위한 세포 플랫폼
AU2017268348A1 (en) 2016-05-18 2018-10-25 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
AU2017266905B2 (en) 2016-05-18 2022-12-15 Albert Einstein College Of Medicine, Inc. Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof
AU2017273147B2 (en) 2016-06-02 2024-06-13 Immunocore Limited Dosing regimen for GP100-specific TCR - anti-CD3 SCFV fusion protein
IL308851A (en) 2016-12-22 2024-01-01 Cue Biopharma Inc Multimeric polypeptides modulate T cells and methods for their use
EP3565829A4 (en) 2017-01-09 2021-01-27 Cue Biopharma, Inc. MULTIMER POLYPEPTIDES T-LYMPHOCYTE MODULATORS AND THEIR METHODS OF USE
CN111010875B (zh) 2017-03-15 2024-04-05 库尔生物制药有限公司 用于调节免疫应答的方法
US20210147550A1 (en) * 2017-08-18 2021-05-20 Joshua Michael Francis Antigen-binding proteins targeting shared antigens
CN111886241A (zh) 2018-01-09 2020-11-03 库尔生物制药有限公司 多聚体t细胞调节多肽及其使用方法
EP3755711A4 (en) * 2018-02-20 2021-11-24 Technion Research & Development Foundation Limited IMMUNOTHERAPEUTIC COMPOSITION FOR THE TREATMENT OF CANCER
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WO2023126544A1 (en) * 2022-01-03 2023-07-06 Aarhus Universitet Proteinaceous compound for generating specific cytotoxic t-cell effect

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Also Published As

Publication number Publication date
JP5148804B2 (ja) 2013-02-20
CA2451353A1 (en) 2002-12-27
WO2002102299A3 (en) 2003-11-27
DK1409547T3 (en) 2018-01-08
JP2005506058A (ja) 2005-03-03
HUP0400231A3 (en) 2010-11-29
US20030017134A1 (en) 2003-01-23
NZ530656A (en) 2007-05-31
CZ200479A3 (cs) 2004-11-10
PL373302A1 (en) 2005-08-22
NZ581793A (en) 2010-07-30
CA2451353C (en) 2012-01-17
EP1409547A4 (en) 2007-05-02
EP1409547A2 (en) 2004-04-21
EP1409547B1 (en) 2017-09-20
ES2652017T3 (es) 2018-01-31
WO2002102299A2 (en) 2002-12-27

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished