CN100542538C - 可控制结合型雌激素天然混合物的释放的基质-膜衣片剂 - Google Patents

可控制结合型雌激素天然混合物的释放的基质-膜衣片剂 Download PDF

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Publication number
CN100542538C
CN100542538C CNB028262034A CN02826203A CN100542538C CN 100542538 C CN100542538 C CN 100542538C CN B028262034 A CNB028262034 A CN B028262034A CN 02826203 A CN02826203 A CN 02826203A CN 100542538 C CN100542538 C CN 100542538C
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CN
China
Prior art keywords
substrate
medicinal
film coated
coated tablet
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB028262034A
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English (en)
Chinese (zh)
Other versions
CN1607943A (zh
Inventor
B·图姆贝克
K·布德
G·克里斯廷
M·威亚德斯
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Abbott Products GmbH
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Solvay Pharmaceuticals GmbH
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Publication date
Application filed by Solvay Pharmaceuticals GmbH filed Critical Solvay Pharmaceuticals GmbH
Publication of CN1607943A publication Critical patent/CN1607943A/zh
Application granted granted Critical
Publication of CN100542538C publication Critical patent/CN100542538C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
CNB028262034A 2001-12-14 2002-12-12 可控制结合型雌激素天然混合物的释放的基质-膜衣片剂 Expired - Fee Related CN100542538C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01129830.4 2001-12-14
EP01129830 2001-12-14

Publications (2)

Publication Number Publication Date
CN1607943A CN1607943A (zh) 2005-04-20
CN100542538C true CN100542538C (zh) 2009-09-23

Family

ID=8179548

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028262034A Expired - Fee Related CN100542538C (zh) 2001-12-14 2002-12-12 可控制结合型雌激素天然混合物的释放的基质-膜衣片剂

Country Status (18)

Country Link
US (1) US8268351B2 (enExample)
EP (1) EP1465602B1 (enExample)
JP (1) JP4695837B2 (enExample)
CN (1) CN100542538C (enExample)
AR (1) AR037760A1 (enExample)
AT (1) ATE438384T1 (enExample)
AU (1) AU2002361396B2 (enExample)
BR (1) BR0215044A (enExample)
CA (1) CA2470207C (enExample)
DE (1) DE50213751D1 (enExample)
DK (1) DK1465602T3 (enExample)
ES (1) ES2328910T3 (enExample)
MX (1) MXPA04005769A (enExample)
PL (1) PL205739B1 (enExample)
PT (1) PT1465602E (enExample)
SI (1) SI1465602T1 (enExample)
TW (1) TWI252111B (enExample)
WO (1) WO2003051336A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7303763B2 (en) * 2001-02-12 2007-12-04 Watson Laboratories, Inc. Compositions for conjugated estrogens and associated methods
US8323692B2 (en) 2002-02-21 2012-12-04 Valeant International Bermuda Controlled release dosage forms
AU2003211146B2 (en) * 2002-02-21 2007-07-19 Valeant International (Barbados) Srl Controlled release dosage forms
US6992075B2 (en) * 2003-04-04 2006-01-31 Barr Laboratories, Inc. C(14) estrogenic compounds
GB0329498D0 (en) * 2003-12-19 2004-01-28 Novartis Ag Organic compounds
JP4521554B2 (ja) * 2004-03-31 2010-08-11 マイラン製薬株式会社 シクロスポリン製剤
DE102004035938A1 (de) * 2004-07-23 2006-02-16 Röhm GmbH & Co. KG Verfahren zur Herstellung von überzogenen Arzneiformen mit stabilem Wirkstofffreigabeprofil
EP1679065A1 (en) 2005-01-07 2006-07-12 OctoPlus Sciences B.V. Controlled release compositions for interferon based on PEGT/PBT block copolymers
JP5162141B2 (ja) * 2007-02-20 2013-03-13 エスエス製薬株式会社 フィルムコーティング用組成物
JP4864024B2 (ja) * 2008-02-15 2012-01-25 エスエス製薬株式会社 時限放出製剤
US20090232897A1 (en) * 2008-03-14 2009-09-17 Bijayananda Sahoo Pharmaceutical compositions comprising conjugated estrogens

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1036328A (zh) * 1987-12-22 1989-10-18 阿克佐公司 治疗更年期疾病和骨质疏松症的药物剂量单位
CN1197387A (zh) * 1995-07-26 1998-10-28 杜拉梅德药品有限公司 共轭雌激素药物组合物及其应用方法
CN1228027A (zh) * 1996-08-30 1999-09-08 德国索尔瓦有限公司 由牝马尿液获取雌激素的方法
CN1234740A (zh) * 1996-08-30 1999-11-10 德国索尔瓦有限公司 由牝马尿获取雌激素的方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3753767A (en) * 1971-08-02 1973-08-21 Colgate Palmolive Co Method of sugar-coating tablets
DE3535536A1 (de) * 1985-10-04 1987-04-09 Lentia Gmbh Verfahren zum gleichzeitigen trocknen und granulieren von extraktstoffen aus enteiweisstem kaelberblut
US5208225A (en) * 1986-02-27 1993-05-04 Warner-Lambert Company Compositions containing fixed combinations
US5108995A (en) * 1987-09-24 1992-04-28 Jencap Research Ltd. Hormone preparation and method
HU9500322D0 (en) * 1994-02-08 1995-03-28 Solvay Deutschland Process for separating estrogenes from the urine of mares with foal
US5458887A (en) * 1994-03-02 1995-10-17 Andrx Pharmaceuticals, Inc. Controlled release tablet formulation
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
IE80467B1 (en) * 1995-07-03 1998-07-29 Elan Corp Plc Controlled release formulations for poorly soluble drugs
DE19540253C2 (de) * 1995-10-28 1998-06-04 Jenapharm Gmbh Mehrphasenpräparat zur Kontrazeption auf der Basis natürlicher Estrogene
AU722739B2 (en) 1996-08-30 2000-08-10 Abbott Products Gmbh Method to obtain oestrogens from mares' urine
AU722084B2 (en) 1996-08-30 2000-07-20 Abbott Products Gmbh Process to obtain oestrogens from mare's urine
ES2234139T3 (es) * 1997-08-11 2005-06-16 Alza Corporation Forma de dosificacion de un agente activo de liberacion prolongada adaptada para la retencion gastrica.
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
DE19845358A1 (de) * 1998-10-02 2000-04-06 Roehm Gmbh Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe
DE60042352D1 (de) * 1999-02-10 2009-07-23 Pfizer Prod Inc Osmotisches System zur Verabreichung von Wirkstoffen, die feste amorphe Dispersionen enthalten
US6706283B1 (en) * 1999-02-10 2004-03-16 Pfizer Inc Controlled release by extrusion of solid amorphous dispersions of drugs
US6632451B2 (en) * 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
WO2000076478A1 (en) * 1999-06-14 2000-12-21 Cosmo S.P.A. Controlled release and taste masking oral pharmaceutical compositions
US20010034340A1 (en) * 2000-03-20 2001-10-25 American Home Products Corporation Hormone replacement therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1036328A (zh) * 1987-12-22 1989-10-18 阿克佐公司 治疗更年期疾病和骨质疏松症的药物剂量单位
CN1197387A (zh) * 1995-07-26 1998-10-28 杜拉梅德药品有限公司 共轭雌激素药物组合物及其应用方法
CN1228027A (zh) * 1996-08-30 1999-09-08 德国索尔瓦有限公司 由牝马尿液获取雌激素的方法
CN1234740A (zh) * 1996-08-30 1999-11-10 德国索尔瓦有限公司 由牝马尿获取雌激素的方法

Also Published As

Publication number Publication date
AU2002361396B2 (en) 2008-02-14
DK1465602T3 (da) 2009-09-28
PL369367A1 (en) 2005-04-18
TWI252111B (en) 2006-04-01
CA2470207A1 (en) 2003-06-26
CN1607943A (zh) 2005-04-20
US8268351B2 (en) 2012-09-18
MXPA04005769A (es) 2004-09-10
ES2328910T3 (es) 2009-11-19
BR0215044A (pt) 2004-11-03
WO2003051336A1 (de) 2003-06-26
CA2470207C (en) 2012-07-10
DE50213751D1 (de) 2009-09-17
SI1465602T1 (sl) 2009-12-31
HK1075005A1 (zh) 2005-12-02
EP1465602A1 (de) 2004-10-13
US20050019408A1 (en) 2005-01-27
JP4695837B2 (ja) 2011-06-08
AU2002361396A1 (en) 2003-06-30
AR037760A1 (es) 2004-12-01
ATE438384T1 (de) 2009-08-15
PT1465602E (pt) 2009-09-07
JP2005513059A (ja) 2005-05-12
PL205739B1 (pl) 2010-05-31
TW200408414A (en) 2004-06-01
EP1465602B1 (de) 2009-08-05

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