CN100525748C - 药剂的新制剂及其制备和应用方法 - Google Patents

药剂的新制剂及其制备和应用方法 Download PDF

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Publication number
CN100525748C
CN100525748C CNB200310121217XA CN200310121217A CN100525748C CN 100525748 C CN100525748 C CN 100525748C CN B200310121217X A CNB200310121217X A CN B200310121217XA CN 200310121217 A CN200310121217 A CN 200310121217A CN 100525748 C CN100525748 C CN 100525748C
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paclitaxel
capxol
drug
dose
particles
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Expired - Lifetime
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CNB200310121217XA
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Chinese (zh)
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CN1515246A (zh
Inventor
内尔·P·代塞
帕奇克·苏-雄
什落莫·马格达西
大卫·C·沙哈地万
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Abraxis Bioscience LLC
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MedImmune LLC
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Priority claimed from US08/926,155 external-priority patent/US6096331A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNB200310121217XA 1997-06-27 1998-06-26 药剂的新制剂及其制备和应用方法 Expired - Lifetime CN100525748C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5102197P 1997-06-27 1997-06-27
US60/051,021 1997-06-27
US08/926,155 1997-09-09
US08/926,155 US6096331A (en) 1993-02-22 1997-09-09 Methods and compositions useful for administration of chemotherapeutic agents

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB98808225XA Division CN100462066C (zh) 1997-06-27 1998-06-26 药剂的新制剂及其制备和应用方法

Publications (2)

Publication Number Publication Date
CN1515246A CN1515246A (zh) 2004-07-28
CN100525748C true CN100525748C (zh) 2009-08-12

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CNB200310121217XA Expired - Lifetime CN100525748C (zh) 1997-06-27 1998-06-26 药剂的新制剂及其制备和应用方法
CNB98808225XA Expired - Lifetime CN100462066C (zh) 1997-06-27 1998-06-26 药剂的新制剂及其制备和应用方法

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US (2) US20080161382A1 (https=)
EP (1) EP1023050B1 (https=)
JP (2) JP4865937B2 (https=)
KR (3) KR100789008B1 (https=)
CN (2) CN100525748C (https=)
AU (1) AU8266298A (https=)
BR (1) BRPI9810945B8 (https=)
CA (1) CA2294981C (https=)
DK (1) DK1023050T3 (https=)
ES (1) ES2435944T3 (https=)
HU (1) HU230338B1 (https=)
IL (2) IL133672A0 (https=)
MX (1) MX337149B (https=)
NO (2) NO332166B1 (https=)
NZ (2) NZ525580A (https=)
PT (1) PT1023050E (https=)
SG (1) SG113402A1 (https=)
WO (1) WO1999000113A1 (https=)

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US20080160095A1 (en) 2008-07-03
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US20080161382A1 (en) 2008-07-03
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JP2011219482A (ja) 2011-11-04
SG113402A1 (en) 2005-08-29
KR20010014254A (ko) 2001-02-26
KR100789008B1 (ko) 2007-12-26
WO1999000113A1 (en) 1999-01-07
KR100923172B1 (ko) 2009-10-22
BRPI9810945B8 (pt) 2021-05-25
EP1023050A1 (en) 2000-08-02
JP4865937B2 (ja) 2012-02-01
EP1023050B1 (en) 2013-09-25
CA2294981A1 (en) 1999-01-07
CN1267214A (zh) 2000-09-20
JP5405527B2 (ja) 2014-02-05
JP2002507976A (ja) 2002-03-12
HUP0003972A2 (hu) 2001-08-28
EP1023050A4 (en) 2006-08-30
ES2435944T3 (es) 2013-12-26
CN1515246A (zh) 2004-07-28
NO996433L (no) 2000-02-14
KR20050042507A (ko) 2005-05-09
NO20120338A1 (no) 2000-02-14
CA2294981C (en) 2012-04-03
NZ525580A (en) 2004-08-27

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