CN100490845C - 一种草药组合物及其在化疗中的应用 - Google Patents

一种草药组合物及其在化疗中的应用 Download PDF

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CN100490845C
CN100490845C CNB018081975A CN01808197A CN100490845C CN 100490845 C CN100490845 C CN 100490845C CN B018081975 A CNB018081975 A CN B018081975A CN 01808197 A CN01808197 A CN 01808197A CN 100490845 C CN100490845 C CN 100490845C
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phy906
chemotherapeutic
cpt
cancer
herbal
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Chinese (zh)
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CN1612743A (zh
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郑永齐
刘淑惠
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Yale University
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Yale University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB018081975A 2000-03-09 2001-03-08 一种草药组合物及其在化疗中的应用 Expired - Lifetime CN100490845C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52205500A 2000-03-09 2000-03-09
US09/522,055 2000-03-09

Publications (2)

Publication Number Publication Date
CN1612743A CN1612743A (zh) 2005-05-04
CN100490845C true CN100490845C (zh) 2009-05-27

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CNB018081975A Expired - Lifetime CN100490845C (zh) 2000-03-09 2001-03-08 一种草药组合物及其在化疗中的应用

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US (1) US7025993B2 (enExample)
EP (1) EP1401458B1 (enExample)
JP (3) JP5064630B2 (enExample)
KR (1) KR100840213B1 (enExample)
CN (1) CN100490845C (enExample)
AT (1) ATE494899T1 (enExample)
AU (1) AU4550801A (enExample)
CA (1) CA2402466C (enExample)
DE (1) DE60143857D1 (enExample)
DK (1) DK1401458T3 (enExample)
ES (1) ES2358639T3 (enExample)
TW (1) TWI324069B (enExample)
WO (1) WO2001066123A2 (enExample)

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US8871279B2 (en) 2000-03-09 2014-10-28 Yale University Use of the combination of PHY906 and a tyrosine kinase inhibitor as a cancer treatment regimen
US7534455B2 (en) * 2000-03-09 2009-05-19 Yale University Herbal composition PHY906 and its use in chemotherapy
WO2008101079A1 (en) * 2007-02-15 2008-08-21 Yale University Herbal-composition phy906 and its use in chemotherapy
EP1487434B1 (en) * 2002-03-06 2007-05-09 The Medical Research and Education Trust Botanical extract compositions with anti-cancer activity comprising isoliquiritigenin
RU2209062C1 (ru) * 2002-03-19 2003-07-27 Институт физиологии им. И.П.Павлова РАН Вещество, обладающее седативным действием
WO2005077370A1 (ja) * 2004-02-13 2005-08-25 Kabushiki Kaisha Yakult Honsha カンプトテシン類含有水溶液製剤
EP2987495A1 (en) 2007-10-25 2016-02-24 Yale University Use of phy906 as treatment for inflammatory bowel disease and/or irritable bowel syndrome
US9778276B2 (en) * 2007-11-20 2017-10-03 Hewlett-Packard Development Company, L.P. Liquid handling device
KR100915457B1 (ko) * 2008-01-31 2009-09-04 세종대학교산학협력단 한국산 겨우살이 추출물이 함유된 미세캡슐을 유효성분으로포함하는 기능성 식품
TWI366466B (en) * 2008-05-08 2012-06-21 Ind Tech Res Inst Herbal extracts capable of inducing immune cells to produce interferon and activating toll-like receptors and the preparation thereof
US8574636B2 (en) * 2008-09-25 2013-11-05 Lifebiotic Medical Research Ltd Herbal formulations
KR101138461B1 (ko) * 2010-02-12 2012-04-26 한국생명공학연구원 감초 추출물을 포함하는 로타바이러스 감염의 예방 또는 치료용 조성물
US8597695B1 (en) 2010-11-13 2013-12-03 Sirbal Ltd. Herbal combinations for treatment of a skin condition
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US8541382B2 (en) 2010-11-13 2013-09-24 Sirbal Ltd. Cardiac glycoside analogs in combination with emodin for cancer therapy
US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US20170049835A1 (en) 2015-07-29 2017-02-23 Sirbal Ltd. Herbal Combinations For Treating Scalp Conditions
CN102716421A (zh) * 2012-06-21 2012-10-10 中国人民解放军第三军医大学第一附属医院 治疗扁平疣的中药口服液及其制备方法
CN102698068B (zh) * 2012-07-02 2013-07-24 张秀香 一种预防化疗所致口腔黏膜炎的口腔护理液制备方法
KR101350143B1 (ko) * 2013-05-30 2014-01-16 재단법인 통합의료진흥원 반하 및 황금 생약 추출물을 포함하는 항암제로 인한 부작용의 경감용 조성물
EP3498288A1 (en) 2013-12-02 2019-06-19 Sirbal Ltd. Herbal combinations for treatment of a skin condition
CN107921282A (zh) * 2015-08-21 2018-04-17 卫理公会医院研究所 选择性抑制肠羧酸酯酶2酶活性的组合物及方法
ES3019570T3 (en) * 2016-05-23 2025-05-20 Univ Yale Improved therapeutic index of anti-immune checkpoint inhibitors using combination therapy comprising a phy906 extract or a scutellaria baicalensis georgi (s) extract
US11517605B2 (en) * 2016-06-22 2022-12-06 Yale University Mechanism based quality control for botanical medicine
JP7132344B2 (ja) 2018-02-28 2022-09-06 チュンアン・ユニヴァーシティ・インダストリー・アカデミック・コーペレーション・ファウンデーション 悪液質および筋損失の予防、改善または治療用組成物
WO2019204471A1 (en) * 2018-04-20 2019-10-24 Yale University Treatment of hepatitis c
WO2020255133A1 (en) * 2019-06-18 2020-12-24 The Cures Ltd. Novel therapeutic preparations comprising scutellaria barbata
CN111011136B (zh) * 2019-11-13 2021-11-02 云南中烟新材料科技有限公司 一种假秦艽的人工种植方法
CN115135327A (zh) * 2019-12-09 2022-09-30 耶鲁大学 用于预防癌症复发的组合物和方法
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Protective effects of Kampo medicines and baicalin againstintestinal toxicity of a new anticancer camptothecinderivative,irinotecan hydrochloride(CPT-11),in rat. TAKASUNA KIYOSHI ET AL.JAPANESE JOURNAL OF CANCER RESEARCH,Vol. 86 No.10. 1995 *
黄芩汤及其组成药物药理作用的初步研究. 黄黎，叶文华，蔡波文，李德凤，刘菊福，刘美兰.中国中药杂志，第15卷第2期. 1999
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Publication number Publication date
DE60143857D1 (de) 2011-02-24
US20030211180A1 (en) 2003-11-13
ES2358639T3 (es) 2011-05-12
KR100840213B1 (ko) 2008-06-23
AU4550801A (en) 2001-09-17
WO2001066123A2 (en) 2001-09-13
JP2012167101A (ja) 2012-09-06
EP1401458A2 (en) 2004-03-31
CA2402466C (en) 2014-11-18
US7025993B2 (en) 2006-04-11
KR20020086627A (ko) 2002-11-18
JP5064630B2 (ja) 2012-10-31
WO2001066123A3 (en) 2004-01-08
EP1401458B1 (en) 2011-01-12
JP2014208684A (ja) 2014-11-06
DK1401458T3 (da) 2011-05-09
CN1612743A (zh) 2005-05-04
CA2402466A1 (en) 2001-09-13
TWI324069B (en) 2010-05-01
ATE494899T1 (de) 2011-01-15
JP2004500390A (ja) 2004-01-08

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