CN100490845C - 一种草药组合物及其在化疗中的应用 - Google Patents

一种草药组合物及其在化疗中的应用 Download PDF

Info

Publication number
CN100490845C
CN100490845C CNB018081975A CN01808197A CN100490845C CN 100490845 C CN100490845 C CN 100490845C CN B018081975 A CNB018081975 A CN B018081975A CN 01808197 A CN01808197 A CN 01808197A CN 100490845 C CN100490845 C CN 100490845C
Authority
CN
China
Prior art keywords
phy906
chemotherapeutic
cpt
cancer
herbal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB018081975A
Other languages
English (en)
Chinese (zh)
Other versions
CN1612743A (zh
Inventor
郑永齐
刘淑惠
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Original Assignee
Yale University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yale University filed Critical Yale University
Publication of CN1612743A publication Critical patent/CN1612743A/zh
Application granted granted Critical
Publication of CN100490845C publication Critical patent/CN100490845C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB018081975A 2000-03-09 2001-03-08 一种草药组合物及其在化疗中的应用 Expired - Lifetime CN100490845C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52205500A 2000-03-09 2000-03-09
US09/522,055 2000-03-09

Publications (2)

Publication Number Publication Date
CN1612743A CN1612743A (zh) 2005-05-04
CN100490845C true CN100490845C (zh) 2009-05-27

Family

ID=24079273

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018081975A Expired - Lifetime CN100490845C (zh) 2000-03-09 2001-03-08 一种草药组合物及其在化疗中的应用

Country Status (13)

Country Link
US (1) US7025993B2 (enExample)
EP (1) EP1401458B1 (enExample)
JP (3) JP5064630B2 (enExample)
KR (1) KR100840213B1 (enExample)
CN (1) CN100490845C (enExample)
AT (1) ATE494899T1 (enExample)
AU (1) AU4550801A (enExample)
CA (1) CA2402466C (enExample)
DE (1) DE60143857D1 (enExample)
DK (1) DK1401458T3 (enExample)
ES (1) ES2358639T3 (enExample)
TW (1) TWI324069B (enExample)
WO (1) WO2001066123A2 (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871279B2 (en) 2000-03-09 2014-10-28 Yale University Use of the combination of PHY906 and a tyrosine kinase inhibitor as a cancer treatment regimen
US7534455B2 (en) * 2000-03-09 2009-05-19 Yale University Herbal composition PHY906 and its use in chemotherapy
WO2003075943A2 (en) * 2002-03-06 2003-09-18 The Medical Research And Education Trust Botanical extract compositions with anti-cancer or phytoestrogenic activity comprising wogonin, isoliquiritigenin and/or coumestrol
RU2209062C1 (ru) * 2002-03-19 2003-07-27 Институт физиологии им. И.П.Павлова РАН Вещество, обладающее седативным действием
CA2556254A1 (en) * 2004-02-13 2005-08-25 Kabushiki Kaisha Yakult Honsha Aqueous solution preparation containing camptothecins
CN101730535A (zh) 2007-02-15 2010-06-09 耶鲁大学 草药组合物phy906及其在化疗中的用途
JP2011500853A (ja) 2007-10-25 2011-01-06 ファィトシューティカ， インコーポレイテッド 炎症性腸疾患および／または過敏性腸管症候群に対する処置としてのｐｈｙ９０６の使用
US9778276B2 (en) * 2007-11-20 2017-10-03 Hewlett-Packard Development Company, L.P. Liquid handling device
KR100915457B1 (ko) * 2008-01-31 2009-09-04 세종대학교산학협력단 한국산 겨우살이 추출물이 함유된 미세캡슐을 유효성분으로포함하는 기능성 식품
TWI366466B (en) * 2008-05-08 2012-06-21 Ind Tech Res Inst Herbal extracts capable of inducing immune cells to produce interferon and activating toll-like receptors and the preparation thereof
PT2341918T (pt) 2008-09-25 2018-06-01 Life Biotech Medical Res Ltd Formulações fitoterapêuticas
KR101138461B1 (ko) * 2010-02-12 2012-04-26 한국생명공학연구원 감초 추출물을 포함하는 로타바이러스 감염의 예방 또는 치료용 조성물
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US8541382B2 (en) 2010-11-13 2013-09-24 Sirbal Ltd. Cardiac glycoside analogs in combination with emodin for cancer therapy
US8734859B1 (en) 2010-11-13 2014-05-27 Sirbal Ltd. Molecular combinations for cancer or other disease treatment
US20170049687A1 (en) 2015-07-29 2017-02-23 Sirbal Ltd. Herbal Combinations For Treating Scalp Conditions
CN102716421A (zh) * 2012-06-21 2012-10-10 中国人民解放军第三军医大学第一附属医院 治疗扁平疣的中药口服液及其制备方法
CN102698068B (zh) * 2012-07-02 2013-07-24 张秀香 一种预防化疗所致口腔黏膜炎的口腔护理液制备方法
KR101350143B1 (ko) * 2013-05-30 2014-01-16 재단법인 통합의료진흥원 반하 및 황금 생약 추출물을 포함하는 항암제로 인한 부작용의 경감용 조성물
EP3498288A1 (en) 2013-12-02 2019-06-19 Sirbal Ltd. Herbal combinations for treatment of a skin condition
CA2995575A1 (en) 2015-08-21 2017-03-02 The Methodist Hospital Compositions and methods for selectively inhibiting intestinal carboxylesterase 2 enzyme activity
KR20190018632A (ko) * 2016-05-23 2019-02-25 예일 유니버시티 Phy906 추출물, 황금(s) 추출물 또는 이러한 추출물로부터의 화합물을 포함하는 병용 요법을 이용한 항-면역 체크포인트 억제제의 개선된 치료 지수
CN109475540A (zh) 2016-06-22 2019-03-15 耶鲁大学 用于植物药的基于机理的质量控制
CN116370527B (zh) 2018-02-28 2025-07-04 乌姆特有限公司 用于预防、减轻或治疗恶病质和肌肉损失的组合物
WO2019204471A1 (en) * 2018-04-20 2019-10-24 Yale University Treatment of hepatitis c
WO2020255133A1 (en) * 2019-06-18 2020-12-24 The Cures Ltd. Novel therapeutic preparations comprising scutellaria barbata
CN111011136B (zh) * 2019-11-13 2021-11-02 云南中烟新材料科技有限公司 一种假秦艽的人工种植方法
US20220339233A1 (en) * 2019-12-09 2022-10-27 Yale University Compositions and methods for preventing recurrence of cancer
WO2021202320A1 (en) * 2020-03-30 2021-10-07 Yale University Methods for treating inflammatory and fibrotic diseases and disorders
CN114642732A (zh) * 2020-12-21 2022-06-21 苏州普瑞森生物科技有限公司 一种组合物及其在制备治疗肿瘤的药物中的应用
CN116712507B (zh) * 2023-08-10 2023-10-20 中国人民解放军总医院第六医学中心 一种辅助乳腺癌化疗的中药组合物及其制备方法、应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5936619A (ja) * 1982-08-23 1984-02-28 Tsumura Juntendo Inc 制癌補助剤
JPS5936621A (ja) * 1982-08-25 1984-02-28 Tsumura Juntendo Inc 脂肪分解促進作用阻害剤
DE69030321T2 (de) * 1989-11-03 1998-01-15 Alexander S Sun Phytotherapie von krebs
US5665393A (en) * 1996-09-03 1997-09-09 International Medical Research, Inc. Herbal composition for treating prostate carcinoma
US6048847A (en) * 1997-09-30 2000-04-11 Dabur Research Foundation Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Protective effects of Kampo medicines and baicalin againstintestinal toxicity of a new anticancer camptothecinderivative,irinotecan hydrochloride(CPT-11),in rat. TAKASUNA KIYOSHI ET AL.JAPANESE JOURNAL OF CANCER RESEARCH,Vol.vol .86 No.no 10. 1995
Protective effects of Kampo medicines and baicalin againstintestinal toxicity of a new anticancer camptothecinderivative,irinotecan hydrochloride(CPT-11),in rat. TAKASUNA KIYOSHI ET AL.JAPANESE JOURNAL OF CANCER RESEARCH,Vol. 86 No.10. 1995 *
黄芩汤及其组成药物药理作用的初步研究. 黄黎，叶文华，蔡波文，李德凤，刘菊福，刘美兰.中国中药杂志，第15卷第2期. 1999
黄芩汤的临床应用及其机理. 杨燕飞.山西中医，第14卷第3期. 1998
黄芩汤的临床应用及其机理. 杨燕飞.山西中医，第14卷第3期. 1998 *

Also Published As

Publication number Publication date
KR20020086627A (ko) 2002-11-18
TWI324069B (en) 2010-05-01
JP2014208684A (ja) 2014-11-06
CA2402466A1 (en) 2001-09-13
JP5064630B2 (ja) 2012-10-31
JP2004500390A (ja) 2004-01-08
ES2358639T3 (es) 2011-05-12
KR100840213B1 (ko) 2008-06-23
WO2001066123A3 (en) 2004-01-08
US7025993B2 (en) 2006-04-11
CN1612743A (zh) 2005-05-04
EP1401458B1 (en) 2011-01-12
JP2012167101A (ja) 2012-09-06
DK1401458T3 (da) 2011-05-09
ATE494899T1 (de) 2011-01-15
EP1401458A2 (en) 2004-03-31
AU4550801A (en) 2001-09-17
CA2402466C (en) 2014-11-18
DE60143857D1 (de) 2011-02-24
US20030211180A1 (en) 2003-11-13
WO2001066123A2 (en) 2001-09-13

Similar Documents

Publication Publication Date Title
CN100490845C (zh) 一种草药组合物及其在化疗中的应用
JP5057987B2 (ja) 薬草組成物ｐｈｙ９０６及びその化学療法における使用
MXPA03003446A (es) Nueva composicion herbacea medicinal para tratar enfermedades del higado y vih.
US20130101688A1 (en) Herbal composition phy906 and its use in chemotherapy
CN100490789C (zh) 一种治疗癌症的中药肠溶胶囊剂的用途
CN101062374B (zh) 一种治疗癌症的中药组合物胶囊的制备方法及其产品
WO2007059685A1 (fr) Calycosine d'astragalus a fonction de resistance contre le coxackievirus
AU2001245508B2 (en) Compositions consisting of PHY906 and chemotherapeutic agents
CN111298061A (zh) 一种清热解毒、祛瘀散结的中药组合物及其制备方法
CN100443093C (zh) 治疗艾滋病的药物
CN100496591C (zh) 治疗胆石症的药物制剂及其制备方法
HK1111910A (en) Herbal composition phy906 and its use in chemotherapy
CN108096528A (zh) 一种用于增强食管癌对化疗药物敏感性的中药组合物及其应用
CN116115714A (zh) 一种抗肿瘤中药组合物及其制备方法和应用
CN120285067A (zh) 一种治疗实体瘤的中药组合物及其制备方法
CN107126527A (zh) 一种治疗肝癌的中药组合物及其制剂
CN119074858A (zh) 一种治疗白血病的组合物及其制备方法、应用
CN107412635A (zh) 一种治疗肺癌的中药组合物及其制剂
CN107412634A (zh) 一种治疗胃癌的中药组合物及其制剂
HK1077737A (en) Herbal composition phy906 and its use in chemotheraphy
CN105853612A (zh) 一种用于甲状腺癌术后碘131放疗的药物组合物
CN104258204A (zh) 一种中药组合物及其在制备治疗肾病综合征药物中的应用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1077737

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1077737

Country of ref document: HK

CX01 Expiry of patent term

Granted publication date: 20090527

CX01 Expiry of patent term