CN100482664C - 1,5-二取代-3,4-二氢-1H-嘧啶并[4,5-d]嘧啶二酮化合物和其在治疗CSBP/P38激酶介导的疾病中的用途 - Google Patents

1,5-二取代-3,4-二氢-1H-嘧啶并[4,5-d]嘧啶二酮化合物和其在治疗CSBP/P38激酶介导的疾病中的用途 Download PDF

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CN100482664C
CN100482664C CNB018076866A CN01807686A CN100482664C CN 100482664 C CN100482664 C CN 100482664C CN B018076866 A CNB018076866 A CN B018076866A CN 01807686 A CN01807686 A CN 01807686A CN 100482664 C CN100482664 C CN 100482664C
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alkyl
dihydro
dingbing
fluoro
aminomethyl phenyl
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CN1422273A (zh
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杰里·L·亚当斯
杰弗里·C·贝姆
拉尔夫·F·霍尔
约翰·J·塔格特
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SmithKline Beecham Corp
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CNB018076866A 2000-03-02 2001-03-02 1,5-二取代-3,4-二氢-1H-嘧啶并[4,5-d]嘧啶二酮化合物和其在治疗CSBP/P38激酶介导的疾病中的用途 Expired - Fee Related CN100482664C (zh)

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US18641900P 2000-03-02 2000-03-02
US60/186,419 2000-03-02

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CN1422273A CN1422273A (zh) 2003-06-04
CN100482664C true CN100482664C (zh) 2009-04-29

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CA2402092C (en) 2012-01-24
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EP1265900B1 (en) 2007-05-16
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