CN100475812C - 作为细胞周期蛋白依赖性激酶抑制剂的吡唑并吡啶 - Google Patents

作为细胞周期蛋白依赖性激酶抑制剂的吡唑并吡啶 Download PDF

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Publication number
CN100475812C
CN100475812C CNB038220113A CN03822011A CN100475812C CN 100475812 C CN100475812 C CN 100475812C CN B038220113 A CNB038220113 A CN B038220113A CN 03822011 A CN03822011 A CN 03822011A CN 100475812 C CN100475812 C CN 100475812C
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CN
China
Prior art keywords
alkyl
aryl
heteroaryl
compound
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB038220113A
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English (en)
Chinese (zh)
Other versions
CN1681816A (zh
Inventor
M·P·德怀尔
T·J·古兹
K·帕鲁奇
R·J·多尔
K·M·基尔蒂卡
V·M·吉里亚瓦拉布汉
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Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Publication of CN1681816A publication Critical patent/CN1681816A/zh
Application granted granted Critical
Publication of CN100475812C publication Critical patent/CN100475812C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB038220113A 2002-09-19 2003-09-17 作为细胞周期蛋白依赖性激酶抑制剂的吡唑并吡啶 Expired - Fee Related CN100475812C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41213802P 2002-09-19 2002-09-19
US60/412,138 2002-09-19

Publications (2)

Publication Number Publication Date
CN1681816A CN1681816A (zh) 2005-10-12
CN100475812C true CN100475812C (zh) 2009-04-08

Family

ID=32030811

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038220113A Expired - Fee Related CN100475812C (zh) 2002-09-19 2003-09-17 作为细胞周期蛋白依赖性激酶抑制剂的吡唑并吡啶

Country Status (18)

Country Link
US (1) US7151104B2 (cg-RX-API-DMAC7.html)
EP (1) EP1539750B1 (cg-RX-API-DMAC7.html)
JP (1) JP4845380B2 (cg-RX-API-DMAC7.html)
KR (1) KR20050072090A (cg-RX-API-DMAC7.html)
CN (1) CN100475812C (cg-RX-API-DMAC7.html)
AR (1) AR041292A1 (cg-RX-API-DMAC7.html)
AT (1) ATE382048T1 (cg-RX-API-DMAC7.html)
AU (1) AU2003270846B2 (cg-RX-API-DMAC7.html)
CA (1) CA2499593C (cg-RX-API-DMAC7.html)
DE (1) DE60318321T2 (cg-RX-API-DMAC7.html)
ES (1) ES2297203T3 (cg-RX-API-DMAC7.html)
IL (1) IL167432A (cg-RX-API-DMAC7.html)
MX (1) MXPA05003059A (cg-RX-API-DMAC7.html)
MY (1) MY136840A (cg-RX-API-DMAC7.html)
NZ (1) NZ538595A (cg-RX-API-DMAC7.html)
TW (1) TWI283243B (cg-RX-API-DMAC7.html)
WO (1) WO2004026872A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200502271B (cg-RX-API-DMAC7.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242469B1 (en) 1996-12-03 2001-06-05 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
KR101173510B1 (ko) 2002-08-23 2012-08-21 슬로안-케테링인스티튜트퍼캔서리서치 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도
JP5117189B2 (ja) * 2004-08-27 2013-01-09 サイクラセル リミテッド プリン及びピリミジンｃｄｋ阻害剤、並びに自己免疫疾患の治療のためのそれらの使用
EP1859797A4 (en) * 2005-02-28 2011-04-13 Eisai R&D Man Co Ltd NEW SIMULTANEOUS USE OF A SULPHONAMIDE COMPOUND AND A MEDIUM AGAINST CANCER
DE602006021401D1 (de) * 2005-02-28 2011-06-01 Eisai R&D Man Co Ltd Neue kombinierte anwendung einer sulfonamid-verbindung zur behandlung von krebs
US7304074B2 (en) 2005-04-05 2007-12-04 Hoffmann-La Roche Inc. Substituted 1,5-naphthyridine azolinones
US7417053B2 (en) 2005-04-07 2008-08-26 Teijin Pharma Limited Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof
AU2006234618A1 (en) * 2005-04-07 2006-10-19 Teijin Pharma Limited Pyrazolo(1,5-a)pyridine derivative or medically acceptable salt thereof
US7700773B2 (en) 2005-09-09 2010-04-20 Schering Corporation 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2H-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors
EA018036B1 (ru) * 2006-11-27 2013-05-30 Х. Лундбекк А/С Гетероариламидные производные
KR20090031122A (ko) * 2007-09-21 2009-03-25 주식회사 중외제약 인다졸 골격을 함유하는 화합물, 이의 제조방법 및 상기화합물을 함유하는 약제학적 조성물
FR2940284B1 (fr) * 2008-12-19 2011-02-18 Sanofi Aventis Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique
UY34305A (es) 2011-09-01 2013-04-30 Novartis Ag Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
US10550121B2 (en) * 2015-03-27 2020-02-04 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
WO2017087409A1 (en) 2015-11-18 2017-05-26 Genzyme Corporation Biomarker of polycystic kidney disease and uses thereof
MX390117B (es) * 2016-09-07 2025-03-20 Haihe Biopharma Co Ltd Compuesto de anillo aromatico de pirido de cinco elementos, metodo de preparacion y uso del mismo.

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202896C (zh) * 2002-02-07 2005-05-25 北京燕化高新技术股份有限公司 空气分离时纯化空气的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7091346B1 (en) * 1995-11-01 2006-08-15 Novartis Ag Purine derivatives and processes for their preparation
JP2002508324A (ja) 1997-12-13 2002-03-19 ブリストル−マイヤーズ スクイブ カンパニー サイクリン依存性キナーゼ阻害剤としてのピラゾロ［３，４−ｂ］ピリジンの使用
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
FR2801308B1 (fr) * 1999-11-19 2003-05-09 Oreal COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES
WO2001056607A1 (en) * 2000-02-03 2001-08-09 Eisai Co., Ltd. Integrin expression inhibitors
WO2002050079A1 (fr) 2000-12-20 2002-06-27 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Inhibiteurs de kinases dependantes des cylines (cdk) et de la glycogene synthase kinase-3 (gsk-3)
WO2002069968A1 (en) * 2001-03-08 2002-09-12 Astrazeneca Ab New use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202896C (zh) * 2002-02-07 2005-05-25 北京燕化高新技术股份有限公司 空气分离时纯化空气的方法

Also Published As

Publication number Publication date
AU2003270846B2 (en) 2006-11-23
MY136840A (en) 2008-11-28
WO2004026872A1 (en) 2004-04-01
CA2499593C (en) 2011-08-16
EP1539750A1 (en) 2005-06-15
JP2006503060A (ja) 2006-01-26
TW200409775A (en) 2004-06-16
ES2297203T3 (es) 2008-05-01
MXPA05003059A (es) 2005-05-27
AR041292A1 (es) 2005-05-11
CA2499593A1 (en) 2004-04-01
NZ538595A (en) 2006-04-28
ZA200502271B (en) 2005-09-19
DE60318321T2 (de) 2008-12-11
IL167432A (en) 2010-05-17
ATE382048T1 (de) 2008-01-15
JP4845380B2 (ja) 2011-12-28
AU2003270846A1 (en) 2004-04-08
KR20050072090A (ko) 2005-07-08
HK1071758A1 (en) 2005-07-29
TWI283243B (en) 2007-07-01
US7151104B2 (en) 2006-12-19
EP1539750B1 (en) 2007-12-26
US20040097516A1 (en) 2004-05-20
CN1681816A (zh) 2005-10-12
DE60318321D1 (en) 2008-02-07

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Granted publication date: 20090408

Termination date: 20120917