TWI283243B - Novel pyrazolopyridines as cyclin dependent kinase inhibitors - Google Patents

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Publication number

TWI283243B

TWI283243B TW092125613A TW92125613A TWI283243B TW I283243 B TWI283243 B TW I283243B TW 092125613 A TW092125613 A TW 092125613A TW 92125613 A TW92125613 A TW 92125613A TW I283243 B TWI283243 B TW I283243B

Authority

TW

Taiwan

Prior art keywords

group

alkyl

compound

aryl

cancer

Prior art date

2002-09-19

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• 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title description 13
• 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title description 8
• 150000005229 pyrazolopyridines Chemical class 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 137
• 238000000034 method Methods 0.000 claims abstract description 36
• 238000011282 treatment Methods 0.000 claims abstract description 19
• 201000010099 disease Diseases 0.000 claims abstract description 18
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 18
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 17
• 108091007914 CDKs Proteins 0.000 claims abstract description 14
• 102000003903 Cyclin-dependent kinases Human genes 0.000 claims abstract description 12
• 108090000266 Cyclin-dependent kinases Proteins 0.000 claims abstract description 12
• 125000000217 alkyl group Chemical group 0.000 claims description 114
• 125000003118 aryl group Chemical group 0.000 claims description 77
• 125000001072 heteroaryl group Chemical group 0.000 claims description 56
• -1 pyrazinylmethyl Chemical group 0.000 claims description 55
• 150000003839 salts Chemical class 0.000 claims description 37
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 32
• 125000000623 heterocyclic group Chemical group 0.000 claims description 28
• 229910052736 halogen Inorganic materials 0.000 claims description 22
• 150000002367 halogens Chemical class 0.000 claims description 22
• 206010028980 Neoplasm Diseases 0.000 claims description 21
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 20
• OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 20
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• 101100439662 Arabidopsis thaliana CHR5 gene Proteins 0.000 claims description 15
• 150000001412 amines Chemical class 0.000 claims description 15
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• 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 claims description 14
• 229910052799 carbon Inorganic materials 0.000 claims description 14
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 13
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 12
• 125000004076 pyridyl group Chemical group 0.000 claims description 12
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 10
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