KR20050072090A - 사이클린 의존성 키나제 억제제로서의 피라졸로피리딘 - Google Patents
사이클린 의존성 키나제 억제제로서의 피라졸로피리딘 Download PDFInfo
- Publication number
- KR20050072090A KR20050072090A KR1020057004435A KR20057004435A KR20050072090A KR 20050072090 A KR20050072090 A KR 20050072090A KR 1020057004435 A KR1020057004435 A KR 1020057004435A KR 20057004435 A KR20057004435 A KR 20057004435A KR 20050072090 A KR20050072090 A KR 20050072090A
- Authority
- KR
- South Korea
- Prior art keywords
- alkyl
- aryl
- group
- heteroaryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 208000005069 pulmonary fibrosis Diseases 0.000 description 1
- 150000005230 pyrazolo[3,4-b]pyridines Chemical class 0.000 description 1
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- 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
- 125000006085 pyrrolopyridyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
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- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
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- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- BTIHMVBBUGXLCJ-OAHLLOKOSA-N seliciclib Chemical compound C=12N=CN(C(C)C)C2=NC(N[C@@H](CO)CC)=NC=1NCC1=CC=CC=C1 BTIHMVBBUGXLCJ-OAHLLOKOSA-N 0.000 description 1
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- 238000007086 side reaction Methods 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
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- 239000007909 solid dosage form Substances 0.000 description 1
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- 208000002320 spinal muscular atrophy Diseases 0.000 description 1
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- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
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- 102000013498 tau Proteins Human genes 0.000 description 1
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- 238000012360 testing method Methods 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000003507 tetrahydrothiofenyl group Chemical group 0.000 description 1
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- 125000001544 thienyl group Chemical group 0.000 description 1
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- 230000016596 traversing start control point of mitotic cell cycle Effects 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41213802P | 2002-09-19 | 2002-09-19 | |
| US60/412,138 | 2002-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050072090A true KR20050072090A (ko) | 2005-07-08 |
Family
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| AR (1) | AR041292A1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE382048T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003270846B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2499593C (cg-RX-API-DMAC7.html) |
| DE (1) | DE60318321T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2297203T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL167432A (cg-RX-API-DMAC7.html) |
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| MY (1) | MY136840A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ538595A (cg-RX-API-DMAC7.html) |
| TW (1) | TWI283243B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004026872A1 (cg-RX-API-DMAC7.html) |
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Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242469B1 (en) | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| KR101173510B1 (ko) | 2002-08-23 | 2012-08-21 | 슬로안-케테링인스티튜트퍼캔서리서치 | 에포틸론, 이의 중간물질과 유사체의 합성 및 이들의 용도 |
| JP5117189B2 (ja) * | 2004-08-27 | 2013-01-09 | サイクラセル リミテッド | プリン及びピリミジンｃｄｋ阻害剤、並びに自己免疫疾患の治療のためのそれらの使用 |
| EP1859797A4 (en) * | 2005-02-28 | 2011-04-13 | Eisai R&D Man Co Ltd | NEW SIMULTANEOUS USE OF A SULPHONAMIDE COMPOUND AND A MEDIUM AGAINST CANCER |
| DE602006021401D1 (de) * | 2005-02-28 | 2011-06-01 | Eisai R&D Man Co Ltd | Neue kombinierte anwendung einer sulfonamid-verbindung zur behandlung von krebs |
| US7304074B2 (en) | 2005-04-05 | 2007-12-04 | Hoffmann-La Roche Inc. | Substituted 1,5-naphthyridine azolinones |
| US7417053B2 (en) | 2005-04-07 | 2008-08-26 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof |
| AU2006234618A1 (en) * | 2005-04-07 | 2006-10-19 | Teijin Pharma Limited | Pyrazolo(1,5-a)pyridine derivative or medically acceptable salt thereof |
| US7700773B2 (en) | 2005-09-09 | 2010-04-20 | Schering Corporation | 4-cyano, 4-amino, and 4-aminomethyl derivatives of pyrazolo[1,5-a]pyridines, pyrazolo[1,5-c]pyrimidines and 2H-indazole compounds and 5-cyano, 5-amino, and 5-aminomethyl derivatives of imidazo[1,2-a]pyridines, and imidazo[1,5-a]pyrazines as cyclin dependent kinase inhibitors |
| EA018036B1 (ru) * | 2006-11-27 | 2013-05-30 | Х. Лундбекк А/С | Гетероариламидные производные |
| KR20090031122A (ko) * | 2007-09-21 | 2009-03-25 | 주식회사 중외제약 | 인다졸 골격을 함유하는 화합물, 이의 제조방법 및 상기화합물을 함유하는 약제학적 조성물 |
| FR2940284B1 (fr) * | 2008-12-19 | 2011-02-18 | Sanofi Aventis | Derives de 6-cycloamino-2,3-di-pyridinyl-imidazo°1,2-b!- pyridazine,leur preparation et leur application en therapeutique |
| UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
| US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
| US10550121B2 (en) * | 2015-03-27 | 2020-02-04 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| WO2017087409A1 (en) | 2015-11-18 | 2017-05-26 | Genzyme Corporation | Biomarker of polycystic kidney disease and uses thereof |
| MX390117B (es) * | 2016-09-07 | 2025-03-20 | Haihe Biopharma Co Ltd | Compuesto de anillo aromatico de pirido de cinco elementos, metodo de preparacion y uso del mismo. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091346B1 (en) * | 1995-11-01 | 2006-08-15 | Novartis Ag | Purine derivatives and processes for their preparation |
| JP2002508324A (ja) | 1997-12-13 | 2002-03-19 | ブリストル−マイヤーズ スクイブ カンパニー | サイクリン依存性キナーゼ阻害剤としてのピラゾロ［３，４−ｂ］ピリジンの使用 |
| SE9802794D0 (sv) * | 1998-08-21 | 1998-08-21 | Astra Ab | New compounds |
| FR2801308B1 (fr) * | 1999-11-19 | 2003-05-09 | Oreal | COMPOSITIONS DE TEINTURE DE FIBRES KERATINIQUES CONTENANT DE DES 3-AMINO PYRAZOLO-[1,(-a]-PYRIDINES, PROCEDE DE TEINTURE, NOUVELLES 3-AMINO PYRAZOLO-[1,5-a]-PYRIDINES |
| WO2001056607A1 (en) * | 2000-02-03 | 2001-08-09 | Eisai Co., Ltd. | Integrin expression inhibitors |
| WO2002050079A1 (fr) | 2000-12-20 | 2002-06-27 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Inhibiteurs de kinases dependantes des cylines (cdk) et de la glycogene synthase kinase-3 (gsk-3) |
| WO2002069968A1 (en) * | 2001-03-08 | 2002-09-12 | Astrazeneca Ab | New use |
| CN1202896C (zh) * | 2002-02-07 | 2005-05-25 | 北京燕化高新技术股份有限公司 | 空气分离时纯化空气的方法 |
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2003
- 2003-09-17 US US10/664,337 patent/US7151104B2/en not_active Expired - Lifetime
- 2003-09-17 TW TW092125613A patent/TWI283243B/zh not_active IP Right Cessation
- 2003-09-17 CN CNB038220113A patent/CN100475812C/zh not_active Expired - Fee Related
- 2003-09-17 AT AT03752559T patent/ATE382048T1/de not_active IP Right Cessation
- 2003-09-17 AR ARP030103374A patent/AR041292A1/es active IP Right Grant
- 2003-09-17 MY MYPI20033535A patent/MY136840A/en unknown
- 2003-09-17 ES ES03752559T patent/ES2297203T3/es not_active Expired - Lifetime
- 2003-09-17 MX MXPA05003059A patent/MXPA05003059A/es active IP Right Grant
- 2003-09-17 DE DE60318321T patent/DE60318321T2/de not_active Expired - Lifetime
- 2003-09-17 KR KR1020057004435A patent/KR20050072090A/ko not_active Abandoned
- 2003-09-17 JP JP2004538405A patent/JP4845380B2/ja not_active Expired - Fee Related
- 2003-09-17 WO PCT/US2003/029841 patent/WO2004026872A1/en not_active Ceased
- 2003-09-17 EP EP03752559A patent/EP1539750B1/en not_active Expired - Lifetime
- 2003-09-17 CA CA2499593A patent/CA2499593C/en not_active Expired - Fee Related
- 2003-09-17 AU AU2003270846A patent/AU2003270846B2/en not_active Ceased
- 2003-09-17 NZ NZ538595A patent/NZ538595A/en not_active IP Right Cessation
-
2005
- 2005-03-15 IL IL167432A patent/IL167432A/en not_active IP Right Cessation
- 2005-03-17 ZA ZA200502271A patent/ZA200502271B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003270846B2 (en) | 2006-11-23 |
| MY136840A (en) | 2008-11-28 |
| WO2004026872A1 (en) | 2004-04-01 |
| CA2499593C (en) | 2011-08-16 |
| EP1539750A1 (en) | 2005-06-15 |
| JP2006503060A (ja) | 2006-01-26 |
| TW200409775A (en) | 2004-06-16 |
| ES2297203T3 (es) | 2008-05-01 |
| MXPA05003059A (es) | 2005-05-27 |
| AR041292A1 (es) | 2005-05-11 |
| CA2499593A1 (en) | 2004-04-01 |
| NZ538595A (en) | 2006-04-28 |
| ZA200502271B (en) | 2005-09-19 |
| DE60318321T2 (de) | 2008-12-11 |
| IL167432A (en) | 2010-05-17 |
| ATE382048T1 (de) | 2008-01-15 |
| JP4845380B2 (ja) | 2011-12-28 |
| AU2003270846A1 (en) | 2004-04-08 |
| HK1071758A1 (en) | 2005-07-29 |
| TWI283243B (en) | 2007-07-01 |
| US7151104B2 (en) | 2006-12-19 |
| CN100475812C (zh) | 2009-04-08 |
| EP1539750B1 (en) | 2007-12-26 |
| US20040097516A1 (en) | 2004-05-20 |
| CN1681816A (zh) | 2005-10-12 |
| DE60318321D1 (en) | 2008-02-07 |
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