CN100459969C - 阳离子决明衍生物及其应用 - Google Patents
阳离子决明衍生物及其应用 Download PDFInfo
- Publication number
- CN100459969C CN100459969C CNB2004800170929A CN200480017092A CN100459969C CN 100459969 C CN100459969 C CN 100459969C CN B2004800170929 A CNB2004800170929 A CN B2004800170929A CN 200480017092 A CN200480017092 A CN 200480017092A CN 100459969 C CN100459969 C CN 100459969C
- Authority
- CN
- China
- Prior art keywords
- agent
- personal care
- care composition
- polygalactomannan
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 244000037364 Cinnamomum aromaticum Species 0.000 title description 50
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 title description 50
- 125000002091 cationic group Chemical group 0.000 title description 48
- 239000000203 mixture Substances 0.000 claims abstract description 76
- 239000003795 chemical substances by application Substances 0.000 claims description 41
- -1 halogen ion Chemical class 0.000 claims description 24
- 210000004209 hair Anatomy 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 150000001768 cations Chemical class 0.000 claims description 17
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims description 16
- 239000003153 chemical reaction reagent Substances 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 14
- 239000004094 surface-active agent Substances 0.000 claims description 10
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 9
- 150000001450 anions Chemical class 0.000 claims description 9
- 208000001840 Dandruff Diseases 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 230000000475 sunscreen effect Effects 0.000 claims description 8
- 239000000516 sunscreening agent Substances 0.000 claims description 8
- 239000003431 cross linking reagent Substances 0.000 claims description 7
- 235000013599 spices Nutrition 0.000 claims description 7
- GZCGUPFRVQAUEE-KCDKBNATSA-N aldehydo-D-galactose Chemical group OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-KCDKBNATSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 239000000645 desinfectant Substances 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 230000000843 anti-fungal effect Effects 0.000 claims description 5
- 229940121375 antifungal agent Drugs 0.000 claims description 5
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 239000000049 pigment Substances 0.000 claims description 5
- 230000003252 repetitive effect Effects 0.000 claims description 5
- 239000000375 suspending agent Substances 0.000 claims description 5
- 125000001118 alkylidene group Chemical group 0.000 claims description 4
- 239000000058 anti acne agent Substances 0.000 claims description 4
- 230000001166 anti-perspirative effect Effects 0.000 claims description 4
- 229940124340 antiacne agent Drugs 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 230000003078 antioxidant effect Effects 0.000 claims description 4
- 239000003213 antiperspirant Substances 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims description 4
- 239000000118 hair dye Substances 0.000 claims description 4
- 239000002917 insecticide Substances 0.000 claims description 4
- 208000035484 Cellulite Diseases 0.000 claims description 3
- 229940124091 Keratolytic Drugs 0.000 claims description 3
- 206010049752 Peau d'orange Diseases 0.000 claims description 3
- 239000002250 absorbent Substances 0.000 claims description 3
- 230000002745 absorbent Effects 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 125000005843 halogen group Chemical group 0.000 claims description 3
- 230000001530 keratinolytic effect Effects 0.000 claims description 3
- 230000003641 microbiacidal effect Effects 0.000 claims description 3
- 229940124561 microbicide Drugs 0.000 claims description 3
- 239000002855 microbicide agent Substances 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 3
- 241000238631 Hexapoda Species 0.000 claims description 2
- 230000002882 anti-plaque Effects 0.000 claims description 2
- 230000023555 blood coagulation Effects 0.000 claims description 2
- 239000003638 chemical reducing agent Substances 0.000 claims description 2
- 239000003086 colorant Substances 0.000 claims description 2
- 239000007854 depigmenting agent Substances 0.000 claims description 2
- 239000003974 emollient agent Substances 0.000 claims description 2
- 239000008266 hair spray Substances 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 239000003589 local anesthetic agent Substances 0.000 claims description 2
- 239000003605 opacifier Substances 0.000 claims description 2
- 239000007800 oxidant agent Substances 0.000 claims description 2
- 230000001590 oxidative effect Effects 0.000 claims description 2
- 239000003380 propellant Substances 0.000 claims description 2
- 238000003892 spreading Methods 0.000 claims description 2
- 230000007480 spreading Effects 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 230000002272 anti-calculus Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000004075 cariostatic agent Substances 0.000 claims 1
- 244000277285 Cassia obtusifolia Species 0.000 abstract description 2
- 235000006719 Cassia obtusifolia Nutrition 0.000 abstract description 2
- 244000201986 Cassia tora Species 0.000 abstract description 2
- 235000014552 Cassia tora Nutrition 0.000 abstract description 2
- 239000000047 product Substances 0.000 description 59
- 210000003491 skin Anatomy 0.000 description 36
- 239000001884 Cassia gum Substances 0.000 description 25
- 239000007788 liquid Substances 0.000 description 23
- 235000019318 cassia gum Nutrition 0.000 description 21
- 239000004744 fabric Substances 0.000 description 20
- 239000000499 gel Substances 0.000 description 18
- 238000000151 deposition Methods 0.000 description 17
- 230000036541 health Effects 0.000 description 17
- 229920000642 polymer Polymers 0.000 description 17
- 230000008021 deposition Effects 0.000 description 15
- 230000000474 nursing effect Effects 0.000 description 15
- 238000005406 washing Methods 0.000 description 15
- 239000002537 cosmetic Substances 0.000 description 14
- 230000000694 effects Effects 0.000 description 14
- 229930182830 galactose Natural products 0.000 description 14
- 239000003814 drug Substances 0.000 description 13
- 239000008187 granular material Substances 0.000 description 12
- 239000006072 paste Substances 0.000 description 12
- 239000012752 auxiliary agent Substances 0.000 description 11
- 238000004140 cleaning Methods 0.000 description 11
- 239000003599 detergent Substances 0.000 description 11
- 210000000582 semen Anatomy 0.000 description 11
- 239000012459 cleaning agent Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 238000006467 substitution reaction Methods 0.000 description 10
- 239000002562 thickening agent Substances 0.000 description 10
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 9
- 229920002907 Guar gum Polymers 0.000 description 8
- 206010052428 Wound Diseases 0.000 description 8
- 208000027418 Wounds and injury Diseases 0.000 description 8
- 230000003750 conditioning effect Effects 0.000 description 8
- 239000000665 guar gum Substances 0.000 description 8
- 229960002154 guar gum Drugs 0.000 description 8
- 239000000843 powder Substances 0.000 description 8
- 239000002453 shampoo Substances 0.000 description 8
- 239000007921 spray Substances 0.000 description 8
- 125000001424 substituent group Chemical group 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 239000000839 emulsion Substances 0.000 description 7
- 239000002979 fabric softener Substances 0.000 description 7
- 239000007943 implant Substances 0.000 description 7
- 239000003381 stabilizer Substances 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 239000000284 extract Substances 0.000 description 6
- 210000002683 foot Anatomy 0.000 description 6
- 239000002674 ointment Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 210000004761 scalp Anatomy 0.000 description 6
- 239000000080 wetting agent Substances 0.000 description 6
- 241001597008 Nomeidae Species 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000007385 chemical modification Methods 0.000 description 5
- 239000000084 colloidal system Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 235000010417 guar gum Nutrition 0.000 description 5
- 239000000017 hydrogel Substances 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000007639 printing Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 229920000926 Galactomannan Polymers 0.000 description 4
- 239000004902 Softening Agent Substances 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 230000003796 beauty Effects 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 125000001309 chloro group Chemical group Cl* 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 239000003349 gelling agent Substances 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 235000002639 sodium chloride Nutrition 0.000 description 4
- 125000006850 spacer group Chemical group 0.000 description 4
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 4
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
- 125000003423 D-mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 230000003213 activating effect Effects 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 150000001277 beta hydroxy acids Chemical class 0.000 description 3
- 238000005282 brightening Methods 0.000 description 3
- 125000001246 bromo group Chemical group Br* 0.000 description 3
- 229920006317 cationic polymer Polymers 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 235000013399 edible fruits Nutrition 0.000 description 3
- 210000004905 finger nail Anatomy 0.000 description 3
- 229910052731 fluorine Inorganic materials 0.000 description 3
- 125000001153 fluoro group Chemical group F* 0.000 description 3
- 239000006260 foam Substances 0.000 description 3
- 238000005187 foaming Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 125000003010 ionic group Chemical group 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 238000005498 polishing Methods 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 3
- 239000002516 radical scavenger Substances 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 239000006254 rheological additive Substances 0.000 description 3
- 230000035807 sensation Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000004753 textile Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- OMDQUFIYNPYJFM-XKDAHURESA-N (2r,3r,4s,5r,6s)-2-(hydroxymethyl)-6-[[(2r,3s,4r,5s,6r)-4,5,6-trihydroxy-3-[(2s,3s,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]methoxy]oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@H](O)[C@H](O)O1 OMDQUFIYNPYJFM-XKDAHURESA-N 0.000 description 2
- NGEWQZIDQIYUNV-UHFFFAOYSA-N 2-hydroxy-3-methylbutyric acid Chemical compound CC(C)C(O)C(O)=O NGEWQZIDQIYUNV-UHFFFAOYSA-N 0.000 description 2
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 235000007627 Caesalpinia Nutrition 0.000 description 2
- 241000522234 Caesalpinia Species 0.000 description 2
- 229920000832 Cutin Polymers 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 229920000161 Locust bean gum Polymers 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 239000004927 clay Substances 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 239000000551 dentifrice Substances 0.000 description 2
- 229940120503 dihydroxyacetone Drugs 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 238000004043 dyeing Methods 0.000 description 2
- 238000005530 etching Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 150000008131 glucosides Chemical class 0.000 description 2
- 230000036571 hydration Effects 0.000 description 2
- 238000006703 hydration reaction Methods 0.000 description 2
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 description 2
- ROBFUDYVXSDBQM-UHFFFAOYSA-N hydroxymalonic acid Chemical compound OC(=O)C(O)C(O)=O ROBFUDYVXSDBQM-UHFFFAOYSA-N 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004900 laundering Methods 0.000 description 2
- 239000000711 locust bean gum Substances 0.000 description 2
- 235000010420 locust bean gum Nutrition 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 229920001206 natural gum Polymers 0.000 description 2
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 2
- WQDGUYZIAJKLAB-UHFFFAOYSA-N octan-2-yl nitrite Chemical compound CCCCCCC(C)ON=O WQDGUYZIAJKLAB-UHFFFAOYSA-N 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 239000013618 particulate matter Substances 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 235000021251 pulses Nutrition 0.000 description 2
- 125000001453 quaternary ammonium group Chemical group 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 239000012209 synthetic fiber Substances 0.000 description 2
- 229920002994 synthetic fiber Polymers 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 210000004906 toe nail Anatomy 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
- 125000006699 (C1-C3) hydroxyalkyl group Chemical group 0.000 description 1
- AFENDNXGAFYKQO-VKHMYHEASA-N (S)-2-hydroxybutyric acid Chemical compound CC[C@H](O)C(O)=O AFENDNXGAFYKQO-VKHMYHEASA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- JKRDADVRIYVCCY-UHFFFAOYSA-N 2-hydroxyoctanoic acid Chemical compound CCCCCCC(O)C(O)=O JKRDADVRIYVCCY-UHFFFAOYSA-N 0.000 description 1
- VOXXWSYKYCBWHO-UHFFFAOYSA-N 3-phenyllactic acid Chemical compound OC(=O)C(O)CC1=CC=CC=C1 VOXXWSYKYCBWHO-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- 244000283070 Abies balsamea Species 0.000 description 1
- 235000007173 Abies balsamea Nutrition 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- LITUBCVUXPBCGA-WMZHIEFXSA-N Ascorbyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O LITUBCVUXPBCGA-WMZHIEFXSA-N 0.000 description 1
- 239000004261 Ascorbyl stearate Substances 0.000 description 1
- DHHFDKNIEVKVKS-FMOSSLLZSA-N Betanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC(C[C@H]2C([O-])=O)=C1[N+]2=C\C=C\1C=C(C(O)=O)N[C@H](C(O)=O)C/1 DHHFDKNIEVKVKS-FMOSSLLZSA-N 0.000 description 1
- DHHFDKNIEVKVKS-MVUYWVKGSA-N Betanin Natural products O=C(O)[C@@H]1NC(C(=O)O)=C/C(=C\C=[N+]/2\[C@@H](C(=O)[O-])Cc3c\2cc(O)c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)c3)/C1 DHHFDKNIEVKVKS-MVUYWVKGSA-N 0.000 description 1
- 241000197194 Bulla Species 0.000 description 1
- NREFLOJMRCLGLS-UHFFFAOYSA-N CC(O)(O)C(O)=O.OCC(O)C(O)=O Chemical compound CC(O)(O)C(O)=O.OCC(O)C(O)=O NREFLOJMRCLGLS-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004858 Canada balsam Substances 0.000 description 1
- 240000008886 Ceratonia siliqua Species 0.000 description 1
- 235000013912 Ceratonia siliqua Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 241001517488 Clavus Species 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000085692 Cordia alliodora Species 0.000 description 1
- 235000004258 Cordia alliodora Nutrition 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 108010016626 Dipeptides Proteins 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 241000792859 Enema Species 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 235000017367 Guainella Nutrition 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 description 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- HDVDLQFPDLTOSI-UHFFFAOYSA-L O[AlH]O Chemical compound O[AlH]O HDVDLQFPDLTOSI-UHFFFAOYSA-L 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 208000005141 Otitis Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 244000025272 Persea americana Species 0.000 description 1
- 235000008673 Persea americana Nutrition 0.000 description 1
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 1
- 244000028344 Primula vulgaris Species 0.000 description 1
- 235000016311 Primula vulgaris Nutrition 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
- 241000195474 Sargassum Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 241000221095 Simmondsia Species 0.000 description 1
- 206010040825 Skin depigmentation Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229920006387 Vinylite Polymers 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 239000002386 air freshener Substances 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- GZCGUPFRVQAUEE-UHFFFAOYSA-N alpha-D-galactose Natural products OCC(O)C(O)C(O)C(O)C=O GZCGUPFRVQAUEE-UHFFFAOYSA-N 0.000 description 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 239000004411 aluminium Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- RZOBLYBZQXQGFY-UHFFFAOYSA-N ammonium lactate Chemical compound [NH4+].CC(O)C([O-])=O RZOBLYBZQXQGFY-UHFFFAOYSA-N 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000003255 anti-acne Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 229960000271 arbutin Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000000607 artificial tear Substances 0.000 description 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 1
- 235000019276 ascorbyl stearate Nutrition 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 239000010426 asphalt Substances 0.000 description 1
- NWCHELUCVWSRRS-UHFFFAOYSA-N atrolactic acid Chemical compound OC(=O)C(O)(C)C1=CC=CC=C1 NWCHELUCVWSRRS-UHFFFAOYSA-N 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000001654 beetroot red Substances 0.000 description 1
- 235000012677 beetroot red Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-RWOPYEJCSA-N beta-D-mannose Chemical group OC[C@H]1O[C@@H](O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-RWOPYEJCSA-N 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 235000002185 betanin Nutrition 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 208000002352 blister Diseases 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 238000009960 carding Methods 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 239000010627 cedar oil Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000005285 chemical preparation method Methods 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 239000001279 citrus aurantifolia swingle expressed oil Substances 0.000 description 1
- 239000010960 cold rolled steel Substances 0.000 description 1
- 239000004567 concrete Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000004332 deodorization Methods 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- HBGGXOJOCNVPFY-UHFFFAOYSA-N diisononyl phthalate Chemical compound CC(C)CCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC(C)C HBGGXOJOCNVPFY-UHFFFAOYSA-N 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 208000019258 ear infection Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 210000003278 egg shell Anatomy 0.000 description 1
- 239000002895 emetic Substances 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000008394 flocculating agent Substances 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 210000004195 gingiva Anatomy 0.000 description 1
- 239000000174 gluconic acid Substances 0.000 description 1
- 235000012208 gluconic acid Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000003966 growth inhibitor Substances 0.000 description 1
- 230000003779 hair growth Effects 0.000 description 1
- 150000003944 halohydrins Chemical group 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229960004337 hydroquinone Drugs 0.000 description 1
- 230000003165 hydrotropic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 description 1
- 229960004705 kojic acid Drugs 0.000 description 1
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229960000448 lactic acid Drugs 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 239000002649 leather substitute Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940078752 magnesium ascorbyl phosphate Drugs 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229960002510 mandelic acid Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000004579 marble Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000000820 nonprescription drug Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000002924 oxiranes Chemical group 0.000 description 1
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- XYFCBTPGUUZFHI-UHFFFAOYSA-O phosphonium Chemical compound [PH4+] XYFCBTPGUUZFHI-UHFFFAOYSA-O 0.000 description 1
- 230000036314 physical performance Effects 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000012744 reinforcing agent Substances 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000011012 sanitization Methods 0.000 description 1
- 239000003229 sclerosing agent Substances 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 239000011864 timber preservative Substances 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000000606 toothpaste Substances 0.000 description 1
- 229940034610 toothpaste Drugs 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 description 1
- PUVAFTRIIUSGLK-UHFFFAOYSA-M trimethyl(oxiran-2-ylmethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CC1CO1 PUVAFTRIIUSGLK-UHFFFAOYSA-M 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
- C11D3/225—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin etherified, e.g. CMC
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
- C11D3/227—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin with nitrogen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
- C11D3/228—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin with phosphorus- or sulfur-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/54—Polymers characterized by specific structures/properties
- A61K2800/542—Polymers characterized by specific structures/properties characterized by the charge
- A61K2800/5426—Polymers characterized by specific structures/properties characterized by the charge cationic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Birds (AREA)
- Biochemistry (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Materials For Medical Uses (AREA)
- Detergent Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及由决明和草决明制成的阳离子衍生的聚半乳甘露聚糖，以及它们在个人护理、居家护理和公共护理组合物中的应用。
Description
相关申请的交叉参考
[0001]该申请要求2003年6月19日提交的美国临时申请60/479,793的优先权。
技术领域
[0002]一般地，本发明涉及聚半乳甘露聚糖衍生物。更具体地，本发明涉及由决明(Cassia tora)和草决明(Cassia obtusifolia)获得的阳离子衍生的半乳甘露聚糖聚合物，以及它们在个人护理、保健、居家、公共和工业产品等中的应用。阳离子衍生的半乳甘露聚糖聚合物可以用作增稠剂、稳定剂、乳化剂、铺展助剂以及用于提高化学及生理活性成分的功效、沉积和输送的载体。除此之外，这些聚合物可以用于提高包括这些聚合物的化妆品制剂的心理感觉和美学性能。
背景技术
[0003]聚半乳甘露聚糖是从豆科植物种子的胚乳中发现的多糖，所述豆科植物如cyamopsis tetragonoloba(瓜尔胶)、Cesalpiniaspinosa(刺云实树胶)、Ceratonia siliqua(刺槐豆胶)以及豆科家族其它成员。聚半乳甘露聚糖由1→4连接的β-D-甘露吡喃糖单元骨架与重复的1→6连接的α-D-半乳糖侧基组成，所述半乳糖侧基接到骨架中甘露吡喃糖残基的C-6原子上。不同豆科属的半乳甘露聚糖聚合物在其接枝到聚甘露吡喃糖骨架上的半乳糖侧链单元出现的频率方面不同。瓜尔胶中含有的聚半乳甘露聚糖中，其D-甘露糖与D-半乳糖单元的平均比为约2:1，对于刺云实树胶为约3:1，对于刺槐豆胶为约4:1。聚半乳甘露聚糖的另一个重要来源是决明和草决明(统称做决明胶(Cassia gum))。决明胶中含有的聚半乳甘露聚糖中的D-甘露糖与D-半乳糖单元的平均比为约5:1。
[0004]由决明胶得到的聚半乳甘露聚糖用图表示结构如下：
聚甘露糖骨架重复单元
其中，n表示约15-约35的整数。另一实施方案中，n表示约20-约30的整数。本发明又一实施方案中，本发明的聚半乳甘露聚糖的数均分子量为约200,000-约300,000(用聚苯乙烯作标准的GPC方法)。
[0005]聚半乳甘露聚糖是对水具有高亲合性的水凝胶。它们在如食品、涂料、个人护理组合物以及油井压裂液的不同应用中，被广泛地用作悬浮剂、增稠剂、乳化剂和胶凝剂。尽管这些聚合物在应用中取得了巨大的成功，但是从水溶性的角度看，使用自然形式的聚半乳甘露聚糖时还是遇到了一些缺陷。未取代的聚甘露糖骨架完全不溶于水。在聚甘露糖骨架的重复甘露糖残基的C-6原子上连接有半乳糖侧基单元增加了聚合物的水溶性，尤其是冷水中的溶解性(即室温和低于室温)。半乳糖侧链单元的取代度越大，聚半乳甘露聚糖在冷水中的溶解性越高。因此，聚半乳甘露聚糖中D-甘露糖单元与D-半乳糖单元的比例越低，冷水溶解性越好。例如，包含在瓜尔胶中的聚半乳甘露聚糖(D-甘露糖单元与D-半乳糖单元的平均比例为2:1)可溶于冷水，而由决明胶得到的聚半乳甘露聚糖(D-甘露糖单元与D-半乳糖单元的平均比例为5:1)仅仅微溶于冷水和热水。
[0006]Bayerlein等人的美国专利4,753,659尤其公开了，通过化学改性聚半乳甘露聚糖能够提高决明胶的冷水溶解度。并公开了决明胶聚半乳甘露聚糖与选择的试剂反应，生成C-6取代的衍生物。例举的反应产物包括C-6取代的和未取代的烷基醚、C-6取代的磷酸酯和C-6取代的季铵化合物。对于化学改性的决明胶聚半乳甘露聚糖所公开的用途包括织物印刷应用、油井压裂液、采矿和爆破应用。
[0007]Chowdhary等人的美国专利5,733,854公开了化学改性的瓜尔胶及其制备方法。根据Chowdhary等人的专利，当分散在水性溶剂或有机溶剂中时，阳离子衍生的瓜尔胶聚半乳甘露聚糖形成无色透明溶液。对于阳离子衍生的瓜尔胶所公开的应用包括将其混入人和居家应用的清洁剂组合物中。公开的其它应用包括个人护理和化妆应用。没有公开阳离子衍生的决明胶在个人护理、医药、居家护理或化妆制剂中的应用。
[0008]阳离子衍生的瓜尔胶聚半乳甘露聚糖的内在缺陷是包含在聚甘露糖骨架上的半乳糖侧链单元的比例高。对于每两个甘露糖骨架重复单元就有一个半乳糖侧链单元。半乳糖侧链单元阻碍了甘露糖骨架单元的C-6原子上的羟基接近衍生试剂。对于大部分来说，仅仅半乳糖侧链单元上的C-6羟基可以被衍生试剂接近从而进行官能化。因此，瓜尔胶聚半乳甘露聚糖上的阳离子基团的取代度较低。
[0009]因此，存在对分子取代度高的衍生聚半乳甘露聚糖的需求，它适合用于增稠剂、稳定剂、乳化剂、铺展助剂和用于提高化学、化妆和生理活性成分的功效、沉积和输送的载体。
例举实施方案的描述
[0010]下面将描述本发明的例举实施方案。根据本文所述的这些例举实施方案，对于本领域技术人员来说，对它的各种改进、适应性修改或改变将变得显而易见。应当理解，根据本发明教导的这些改进、适应性修改或改变将被认为包括在本发明范围和精神范围内，和通过这些改进、适应性修改或改变，所述的这些教导将推进本领域。
[0011]一方面，本发明的实施方案涉及聚半乳甘露聚糖组合物，其被衍生处理从而比现有的聚半乳甘露聚糖组合物具有更高的分子取代度。在本发明的一些实施方案中，从决明和草决明(决明胶)种子的胚乳中分离的聚半乳甘露聚糖被后官能化为含有重复侧挂非离子、阴离子和阳离子部分。本发明的一些例举实施方案涉及阳离子改性的决明胶聚半乳甘露聚糖。其它实施方案涉及分子取代的决明胶聚半乳甘露聚糖，它们非常适合用作增稠剂、稳定剂、乳化剂、铺展助剂以及用于提高化学及生理活性成分的功效、沉积和输送的载体。还有一些其它实施方案涉及含有分子取代的决明胶聚半乳甘露聚糖的个人护理、居家护理、食品和工业组合物。
[0012]整个说明书中，术语“分子取代的”和“分子取代”表示在决明胶衍生的聚半乳甘露聚糖的半乳糖侧基单元的C-6碳原子和/或甘露糖重复骨架单元的C-6碳原子上悬挂选自含有非离子、阴离子、阳离子和两性离子部分以及它们组合的取代基。含有这些部分的功能化试剂与羟基反应，所述羟基连接到组成决明胶衍生的聚半乳甘露聚糖的半乳糖及甘露糖残基的C-6碳原子上。换句话说，羟基被来自官能化试剂的部分代替。在一个实施方案中，C-6碳原子上的羟基被来
聚半乳甘露聚糖骨架重复单元
[0013]本发明一些实施方案中，R独立地表示氢原子、非离子基团、阴离子基团、阳离子基团和两性基团，前提是所有R基团不能同时为氢原子。其它实施方案中，R独立地选自式：-AR1
其中，A是含有1-6个碳原子的亚烷基间隔基，R1表示非离子取代基、阴离子取代基、阳离子取代基和两性取代基。另一实施方案中，亚烷基含有2、3、4或5个碳原子。亚烷基间隔基任选地被选自下面的基团单取代或多取代：C1-C3烷基、C1-C3卤代烷基、C1-C3羟烷基、羟基、卤原子(溴原子、氯原子、氟原子和碘原子)以及它们的组合。例举的非离子R1取代基是-OH。-AR1定义下的说明性非离子基团可以用下式表示：-亚烷基-OH
其中，亚烷基间隔基定义如上。代表性的非离子基团包括但不限于羟甲基、羟乙基、羟丙基和羟丁基。
[0014]例举的阴离子R1取代基是-COOH、-SO3H、-OP(O)(OH)(OH)和-P(O)(OH)(OH)。-AR1定义下的说明性阴离子基团可以用下式表示：
-亚烷基-COOH
-亚烷基-SO3H
-亚烷基-OP(O)(OH)(OH)
-亚烷基-P(O)(OH)(OH)
其中，亚烷基间隔基定义如上。代表性的阴离子基团包括但不限于羧甲基、羧乙基和羧丙基。
[0015]R1定义下的例举阳离子取代基包括基团-N(R2)2表示的伯胺、仲胺和叔胺，以及基团-N(R3)3 +X-，-S(R3)2 +X-，-P(R3)3 +X-表示的季铵、锍和鏻衍生物，其中R2独立地表示氢原子、直链或支链C1-C5烷基、苯基和苄基；R3独立地表示C1-C24烷基、苄基和苯基；X是平衡鎓阳离子上的电荷的合适阴离子。一个实施方案中，X是选自溴原子、氯原子、氟原子和碘原子的卤阴离子。R2和R3定义下的烷基、苄基和苯基取代基可以任选地用选自C1-C3烷基、羟基、卤原子(溴原子、氯原子、氟原子和碘原子)以及它们组合的基团单取代或多取代。-AR1定义下的说明性阳离子基团可以用下式表示：
-亚烷基-N(R2)2
-亚烷基-N(R3)3 +X-
-亚烷基-S(R3)2 +X-
-亚烷基-P(R3)3 +X-
其中，亚烷基、R2、R3和X定义如上。-AR1定义下的代表性阳离子基团是季铵基团，它包括但不限于下式：
其中，R3选自甲基、癸基、十二烷基、十四烷基、椰油烷基、十二烷基和十八烷基，R4选自氢原子和氯原子。
[0016]两性取代基是既含有正电荷又含有负电荷的任何基团或残基。代表性的两性取代基包括甜菜碱、氨基酸、二肽、三肽和多肽残基。
[0017]未衍生的决明胶或决明粉可以Diagum商标从Noveon，Inc.商购。如上所述，决明胶聚半乳甘露聚糖的衍生发生在半乳糖侧基单元和/或骨架甘露糖重复单元的C-6羟基上。半乳糖侧基单元的空间位阻控制了能够发生在聚半乳甘露聚糖的C-6羟基上的取代量。决明胶聚半乳甘露聚糖在C-6羟基的取代度上不同于其它聚半乳甘露聚糖，这是因为决明的结构提供了更容易接近(即，更低空间位阻)的C-6羟基反应位，从而产生更高的官能团取代度。在其中发生离子基取代的本发明实施方案中，与类似衍生的现有聚半乳甘露聚糖相比，衍生的决明胶聚半乳甘露聚糖的电荷密度范围将更宽。在本发明一些实施方案中，季铵阳离子取代度可高达60％以及更高。术语“取代度”表示用改性取代基(例如，5个可得的C-6羟基中的3个被改性)改性了的每个聚半乳甘露聚糖重复单元(用上述括号内重复单元结构表示)中可得的C-6羟基的百分比。相反，衍生的现有瓜尔聚半乳甘露聚糖的取代度仅为33％。
[0018]决明聚半乳甘露聚糖C-6羟基的衍生可以通过本领域技术人员熟知的方法完成。一般来说，C-6羟基可与能够与其共反应的任何官能化试剂反应。例如，为了用本发明的非离子、阴离子、阳离子和两性取代基官能化C-6羟基，使决明胶聚半乳甘露聚糖上的C-6羟基与官能化试剂反应，所述试剂含有相应的非离子、阴离子、阳离子和两性取代基，以及能够与C-6羟基反应的官能团部分。官能化反应是在适宜温度下在合适溶剂中进行的。通过调整加入到决明聚半乳甘露聚糖中的官能化试剂的化学计量量，能够控制聚半乳甘露聚糖C-6羟基原子上的官能团取代的数量(取代度)。对于决明胶聚半乳甘露聚糖的官能化方法描述于美国专利4,753,659中，该文献被引入本文中以供参考。衍生聚半乳甘露聚糖的其它方法参见美国专利5,733,854。
[0019]在例举反应中，决明胶聚半乳甘露聚糖能够用共反应性的季铵化合物官能化，所述季铵化合物含有环氧基团或卤代醇基团。在一个实施方案中，在碱性水介质中，在约52℃下，决明聚半乳甘露聚糖能够与缩水甘油基三甲基氯化铵(75％水溶液)反应，生成所需要的2-羟基-3-(三甲基铵)丙基决明半乳甘露聚糖氯化物。该反应用下
[0020]决明胶的化学改性在骨架上引入了非离子、阴离子、阳离子和两性离子部分和其组合。这种化学改性造成各种物性的变化。例如，衍生的决明胶具有冷水溶解性或其提高了冷水溶解性。它能够在冷水中形成水合物，并且通过在冷水中形成胶体触变分散液产生粘度。
[0021]本发明的一些实施方案涉及阳离子决明衍生物在个人护理、卫生保健、居家、公共和工业产品应用等中作为多官能聚合物成分的应用。阳离子决明聚合物可以用作乳化剂、铺展助剂以及用于提高化学和生理活性成分以及化妆材料的功效、沉积和输送的载体，以及用于提高包括它们的制剂的心理感觉和美学性能的载体。本文中所用的术语“个人护理产品”包括但不限于化妆品、梳妆用品、药疗化妆品、美容助剂、用于人类和动物的皮肤、头发、头皮和指甲上的个人卫生和清洁产品。本发明所用的术语“卫生保健产品”包括但不限于药品、药物化妆品、口腔护理产品(嘴、牙齿)、眼睛护理产品、耳朵护理产品、和OTC产品和应用，如贴片、膏药、敷料等。该术语还包括外部使用或深入人体和动物体内部用于改善与健康有关或医疗状况的医疗器件。术语“体”包括整个身体(面、躯干、四肢、手和脚)的角质(头发、指甲)和非角质皮肤部位，人体开孔的组织和眼睛。术语“皮肤”包括头皮和粘膜。本发明所用的术语“居家护理产品”包括但不限于家庭里用于保护和/或清洁表面的产品，包括用于保持厨房和浴室的卫生条件的抗菌清洁产品，以及用于清洁织物等的洗涤产品等。本发明所用的术语“公共和工业产品”包括但不限于在包括医院和卫生保健部门的工业和公共环境中，用于保护和/或清洁或维持卫生条件所用的产品等。
[0022]在给定的组合物或应用中，本发明的阳离子决明衍生物能够(但不是必须)起一种以上的功能，如增稠剂和调理剂、成膜剂和载体或沉积助剂等。可以采用的阳离子决明衍生物的量取决于在制剂中使用它们的目的，并且可以由制剂领域的熟练技术人员确定。因此，只要达到了物理化学性能和功效，以组合物总重量计，有用的阳离子决明衍生物的量通常在约0.01％至约25％范围内变化，但是并不限于此。
[0023]含有阳离子决明衍生物的组合物可以包装在容器中并从中分配，所述容器非限定性地例如瓶、管、喷雾器、抹布、滚擦式容器、贴片等。对可以混入这些衍生物的产品的形式没有限制，只要达到了使用该产品的目的。例如，含有阳离子决明衍生物的个人和卫生保健产品可以涂布到皮肤、头发、头皮和指甲上，或者涂布到硬表面或洗涤织物上，而不管它是胶体、喷雾(液体或泡沫)、乳液(乳膏、洗液、糊剂)、液体(洗液、香波)、棒、软膏、栓剂等形式。
[0024]本发明的阳离子决明衍生物适合用于制备个人护理(化妆品、梳妆用品、药疗化妆品)和局部卫生护理产品，包括但不限于头发护理产品(香波、组合香波如二合一调理香波)，香波后漂洗液，定型和保持发型剂(包括定型助剂如发胶和喷雾剂、化妆助剂如发蜡、调理剂、烫发用品、松弛剂、头发光滑产品等)，皮肤护理制品(脸、身体、手、头皮和脚)如乳膏、洗液和清洁产品、防粉刺产品、抗老化产品(剥离剂、溶角蛋白剂、抗蜂窝炎剂、防皱等)，皮肤保护剂(防晒产品如防晒霜、遮阳、阻隔乳膏、油、硅氧烷等)，皮肤着色产品(增白剂、光亮剂、无太阳晒黑促进剂等)，染发剂(头发染料、染发洗液、高亮剂、漂白剂等)，有色皮肤染色剂(脸和身体化妆、粉底乳膏、染眉毛油、口红、护唇产品等)，沐浴产品(身体清洁剂、身体洗液、淋浴胶、液体肥皂、肥皂块、合成洗涤块、调节液体沐浴油、水泡浴、沐浴粉等)，指甲护理产品(抛光剂、抛光清除剂、增强剂、增长剂、硬化剂、表皮清除剂、软化剂等)。
[0025]包括阳离子决明衍生物的梳妆和卫生美容助剂包括但不限于脱发产品(刮胡须乳膏和洗液、脱毛剂、刮胡须后皮肤调理剂等)；除臭剂和防汗剂；口腔护理产品(嘴、牙齿、牙龈)如漱口水、牙粉如牙膏、牙粉、牙齿抛光剂、牙齿增白剂、呼吸清凉剂、托牙粘合剂等；面部和身体头发漂白剂等。含有阳离子决明衍生物的其它卫生和美容助剂包括但不限于含有合成晒黑促进剂如二羟基丙酮(DHA)、酪氨酸、酪氨酸酯等的无太阳晒黑应用；含有活性成分如曲酸、氢醌、熊果甙、水果、蔬菜或植物提取物(柠檬果皮提取物、洋甘菊、绿茶、桑椹提取物等)、抗坏血酸和其衍生物抗坏血酸棕榈酸酯、抗坏血酸硬脂酸酯、抗坏血酸磷酸镁等)的皮肤脱色、增白和光亮制剂；脚部护理产品，如角质软化的鸡眼和茧除去剂、脚浸泡液、脚粉(治疗的如抗真菌脚癣粉、软膏、喷剂等，防汗剂粉末或非治疗效果的吸湿粉)、脚部喷剂(非治疗作用的，如冷却、除臭喷剂等)、和脚部和趾甲调理剂(洗液、乳膏、趾甲软化剂等)。
[0026]包括阳离子决明衍生物作为铺展助剂和成膜剂的局部卫生和美容助剂包括但不限于保护皮肤喷剂、乳膏、洗液、凝胶、贴片、粉末产品如昆虫驱赶剂、止痒、抗菌剂、消毒剂、遮阳剂、防晒剂、皮肤紧缩和调色奶液和洗液、除疣组合物等。
[0027]阳离子决明衍生物尤其用作颗粒的悬浮剂，使之适合用于含有颗粒、微摩擦剂和摩擦剂的皮肤产品，如沐浴凝胶、含有表皮脱落擦洗剂的化妆和皮肤清洁剂。典型的颗粒包括但不限于壳、种子和石头粒，如杏仁、杏(种子、壳的粉末、壳)、鳄梨、椰子、玉米穗轴、橄榄、桃子、蔷薇果种子、胡桃壳等，硅酸铝、西蒙得木(蜡、种子粉)、牡蛎壳粉、均匀的樱草种子、研磨的赤豆等，聚乙烯(颗粒、小球)、聚乙烯(和)羟基纤维素颗粒、微晶纤维素、聚苯乙烯、聚苯乙烯(和)滑石颗粒、研磨的浮石、研磨的丝瓜、研磨的海藻、大米、燕麦皮、硅石(水合的、胶体等)、研磨的蛋壳、研磨的罂粟壳、盐如氯化钠、死海盐等，和它们的混合物。
[0028]阳离子决明衍生物可以在多种皮肤病学、药疗化妆品组合物中用作增稠剂和成膜剂，所述组合物用于局部改善由于老化、干燥、光损伤、粉刺等引起的皮肤状况，包括调理剂、湿润剂、抗氧化剂、剥离剂、溶角蛋白剂、维生素等。阳离子决明衍生物可以用作增稠剂，用于活性皮肤处理洗液和乳膏，其含有作为活性成分的酸性防老化剂、抗蜂窝炎剂和防粉刺剂如α-羟基酸(AHA)、β-羟基酸(BHA)、α-氨基酸、α-酮酸(AKA)和它们的混合物。在这些药疗化妆品中，AHA可包括但不限于乳酸，乙醇酸，果酸如苹果酸、柠檬酸、酒石酸，含有AHA的天然化合物的提取物如苹果提取物、杏提取物等，蜂蜜提取物，2-羟基辛酸，甘油酸(二羟基丙酸)，丙醇二酸(羟基丙烷二酸)，葡糖酸，杏仁酸，二苯乙醇酸，壬二酸，乙酸，α-lopioc acid，水杨酸，AHA盐和衍生物，如精氨酸羟乙酸盐、乳酸铵、乳酸钠、α-羟基丁酸、α-羟基异丁酸、α-羟基异癸酸、α-羟基异戊酸、阿卓乳酸等。BHA可包括但不限于3-羟基丙酸、β-羟基丁酸、β-苯基乳酸、β-苯基丙酮酸等。α-氨基酸包括但不限于α-氨基二羧酸如天门冬氨酸、谷氨酸、和它们的混合物，有时与果酸组合使用。AKA包括丙酮酸。有些抗老化组合物中，酸性活性剂可以是视黄酸、卤代羧酸如三氯乙酸、酸性抗氧剂如抗坏血酸(维生素C)、无机酸、植酸、溶血磷脂酸等。举例说明，有些抗粉刺剂可包括水杨酸、水杨酸衍生物如5-辛酰基水杨酸、视黄酸及其衍生物。
[0029]包括阳离子决明衍生物的其它卫生保健产品包括医疗制品，如局部和非局部药物和器件。在药物制剂中，阳离子决明衍生物可以用作增稠剂和/或润膏剂，用于例如但不限于乳膏、润发脂、凝胶、糊剂、软膏、药片、胶囊、导泻液(灌肠剂、催吐药、结肠药等)、栓剂、抗真菌泡沫、眼用产品(眼用产品如眼泪、人工眼泪、青光眼药物、输送滴液、隐形镜片清洁剂等)、耳朵用产品(蜡软化剂、蜡除去剂、耳炎药物输送滴液等)、鼻子用产品(滴液、软膏、喷剂等)、伤口护理(液体绷带、伤口敷料、抗生素乳膏、软膏等)的产品中。
[0030]阳离子决明衍生物可以在居家护理、公共和工业应用(I&I)中用作流变改性剂、织物调理剂，尤其是通过粘附在表面上来提高功效，或者提高消毒剂和杀微生物制剂的功效，以及与传统织物软化剂一起协同地提高织物软化功效。含有阳离子决明衍生物的典型居家和I&I产品包括但不限于洗涤和织物护理产品如洗涤剂、织物软化剂(液体或片材)、熨烫喷雾剂、干洗助剂、防皱喷雾剂、污渍除去剂等；用于厨房和浴室以及本发明中采用或设置的工具和器具的硬表面清洁剂，如抽水马桶凝胶、浴盆和喷淋管清洁剂、硬水沉积物清除剂、地板和瓷砖清洁剂、墙壁清洁剂、地板和镀铬家具抛光剂、碱性可剥离的乙烯基树脂地板清洁剂、大理石和瓷砖清洁剂、空气清新剂凝胶、用于餐具的液体清洁剂等；消毒清洁剂如抽水马桶和坐浴盆清洁剂、消毒洗手肥皂、房间除臭剂等。
[0031]阳离子决明衍生物可以用作工业产品应用中的流变改性剂、分散剂、稳定剂、促进剂等，所述工业产品应用例如但不限于织物加工、整理、印刷和印染助剂，保护性可洗涤表面涂层，通过浸透无纺织物、针织织物或无纺织物和天然或合成纤维来制造合成皮革；水处理(废水、冷却水、饮用水净化等)；化学品排放污染(酸性排放吸收剂等)；皮革和兽皮(加工助剂、整理、压印等)；纸和造纸(表面涂层，如彩色涂层、抗静电涂层等、浆粕粘合剂、表面施胶剂、干和湿强度提高剂、制造合成纤维如无纺织物、湿法成网毛毡等)；印刷(油墨、防芯吸喷墨打印机油墨、在用于在丙烯酸织物上印刷的含有阳离子染料的油墨制剂中用作增稠剂等)；涂料(颜料和研磨添加剂、环氧乳胶的交联剂、用于粘土、颜料等的颗粒悬浮助剂)；工厂排放物处理(用于造纸厂排放物中的酚类的絮凝剂等)；金属加工(酸性蚀刻清洁剂、低pH金属涂层、在冷轧钢加工中的酸洗剂等)；木材防腐剂；和用于建筑物和道路的工业结构产品(水泥增塑剂、低pH下的沥青乳液稳定剂、水泥的酸性蚀刻、以及混凝土、砂浆、油灰等的稠度改性剂)。阳离子决明衍生物还可以在除锈剂、酸性卡车清洁剂、污垢清洁剂等中作为增稠剂，在含有颗粒如粘土、颜料(二氧化钛、碳酸钙和其它矿物)、摩擦剂等的产品中用作分散稳定剂，所述含有颗粒的产品用于各种上述工业应用以及钻探泥浆和油井压裂液。
[0032]上述产品通常含有本领域已知的各种常规添加剂和助剂，有些可以起一种以上的功能。用量随产品用途和特征的不同而不同，并且可以容易地由制剂领域的熟练技术人员和文献确定。
[0033]已知，通过混入药物或医药上可接受的化合物，并且通过控制制备产品的条件，配制的用于个人护理和局部、皮肤病学、卫生保健的组合物(涂覆到皮肤和粘膜上用于清洁或安慰)可以与多种相同或类似的生理上可接受的成分复配，并且被配制成相同或类似的产品形式，主要区别于所选成分的纯度。同样，居家和I&I产品中所用的多种成分与上面的相同或类似，主要区别于所用含量和成分纯度级别。还知道，选择和允许使用的成分含量还要受到国家、地区、地方和国际级的政府管理。因此，本发明对于用于个人护理和卫生保健品的各种有用成分的讨论可以适用于居家和I&I产品和工业应用。
[0034]在含有阳离子决明衍生物聚合物的配制的组合物中，成分的选择和含量取决于产品及其功能，这对于本领域技术人员来说是众所周知的。用于个人护理和局部卫生保健品中的配方成分(除了这里没有出现的上述组分之外)通常包括但不限于溶剂、表面活性剂(作为清洁剂、乳化剂、泡沫促进剂、水溶助剂、加溶剂和悬浮剂)、非表面活性剂型悬浮剂、乳化剂、皮肤调理剂(润肤剂、湿润剂等)、头发调理剂(包括硅氧烷和硅油)、头发定型剂、成膜剂、皮肤保护剂、粘合剂、螯合剂、抗微生物剂、杀真菌剂、去头屑剂、摩擦剂、粘合剂、吸收剂、着色剂、除臭剂、防汗剂、湿润剂、遮光剂和珠光剂、抗氧化剂、防腐剂、推进剂、铺展剂、防晒剂、无太阳皮肤晒黑促进剂、紫外光吸收剂、pH调理剂、植物性药物、染发剂、氧化剂、还原剂、皮肤漂白剂、颜料、生理活性剂、抗炎药剂、局部麻醉剂、香料和香料加溶剂等。举例说明，口腔护理产品中除了表面活性剂、摩擦剂、湿润剂、填料和香料之外，包括防龋齿、防牙垢和/或防蚀斑剂。关于物质和它们的常规功能以及产品分类的详细清单通常参见CFTA Dictionary，尤其是第2卷，第4、5部分。
[0035]由于其水溶胀性能，阳离子决明衍生物往往在水基体系中用作胶凝剂。例如，阳离子决明衍生物通常在空气处理凝胶中用作胶凝剂，所述空气处理凝胶被设计成从凝胶中连续释放出挥发性空气处理剂。挥发性空气处理组分可包括使空气清新的成分如消毒剂、杀菌剂、杀虫剂、杀真菌剂、除臭剂、害虫驱赶剂、散发气味的材料和它们的混合物。散发气味的材料包括玫瑰油、梨莓油、柠檬油、绿薄荷油、冬青油、香柏油、加拿大香脂油等。这些油可以与香料如芳香酯、醛、酮和混合香料领域的技术人员已知的其它化合物组合使用。在一实施方案中，胶凝剂的含量为约0.5-约25wt％，另一实施方案中，为约0.75-约15wt％，又一实施方案中，为约1-5wt％，其中重量百分比是基于组合物的总重量。
[0036]阳离子决明衍生物还可以用于形成伤口敷料和医疗器件中所用的水凝胶。伤口如受伤、手术等引起的伤口的愈合很大程度上取决于所用的敷料。常规绷带往往不能提供最佳的效果。还采取特殊的减缓或减小压力的措施。湿润的敷料往往是有益的，它使失水的组织再次获得水份，增加了血管生成(新血管的增殖)、使细菌的生长降低到最小、物理保护、并保持合适的pH值以刺激氧气的释放和使蛋白水解酶更有效地工作。
[0037]可倾倒的水基天然或合成的水溶性或水溶胀性凝胶形成的水凝胶可以用于伤口敷料。起初，它们是足以倾倒或铺展到伤口上的流体，但是使用后，能够形成仍然保持聚合的水凝胶水合状态的湿润的固态弹性保护性胶体。
[0038]已经开发了适合植入体内的医疗器件，用于促进体液流动，用作血管移植物或者用于其它目的。通常，这些器件包括支架、导管、或套管、塞、收缩器、组织或生物密封剂等。许多用作植入物的这些器件由耐用的、不降解的塑料如聚氨酯、聚丙烯酸酯和硅氧烷聚合物等制成。有些情况下，它们由可生物降解的聚合物制成，这种聚合物在一定时间内在体内保持稳定，但是最终将降解成容易从人体排出的小分子。由阳离子改性的决明胶聚半乳甘露聚糖制成的交联水凝胶被设想用于制备这些医疗器件。它们具有优异的生物相容性，和已经表现出降低诱导血栓、包被和发炎的趋势。这些应用中，用于伤口愈合或植入物的水凝胶聚合物胶体是阳离子决明衍生物。含有阳离子决明的组合物与水混合时，在使用或不使用交联剂的情况下，将形成固态温度不可逆的弹性凝胶，即柔韧凝胶，以辅助形成非流体体系。典型的凝胶含有3-15wt％的阳离子决明衍生物。更大用量的聚合物和交联剂将得到更坚固的凝胶，或者具有更好的物理机械性能(模量、屈服应力、强度)的凝胶。该凝胶体中应该含有充足的水分，以提供将凝胶倾倒到或铺展到伤口上所需要的初始流动性，或者对于植入体来说，将凝胶通过内窥镜嵌入人体所需要的初始流动性。然后，使用离子和非离子交联剂来固化凝胶，并控制交联密度(即，凝胶体的最终的机械物理性能)。对于大多数应用来说，交联剂的含量为0-8wt％，更优选0.1-5wt％。可以采用任何合适的无毒交联剂，包括半乳糖、甘露糖、含有半乳糖和甘露糖中一种或两种的低聚糖类、硼砂、有机钛酸酯、硼酸、双环氧化物、多羧酸、戊二醛、二羟基铝、碳酸钠、柠檬酸、以及钙、镁和铝阳离子中任何的可溶物质。对于植入体来说，当植入器件植入体内后，可以容易地、选择性地在体内替换离子交联剂，使该器件在体内溶胀和变软，提高了病人的舒服感。该器件将保持它原来的构型，没有破碎。如果需要，下述任何一种物质都可以包括在组合物中：药物和消毒剂、伤口愈合促进剂如维生素、血液促凝剂、抗生素、氧源等。
[0039]阳离子聚合物往往在皮肤和/或头发组合物中被用作调理剂。季铵化的聚合物用于香波和调理剂中以促进梳理性。正电性的氮与负电性的头发纤维结合形成膜。它们还使得头发摸起来更柔软、更光滑，而不产生太多的堆积。阳离子决明衍生物可以在调理清洁配方中用作部分阳离子聚合物调理剂，所述调理清洁配方不但使头发具有清洁、湿解缠结、干解缠结和易于处理的性能，而且相对没有刺激性。因此，该组合物适合儿童以及皮肤敏感的成人和眼部使用。
[0040]在护肤制剂中，阳离子决明衍生物在超柔和皮肤清洁组合物或湿润组合物中用作聚合物皮肤感觉和皮肤柔和助剂。阳离子决明衍生物提供了皮肤调理、皮肤柔和和湿润性，同时保持了所需的起泡性能。尽管多次使用后会使皮肤过分脱脂或者过分干燥，但是该阳离子决明衍生物还是通过避免皮肤刺激显示出理想的丝滑、柔软光滑的使用感觉。正电性的阳离子决明衍生物能够与皮肤上的负电性点结合，从而在使用后产生柔软的皮肤感觉。通过降低粘性和油腻性并提高光滑性，它改进了皮肤的感觉。
[0041]本发明的阳离子决明衍生物可以在乳液中用作流变改性剂或乳液稳定剂。本发明的阳离子决明衍生物为发泡乳液组合物提供了更好的乳液稳定性。对于具有良好的皮肤病学相容性的皮肤清洁组合物的需求日益增加。尤其是发现，将烷基低聚糖甙用作非离子表面活性剂是有利的，因为它有助于起泡和清洁性能、生物降解性和皮肤病学相容性。然而，含有该烷基低聚糖甙的乳液缺乏化妆吸引力。这些组合物不易于被皮肤吸收，当涂覆到皮肤上时，它们不形成乳脂状的微泡，而是形成粗糙的大泡。含有阳离子聚合物如阳离子决明衍生物的制剂导致大量乳脂状微泡的形成，这些微泡易于被皮肤吸收，且具有高清洁和加脂性能。
[0042]因此，非常需要具有良好的调理和起泡性能的清洁组合物。由于阴离子表面活性剂(与其它表面活性剂相比，它表现出优异的清洁性能和高度的起泡性)和阳离子聚合物(它提供调理性和/或辅助治疗剂沉积到皮肤或头发上)之间内在的不相容性，因此这一点难以实现。这种阴离子表面活性剂在清洁组合物中的存在还妨碍治疗剂的沉积，因为该组合物被设计成在冲洗过程中从头发、头皮和皮肤上除去油、脂和污物以及颗粒物。在个人护理应用中，本发明的阳离子决明衍生物能与表面活性剂、水溶性试剂(例如硅氧烷)一起使用，提供一种用于治疗剂、调理剂、湿润剂等的改进输送体系。治疗剂的实例包括但不限于解缠结/湿梳理剂、湿润剂、防粉刺剂、防脱发剂、毛发生长抑制剂、草本植物提取物等。
[0043]为了在用清洁组合物产品清洗过的表面上赋予所需的残留性能，在该产品中混入了各种水不溶性的颗粒(乳油的固体或液体颗粒)。例如，含有颗粒去头皮屑试剂的香波组合物，除非冲洗后该试剂沉积并保留在头发和头皮上时，否则将不起作用。各种洗衣洗涤剂和个人护理沐浴露中也使用了颗粒抗微生物剂，以给织物和头发和皮肤表面赋予残留的抗微生物活性。洗涤剂组合物中也使用了各种其它的水不溶性或微溶性颗粒材料如防晒剂、织物柔软剂、织物增亮剂、织物增白剂等。它们的活性依赖于颗粒在洗涤过的基质(皮肤、头发、织物等)上的沉积和保留。由于它们特有的本性，有效的洗涤剂组合物倾向于将颗粒物质在洗涤过的表面上的停留最小化。因此，在基质表面洗涤和冲洗后，在洗涤剂组合物中实际上仅仅较少部分的活性剂保留了下来。由于活性剂的活性取决于沉积和保留在表面上的颗粒的量，因此非常需要一种提高活性剂沉积和保留的方法。本发明的阳离子决明衍生物适合于该目的。
[0044]在定型香波中，本发明阳离子决明衍生物作为沉积助剂来提高水不溶性定型组合物的沉积的使用提高了头发的定型效果(调理、卷曲保持性、出色的发感)。本发明的阳离子决明衍生物可以与水不溶性头发定型聚合物组合用作沉积助剂，所述水不溶性头发定型聚合物选自(甲基)丙烯酸酯共聚物和硅氧烷接枝的(甲基)丙烯酸酯。实例包括丙烯酸叔丁酯/丙烯酸2-乙基己酯共聚物、丙烯酸叔丁酯/甲基丙烯酸2-乙基己酯共聚物、丙烯酸叔丁酯/甲基丙烯酸2-乙基己酯/聚二甲基硅氧烷大分子和甲基丙烯酸叔丁酯/甲基丙烯酸2-乙基己酯/聚二甲基硅氧烷大分子共聚物、和它们的混合物。
[0045]如上所述，清洁组合物中使用了各种水不溶性或微溶性颗粒材料如防晒剂、织物软化剂、织物增亮剂、织物增白剂、杀虫剂等。它们的活性取决于颗粒在洗涤过的表面上的沉积和保留。由于它们的特有本性，有效的洗涤剂组合物倾向于将颗粒材料在洗涤过的表面上的保留最小化。因此，在表面洗涤和冲洗后，事实上，在该洗涤剂组合物中仅仅较少部分的试剂保留了下来。由于功能试剂的活性取决于颗粒在表面上沉积和保留下来的量，因此非常需要一种提高沉积的过程。阳离子决明衍生物可以用作这些颗粒物质的沉积助剂：例如用于在洗涤过程中，在织物表面上沉积织物软化剂，或者用于在卫生处理过程中在硬表面上沉积杀虫剂。举例说明，与常规洗衣洗涤剂成分如表面活性剂、助洗剂等一起使用阳离子决明衍生物，由于织物软化剂更好地沉积在表面上，因此提高了软化性能，并明显地提高了储存稳定性。作为沉积助剂的阳离子决明衍生物的用量为整个组合物的约0.05-约5wt％。在本发明一实施方案中，当在包括了表面活性剂的组合物中使用时，阳离子决明与表面活性剂的重量比约10:1-约1:10。
[0046]阳离子决明衍生物还可以在洗衣洗涤剂组合物中用作污渍脱除剂。洗衣过程中，这些聚合物吸附在浸入洗涤液的织物表面上。吸附的聚合物形成亲水层，在从洗涤液中取出并干燥后，所述亲水层仍然保留在织物上，因此使洗涤织物具有了污渍脱除性能。少量的阳离子决明衍生物(0.3-5wt％)结合典型的织物软化剂可产生污渍脱除性能，而并不影响重新穿着时织物的白度。
Claims (14)
1.一种个人护理组合物，所述组合物包括聚半乳甘露聚糖，所述聚半乳甘露聚糖具有包含D-甘露糖与D-半乳糖残基比为5:1的重复单元，其中甘露糖和半乳糖残基的侧挂C-6羟基取代基上的部分氢基被下式表示的基团取代：-AR1
其中，A是含有1-6个碳原子的取代或未取代亚烷基，R1独立地选自-N(R3)3 +X-，-S(R3)2 +X-和-P(R3)3 +X-，其中R3独立地表示取代或未取代的C1-C24烷基、取代或未取代的苄基和取代或未取代的苯基；X是平衡鎓阳离子上电荷的任何合适的阴离子；所述组合物还包括选自下面的成分：表面活性剂、非表面活性剂悬浮剂、头发调理剂、头发定型剂、成膜剂、皮肤保护剂、粘合剂、螯合剂、消毒剂、杀昆虫剂、害虫驱赶剂、有气味的材料、杀微生物剂、去头皮屑试剂、摩擦剂、着色剂、除臭剂、防汗剂、遮光剂和珠光剂、抗氧化剂、防腐剂、推进剂、铺展剂、剥离剂、溶角蛋白剂、血液凝固剂、维生素、人工晒黑促进剂、紫外线吸收剂、pH调节剂、植物性药材、染发剂、氧化剂、还原剂、皮肤漂白剂、抗炎剂、局部麻醉剂、香料增溶剂、和它们的组合。
2.权利要求1的个人护理组合物，其中所述烷基、亚烷基、苯基和苄基被选自C1-C3烷基、羟基和卤原子的基团单取代或独立地多取代。
3.权利要求1的个人护理组合物，其中X是卤离子。
4.权利要求1的个人护理组合物，其中至少一个C-6羟基氢被-AR1取代基所取代。
5.权利要求1的个人护理组合物，其中所述聚半乳甘露聚糖的数均分子量为200,000至300,000。
6.权利要求1的个人护理组合物，其中所述聚半乳甘露聚糖的重复单元用下式表示：
其中，R独立地表示氢和-AR1，其中-AR1定义同上。
7.权利要求6的个人护理组合物，其中n表示15至35的整数。
8.权利要求1或2的个人护理组合物，还包括溶剂。
9.权利要求1的个人护理组合物，还包括选自酸性抗老化剂、抗蜂窝炎剂、防粉刺剂和它们的组合的成分。
10.权利要求1的个人护理组合物，还包括交联剂。
11.权利要求1的个人护理组合物，还包括选自防龋齿剂、防牙垢剂、防蚀斑剂、香料和它们的组合的成分。
12.权利要求1的个人护理组合物，其中所述杀微生物剂选自抗生素、杀真菌剂、及其组合。
13.权利要求1的个人护理组合物，包括选自下面的成分：防晒剂、润肤剂、增湿剂、乳化剂、颜料、香料、微摩擦剂和它们的组合。
14.权利要求8的个人护理组合物，其中所述溶剂是水。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47979303P | 2003-06-19 | 2003-06-19 | |
| US60/479,793 | 2003-06-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1809334A CN1809334A (zh) | 2006-07-26 |
| CN100459969C true CN100459969C (zh) | 2009-02-11 |
Family
ID=33539223
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004800170929A Expired - Lifetime CN100459969C (zh) | 2003-06-19 | 2004-06-18 | 阳离子决明衍生物及其应用 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US7262157B2 (zh) |
| EP (1) | EP1658044B1 (zh) |
| JP (2) | JP4796960B2 (zh) |
| CN (1) | CN100459969C (zh) |
| AT (1) | ATE346585T1 (zh) |
| BR (1) | BRPI0410671B1 (zh) |
| DE (1) | DE602004003507T2 (zh) |
| ES (1) | ES2276326T3 (zh) |
| MX (1) | MXPA05013684A (zh) |
| WO (1) | WO2004112733A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230263823A1 (en) * | 2021-02-19 | 2023-08-24 | Can Technologies, Inc. | Feces binder in feed for fish |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05013684A (es) * | 2003-06-19 | 2006-02-24 | Noveon Ip Holdings Corp | Derivados de casia cationicos y aplicaciones para los mismos. |
| US7759296B2 (en) * | 2003-06-19 | 2010-07-20 | Lubrizol Advanced Materials, Inc. | Cationic polymers and fixative application therefor |
| BRPI0514752B1 (pt) * | 2004-08-31 | 2016-12-13 | Hercules Inc | processos para preparar composições com odor reduzido |
| US9198847B2 (en) * | 2004-11-05 | 2015-12-01 | The Procter & Gamble Company | Personal care composition containing a non-guar galactomannan polymer derivative and an anionic surfactant system |
| US20060099167A1 (en) * | 2004-11-05 | 2006-05-11 | Staudigel James A | Personal care composition containing a non-guar galactomannan polymer derivative |
| US8450294B2 (en) * | 2004-12-16 | 2013-05-28 | Lubrizol Advanced Materials, Inc. | Shampoo compositions |
| US20090176674A1 (en) * | 2006-01-09 | 2009-07-09 | The Procter & Gamble Company | Personal care compositions containing cationic synthetic copolymer and a detersive surfactant |
| US9427391B2 (en) * | 2006-01-09 | 2016-08-30 | The Procter & Gamble Company | Personal care compositions containing cationic synthetic copolymer and a detersive surfactant |
| WO2007101048A2 (en) | 2006-02-24 | 2007-09-07 | Lubrizol Advanced Materials, Inc. | Polymerizable silicone copolyol macromers and polymers made therefrom |
| BRPI0708169B1 (pt) | 2006-02-24 | 2015-08-04 | Lubrizol Advanced Mat Inc | Composição |
| US20070292380A1 (en) * | 2006-06-16 | 2007-12-20 | James Anthony Staudigel | Hair conditioning composition containing a non-guar galactomannan polymer derivative |
| WO2008076178A1 (en) * | 2006-11-03 | 2008-06-26 | Hercules Incorporated | Dispersible non-borate metal salt or chelate treated polygalactomannan polymers for use in personal care and household care applications |
| CN101568326A (zh) * | 2006-12-21 | 2009-10-28 | 宝洁公司 | 包含硅氧烷弹性体的个人护理组合物 |
| US7618857B2 (en) * | 2007-01-17 | 2009-11-17 | International Business Machines Corporation | Method of reducing detrimental STI-induced stress in MOSFET channels |
| CN101437487A (zh) * | 2007-07-17 | 2009-05-20 | 宝洁公司 | 包含非瓜耳型半乳甘露聚糖聚合物衍生物的毛发调理组合物 |
| WO2010014219A1 (en) * | 2008-07-30 | 2010-02-04 | Rhodia, Inc. | Methods of producing cross-linked polysaccharide particles |
| US8460687B1 (en) | 2009-07-07 | 2013-06-11 | Cosmoceutical Research Center | Peeling compositions |
| US8008242B1 (en) * | 2009-08-10 | 2011-08-30 | The United States Of America, As Represented By The Secretary Of Agriculture | Biodegradable abrasive compositions |
| ES2507142T3 (es) * | 2009-12-14 | 2014-10-14 | Lubrizol Advanced Materials, Inc. | Derivados de Cassia |
| EP2563818B1 (en) * | 2010-04-29 | 2014-12-17 | Lubrizol Advanced Materials, Inc. | Cassia derivatives |
| CN103747777A (zh) * | 2011-06-10 | 2014-04-23 | 路博润高级材料公司 | 决明衍生物 |
| ITVA20120014A1 (it) | 2012-05-28 | 2013-11-29 | Lamberti Spa | Composizione comprendente un legante idraulico |
| DE102012105019A1 (de) * | 2012-06-11 | 2013-12-12 | Gräfe Chemie GmbH | Verfahren zur Herstellung einer Zusammensetzung umfassend kationisierte Stärke und kationisiertes Polygalactomannan |
| CN105431133A (zh) | 2013-06-18 | 2016-03-23 | 路博润高级材料公司 | 基于改性半乳甘露聚糖的胶态稳定的分散体 |
| AU2014289728A1 (en) | 2013-07-08 | 2016-01-21 | Rhodia Operations | Growth enhancement of plant |
| US9358256B2 (en) | 2013-07-11 | 2016-06-07 | Links Medical Products, Inc. | Gap-patterned foam dressing and method of making same |
| ITVA20130048A1 (it) | 2013-09-04 | 2015-03-05 | Lamberti Spa | Composizioni cosmetiche e per la cura della casa |
| WO2015054026A2 (en) * | 2013-10-07 | 2015-04-16 | Hercules Incorporated | Dihydroxyalkyl substituted polygalactomannan, and methods for producing and using the same |
| EP2898774A1 (en) * | 2014-01-28 | 2015-07-29 | Archroma IP GmbH | Composition for the treatment of textile materials |
| WO2019025233A1 (en) * | 2017-08-03 | 2019-02-07 | Basf Se | COSMETIC COMPOSITIONS COMPRISING A POLYMER OF BIOLOGICAL ORIGIN |
| MX2020010178A (es) * | 2018-03-30 | 2020-10-28 | Isp Investments Llc | Composiciones para el peinado del cabello que comprenden poligalactomanos y un metodo para el uso de las mismas. |
| US20220304904A1 (en) | 2019-06-24 | 2022-09-29 | Rossana Castellana | Formulation for odontological and dermatological use containing trchloroacetate salts and hydroxyacids |
| KR102371680B1 (ko) * | 2020-03-27 | 2022-03-07 | (주)아모레퍼시픽 | 노화 피부세포 주변 환경변화 유도 촉진용 조성물 및 이를 이용한 마스크시트 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4661475A (en) * | 1983-09-30 | 1987-04-28 | Diamalt Aktiengesellschaft | Gelling agents and thickeners based on Cassia-galactomannans |
| US4753659A (en) * | 1983-12-29 | 1988-06-28 | Diamalt Aktiengesellschaft | Derivatives of cassia tora polysaccarides and their use |
| US5733854A (en) * | 1996-10-25 | 1998-03-31 | Rhone-Poulenc Inc. | Cleaning compositions including derivatized guar gum composition including nonionic and cationic groups which demonstrate excellent solution clarity properties |
| DE10047278A1 (de) * | 2000-09-25 | 2002-04-11 | Manfred Kuhn | Gelier- und Verdickungsmittel auf der Basis von von heißwasserunlöslichen Bestandteilen befreiten Cassia-Galaktomannan |
| WO2003008456A2 (de) * | 2001-07-18 | 2003-01-30 | Noveon Ip Holdings Corp. | Galactomannan mit verändertem mannose zu galactose verhältnis |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK219779A (da) * | 1978-05-31 | 1979-12-01 | Nicholas Pty Ltd | Anti-caries praeparater |
| DE3347469A1 (de) * | 1983-12-29 | 1985-07-11 | Diamalt AG, 8000 München | Substituierte alkylaether von cassia-polysacchariden und deren verwendung als verdickungsmittel |
| JP3336688B2 (ja) * | 1993-06-30 | 2002-10-21 | ライオン株式会社 | 口腔用組成物 |
| JPH07173028A (ja) * | 1993-12-17 | 1995-07-11 | Nichiden Kagaku Kk | 化粧品基材 |
| JP4069228B2 (ja) * | 1998-09-30 | 2008-04-02 | 東邦化学工業株式会社 | 頭髪用化粧料に優れたコンディショニング特性を与えるカチオン性ポリマー |
| JP2001122905A (ja) * | 1999-10-22 | 2001-05-08 | Unitika Ltd | 吸水材及びその製造方法 |
| JP2002249421A (ja) * | 2001-02-22 | 2002-09-06 | Unitika Ltd | 制汗性化粧品及び制汗剤 |
| MXPA05013684A (es) * | 2003-06-19 | 2006-02-24 | Noveon Ip Holdings Corp | Derivados de casia cationicos y aplicaciones para los mismos. |
-
2004
- 2004-06-18 MX MXPA05013684A patent/MXPA05013684A/es active IP Right Grant
- 2004-06-18 US US10/874,296 patent/US7262157B2/en active Active
- 2004-06-18 BR BRPI0410671-7A patent/BRPI0410671B1/pt active IP Right Grant
- 2004-06-18 WO PCT/US2004/019426 patent/WO2004112733A1/en active IP Right Grant
- 2004-06-18 JP JP2006517362A patent/JP4796960B2/ja not_active Expired - Lifetime
- 2004-06-18 ES ES04755546T patent/ES2276326T3/es not_active Expired - Lifetime
- 2004-06-18 CN CNB2004800170929A patent/CN100459969C/zh not_active Expired - Lifetime
- 2004-06-18 AT AT04755546T patent/ATE346585T1/de not_active IP Right Cessation
- 2004-06-18 DE DE602004003507T patent/DE602004003507T2/de not_active Expired - Lifetime
- 2004-06-18 EP EP04755546A patent/EP1658044B1/en not_active Revoked
-
2007
- 2007-08-23 US US11/843,920 patent/US7439214B2/en not_active Expired - Lifetime
-
2008
- 2008-10-20 US US12/254,437 patent/US7704934B2/en not_active Expired - Lifetime
-
2009
- 2009-06-22 JP JP2009147887A patent/JP2009209155A/ja not_active Withdrawn
-
2010
- 2010-03-26 US US12/732,659 patent/US7923422B2/en not_active Expired - Lifetime
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4661475A (en) * | 1983-09-30 | 1987-04-28 | Diamalt Aktiengesellschaft | Gelling agents and thickeners based on Cassia-galactomannans |
| US4753659A (en) * | 1983-12-29 | 1988-06-28 | Diamalt Aktiengesellschaft | Derivatives of cassia tora polysaccarides and their use |
| US5733854A (en) * | 1996-10-25 | 1998-03-31 | Rhone-Poulenc Inc. | Cleaning compositions including derivatized guar gum composition including nonionic and cationic groups which demonstrate excellent solution clarity properties |
| DE10047278A1 (de) * | 2000-09-25 | 2002-04-11 | Manfred Kuhn | Gelier- und Verdickungsmittel auf der Basis von von heißwasserunlöslichen Bestandteilen befreiten Cassia-Galaktomannan |
| WO2003008456A2 (de) * | 2001-07-18 | 2003-01-30 | Noveon Ip Holdings Corp. | Galactomannan mit verändertem mannose zu galactose verhältnis |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230263823A1 (en) * | 2021-02-19 | 2023-08-24 | Can Technologies, Inc. | Feces binder in feed for fish |
| US11903964B2 (en) * | 2021-02-19 | 2024-02-20 | Can Technologies, Inc. | Feces binder in feed for fish |
Also Published As
| Publication number | Publication date |
|---|---|
| US20090047227A1 (en) | 2009-02-19 |
| JP2007521270A (ja) | 2007-08-02 |
| US7439214B2 (en) | 2008-10-21 |
| DE602004003507D1 (de) | 2007-01-11 |
| US7704934B2 (en) | 2010-04-27 |
| EP1658044B1 (en) | 2006-11-29 |
| DE602004003507T2 (de) | 2007-09-13 |
| BRPI0410671A (pt) | 2006-06-20 |
| US20080004340A1 (en) | 2008-01-03 |
| US7923422B2 (en) | 2011-04-12 |
| MXPA05013684A (es) | 2006-02-24 |
| JP2009209155A (ja) | 2009-09-17 |
| CN1809334A (zh) | 2006-07-26 |
| US20050026794A1 (en) | 2005-02-03 |
| ES2276326T3 (es) | 2007-06-16 |
| US7262157B2 (en) | 2007-08-28 |
| US20100178261A1 (en) | 2010-07-15 |
| ATE346585T1 (de) | 2006-12-15 |
| WO2004112733A1 (en) | 2004-12-29 |
| EP1658044A1 (en) | 2006-05-24 |
| BRPI0410671B1 (pt) | 2014-08-19 |
| JP4796960B2 (ja) | 2011-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100459969C (zh) | 阳离子决明衍生物及其应用 | |
| RU2458679C2 (ru) | Диспергирующиеся обработанные глиоксалем катионогенные полигалактоманнаны | |
| CN101080214B (zh) | 制备水解胶体的方法 | |
| CN100420717C (zh) | 用于疏水性修饰表面并增强活性物质向用其处理的表面递送包含阴离子官能化聚有机硅氧烷的组合物 | |
| CN103068865B (zh) | 结构化的丙烯酸酯共聚物增稠剂 | |
| JP4619114B2 (ja) | カチオン性ポリマー組成物、および、そのコンディショニング用途における使用 | |
| KR101118460B1 (ko) | 컨디셔닝 용도에서의 양이온성의 산화된 다당류 | |
| JP5712132B2 (ja) | 混合カチオン性置換基を有する非セルロース性多糖を含む洗浄剤 | |
| US20050227902A1 (en) | Cationic, oxidized polysaccharides in conditioning applications | |
| JP2007536385A (ja) | ガラクトマンナンハイドロコロイド | |
| RU2008110179A (ru) | Очищающие композиции, содержащие пленку | |
| CN105209122A (zh) | 组合物和制备具有提高的沉积性能的个人护理组合物的方法 | |
| WO2004099259A1 (ja) | カチオン変性アルギン酸誘導体及び該物質を含む化粧料組成物 | |
| KR100520242B1 (ko) | 발 세정용 발포성 과립 또는 정제의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20090211 |