CN100457723C - 制备氨基甲酸2-(取代苯基)-2-羟基-乙酯的方法 - Google Patents

制备氨基甲酸2-(取代苯基)-2-羟基-乙酯的方法 Download PDF

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Publication number
CN100457723C
CN100457723C CNB028281128A CN02828112A CN100457723C CN 100457723 C CN100457723 C CN 100457723C CN B028281128 A CNB028281128 A CN B028281128A CN 02828112 A CN02828112 A CN 02828112A CN 100457723 C CN100457723 C CN 100457723C
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CN
China
Prior art keywords
compound
formula
ether
reaction
alcohol
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Expired - Lifetime
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CNB028281128A
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English (en)
Chinese (zh)
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CN1620425A (zh
Inventor
M·雷
T·奥滕
D·科雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SK Biopharmaceuticals Co Ltd
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
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Publication of CN1620425A publication Critical patent/CN1620425A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1786—Unsaturated ethers containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB028281128A 2001-12-21 2002-12-19 制备氨基甲酸2-(取代苯基)-2-羟基-乙酯的方法 Expired - Lifetime CN100457723C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP01205097.7 2001-12-21
EP01205097 2001-12-21
US41808402P 2002-10-11 2002-10-11
US60/418,084 2002-10-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2008102106749A Division CN101343243A (zh) 2001-12-21 2002-12-19 制备氨基甲酸2-(取代苯基)-2-羟基-乙酯的方法

Publications (2)

Publication Number Publication Date
CN1620425A CN1620425A (zh) 2005-05-25
CN100457723C true CN100457723C (zh) 2009-02-04

Family

ID=26077052

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028281128A Expired - Lifetime CN100457723C (zh) 2001-12-21 2002-12-19 制备氨基甲酸2-(取代苯基)-2-羟基-乙酯的方法

Country Status (22)

Country Link
EP (2) EP1461309A1 (https=)
JP (1) JP4610899B2 (https=)
KR (1) KR20090097966A (https=)
CN (1) CN100457723C (https=)
AR (1) AR038055A1 (https=)
AU (3) AU2002358806B2 (https=)
BG (1) BG108759A (https=)
BR (1) BR0215237A (https=)
CA (2) CA2681964A1 (https=)
CZ (1) CZ2004718A3 (https=)
EE (1) EE05381B1 (https=)
HR (1) HRP20040557A2 (https=)
HU (1) HUP0402491A2 (https=)
IL (3) IL162405A0 (https=)
MX (1) MXPA04006135A (https=)
MY (1) MY142415A (https=)
NO (1) NO20043105L (https=)
NZ (1) NZ533592A (https=)
PL (1) PL370977A1 (https=)
SK (1) SK2572004A3 (https=)
TW (1) TWI333944B (https=)
WO (1) WO2003053916A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767843B2 (en) * 2006-03-02 2010-08-03 Apotex Pharmachem Inc. Process for the preparation of phenylcarbamates
JP2010505856A (ja) * 2006-10-06 2010-02-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ （ｓ）−（＋）−２−（２−クロロフェニル）−２−ヒドロキシ−エチルカルバメートの新規結晶
US20090105498A1 (en) * 2007-10-18 2009-04-23 Porstmann Frank Improved process for preparing 2-(substituted phenyol)-2-hydroxy-ethyl-carbamates
US8609849B1 (en) 2010-11-30 2013-12-17 Fox Chase Chemical Diversity Center, Inc. Hydroxylated sulfamides exhibiting neuroprotective action and their method of use
MX353024B (es) * 2011-12-27 2017-12-18 Bio Pharm Solutions Co Ltd Compuestos de fenil carbamato para uso en la prevencion o tratamiento de epilepsia.
KR102421006B1 (ko) * 2016-05-19 2022-07-14 에스케이바이오팜 주식회사 두통의 예방학적 치료를 위한 카바메이트 화합물의 용도

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504108A (en) * 1990-01-12 1996-04-02 The Ohio State University Research Foundation Optically pure 4-aryl-2-hydroxytetronic acids
WO1997026241A1 (en) * 1996-01-16 1997-07-24 Sk Corporation Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
WO2001040168A1 (en) * 1999-11-29 2001-06-07 Mitsubishi Rayon Co., Ltd. Acetalsulfonate derivative, process for producing the same, and process for producing styrene oxide derivative

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5671M (https=) * 1965-04-23 1968-01-02
JP3010497B2 (ja) * 1990-05-31 2000-02-21 チッソ株式会社 光学活性α―ヒドロキシエステル類の製造方法
US5831133A (en) 1994-10-19 1998-11-03 Firmenich Sa Process for the preparation of alcohols

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5504108A (en) * 1990-01-12 1996-04-02 The Ohio State University Research Foundation Optically pure 4-aryl-2-hydroxytetronic acids
WO1997026241A1 (en) * 1996-01-16 1997-07-24 Sk Corporation Halogen substituted carbamate compounds from 2-phenyl-1,2-ethanediol
WO2001040168A1 (en) * 1999-11-29 2001-06-07 Mitsubishi Rayon Co., Ltd. Acetalsulfonate derivative, process for producing the same, and process for producing styrene oxide derivative

Also Published As

Publication number Publication date
EP2248799B1 (en) 2015-05-20
MXPA04006135A (es) 2004-11-01
EP2248799A1 (en) 2010-11-10
TWI333944B (en) 2010-12-01
MY142415A (en) 2010-11-30
EE05381B1 (et) 2011-02-15
BG108759A (bg) 2005-03-31
EE200400098A (et) 2004-10-15
AU2002358806B2 (en) 2009-09-10
HUP0402491A2 (hu) 2005-04-28
CA2471485A1 (en) 2003-07-03
EP1461309A1 (en) 2004-09-29
CN1620425A (zh) 2005-05-25
NO20043105L (no) 2004-07-20
AR038055A1 (es) 2004-12-22
IL162405A (en) 2011-08-31
IL213960A0 (en) 2011-08-31
IL162405A0 (en) 2005-11-20
JP4610899B2 (ja) 2011-01-12
NZ533592A (en) 2006-05-26
AU2009212987A1 (en) 2009-10-01
WO2003053916A1 (en) 2003-07-03
CA2681964A1 (en) 2003-07-03
SK2572004A3 (sk) 2005-02-04
HRP20040557A2 (en) 2005-04-30
BR0215237A (pt) 2004-11-16
CA2471485C (en) 2011-05-24
PL370977A1 (en) 2005-06-13
KR20090097966A (ko) 2009-09-16
JP2005513126A (ja) 2005-05-12
TW200405809A (en) 2004-04-16
AU2011201613A1 (en) 2011-04-28
CZ2004718A3 (cs) 2004-12-15
AU2002358806A1 (en) 2003-07-09

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C06 Publication
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SE01 Entry into force of request for substantive examination
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GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20180111

Address after: 110-110, South Korea's bell Road District 99 cave

Patentee after: SK BIOPHARMACEUTICALS Co.,Ltd.

Address before: New jersey, USA

Patentee before: ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, Inc.

Effective date of registration: 20180111

Address after: New jersey, USA

Patentee after: ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, Inc.

Address before: New jersey, USA

Patentee before: ORTHO-MCNEIL PHARMACEUTICAL, Inc.

TR01 Transfer of patent right
CX01 Expiry of patent term

Granted publication date: 20090204

CX01 Expiry of patent term