CN100455574C - 噻唑啉酸衍生物 - Google Patents

噻唑啉酸衍生物 Download PDF

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Publication number
CN100455574C
CN100455574C CNB998099899A CN99809989A CN100455574C CN 100455574 C CN100455574 C CN 100455574C CN B998099899 A CNB998099899 A CN B998099899A CN 99809989 A CN99809989 A CN 99809989A CN 100455574 C CN100455574 C CN 100455574C
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CN
China
Prior art keywords
carbon atoms
compound
iron
alkyl group
compound according
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Expired - Fee Related
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CNB998099899A
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English (en)
Chinese (zh)
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CN1313856A (zh
Inventor
小雷蒙德·J·伯杰恩
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University of Florida Research Foundation Inc
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University of Florida Research Foundation Inc
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Publication of CN1313856A publication Critical patent/CN1313856A/zh
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Game Rules And Presentations Of Slot Machines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
CNB998099899A 1998-08-31 1999-08-31 噻唑啉酸衍生物 Expired - Fee Related CN100455574C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/144,103 US6083966A (en) 1998-08-31 1998-08-31 Thiazoline acid derivatives
US09/144,103 1998-08-31

Publications (2)

Publication Number Publication Date
CN1313856A CN1313856A (zh) 2001-09-19
CN100455574C true CN100455574C (zh) 2009-01-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998099899A Expired - Fee Related CN100455574C (zh) 1998-08-31 1999-08-31 噻唑啉酸衍生物

Country Status (23)

Country Link
US (9) US6083966A (https=)
EP (1) EP1109795B1 (https=)
JP (3) JP4817498B2 (https=)
KR (1) KR20010074907A (https=)
CN (1) CN100455574C (https=)
AT (1) ATE317392T1 (https=)
AU (1) AU759851B2 (https=)
BR (1) BR9913441B1 (https=)
CA (1) CA2342210C (https=)
CZ (1) CZ2001711A3 (https=)
DE (1) DE69929807T2 (https=)
EA (1) EA200100261A1 (https=)
ES (1) ES2260933T3 (https=)
HU (1) HUP0103165A3 (https=)
IL (2) IL141611A0 (https=)
NO (1) NO321028B1 (https=)
NZ (1) NZ509899A (https=)
PL (1) PL346852A1 (https=)
PT (1) PT1109795E (https=)
TR (1) TR200100541T2 (https=)
UA (1) UA57161C2 (https=)
WO (1) WO2000012493A1 (https=)
YU (1) YU21801A (https=)

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* Cited by examiner, † Cited by third party
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US6083966A (en) * 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
EP1488791A3 (en) * 1998-09-21 2005-04-06 University Of Florida Research Foundation, Inc. Antimalarial agents
CN1585639A (zh) * 1998-09-21 2005-02-23 佛罗里达大学研究基金会 抗疟疾制剂
US6806363B1 (en) * 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
WO2001028595A1 (en) 1999-10-15 2001-04-26 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
US6689788B1 (en) * 2000-08-25 2004-02-10 University Of Florida Method and composition for treatment of inflammatory bowel disease
CA2427146A1 (en) * 2000-10-25 2002-07-18 Mayo Foundation For Medical Education And Research Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
US7038073B2 (en) * 2002-05-15 2006-05-02 Genzyme Corporation Synthesis of 2-alkyl amino acids
US20040044220A1 (en) * 2002-08-22 2004-03-04 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
US20040132789A1 (en) * 2002-08-22 2004-07-08 University Of Florida Antioxidant and radical scavenging activity of synthetic analogs of desferrithiocin
JPWO2004031163A1 (ja) * 2002-10-01 2006-02-02 株式会社カネカ 光学活性α−置換システインまたはその塩の製造方法並びにその合成中間体及びその製造方法
US20040185028A1 (en) * 2003-03-19 2004-09-23 Zhenze Hu Antimicrobial compositions containing ethanolamine buffer and biguanide disinfectant
WO2005034949A1 (en) * 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
JP2007505044A (ja) * 2003-09-09 2007-03-08 ユニバーシティ オブ フロリダ リサーチ ファウンデイション、インコーポレイテッド ポリアミン−金属キレーター接合体
WO2005055931A2 (en) * 2003-12-03 2005-06-23 University Of Medicine And Dentistry Of New Jersey Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses
WO2005075475A1 (ja) * 2004-02-04 2005-08-18 Shionogi & Co., Ltd. Ｈｉｖインテグラーゼ阻害活性を有するナフチリジン誘導体
TR201910900T4 (tr) * 2005-04-04 2019-08-21 Univ Florida Desferritiyokin polieter analogları.
US7365371B2 (en) 2005-08-04 2008-04-29 Cree, Inc. Packages for semiconductor light emitting devices utilizing dispensed encapsulants
EP2101764A4 (en) * 2006-12-12 2010-02-17 Univ Florida ACTINIDE DECORATION AGENT WITH DESFERRITHIOCIN ANALOGON
WO2008115433A1 (en) * 2007-03-15 2008-09-25 University Of Florida Desferrithiocin polyether analogues
MY163516A (en) * 2008-07-14 2017-09-15 Ferrokin Biosciences Inc Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
EP2566854A4 (en) 2010-05-04 2013-11-06 Shire Llc DESAZADESFERROTHIOCIN AND DEAZADESFERROTHIOCIN POLYETHER ANALOGS AS METAL CHELATORS
CN103562379A (zh) * 2011-05-19 2014-02-05 国立大学法人德岛大学 细胞分化诱导剂以及分化诱导方法
EP3620161A1 (en) 2011-12-16 2020-03-11 University of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
JP6353751B2 (ja) * 2013-09-25 2018-07-04 国立大学法人電気通信大学 新規複素環式化合物及びその塩、並びに、発光基質組成物
AU2014352780A1 (en) * 2013-11-22 2016-06-09 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
KR20170140306A (ko) 2015-04-27 2017-12-20 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도

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WO1994011367A1 (en) * 1992-11-16 1994-05-26 University Of Florida Research Foundation Inc. 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives

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JP2007505044A (ja) 2003-09-09 2007-03-08 ユニバーシティ オブ フロリダ リサーチ ファウンデイション、インコーポレイテッド ポリアミン−金属キレーター接合体
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TR201910900T4 (tr) 2005-04-04 2019-08-21 Univ Florida Desferritiyokin polieter analogları.
EP2101764A4 (en) * 2006-12-12 2010-02-17 Univ Florida ACTINIDE DECORATION AGENT WITH DESFERRITHIOCIN ANALOGON
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WO1994011367A1 (en) * 1992-11-16 1994-05-26 University Of Florida Research Foundation Inc. 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives

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Publication number Publication date
WO2000012493A9 (en) 2002-04-11
HK1035720A1 (en) 2003-04-24
US6083966A (en) 2000-07-04
JP5520875B2 (ja) 2014-06-11
CN1313856A (zh) 2001-09-19
US20030236417A1 (en) 2003-12-25
EP1109795A4 (en) 2002-01-16
CZ2001711A3 (cs) 2001-09-12
US7531563B2 (en) 2009-05-12
YU21801A (sh) 2005-07-19
JP4817498B2 (ja) 2011-11-16
US6525080B1 (en) 2003-02-25
US20050033057A1 (en) 2005-02-10
EP1109795A1 (en) 2001-06-27
WO2000012493A1 (en) 2000-03-09
CA2342210A1 (en) 2000-03-09
CA2342210C (en) 2009-03-10
HUP0103165A2 (hu) 2002-01-28
NO321028B1 (no) 2006-02-27
AU759851B2 (en) 2003-05-01
HUP0103165A3 (en) 2003-03-28
NZ509899A (en) 2003-12-19
ES2260933T3 (es) 2006-11-01
JP2002523500A (ja) 2002-07-30
IL141611A0 (en) 2002-03-10
NO20011003L (no) 2001-02-27
TR200100541T2 (tr) 2001-11-21
IL141611A (en) 2006-12-31
USRE39132E1 (en) 2006-06-13
BR9913441A (pt) 2001-10-23
US6521652B1 (en) 2003-02-18
PL346852A1 (en) 2002-03-11
KR20010074907A (ko) 2001-08-09
US20070238767A1 (en) 2007-10-11
NO20011003D0 (no) 2001-02-27
US7126004B2 (en) 2006-10-24
DE69929807D1 (de) 2006-04-20
US20100094016A1 (en) 2010-04-15
AU5789799A (en) 2000-03-21
DE69929807T2 (de) 2006-11-02
JP2014065730A (ja) 2014-04-17
EA200100261A1 (ru) 2001-10-22
BR9913441B1 (pt) 2013-10-29
EP1109795B1 (en) 2006-02-08
JP2011178797A (ja) 2011-09-15
US6559315B1 (en) 2003-05-06
US8008502B2 (en) 2011-08-30
ATE317392T1 (de) 2006-02-15
UA57161C2 (uk) 2003-06-16
PT1109795E (pt) 2006-06-30

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