CN100430380C - 用作放射指示剂和显象剂的吡啶基乙炔类化合物 - Google Patents

用作放射指示剂和显象剂的吡啶基乙炔类化合物 Download PDF

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Publication number
CN100430380C
CN100430380C CNB2004800273094A CN200480027309A CN100430380C CN 100430380 C CN100430380 C CN 100430380C CN B2004800273094 A CNB2004800273094 A CN B2004800273094A CN 200480027309 A CN200480027309 A CN 200480027309A CN 100430380 C CN100430380 C CN 100430380C
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CN
China
Prior art keywords
formula
compound
methyl
acid addition
cyclohex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB2004800273094A
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English (en)
Chinese (zh)
Other versions
CN1856468A (zh
Inventor
F·加斯帕里尼
Y·奥贝松
L·凯斯勒
S·M·阿梅塔梅
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Novartis AG
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Novartis AG
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Publication date
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Publication of CN1856468A publication Critical patent/CN1856468A/zh
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Publication of CN100430380C publication Critical patent/CN100430380C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB2004800273094A 2003-09-26 2004-09-24 用作放射指示剂和显象剂的吡啶基乙炔类化合物 Expired - Fee Related CN100430380C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0322612.3 2003-09-26
GBGB0322612.3A GB0322612D0 (en) 2003-09-26 2003-09-26 Organic compounds

Publications (2)

Publication Number Publication Date
CN1856468A CN1856468A (zh) 2006-11-01
CN100430380C true CN100430380C (zh) 2008-11-05

Family

ID=29286926

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800273094A Expired - Fee Related CN100430380C (zh) 2003-09-26 2004-09-24 用作放射指示剂和显象剂的吡啶基乙炔类化合物

Country Status (13)

Country Link
US (2) US8674110B2 (https=)
EP (1) EP1670762B1 (https=)
JP (1) JP4965255B2 (https=)
CN (1) CN100430380C (https=)
AU (2) AU2004275971B2 (https=)
BR (1) BRPI0414732A (https=)
CA (1) CA2539469C (https=)
ES (1) ES2400713T3 (https=)
GB (1) GB0322612D0 (https=)
MX (1) MXPA06003424A (https=)
PL (1) PL1670762T3 (https=)
PT (1) PT1670762E (https=)
WO (1) WO2005030723A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
US8349852B2 (en) 2009-01-13 2013-01-08 Novartis Ag Quinazolinone derivatives useful as vanilloid antagonists
WO2011092290A1 (en) 2010-02-01 2011-08-04 Novartis Ag Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists
AR080056A1 (es) 2010-02-01 2012-03-07 Novartis Ag Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531490B1 (en) 2010-02-02 2014-10-15 Novartis AG Cyclohexyl amide derivatives as crf receptor antagonists
EA023020B1 (ru) * 2010-07-09 2016-04-29 Рекордати Айерленд Лимитед Спирогетероциклические соединения и их применение в качестве антагонистов mglu5
AR086554A1 (es) 2011-05-27 2014-01-08 Novartis Ag Derivados de la piperidina 3-espirociclica como agonistas de receptores de la ghrelina
JP2015525202A (ja) 2012-05-03 2015-09-03 ノバルティス アーゲー グレリン受容体アゴニストとしての２，７−ジアザ−スピロ［４，５］デカ−７−イル誘導体のｌ−リンゴ酸塩およびその結晶形態

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016121A1 (en) * 1999-08-31 2001-03-08 Merck & Co., Inc. Heterocyclic compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6843979B2 (en) 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
EP1048302A3 (en) 1999-04-30 2002-07-17 Pfizer Products Inc. Radiotracers for in vivo study of acetylcholinesterase and Alzheimer's disease
WO2001001621A2 (en) * 1999-06-30 2001-01-04 Sun Microsystems, Inc. Customizing web content based on network conditions
GB0103045D0 (en) * 2001-02-07 2001-03-21 Novartis Ag Organic Compounds
JP4070431B2 (ja) 2001-07-10 2008-04-02 ジーイー・ヘルスケア・リミテッド モノアミン再取込み部位のマッピング用ヨウ素付加神経プローブ
WO2004038374A2 (en) 2002-10-24 2004-05-06 Merck & Co., Inc. Alkyne derivatives as tracers for metabotropic glutamate receptor binding

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016121A1 (en) * 1999-08-31 2001-03-08 Merck & Co., Inc. Heterocyclic compounds and methods of use thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
[3H] -M-MPEP,a Potent Subtype-Selective .... GASPARINI,F.等.BIOORG. MED. CHEM. LETT.,Vol.12 . 2002 *

Also Published As

Publication number Publication date
AU2004275971B2 (en) 2008-10-02
MXPA06003424A (es) 2006-06-20
CA2539469A1 (en) 2005-04-07
AU2008261192B2 (en) 2011-08-04
BRPI0414732A (pt) 2006-11-21
PL1670762T3 (pl) 2013-05-31
AU2008261192A1 (en) 2009-01-22
ES2400713T3 (es) 2013-04-11
CN1856468A (zh) 2006-11-01
EP1670762B1 (en) 2012-12-05
US20140142318A1 (en) 2014-05-22
JP2007506698A (ja) 2007-03-22
JP4965255B2 (ja) 2012-07-04
CA2539469C (en) 2012-06-19
WO2005030723A1 (en) 2005-04-07
EP1670762A1 (en) 2006-06-21
US8674110B2 (en) 2014-03-18
PT1670762E (pt) 2013-02-07
AU2004275971A1 (en) 2005-04-07
US20090010838A1 (en) 2009-01-08
GB0322612D0 (en) 2003-10-29

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Owner name: NOVARTIS CO., LTD.

Free format text: FORMER NAME: NOVARTIS AG

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Granted publication date: 20081105

Termination date: 20140924

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