CN100415234C - 生物利用度提高的抗真菌组合物 - Google Patents

生物利用度提高的抗真菌组合物 Download PDF

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Publication number
CN100415234C
CN100415234C CNB028077407A CN02807740A CN100415234C CN 100415234 C CN100415234 C CN 100415234C CN B028077407 A CNB028077407 A CN B028077407A CN 02807740 A CN02807740 A CN 02807740A CN 100415234 C CN100415234 C CN 100415234C
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CN
China
Prior art keywords
liquid suspension
liquid
sorbitan
suspension
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB028077407A
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English (en)
Chinese (zh)
Other versions
CN1499930A (zh
Inventor
S·夏普
J·塞奎拉
D·哈里斯
S·马哈沙布德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Publication date
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Application filed by Schering Corp filed Critical Schering Corp
Publication of CN1499930A publication Critical patent/CN1499930A/zh
Application granted granted Critical
Publication of CN100415234C publication Critical patent/CN100415234C/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB028077407A 2001-04-03 2002-04-01 生物利用度提高的抗真菌组合物 Expired - Lifetime CN100415234C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28113901P 2001-04-03 2001-04-03
US60/281,139 2001-04-03

Publications (2)

Publication Number Publication Date
CN1499930A CN1499930A (zh) 2004-05-26
CN100415234C true CN100415234C (zh) 2008-09-03

Family

ID=23076102

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028077407A Expired - Lifetime CN100415234C (zh) 2001-04-03 2002-04-01 生物利用度提高的抗真菌组合物

Country Status (18)

Country Link
US (2) US20030055067A1 (https=)
EP (2) EP1372394A1 (https=)
JP (2) JP4308902B2 (https=)
KR (1) KR100607742B1 (https=)
CN (1) CN100415234C (https=)
AR (1) AR033096A1 (https=)
AU (1) AU2002257104B2 (https=)
BR (1) BR0208626A (https=)
CA (1) CA2443089C (https=)
HU (1) HUP0400856A3 (https=)
MX (1) MXPA03009021A (https=)
NO (1) NO20034419L (https=)
NZ (1) NZ528363A (https=)
PE (1) PE20020994A1 (https=)
PL (1) PL212985B1 (https=)
TW (1) TWI311464B (https=)
WO (1) WO2002080678A1 (https=)
ZA (1) ZA200307684B (https=)

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US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US20030072807A1 (en) * 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
JP2005504090A (ja) 2001-09-26 2005-02-10 バクスター・インターナショナル・インコーポレイテッド 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製
US20060160823A1 (en) * 2004-05-28 2006-07-20 Leonore Witchey-Lakshmanan Particulate-stabilized injectable pharmaceutical compositions of Posaconazole
TWI290051B (en) * 2004-05-28 2007-11-21 Schering Corp Particulate-stabilized injectable pharmaceutical compositions of Posaconazole
US20060009469A1 (en) * 2004-05-28 2006-01-12 Leonore Witchey-Lakshmanan Particulate-stabilized injectable pharmacutical compositions of posaconazole
US7473684B2 (en) * 2005-09-16 2009-01-06 Selamine Limited Bisphosphonate formulation
JP2009538927A (ja) 2006-05-30 2009-11-12 エラン ファーマ インターナショナル，リミティド ナノ粒子状のポサコナゾール製剤
WO2007144362A1 (en) 2006-06-14 2007-12-21 Intervet International B.V. A suspension comprising benzimidazole carbamate and a polysorbate
GB0624087D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril combination salt
GB0624084D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amino acid salts
GB0624090D0 (en) * 2006-12-01 2007-01-10 Selamine Ltd Ramipril amine salts
FR2910323A1 (fr) * 2006-12-26 2008-06-27 Virbac Sa Sa Composition liquide anhydre destinee a etre incorporee a l'eau de boisson des animaux d'elevage.
DE102008004893A1 (de) 2008-01-17 2009-07-23 Add Technologies Ltd. Trägerpellets, Verfahren zu deren Herstellung und deren Verwendung
CN104983701A (zh) * 2008-04-15 2015-10-21 默沙东公司 优选含有泊沙康唑和hpmcas的固体分散体形式的口服药物组合物
JP2011516613A (ja) * 2008-04-15 2011-05-26 シェーリング コーポレイション 好ましくはポサコナゾールおよびｈｐｍｃａｓを含む固体分散物中の経口用薬学的組成物
EP2130540A1 (en) * 2008-06-02 2009-12-09 Sandoz AG Pharmaceutical compositions containing a crystalline form of posaconazole
EP2141159A1 (en) 2008-07-03 2010-01-06 Sandoz AG A Crystalline form of posaconazole
WO2011003992A1 (en) 2009-07-09 2011-01-13 Sandoz Ag A crystalline form of posaconazole
CN102906087B (zh) 2010-05-19 2016-03-23 桑多斯股份公司 制备手性三唑酮的方法
AU2011254657B2 (en) 2010-05-19 2016-02-04 Sandoz Ag Preparation of posaconazole intermediates
EP2571847B1 (en) 2010-05-19 2016-09-21 Sandoz AG Process for the preparation of chiral hydrazides
JP5955837B2 (ja) 2010-05-19 2016-07-20 サンド・アクチエンゲゼルシヤフト ポサコナゾール及びポサコナゾール中間体の精製
CA2838051C (en) 2011-06-16 2019-09-24 Sandoz Ag Process for the preparation of a chiral compound
US20150164890A1 (en) 2012-06-14 2015-06-18 Sandoz Ag Pharmaceutical compositions comprising crystalline posaconazole
EP3227277B1 (en) 2014-12-05 2020-02-05 Pulmocide Limited Antimycotic compound
KR102653821B1 (ko) 2015-05-21 2024-04-02 풀모사이드 리미티드 항진균성 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-트리아졸-1-일)메틸)-5-(2,4-디플루오로페닐)테트라하이드로푸란-3-일)메톡시)-3-메틸페닐)피페라진-1-일)-n-(2-하이드록시사이클로헥실)벤즈아미드 또는 이의 약학적으로 허용가능한 염.
CN105030668B (zh) * 2015-06-26 2018-03-27 济川药业集团有限公司 泊沙康唑口服混悬剂及其制备方法
CN106333925B (zh) * 2015-07-10 2019-06-18 上海美悦生物科技发展有限公司 一种泊沙康唑液体混悬剂及其制备方法
KR102240920B1 (ko) * 2015-12-30 2021-04-16 브이피에스-3, 엘엘씨 금속 효소 억제 화합물
CN106389390A (zh) * 2016-06-30 2017-02-15 重庆华邦制药有限公司 泊沙康唑涂膜剂及其制备方法
CN107625729A (zh) * 2017-09-29 2018-01-26 重庆华邦制药有限公司 泊沙康唑口服混悬液及其制备方法
CN110507609B (zh) * 2018-05-21 2021-09-17 上海医药工业研究院 泊沙康唑口服混悬剂的制备方法
GB201917867D0 (en) 2019-12-06 2020-01-22 Pulmocide Ltd Polymorphs
IL298010A (en) * 2020-05-12 2023-01-01 Cellix Bio Private Ltd A process for preparing salts of triazole compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0499299A2 (en) * 1991-01-25 1992-08-19 NanoSystems L.L.C. Surface modified drug nanoparticles
WO1995017407A1 (en) * 1993-12-21 1995-06-29 Schering Corporation Tetrahydrofuran antifungals
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability

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US4533254A (en) 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US4788220A (en) * 1987-07-08 1988-11-29 American Home Products Corporation (Del.) Pediatric ibuprofen compositions
NZ234143A (en) * 1989-06-28 1991-10-25 Mcneil Ppc Inc Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents
US5552160A (en) 1991-01-25 1996-09-03 Nanosystems L.L.C. Surface modified NSAID nanoparticles
US5399363A (en) 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
AU642066B2 (en) 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
US5661151A (en) 1993-12-21 1997-08-26 Schering Corporation Tetrahydrofuran antifungals
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
US5580579A (en) * 1995-02-15 1996-12-03 Nano Systems L.L.C. Site-specific adhesion within the GI tract using nanoparticles stabilized by high molecular weight, linear poly (ethylene oxide) polymers
AU7587496A (en) * 1995-11-20 1997-06-11 Banyu Pharmaceutical Co., Ltd. Antifungal composition
US5846971A (en) 1996-06-28 1998-12-08 Schering Corporation Oral antifungal composition
EP0995435B1 (en) * 1997-05-14 2007-04-25 Senju Pharmaceutical Co., Ltd. Aqueous suspension preparations with excellent redispersibility
HK1039458B (zh) 1998-05-29 2006-09-01 Skyepharma Canada Inc. 熱保護微粒組合物及其最終蒸汽滅菌的方法
US20050048126A1 (en) * 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0499299A2 (en) * 1991-01-25 1992-08-19 NanoSystems L.L.C. Surface modified drug nanoparticles
WO1995017407A1 (en) * 1993-12-21 1995-06-29 Schering Corporation Tetrahydrofuran antifungals
US5834472A (en) * 1996-05-24 1998-11-10 Schering Corporation Antifungal composition with enhanced bioavailability

Also Published As

Publication number Publication date
EP2090165A2 (en) 2009-08-19
CA2443089A1 (en) 2002-10-17
NO20034419L (no) 2003-12-02
JP2008120836A (ja) 2008-05-29
EP1372394A1 (en) 2004-01-02
EP2090165A3 (en) 2012-03-28
KR20030087052A (ko) 2003-11-12
AU2002257104B2 (en) 2006-02-09
BR0208626A (pt) 2004-03-09
CA2443089C (en) 2011-11-01
US8263600B2 (en) 2012-09-11
KR100607742B1 (ko) 2006-08-01
AR033096A1 (es) 2003-12-03
MXPA03009021A (es) 2004-02-12
ZA200307684B (en) 2005-03-30
PE20020994A1 (es) 2002-11-01
HUP0400856A3 (en) 2012-09-28
PL363965A1 (en) 2004-11-29
CN1499930A (zh) 2004-05-26
HUP0400856A2 (hu) 2004-08-30
JP4308902B2 (ja) 2009-08-05
US20030055067A1 (en) 2003-03-20
US20110244004A1 (en) 2011-10-06
WO2002080678A1 (en) 2002-10-17
NO20034419D0 (no) 2003-10-02
TWI311464B (en) 2009-07-01
NZ528363A (en) 2005-04-29
PL212985B1 (pl) 2012-12-31
JP2004527525A (ja) 2004-09-09

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C56 Change in the name or address of the patentee

Owner name: MSD CORP.

Free format text: FORMER NAME: SCHERING CORP (US)

CP03 Change of name, title or address

Address after: new jersey

Patentee after: Schering Corporation

Address before: New Jersey Kai Neal Hill Ping Road No. 2000 at Angelo

Patentee before: SCHERING CORP (US)

CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20080903