CN100413862C - 取代的噻唑-苯并异噻唑二氧化物衍生物、其制备方法和其用途 - Google Patents

取代的噻唑-苯并异噻唑二氧化物衍生物、其制备方法和其用途 Download PDF

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Publication number
CN100413862C
CN100413862C CNB2004800220877A CN200480022087A CN100413862C CN 100413862 C CN100413862 C CN 100413862C CN B2004800220877 A CNB2004800220877 A CN B2004800220877A CN 200480022087 A CN200480022087 A CN 200480022087A CN 100413862 C CN100413862 C CN 100413862C
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China
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alkyl
aryl
heterocycle
coo
alkylene
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Expired - Fee Related
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CNB2004800220877A
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English (en)
Chinese (zh)
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CN1829715A (zh
Inventor
S·佩特里
K-H·巴林豪斯
N·特纳格尔斯
G·米勒
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Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CNB2004800220877A 2003-07-28 2004-07-15 取代的噻唑-苯并异噻唑二氧化物衍生物、其制备方法和其用途 Expired - Fee Related CN100413862C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10334309A DE10334309A1 (de) 2003-07-28 2003-07-28 Substituierte Thiazol-Benzoisothiazoldioxidderivate, Verfahren zu deren Herstellung und deren Verwendung
DE10334309.1 2003-07-28

Publications (2)

Publication Number Publication Date
CN1829715A CN1829715A (zh) 2006-09-06
CN100413862C true CN100413862C (zh) 2008-08-27

Family

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CNB2004800220877A Expired - Fee Related CN100413862C (zh) 2003-07-28 2004-07-15 取代的噻唑-苯并异噻唑二氧化物衍生物、其制备方法和其用途

Country Status (37)

Country Link
EP (1) EP1651644B1 (enExample)
JP (1) JP2007500145A (enExample)
KR (1) KR20060052886A (enExample)
CN (1) CN100413862C (enExample)
AR (1) AR045113A1 (enExample)
AT (1) ATE346065T1 (enExample)
AU (1) AU2004261370B2 (enExample)
BR (1) BRPI0412997A (enExample)
CA (1) CA2533673A1 (enExample)
CR (1) CR8202A (enExample)
CY (1) CY1105962T1 (enExample)
DE (2) DE10334309A1 (enExample)
DK (1) DK1651644T3 (enExample)
EC (1) ECSP066326A (enExample)
ES (1) ES2276319T3 (enExample)
GT (1) GT200400146A (enExample)
IL (1) IL173289A0 (enExample)
JO (1) JO2449B1 (enExample)
MA (1) MA27932A1 (enExample)
MY (1) MY141197A (enExample)
NO (1) NO20060908L (enExample)
NZ (1) NZ544975A (enExample)
OA (1) OA13198A (enExample)
PA (1) PA8607201A1 (enExample)
PE (1) PE20050326A1 (enExample)
PL (1) PL1651644T3 (enExample)
PT (1) PT1651644E (enExample)
RS (1) RS20060015A (enExample)
RU (1) RU2350613C2 (enExample)
SA (1) SA04250332B1 (enExample)
SI (1) SI1651644T1 (enExample)
TN (1) TNSN06030A1 (enExample)
TW (1) TW200524923A (enExample)
UA (1) UA83057C2 (enExample)
UY (1) UY28443A1 (enExample)
WO (1) WO2005012295A1 (enExample)
ZA (1) ZA200510378B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004026532A1 (de) * 2004-05-29 2006-01-05 Sanofi-Aventis Deutschland Gmbh Substituierte Oxazol-Benzoisothiazoldioxidderivate, Verfahren zu deren Herstellung und deren Verwendung
CN101415683B (zh) 2006-03-31 2013-07-17 诺瓦提斯公司 新化合物
AU2007283113A1 (en) 2006-08-08 2008-02-14 Sanofi-Aventis Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US8470841B2 (en) 2008-07-09 2013-06-25 Sanofi Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
JP2013503135A (ja) 2009-08-26 2013-01-31 サノフイ 新規な結晶性複素芳香族フルオログリコシド水和物、その化合物を含んでなる医薬及びその使用
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2683703B1 (de) 2011-03-08 2015-05-27 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683698B1 (de) 2011-03-08 2017-10-04 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2025017207A1 (en) * 2023-07-20 2025-01-23 Cemm - Forschungszentrum Für Molekulare Medizin Gmbh Inhibitors of smndc1 and their therapeutic use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539584A (en) * 1967-11-14 1970-11-10 Colgate Palmolive Co 5-substituted-2,1-benzisothiazolines
WO2000076501A1 (en) * 1999-06-16 2000-12-21 Smithkline Beecham Corporation Il-8 receptor antagonists
WO2002011722A1 (de) * 2000-08-09 2002-02-14 Aventis Pharma Deutschland Gmbh Substituierte und unsubstituierte benzooxathiazole sowie daraus abgeleitete verbindungen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04128276A (ja) * 1990-09-19 1992-04-28 Pfizer Pharmaceut Co Ltd アミノベンゾサルタム誘導体およびその用途
RU2164226C2 (ru) * 1995-06-02 2001-03-20 Санофи-Синтелябо Производные 5-(гидроксиметил)-оксазолидин-2-она, способы их получения, лекарство и фармацевтический состав

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539584A (en) * 1967-11-14 1970-11-10 Colgate Palmolive Co 5-substituted-2,1-benzisothiazolines
WO2000076501A1 (en) * 1999-06-16 2000-12-21 Smithkline Beecham Corporation Il-8 receptor antagonists
WO2002011722A1 (de) * 2000-08-09 2002-02-14 Aventis Pharma Deutschland Gmbh Substituierte und unsubstituierte benzooxathiazole sowie daraus abgeleitete verbindungen
US20020055523A1 (en) * 2000-08-09 2002-05-09 Stefan Petry Substituted and unsubstituted benzooxathiazoles and compounds derived therefrom

Also Published As

Publication number Publication date
AU2004261370A1 (en) 2005-02-10
PL1651644T3 (pl) 2007-03-30
DK1651644T3 (da) 2007-03-26
HK1091825A1 (en) 2007-01-26
RS20060015A (sr) 2007-12-31
PT1651644E (pt) 2007-01-31
EP1651644B1 (de) 2006-11-22
MA27932A1 (fr) 2006-06-01
UA83057C2 (ru) 2008-06-10
IL173289A0 (en) 2006-06-11
SA04250332B1 (ar) 2008-02-25
ATE346065T1 (de) 2006-12-15
DE10334309A1 (de) 2005-03-03
TW200524923A (en) 2005-08-01
NZ544975A (en) 2010-02-26
SI1651644T1 (sl) 2007-02-28
DE502004002117D1 (de) 2007-01-04
CN1829715A (zh) 2006-09-06
WO2005012295A1 (de) 2005-02-10
BRPI0412997A (pt) 2006-10-03
CR8202A (es) 2008-10-15
ZA200510378B (en) 2006-11-29
CA2533673A1 (en) 2005-02-10
NO20060908L (no) 2006-02-24
OA13198A (en) 2006-12-13
PE20050326A1 (es) 2005-06-16
AR045113A1 (es) 2005-10-19
CY1105962T1 (el) 2011-04-06
JP2007500145A (ja) 2007-01-11
JO2449B1 (en) 2008-10-09
RU2350613C2 (ru) 2009-03-27
TNSN06030A1 (en) 2007-10-03
UY28443A1 (es) 2005-02-28
EP1651644A1 (de) 2006-05-03
PA8607201A1 (es) 2005-03-03
KR20060052886A (ko) 2006-05-19
ECSP066326A (es) 2006-07-28
ES2276319T3 (es) 2007-06-16
MY141197A (en) 2010-03-31
AU2004261370B2 (en) 2009-07-16
GT200400146A (es) 2005-08-12
RU2006106231A (ru) 2006-06-27

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