CN100404502C - 通过不对称氧化而对映选择性合成莫达非尼的单一对映异构体的方法 - Google Patents

通过不对称氧化而对映选择性合成莫达非尼的单一对映异构体的方法 Download PDF

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Publication number
CN100404502C
CN100404502C CNB2004800298265A CN200480029826A CN100404502C CN 100404502 C CN100404502 C CN 100404502C CN B2004800298265 A CNB2004800298265 A CN B2004800298265A CN 200480029826 A CN200480029826 A CN 200480029826A CN 100404502 C CN100404502 C CN 100404502C
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China
Prior art keywords
formula
sulfide
enantiomer
chiral ligand
ligand complex
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Expired - Fee Related
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CNB2004800298265A
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English (en)
Chinese (zh)
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CN1867544A (zh
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F·勒彼埃
G·迪雷
L·普拉
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Cephalon France SAS
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Cephalon France SAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
CNB2004800298265A 2003-09-19 2004-09-17 通过不对称氧化而对映选择性合成莫达非尼的单一对映异构体的方法 Expired - Fee Related CN100404502C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03292312.0 2003-09-19
EP03292312A EP1516869A1 (en) 2003-09-19 2003-09-19 Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US60/507,089 2003-10-01

Publications (2)

Publication Number Publication Date
CN1867544A CN1867544A (zh) 2006-11-22
CN100404502C true CN100404502C (zh) 2008-07-23

Family

ID=34178643

Family Applications (1)

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CNB2004800298265A Expired - Fee Related CN100404502C (zh) 2003-09-19 2004-09-17 通过不对称氧化而对映选择性合成莫达非尼的单一对映异构体的方法

Country Status (21)

Country Link
US (2) US7317126B2 (enExample)
EP (2) EP1516869A1 (enExample)
JP (1) JP4713480B2 (enExample)
KR (1) KR101136703B1 (enExample)
CN (1) CN100404502C (enExample)
AT (1) ATE365711T1 (enExample)
AU (1) AU2004274248B2 (enExample)
BR (1) BRPI0414298B1 (enExample)
CA (1) CA2538697C (enExample)
DE (1) DE602004007278T2 (enExample)
DK (1) DK1663963T3 (enExample)
EA (1) EA009385B1 (enExample)
ES (1) ES2289556T3 (enExample)
MX (1) MXPA06002935A (enExample)
NZ (1) NZ545739A (enExample)
PL (1) PL1663963T3 (enExample)
PT (1) PT1663963E (enExample)
SI (1) SI1663963T1 (enExample)
UA (1) UA85196C2 (enExample)
WO (1) WO2005028428A1 (enExample)
ZA (1) ZA200601962B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1702915A1 (en) * 2005-03-14 2006-09-20 Cephalon France Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
CN1321978C (zh) * 2005-04-29 2007-06-20 浙江工业大学 一种2－（二苯基甲基亚硫酰基）乙酰胺的合成方法
WO2007027328A2 (en) * 2005-07-28 2007-03-08 University Of Iowa Research Foundation Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
US20070293702A1 (en) * 2006-02-21 2007-12-20 Viviana Braude Novel crystalline forms of armodafinil and preparation thereof
CA2634133A1 (en) 2006-03-01 2007-09-13 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of armodafinil
WO2008070143A1 (en) * 2006-12-06 2008-06-12 Teva Pharmaceutical Industries Ltd. Processes for preparing armodafinil intermediate
CA2688430A1 (en) * 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
WO2009024863A2 (en) * 2007-06-26 2009-02-26 Actavis Group Ptc Ehf Process for the preparation of modafinil enantiomers
US7960586B2 (en) * 2007-08-16 2011-06-14 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
EP2454242B1 (de) * 2009-07-16 2014-10-15 Bayer CropScience AG Verfahren zur herstellung von chiralen 3-triazolyl-sulfoxid-derivaten
EP2521546A4 (en) * 2010-01-07 2013-06-26 Vivus Inc TREATMENT OF THE OBSTRUCTIVE SLEEP APNEO SYNDROME COMBINED WITH ANTIBODY ANTIBODY AND AN ADDITIONAL ACTIVE SUBSTANCE
RU2448954C1 (ru) * 2010-10-18 2012-04-27 Учреждение Российской академии наук Институт катализа им. Г.К. Борескова Сибирского отделения РАН Способ получения сульфоксидов
WO2012078800A2 (en) 2010-12-08 2012-06-14 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
FR2970711B1 (fr) * 2011-01-20 2016-03-04 Hopitaux Paris Assist Publique La lauflumide et ses enantiomeres, preparation et utilisations therapeutiques
RU2477316C1 (ru) * 2011-12-29 2013-03-10 Учреждение Российской академии наук Институт экологии и генетики микроорганизмов Уральского отделения РАН Биокаталитический способ получения (r)-фенилметилового сульфоксида
CN104447440B (zh) * 2013-09-12 2016-05-18 中国科学院大连化学物理研究所 一种催化不对称氧化硫醚的方法
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
ES2645483T3 (es) 2014-08-13 2017-12-05 Red Bull Gmbh Compuestos heterocíclicos con actividad de mejora de la memoria de trabajo
CA2989243C (en) 2014-08-13 2023-03-14 Red Bull Gmbh Heterocyclic compounds with working memory enhancing activity
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
CN110698482A (zh) * 2019-10-29 2020-01-17 株洲千金药业股份有限公司 一种s型手性亚砜类化合物的制备方法
CN110746428A (zh) * 2019-10-29 2020-02-04 株洲千金药业股份有限公司 一种r型手性亚砜类化合物的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177290A (en) * 1977-03-31 1979-12-04 Laboratoire L. Lafon Acetamide derivatives
EP0233106A1 (fr) * 1986-01-31 1987-08-19 Laboratoire L. Lafon (-)-Benzhydrylsulfinylacétamide, procédé de préparation et utilisation en thérapeutique
WO2002010125A1 (en) * 2000-07-27 2002-02-07 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same
EP1260501A1 (en) * 2001-05-13 2002-11-27 Chemagis Ltd. Process for the preparation of diphenylmethylthioacetamide

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098824A (en) 1975-10-02 1978-07-04 Laboratoire L. Lafon Benzhydrylsulphinyl derivatives
FR2528038B2 (fr) * 1982-06-04 1985-08-09 Lafon Labor Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1437345A1 (en) 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4177290A (en) * 1977-03-31 1979-12-04 Laboratoire L. Lafon Acetamide derivatives
EP0233106A1 (fr) * 1986-01-31 1987-08-19 Laboratoire L. Lafon (-)-Benzhydrylsulfinylacétamide, procédé de préparation et utilisation en thérapeutique
US4927855A (en) * 1986-01-31 1990-05-22 Laboratoire L. Lafon Levorotatory isomer of benzhydrylsulfinyl derivatives
WO2002010125A1 (en) * 2000-07-27 2002-02-07 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same
EP1260501A1 (en) * 2001-05-13 2002-11-27 Chemagis Ltd. Process for the preparation of diphenylmethylthioacetamide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
. S.H.ZHAO ET AL.Organic syntheses,Vol.VIII . 1993 *

Also Published As

Publication number Publication date
US7812193B2 (en) 2010-10-12
SI1663963T1 (sl) 2007-12-31
BRPI0414298A (pt) 2006-11-14
MXPA06002935A (es) 2006-06-14
EA200600593A1 (ru) 2006-08-25
CA2538697C (en) 2012-11-13
CA2538697A1 (en) 2005-03-31
ZA200601962B (en) 2007-06-27
NZ545739A (en) 2010-01-29
KR101136703B1 (ko) 2012-05-24
ES2289556T3 (es) 2008-02-01
US20050080256A1 (en) 2005-04-14
ATE365711T1 (de) 2007-07-15
EP1516869A1 (en) 2005-03-23
US20080171896A1 (en) 2008-07-17
PL1663963T3 (pl) 2007-11-30
WO2005028428A1 (en) 2005-03-31
EP1663963A1 (en) 2006-06-07
EA009385B1 (ru) 2007-12-28
BRPI0414298B1 (pt) 2021-06-08
CN1867544A (zh) 2006-11-22
DK1663963T3 (da) 2007-10-29
JP2007505891A (ja) 2007-03-15
UA85196C2 (ru) 2009-01-12
PT1663963E (pt) 2007-10-19
DE602004007278T2 (de) 2008-02-28
EP1663963B1 (en) 2007-06-27
KR20070009968A (ko) 2007-01-19
US7317126B2 (en) 2008-01-08
AU2004274248A1 (en) 2005-03-31
DE602004007278D1 (de) 2007-08-09
JP4713480B2 (ja) 2011-06-29
AU2004274248B2 (en) 2010-08-26

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