JP4713480B2 - 不斉酸化によるモダフィニルの単一エナンチオマーのエナンチオ選択的合成方法 - Google Patents

不斉酸化によるモダフィニルの単一エナンチオマーのエナンチオ選択的合成方法 Download PDF

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Publication number
JP4713480B2
JP4713480B2 JP2006526728A JP2006526728A JP4713480B2 JP 4713480 B2 JP4713480 B2 JP 4713480B2 JP 2006526728 A JP2006526728 A JP 2006526728A JP 2006526728 A JP2006526728 A JP 2006526728A JP 4713480 B2 JP4713480 B2 JP 4713480B2
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Japan
Prior art keywords
formula
chiral ligand
sulfide
ligand complex
compound
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Japanese (ja)
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JP2007505891A (ja
JP2007505891A5 (enExample
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ルビエール，フランソワ
デュレ，ジェラール
プラ，ローレンス
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Cephalon France SAS
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Cephalon France SAS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
JP2006526728A 2003-09-19 2004-09-17 不斉酸化によるモダフィニルの単一エナンチオマーのエナンチオ選択的合成方法 Expired - Fee Related JP4713480B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP03292312A EP1516869A1 (en) 2003-09-19 2003-09-19 Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP03292312.0 2003-09-19
US50708903P 2003-10-01 2003-10-01
US60/507,089 2003-10-01
PCT/IB2004/003026 WO2005028428A1 (en) 2003-09-19 2004-09-17 Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

Publications (3)

Publication Number Publication Date
JP2007505891A JP2007505891A (ja) 2007-03-15
JP2007505891A5 JP2007505891A5 (enExample) 2007-11-22
JP4713480B2 true JP4713480B2 (ja) 2011-06-29

Family

ID=34178643

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006526728A Expired - Fee Related JP4713480B2 (ja) 2003-09-19 2004-09-17 不斉酸化によるモダフィニルの単一エナンチオマーのエナンチオ選択的合成方法

Country Status (21)

Country Link
US (2) US7317126B2 (enExample)
EP (2) EP1516869A1 (enExample)
JP (1) JP4713480B2 (enExample)
KR (1) KR101136703B1 (enExample)
CN (1) CN100404502C (enExample)
AT (1) ATE365711T1 (enExample)
AU (1) AU2004274248B2 (enExample)
BR (1) BRPI0414298B1 (enExample)
CA (1) CA2538697C (enExample)
DE (1) DE602004007278T2 (enExample)
DK (1) DK1663963T3 (enExample)
EA (1) EA009385B1 (enExample)
ES (1) ES2289556T3 (enExample)
MX (1) MXPA06002935A (enExample)
NZ (1) NZ545739A (enExample)
PL (1) PL1663963T3 (enExample)
PT (1) PT1663963E (enExample)
SI (1) SI1663963T1 (enExample)
UA (1) UA85196C2 (enExample)
WO (1) WO2005028428A1 (enExample)
ZA (1) ZA200601962B (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
EP1702915A1 (en) * 2005-03-14 2006-09-20 Cephalon France Process for enantioselective synthesis of single enantiomers of thio-substituted arylmethanesulfinyl derivatives by asymmetric oxidation
CN1321978C (zh) * 2005-04-29 2007-06-20 浙江工业大学 一种2－（二苯基甲基亚硫酰基）乙酰胺的合成方法
WO2007027328A2 (en) * 2005-07-28 2007-03-08 University Of Iowa Research Foundation Microbial sulfoxidation and amidation of benzhdrylsulfanyl carboxylic acids and uses thereof
US20070293702A1 (en) * 2006-02-21 2007-12-20 Viviana Braude Novel crystalline forms of armodafinil and preparation thereof
WO2007103221A2 (en) 2006-03-01 2007-09-13 Teva Pharmaceutical Industries Ltd. An improved process for the preparation of armodafinil
WO2008070143A1 (en) * 2006-12-06 2008-06-12 Teva Pharmaceutical Industries Ltd. Processes for preparing armodafinil intermediate
EP2155664A2 (en) * 2007-06-04 2010-02-24 Generics Ýuk¨Limited Novel process
WO2009024863A2 (en) * 2007-06-26 2009-02-26 Actavis Group Ptc Ehf Process for the preparation of modafinil enantiomers
US7960586B2 (en) * 2007-08-16 2011-06-14 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
CN102471290B (zh) * 2009-07-16 2016-02-03 拜耳知识产权有限责任公司 手性3-三唑基亚砜衍生物的制备方法
AU2011203970A1 (en) * 2010-01-07 2012-07-12 Vivus, Inc. Treatment of obstructive sleep apnea syndrome with a combination of a carbonic anhydrase inhibitor and an additional active agent
RU2448954C1 (ru) * 2010-10-18 2012-04-27 Учреждение Российской академии наук Институт катализа им. Г.К. Борескова Сибирского отделения РАН Способ получения сульфоксидов
EP2649187B1 (en) 2010-12-08 2017-11-22 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
FR2970711B1 (fr) * 2011-01-20 2016-03-04 Hopitaux Paris Assist Publique La lauflumide et ses enantiomeres, preparation et utilisations therapeutiques
RU2477316C1 (ru) * 2011-12-29 2013-03-10 Учреждение Российской академии наук Институт экологии и генетики микроорганизмов Уральского отделения РАН Биокаталитический способ получения (r)-фенилметилового сульфоксида
CN104447440B (zh) * 2013-09-12 2016-05-18 中国科学院大连化学物理研究所 一种催化不对称氧化硫醚的方法
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
HUE035104T2 (en) 2014-08-13 2018-05-02 Red Bull Gmbh Heterocyclic compounds with activity memory stimulating activity
CA2989243C (en) 2014-08-13 2023-03-14 Red Bull Gmbh Heterocyclic compounds with working memory enhancing activity
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
CN110698482A (zh) * 2019-10-29 2020-01-17 株洲千金药业股份有限公司 一种s型手性亚砜类化合物的制备方法
CN110746428A (zh) * 2019-10-29 2020-02-04 株洲千金药业股份有限公司 一种r型手性亚砜类化合物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4127722A (en) * 1975-10-02 1978-11-28 Laboratoire L. Lafon Benzhydrylsulphinyl derivatives
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2528038B2 (fr) * 1982-06-04 1985-08-09 Lafon Labor Derives de benzhydrylsulfinylacetamide et leur utilisation en therapeutique
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
CA2634702C (en) * 2000-07-27 2011-07-19 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same
IL143106A (en) * 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
FR2849029B1 (fr) 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
EP1437345A1 (en) 2003-01-13 2004-07-14 Organisation de Synthese Mondiale Orsymonde Novel method for preparing methyl 2-diphenylmethylsulfinylacetate
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation

Also Published As

Publication number Publication date
AU2004274248A1 (en) 2005-03-31
CA2538697A1 (en) 2005-03-31
JP2007505891A (ja) 2007-03-15
ES2289556T3 (es) 2008-02-01
UA85196C2 (ru) 2009-01-12
BRPI0414298A (pt) 2006-11-14
WO2005028428A1 (en) 2005-03-31
EP1663963A1 (en) 2006-06-07
DE602004007278D1 (de) 2007-08-09
SI1663963T1 (sl) 2007-12-31
KR20070009968A (ko) 2007-01-19
BRPI0414298B1 (pt) 2021-06-08
CN1867544A (zh) 2006-11-22
PL1663963T3 (pl) 2007-11-30
ATE365711T1 (de) 2007-07-15
KR101136703B1 (ko) 2012-05-24
AU2004274248B2 (en) 2010-08-26
EP1516869A1 (en) 2005-03-23
DE602004007278T2 (de) 2008-02-28
NZ545739A (en) 2010-01-29
CA2538697C (en) 2012-11-13
US7317126B2 (en) 2008-01-08
DK1663963T3 (da) 2007-10-29
MXPA06002935A (es) 2006-06-14
EA009385B1 (ru) 2007-12-28
EA200600593A1 (ru) 2006-08-25
US20080171896A1 (en) 2008-07-17
EP1663963B1 (en) 2007-06-27
CN100404502C (zh) 2008-07-23
PT1663963E (pt) 2007-10-19
ZA200601962B (en) 2007-06-27
US20050080256A1 (en) 2005-04-14
US7812193B2 (en) 2010-10-12

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