CN100372612C - 用于液体的并联式定量配给的装置 - Google Patents

用于液体的并联式定量配给的装置 Download PDF

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Publication number
CN100372612C
CN100372612C CNB2003101197659A CN200310119765A CN100372612C CN 100372612 C CN100372612 C CN 100372612C CN B2003101197659 A CNB2003101197659 A CN B2003101197659A CN 200310119765 A CN200310119765 A CN 200310119765A CN 100372612 C CN100372612 C CN 100372612C
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CN
China
Prior art keywords
housing
recess
chamber
channel
membrane
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Expired - Lifetime
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CNB2003101197659A
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English (en)
Chinese (zh)
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CN1506670A (zh
Inventor
比吉特·米勒-肖吕斯
拉尔夫-彼得·彼得斯
霍尔格·巴托斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Microparts GmbH
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Boehringer Ingelheim Microparts GmbH
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
    • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
    • B41J2/00—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed
    • B41J2/005—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
    • B41J2/01—Ink jet
    • B41J2/17—Ink jet characterised by ink handling
    • B41J2/175—Ink supply systems ; Circuit parts therefor
    • B41J2/17566—Ink level or ink residue control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1041—Ink-jet like dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1044—Using pneumatic means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1065—Multiple transfer devices
    • G01N35/1072—Multiple transfer devices with provision for selective pipetting of individual channels

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Coating Apparatus (AREA)
  • Particle Formation And Scattering Control In Inkjet Printers (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
CNB2003101197659A 2002-12-06 2003-12-05 用于液体的并联式定量配给的装置 Expired - Lifetime CN100372612C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10257004A DE10257004A1 (de) 2002-12-06 2002-12-06 Vorrichtung zur parallelen Dosierung von Flüssigkeiten
DE10257004.3 2002-12-06

Publications (2)

Publication Number Publication Date
CN1506670A CN1506670A (zh) 2004-06-23
CN100372612C true CN100372612C (zh) 2008-03-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2003101197659A Expired - Lifetime CN100372612C (zh) 2002-12-06 2003-12-05 用于液体的并联式定量配给的装置

Country Status (5)

Country Link
US (1) US7036917B2 (https=)
EP (1) EP1426108B1 (https=)
JP (1) JP4566552B2 (https=)
CN (1) CN100372612C (https=)
DE (1) DE10257004A1 (https=)

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US7148257B2 (en) * 2002-03-04 2006-12-12 Merck Hdac Research, Llc Methods of treating mesothelioma with suberoylanilide hydroxamic acid
DE10357273B4 (de) * 2003-12-05 2006-11-16 Boehringer Ingelheim Microparts Gmbh Entkopplungsmittel
DE102005016509A1 (de) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
US7731907B2 (en) * 2005-04-09 2010-06-08 Boehringer Ingelheim Microparts Gmbh Device and process for testing a sample liquid
DE102005016508A1 (de) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
DE102005042601A1 (de) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
DE102005017653A1 (de) * 2005-04-15 2006-10-19 Boehringer Ingelheim Microparts Gmbh Vorrichtung und Verfahren zur Manipulation einer Flüssigkeit
SG151281A1 (en) * 2005-04-25 2009-04-30 Ulvac Inc Integral printhead assembly
WO2006116574A2 (en) * 2005-04-25 2006-11-02 Litrex Corporation Dynamic printhead alignment assembly
CN101238463B (zh) * 2005-04-25 2013-07-10 株式会社爱发科 可旋转印刷头阵列
CN101400432B (zh) * 2006-03-09 2012-02-15 积水化学工业株式会社 微量流体设备及微量液体稀释方法
CN101225927A (zh) * 2006-12-28 2008-07-23 亚申科技研发中心（上海）有限公司 流体分配装置
US8016260B2 (en) * 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
US8100293B2 (en) * 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
EP3034117B1 (en) * 2009-09-11 2017-11-29 F. Hoffmann-La Roche AG Micro-fluidic chambers for use in liquid medicament delivery systems
WO2011120773A1 (de) * 2010-03-31 2011-10-06 Boehringer Ingelheim Microparts Gmbh Bauteil eines biosensors und verfahren zur herstellung
EP2409765A1 (en) * 2010-07-21 2012-01-25 F. Hoffmann-La Roche AG Microfluidic system and process for mixing liquid fluids
US9081001B2 (en) 2012-05-15 2015-07-14 Wellstat Diagnostics, Llc Diagnostic systems and instruments
US9213043B2 (en) 2012-05-15 2015-12-15 Wellstat Diagnostics, Llc Clinical diagnostic system including instrument and cartridge
US9625465B2 (en) 2012-05-15 2017-04-18 Defined Diagnostics, Llc Clinical diagnostic systems
US11291993B2 (en) * 2017-11-29 2022-04-05 Sekisui Chemical Co., Ltd. Micro-fluid chip
CN109991035B (zh) * 2017-12-29 2021-12-24 台达电子工业股份有限公司 微量取样装置
CN112570050B (zh) * 2019-09-27 2022-07-19 厦门大学 一种流体输运控制系统及方法
DE102020210855A1 (de) * 2020-08-27 2022-03-03 Volkswagen Aktiengesellschaft Verteileinrichtung zur Verteilung von Fluidströmen sowie Verfahren zum Betrieb eines Kraftfahrzeugs mit einem Verbrennungsmotor

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WO2000041550A2 (en) * 1999-01-18 2000-07-20 The Wahoo Trust Apparatus for measuring and delivery of small volumes of fluid
US20010038402A1 (en) * 2000-02-24 2001-11-08 Gokhan Percin Micromachined two-dimensional array droplet ejectors
DE10041536A1 (de) * 2000-08-24 2002-03-07 Roland Zengerle Vorrichtung und Verfahren zum berührungslosen Aufbringen von Mikrotröpfchen auf ein Substrat
DE10102152C1 (de) * 2001-01-18 2002-06-20 Roland Zengerle Vorrichtung und Verfahren zum Dosieren kleiner Flüssigkeitsmengen
US6448090B1 (en) * 1999-07-09 2002-09-10 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using alternating pressure waveforms

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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000041550A2 (en) * 1999-01-18 2000-07-20 The Wahoo Trust Apparatus for measuring and delivery of small volumes of fluid
US6448090B1 (en) * 1999-07-09 2002-09-10 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using alternating pressure waveforms
US20010038402A1 (en) * 2000-02-24 2001-11-08 Gokhan Percin Micromachined two-dimensional array droplet ejectors
DE10041536A1 (de) * 2000-08-24 2002-03-07 Roland Zengerle Vorrichtung und Verfahren zum berührungslosen Aufbringen von Mikrotröpfchen auf ein Substrat
DE10102152C1 (de) * 2001-01-18 2002-06-20 Roland Zengerle Vorrichtung und Verfahren zum Dosieren kleiner Flüssigkeitsmengen

Also Published As

Publication number Publication date
JP2004188416A (ja) 2004-07-08
EP1426108A1 (de) 2004-06-09
US7036917B2 (en) 2006-05-02
CN1506670A (zh) 2004-06-23
US20040183869A1 (en) 2004-09-23
DE10257004A1 (de) 2004-06-17
EP1426108B1 (de) 2018-07-18
JP4566552B2 (ja) 2010-10-20

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