JP7036746B2 - マイクロ流体チップ - Google Patents
マイクロ流体チップ Download PDFInfo
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- JP7036746B2 JP7036746B2 JP2018562697A JP2018562697A JP7036746B2 JP 7036746 B2 JP7036746 B2 JP 7036746B2 JP 2018562697 A JP2018562697 A JP 2018562697A JP 2018562697 A JP2018562697 A JP 2018562697A JP 7036746 B2 JP7036746 B2 JP 7036746B2
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- flow path
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B81—MICROSTRUCTURAL TECHNOLOGY
- B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
- B81B1/00—Devices without movable or flexible elements, e.g. microcapillary devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/14—Process control and prevention of errors
- B01L2200/141—Preventing contamination, tampering
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
Description
2…チップ本体
3…流路構造
4…主流路
4a~4d…内壁
5…流入口
6…流出口
7~9…バルブ
11~13…分岐流路
14,15…副分岐流路
16~18…流路抵抗部
19…接続流路
21,24,27,31,32,41,51…流路構造
22,23,25,26,28,29,42,43…副分岐流路
52~54…バルブ
Claims (8)
- 流体が送液される流路構造を有するマイクロ流体チップであって、
前記流路構造が、流体が流入される流入口と、流体が流出される流出口とを有する主流路と、
前記主流路に接続されており、前記主流路に接続されている側が流入端であり、前記流入端と反対側の端部が流出端である複数の分岐流路と、
前記複数の分岐流路の内、隣り合っている少なくとも一対の分岐流路間において、前記主流路に接続されている副分岐流路とを有し、
前記副分岐流路の前記主流路に接続されている側が流入端であり、
前記副分岐流路は、流出端を有していない、マイクロ流体チップ。 - 2つ以上の分岐流路の流入端が共有している主流路の内壁面に前記副分岐流路の流入端が開口している、請求項1に記載のマイクロ流体チップ。
- 前記主流路の、前記分岐流路及び前記副分岐流路が開口している内壁が、前記分岐流路が延びる方向と直交する方向に位置している内壁である、請求項2に記載のマイクロ流体チップ。
- 前記主流路の横断面が矩形である、請求項3に記載のマイクロ流体チップ。
- 隣り合う分岐流路間の全ての位置に、前記副分岐流路が設けられている、請求項1~4のいずれか1項に記載のマイクロ流体チップ。
- 流体が送液される流路構造を有するマイクロ流体チップであって、
前記流路構造が、流体が流入される流入口と、流体が流出される流出口とを有する主流路と、
前記主流路に接続されており、前記主流路に接続されている側が流入端であり、前記流入端と反対側の端部が流出端である複数の分岐流路と、
前記複数の分岐流路の内、隣り合っている少なくとも一対の分岐流路間において、前記主流路に接続されている副分岐流路とを有し、
前記副分岐流路の前記主流路に接続されている側が流入端であり、
前記副分岐流路の前記主流路に接続されている流入端における流路断面積よりも、流路断面積が大きい部分が前記副分岐流路に設けられている、マイクロ流体チップ。 - 前記複数の分岐流路の前記流出端側に接続されている接続流路をさらに備え、該接続流路が、前記主流路に接続されている、請求項1~6のいずれか1項に記載のマイクロ流体チップ。
- 前記主流路の流入端と前記流出端とに、流体の移動を封止することができる、封止部が設けられている、請求項1~7のいずれか1項に記載のマイクロ流体チップ。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017229079 | 2017-11-29 | ||
JP2017229079 | 2017-11-29 | ||
PCT/JP2018/042916 WO2019107231A1 (ja) | 2017-11-29 | 2018-11-21 | マイクロ流体チップ |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2019107231A1 JPWO2019107231A1 (ja) | 2020-10-08 |
JP7036746B2 true JP7036746B2 (ja) | 2022-03-15 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2018562697A Active JP7036746B2 (ja) | 2017-11-29 | 2018-11-21 | マイクロ流体チップ |
Country Status (5)
Country | Link |
---|---|
US (1) | US11291993B2 (ja) |
EP (1) | EP3718958B1 (ja) |
JP (1) | JP7036746B2 (ja) |
CN (1) | CN110785373B (ja) |
WO (1) | WO2019107231A1 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6339274B1 (ja) * | 2017-06-19 | 2018-06-06 | 積水化学工業株式会社 | マイクロ流体デバイス |
CN114152721A (zh) * | 2020-09-07 | 2022-03-08 | 株式会社岛津制作所 | 试验装置、压入方法以及微流路器件 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005513441A (ja) | 2001-02-07 | 2005-05-12 | バイオマイクロ システムズ インコーポレイテッド | 受動流体制御構造を組込んだ三次元マイクロフルイディクス |
WO2006116616A3 (en) | 2005-04-26 | 2007-09-27 | Applera Corp | Systems and methods for multiple analyte detection |
JP2008253261A (ja) | 2007-03-30 | 2008-10-23 | F Hoffmann La Roche Ag | 温度駆動型マイクロ流体バルブ |
US20100105866A1 (en) | 2005-09-08 | 2010-04-29 | President And Fellows Of Harvard College | Microfluidic manipulation of fluids and reactions |
WO2017075295A1 (en) | 2015-10-27 | 2017-05-04 | Berkeley Lights, Inc. | Microfluidic electrowetting device apparatus having a covalently bound hydrophobic surface |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001281233A (ja) * | 2000-03-28 | 2001-10-10 | Inst Of Physical & Chemical Res | 水性分配用マイクロチップおよびそれを用いた水性分配方法 |
JP4148778B2 (ja) | 2001-03-09 | 2008-09-10 | バイオミクロ システムズ インコーポレイティッド | アレイとのミクロ流体的インターフェース機器 |
US20040109793A1 (en) | 2002-02-07 | 2004-06-10 | Mcneely Michael R | Three-dimensional microfluidics incorporating passive fluid control structures |
DE10257004A1 (de) * | 2002-12-06 | 2004-06-17 | Steag Microparts Gmbh | Vorrichtung zur parallelen Dosierung von Flüssigkeiten |
JP3959436B2 (ja) * | 2003-08-29 | 2007-08-15 | 独立行政法人物質・材料研究機構 | 流れ変動構造及びマイクロミキサ |
US20060094004A1 (en) | 2004-10-28 | 2006-05-04 | Akihisa Nakajima | Micro-reactor, biological material inspection device, and microanalysis system |
JP2006217818A (ja) | 2005-02-08 | 2006-08-24 | Konica Minolta Medical & Graphic Inc | 遺伝子検査用マイクロリアクタならびに遺伝子検査方法 |
CN101171520A (zh) * | 2005-06-23 | 2008-04-30 | 爱科来株式会社 | 分析用具 |
JP2007218838A (ja) * | 2006-02-20 | 2007-08-30 | Kawamura Inst Of Chem Res | 微量試料の導入方法およびマイクロ流体デバイス |
CA2580589C (en) * | 2006-12-19 | 2016-08-09 | Fio Corporation | Microfluidic detection system |
US8697010B2 (en) * | 2007-12-19 | 2014-04-15 | Shimadzu Corporation | Dispensing device |
JP2009284769A (ja) * | 2008-05-27 | 2009-12-10 | Sony Corp | マイクロ基板 |
US9409170B2 (en) * | 2013-06-24 | 2016-08-09 | Hewlett-Packard Development Company, L.P. | Microfluidic mixing device |
TWI523684B (zh) * | 2014-07-15 | 2016-03-01 | Metal Ind Res & Dev Ct | Combined microsphere manufacturing device |
CN205413067U (zh) * | 2016-03-16 | 2016-08-03 | 郑州大学 | 用于微流控层流研究的生物芯片 |
CN106195439B (zh) * | 2016-09-12 | 2018-08-24 | 北京天健惠康生物科技有限公司 | 基于流路状态的微阀系统 |
-
2018
- 2018-11-21 EP EP18883728.0A patent/EP3718958B1/en active Active
- 2018-11-21 JP JP2018562697A patent/JP7036746B2/ja active Active
- 2018-11-21 US US16/759,974 patent/US11291993B2/en active Active
- 2018-11-21 CN CN201880042288.5A patent/CN110785373B/zh active Active
- 2018-11-21 WO PCT/JP2018/042916 patent/WO2019107231A1/ja unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005513441A (ja) | 2001-02-07 | 2005-05-12 | バイオマイクロ システムズ インコーポレイテッド | 受動流体制御構造を組込んだ三次元マイクロフルイディクス |
WO2006116616A3 (en) | 2005-04-26 | 2007-09-27 | Applera Corp | Systems and methods for multiple analyte detection |
US20100105866A1 (en) | 2005-09-08 | 2010-04-29 | President And Fellows Of Harvard College | Microfluidic manipulation of fluids and reactions |
JP2008253261A (ja) | 2007-03-30 | 2008-10-23 | F Hoffmann La Roche Ag | 温度駆動型マイクロ流体バルブ |
WO2017075295A1 (en) | 2015-10-27 | 2017-05-04 | Berkeley Lights, Inc. | Microfluidic electrowetting device apparatus having a covalently bound hydrophobic surface |
Also Published As
Publication number | Publication date |
---|---|
EP3718958B1 (en) | 2023-11-01 |
EP3718958A4 (en) | 2021-08-18 |
EP3718958A1 (en) | 2020-10-07 |
CN110785373A (zh) | 2020-02-11 |
WO2019107231A1 (ja) | 2019-06-06 |
CN110785373B (zh) | 2023-11-17 |
US11291993B2 (en) | 2022-04-05 |
JPWO2019107231A1 (ja) | 2020-10-08 |
US20200276581A1 (en) | 2020-09-03 |
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