CN100369906C - 制备3-脒基苯丙氨酸衍生物的方法 - Google Patents
制备3-脒基苯丙氨酸衍生物的方法 Download PDFInfo
- Publication number
- CN100369906C CN100369906C CNB038047144A CN03804714A CN100369906C CN 100369906 C CN100369906 C CN 100369906C CN B038047144 A CNB038047144 A CN B038047144A CN 03804714 A CN03804714 A CN 03804714A CN 100369906 C CN100369906 C CN 100369906C
- Authority
- CN
- China
- Prior art keywords
- general formula
- compound
- solution
- forms
- perhaps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/205—Radicals derived from carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH347/2002 | 2002-02-28 | ||
CH00347/02A CH695999A5 (de) | 2002-02-28 | 2002-02-28 | Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten. |
CH347/02 | 2002-02-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1639142A CN1639142A (zh) | 2005-07-13 |
CN100369906C true CN100369906C (zh) | 2008-02-20 |
Family
ID=27762105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB038047144A Expired - Lifetime CN100369906C (zh) | 2002-02-28 | 2003-02-28 | 制备3-脒基苯丙氨酸衍生物的方法 |
Country Status (12)
Country | Link |
---|---|
US (5) | US7211670B2 (ja) |
EP (1) | EP1480963B1 (ja) |
JP (2) | JP5247970B2 (ja) |
CN (1) | CN100369906C (ja) |
AT (1) | ATE361285T1 (ja) |
AU (1) | AU2003205498A1 (ja) |
CH (1) | CH695999A5 (ja) |
DE (1) | DE50307171D1 (ja) |
DK (1) | DK1480963T3 (ja) |
ES (1) | ES2282601T3 (ja) |
PT (1) | PT1480963E (ja) |
WO (1) | WO2003072559A1 (ja) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH695999A5 (de) * | 2002-02-28 | 2006-11-15 | Wilex Ag | Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten. |
DE10323898A1 (de) * | 2003-05-26 | 2004-12-23 | Wilex Ag | Hydroxyamidin- und Hydroxyguanidin-Verbindungen als Urokinase-Hemmstoffe |
JP5096157B2 (ja) * | 2004-10-14 | 2012-12-12 | ヴィレックス アクチェンゲゼルシャフト | 芳香族スルホン酸を用いて塩を沈殿および再結晶させることによって3−ヒドロキシ−アミジノ−フェニルアラニン誘導体を精製する方法 |
DE102004057195A1 (de) * | 2004-11-26 | 2006-06-01 | Wilex Ag | Kristalline Modifikationen von N-Alpha-(2,4,6-Triisopropylphenylsulfonyl)-3-hydroxyamidino-(L)-phenylalanin-4-ethoxycarbonylpiperazid und/oder Salzen davon |
EP2832724A4 (en) * | 2012-03-29 | 2015-09-23 | Toray Industries | NIPETIC ACID DERIVATIVE AND ITS USE FOR MEDICAL PURPOSES |
US11045453B1 (en) | 2020-03-10 | 2021-06-29 | Redhill Biopharma Ltd. | Serine protease inhibitor for treating coronavirus infection |
US11471448B2 (en) | 2020-12-15 | 2022-10-18 | Redhill Biopharma Ltd. | Sphingosine kinase 2 inhibitor for treating coronavirus infection in moderately severe patients with pneumonia |
CN114105910B (zh) * | 2021-11-02 | 2024-04-12 | 北京悦康科创医药科技股份有限公司 | 一种羟基脒基苯丙氨酸衍生物、药物组合物与用途 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000017158A1 (de) * | 1998-09-18 | 2000-03-30 | Pentapharm Ag | Urokinase-inhibitoren |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2375611A (en) * | 1941-08-19 | 1945-05-08 | May & Baker Ltd | Production of amidines |
EP0511347A1 (de) * | 1990-11-15 | 1992-11-04 | Pentapharm A.G. | Meta-substituierte phenylalanin-derivate |
DE4443390A1 (de) | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
CH689611A5 (de) * | 1995-03-01 | 1999-07-15 | Pentapharm Ag | Urokinase-Inhibitoren. |
KR0173034B1 (ko) | 1995-04-28 | 1999-03-30 | 성재갑 | 선택적 트롬빈 억제제 |
TW513402B (en) | 1997-05-30 | 2002-12-11 | Daiichi Seiyaku Co | Process for preparing 3-(7-amidino-2-naphthyl)-2-phenylpropionic acid derivatives |
DE10002510A1 (de) | 2000-01-21 | 2001-07-26 | Boehringer Ingelheim Pharma | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
ATE325810T1 (de) | 2000-01-28 | 2006-06-15 | Sanofi Aventis Deutschland | Verfahren zur herstellung von acetylamidiniophenylalanyl-cyclohexylglycyl- pyridylalaninamiden |
CH695999A5 (de) * | 2002-02-28 | 2006-11-15 | Wilex Ag | Verfahren zur Herstellung von 3- Amidinophenylalanin-Derivaten. |
-
2002
- 2002-02-28 CH CH00347/02A patent/CH695999A5/de not_active IP Right Cessation
-
2003
- 2003-02-28 AU AU2003205498A patent/AU2003205498A1/en not_active Abandoned
- 2003-02-28 JP JP2003571265A patent/JP5247970B2/ja not_active Expired - Lifetime
- 2003-02-28 ES ES03702270T patent/ES2282601T3/es not_active Expired - Lifetime
- 2003-02-28 PT PT03702270T patent/PT1480963E/pt unknown
- 2003-02-28 DE DE50307171T patent/DE50307171D1/de not_active Expired - Lifetime
- 2003-02-28 AT AT03702270T patent/ATE361285T1/de active
- 2003-02-28 US US10/506,256 patent/US7211670B2/en not_active Expired - Lifetime
- 2003-02-28 DK DK03702270T patent/DK1480963T3/da active
- 2003-02-28 WO PCT/CH2003/000147 patent/WO2003072559A1/de active IP Right Grant
- 2003-02-28 CN CNB038047144A patent/CN100369906C/zh not_active Expired - Lifetime
- 2003-02-28 EP EP03702270A patent/EP1480963B1/de not_active Expired - Lifetime
-
2007
- 2007-01-29 US US11/699,228 patent/US7884206B2/en active Active
-
2010
- 2010-07-02 JP JP2010152309A patent/JP2010265288A/ja active Pending
- 2010-10-15 US US12/905,769 patent/US8088921B2/en not_active Ceased
-
2011
- 2011-11-18 US US13/300,237 patent/US8642761B2/en not_active Expired - Lifetime
-
2013
- 2013-12-31 US US14/145,892 patent/USRE46424E1/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000017158A1 (de) * | 1998-09-18 | 2000-03-30 | Pentapharm Ag | Urokinase-inhibitoren |
Non-Patent Citations (6)
Title |
---|
"3-Amidinophenylalanine-based Inhibitors of Urokinase". STURZEBECHER J ET AL.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,,Vol.9 No.21. 1999 * |
"3-Amidinophenylalanine-based Inhibitors of Urokinase". STURZEBECHER J ET AL.BIOORGANIC & * |
"A VERSATILE SYNTHESIS OF AMIDINESFROMNITRILESVIA AMIDOXIMES". JUDKINS B D ET AL.SYNTHETIC COMMUNICATIONS, MARCEL DEKKER, INC., BASEL, CH,Vol.26 No.23. 1996 * |
"EFFICIENT KG-SCALE SYNTHESIS OF THROMBININHIBITOR CRC 220". JENDARLLA H ET AL.TETRAHEDRON,Vol.51 No.44. 1995 * |
"NEW QUINOXALINE ND PYRIMIDO4,5-BQUINOXALINEDERIVATIVES. POTENTIAL ANTIHYPERTENSIVE ANDBLOOD PLATELET ANTIAGGREGATING AGENTS". MONGE A ET AL.JOURNAL OF HETEROCYCLIC CHEMISTRY,Vol.26 . 1989 * |
MEDICINAL CHEMISTRY LETTERS,,Vol.9 No.21. 1999 * |
Also Published As
Publication number | Publication date |
---|---|
US20070123706A1 (en) | 2007-05-31 |
AU2003205498A1 (en) | 2003-09-09 |
JP2005532270A (ja) | 2005-10-27 |
US20110087025A1 (en) | 2011-04-14 |
ATE361285T1 (de) | 2007-05-15 |
ES2282601T3 (es) | 2007-10-16 |
EP1480963B1 (de) | 2007-05-02 |
US7884206B2 (en) | 2011-02-08 |
CH695999A5 (de) | 2006-11-15 |
DE50307171D1 (de) | 2007-06-14 |
USRE46424E1 (en) | 2017-06-06 |
US20050176962A1 (en) | 2005-08-11 |
US8088921B2 (en) | 2012-01-03 |
PT1480963E (pt) | 2007-05-31 |
WO2003072559A1 (de) | 2003-09-04 |
EP1480963A1 (de) | 2004-12-01 |
CN1639142A (zh) | 2005-07-13 |
JP2010265288A (ja) | 2010-11-25 |
JP5247970B2 (ja) | 2013-07-24 |
DK1480963T3 (da) | 2007-09-10 |
US7211670B2 (en) | 2007-05-01 |
US20120065398A1 (en) | 2012-03-15 |
US8642761B2 (en) | 2014-02-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: WILUX AG Free format text: FORMER OWNER: PENTAPHARM AG Effective date: 20051230 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20051230 Address after: Munich, Germany Applicant after: Wilex AG Address before: Basel, Switzerland Applicant before: Pentapharm AG |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee | ||
CP01 | Change in the name or title of a patent holder |
Address after: Munich, Germany Patentee after: WILEX AG Address before: Munich, Germany Patentee before: Wilex AG |
|
ASS | Succession or assignment of patent right |
Owner name: GUANGZHOU LINGSHENG MEDICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: WILEX AG Effective date: 20150821 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150821 Address after: 510663 Guangdong city of Guangzhou province Luogang District Science City Moon Road No. 3 international business incubator A904 Patentee after: LINK HEALTH Group Address before: Munich, Germany Patentee before: Wilex AG |
|
CX01 | Expiry of patent term | ||
CX01 | Expiry of patent term |
Granted publication date: 20080220 |