CN100361967C - 2-氰基-3-羟基-n-(苯基)丁-2-烯酰胺的制备方法 - Google Patents

2-氰基-3-羟基-n-(苯基)丁-2-烯酰胺的制备方法 Download PDF

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Publication number
CN100361967C
CN100361967C CNB2004800058365A CN200480005836A CN100361967C CN 100361967 C CN100361967 C CN 100361967C CN B2004800058365 A CNB2004800058365 A CN B2004800058365A CN 200480005836 A CN200480005836 A CN 200480005836A CN 100361967 C CN100361967 C CN 100361967C
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China
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compound
solvent
formula
mol
acid
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Expired - Lifetime
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CNB2004800058365A
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English (en)
Chinese (zh)
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CN1756737A (zh
Inventor
J·哈赫特尔
B·奈泽斯
W·施瓦布
R·乌茨
M·察恩
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Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/26—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CNB2004800058365A 2003-03-18 2004-03-06 2-氰基-3-羟基-n-(苯基)丁-2-烯酰胺的制备方法 Expired - Lifetime CN100361967C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10311763A DE10311763A1 (de) 2003-03-18 2003-03-18 Verfahren zur Herstellung von 2-Cyan-3-hydroxy-N-(phenyl)but-2-enamiden
DE10311763.6 2003-03-18

Publications (2)

Publication Number Publication Date
CN1756737A CN1756737A (zh) 2006-04-05
CN100361967C true CN100361967C (zh) 2008-01-16

Family

ID=32945937

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800058365A Expired - Lifetime CN100361967C (zh) 2003-03-18 2004-03-06 2-氰基-3-羟基-n-(苯基)丁-2-烯酰胺的制备方法

Country Status (20)

Country Link
EP (1) EP1606246B1 (https=)
JP (1) JP4546952B2 (https=)
KR (1) KR101072237B1 (https=)
CN (1) CN100361967C (https=)
AR (1) AR043624A1 (https=)
AT (1) ATE468323T1 (https=)
AU (1) AU2004222139B2 (https=)
CA (1) CA2519209C (https=)
CY (1) CY1110722T1 (https=)
DE (2) DE10311763A1 (https=)
DK (1) DK1606246T3 (https=)
ES (1) ES2346215T3 (https=)
IL (1) IL170934A (https=)
MX (1) MXPA05009764A (https=)
PL (1) PL1606246T3 (https=)
PT (1) PT1606246E (https=)
RU (1) RU2330838C2 (https=)
SI (1) SI1606246T1 (https=)
TW (1) TW200503995A (https=)
WO (1) WO2004083165A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105272882A (zh) * 2014-07-23 2016-01-27 欣凯医药化工中间体（上海）有限公司 一种环保简便制备泰瑞米特的方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2724861A1 (en) 2008-06-05 2009-12-10 Alembic Limited A process for preparing teriflunomide
EP2807142B1 (en) 2012-01-28 2019-09-04 Optmed Inc. Improved methylidene malonate process
CN104995166A (zh) * 2013-01-29 2015-10-21 Opt迈德有限公司 改进的1,1-二取代的乙烯方法
CN104693070A (zh) * 2013-12-10 2015-06-10 深圳翰宇药业股份有限公司 一种特立氟胺的合成方法
CN116924937A (zh) * 2022-04-02 2023-10-24 江苏康缘药业股份有限公司 2-氰基-3-羟基-2-丁烯-(4-三氟甲基-苯基)酰胺制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
DE19636974A1 (de) * 1996-09-12 1998-03-19 Hoechst Ag 2-Cyano-3,5-dihydroxy-hex-2-en- carbonsäureamidderivate
WO2002034251A1 (en) * 2000-10-20 2002-05-02 Parker Hughes Institute Treatment of asthma with lfm analogues

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105272882A (zh) * 2014-07-23 2016-01-27 欣凯医药化工中间体（上海）有限公司 一种环保简便制备泰瑞米特的方法
CN105272882B (zh) * 2014-07-23 2019-05-31 欣凯医药化工中间体（上海）有限公司 一种环保简便制备泰瑞米特的方法

Also Published As

Publication number Publication date
ES2346215T3 (es) 2010-10-13
CA2519209A1 (en) 2004-09-30
AR043624A1 (es) 2005-08-03
EP1606246A1 (de) 2005-12-21
CA2519209C (en) 2011-12-06
PL1606246T3 (pl) 2010-10-29
TW200503995A (en) 2005-02-01
DK1606246T3 (da) 2010-09-06
AU2004222139A1 (en) 2004-09-30
DE10311763A1 (de) 2004-10-07
CY1110722T1 (el) 2015-06-10
JP4546952B2 (ja) 2010-09-22
SI1606246T1 (sl) 2010-08-31
RU2005132162A (ru) 2006-02-10
JP2006520345A (ja) 2006-09-07
CN1756737A (zh) 2006-04-05
AU2004222139B2 (en) 2010-03-04
KR101072237B1 (ko) 2011-10-12
IL170934A (en) 2009-11-18
PT1606246E (pt) 2010-07-21
HK1086818A1 (zh) 2006-09-29
EP1606246B1 (de) 2010-05-19
DE502004011176D1 (de) 2010-07-01
ATE468323T1 (de) 2010-06-15
KR20050120647A (ko) 2005-12-22
RU2330838C2 (ru) 2008-08-10
MXPA05009764A (es) 2005-10-26
WO2004083165A1 (de) 2004-09-30

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