AU2004222139B2 - Method for producing 2-cyan-3-hydroxy-N-(phenyl)but-2-ene amides - Google Patents

Method for producing 2-cyan-3-hydroxy-N-(phenyl)but-2-ene amides Download PDF

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Publication number
AU2004222139B2
AU2004222139B2 AU2004222139A AU2004222139A AU2004222139B2 AU 2004222139 B2 AU2004222139 B2 AU 2004222139B2 AU 2004222139 A AU2004222139 A AU 2004222139A AU 2004222139 A AU2004222139 A AU 2004222139A AU 2004222139 B2 AU2004222139 B2 AU 2004222139B2
Authority
AU
Australia
Prior art keywords
compound
formula
phenyl
mol
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2004222139A
Other languages
English (en)
Other versions
AU2004222139A1 (en
Inventor
Jochen Hachtel
Bernd Neises
Wilfried Schwab
Roland Utz
Martin Zahn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Publication of AU2004222139A1 publication Critical patent/AU2004222139A1/en
Assigned to SANOFI-AVENTIS DEUTSCHLAND GMBH reassignment SANOFI-AVENTIS DEUTSCHLAND GMBH Request for Assignment Assignors: AVENTIS PHARMA DEUTSCHLAND GMBH
Application granted granted Critical
Publication of AU2004222139B2 publication Critical patent/AU2004222139B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/26—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AU2004222139A 2003-03-18 2004-03-06 Method for producing 2-cyan-3-hydroxy-N-(phenyl)but-2-ene amides Expired AU2004222139B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10311763A DE10311763A1 (de) 2003-03-18 2003-03-18 Verfahren zur Herstellung von 2-Cyan-3-hydroxy-N-(phenyl)but-2-enamiden
DE10311763.6 2003-03-18
PCT/EP2004/002311 WO2004083165A1 (de) 2003-03-18 2004-03-06 Verfahren zur hertellung von 2-cyan-3-hydroxy-n-(phenyl)but-2-enamiden

Publications (2)

Publication Number Publication Date
AU2004222139A1 AU2004222139A1 (en) 2004-09-30
AU2004222139B2 true AU2004222139B2 (en) 2010-03-04

Family

ID=32945937

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004222139A Expired AU2004222139B2 (en) 2003-03-18 2004-03-06 Method for producing 2-cyan-3-hydroxy-N-(phenyl)but-2-ene amides

Country Status (20)

Country Link
EP (1) EP1606246B1 (https=)
JP (1) JP4546952B2 (https=)
KR (1) KR101072237B1 (https=)
CN (1) CN100361967C (https=)
AR (1) AR043624A1 (https=)
AT (1) ATE468323T1 (https=)
AU (1) AU2004222139B2 (https=)
CA (1) CA2519209C (https=)
CY (1) CY1110722T1 (https=)
DE (2) DE10311763A1 (https=)
DK (1) DK1606246T3 (https=)
ES (1) ES2346215T3 (https=)
IL (1) IL170934A (https=)
MX (1) MXPA05009764A (https=)
PL (1) PL1606246T3 (https=)
PT (1) PT1606246E (https=)
RU (1) RU2330838C2 (https=)
SI (1) SI1606246T1 (https=)
TW (1) TW200503995A (https=)
WO (1) WO2004083165A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2724861A1 (en) 2008-06-05 2009-12-10 Alembic Limited A process for preparing teriflunomide
EP2807142B1 (en) 2012-01-28 2019-09-04 Optmed Inc. Improved methylidene malonate process
CN104995166A (zh) * 2013-01-29 2015-10-21 Opt迈德有限公司 改进的1,1-二取代的乙烯方法
CN104693070A (zh) * 2013-12-10 2015-06-10 深圳翰宇药业股份有限公司 一种特立氟胺的合成方法
CN105272882B (zh) * 2014-07-23 2019-05-31 欣凯医药化工中间体（上海）有限公司 一种环保简便制备泰瑞米特的方法
CN116924937A (zh) * 2022-04-02 2023-10-24 江苏康缘药业股份有限公司 2-氰基-3-羟基-2-丁烯-(4-三氟甲基-苯基)酰胺制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700822A (en) * 1994-01-07 1997-12-23 The Regents Of The University Of California Treatment of platelet derived growth factor related disorders such as cancers

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
DE19636974A1 (de) * 1996-09-12 1998-03-19 Hoechst Ag 2-Cyano-3,5-dihydroxy-hex-2-en- carbonsäureamidderivate
WO2002034251A1 (en) * 2000-10-20 2002-05-02 Parker Hughes Institute Treatment of asthma with lfm analogues

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5700822A (en) * 1994-01-07 1997-12-23 The Regents Of The University Of California Treatment of platelet derived growth factor related disorders such as cancers

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUTAPA GHOSH ET AL: "Three leflunomide analogs" ACTA CRYSTALLOGR. SECT. C CRYST. STRUCT. COMMUN., 2000, vol. 56, no. 10, pages 1254-1257 *

Also Published As

Publication number Publication date
ES2346215T3 (es) 2010-10-13
CA2519209A1 (en) 2004-09-30
AR043624A1 (es) 2005-08-03
EP1606246A1 (de) 2005-12-21
CA2519209C (en) 2011-12-06
PL1606246T3 (pl) 2010-10-29
TW200503995A (en) 2005-02-01
DK1606246T3 (da) 2010-09-06
AU2004222139A1 (en) 2004-09-30
DE10311763A1 (de) 2004-10-07
CY1110722T1 (el) 2015-06-10
JP4546952B2 (ja) 2010-09-22
SI1606246T1 (sl) 2010-08-31
RU2005132162A (ru) 2006-02-10
JP2006520345A (ja) 2006-09-07
CN1756737A (zh) 2006-04-05
KR101072237B1 (ko) 2011-10-12
IL170934A (en) 2009-11-18
PT1606246E (pt) 2010-07-21
HK1086818A1 (zh) 2006-09-29
EP1606246B1 (de) 2010-05-19
DE502004011176D1 (de) 2010-07-01
CN100361967C (zh) 2008-01-16
ATE468323T1 (de) 2010-06-15
KR20050120647A (ko) 2005-12-22
RU2330838C2 (ru) 2008-08-10
MXPA05009764A (es) 2005-10-26
WO2004083165A1 (de) 2004-09-30

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Legal Events

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PC1 Assignment before grant (sect. 113)

Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH

Free format text: FORMER APPLICANT(S): AVENTIS PHARMA DEUTSCHLAND GMBH

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired