CN100357443C - 编码血管生成基因的副粘病毒载体及其应用 - Google Patents

编码血管生成基因的副粘病毒载体及其应用 Download PDF

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CN100357443C
CN100357443C CNB018222900A CN01822290A CN100357443C CN 100357443 C CN100357443 C CN 100357443C CN B018222900 A CNB018222900 A CN B018222900A CN 01822290 A CN01822290 A CN 01822290A CN 100357443 C CN100357443 C CN 100357443C
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gene
cell
sequence
expression
virus
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CN1487999A (zh
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米满吉和
居石克夫
福村正之
侯晓刚
长谷川护
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Dnavec Research Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18811Sendai virus
    • C12N2760/18841Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/30Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB018222900A 2000-11-27 2001-11-27 编码血管生成基因的副粘病毒载体及其应用 Expired - Lifetime CN100357443C (zh)

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JP359374/2000 2000-11-27
JP2000359374 2000-11-27

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CN1487999A CN1487999A (zh) 2004-04-07
CN100357443C true CN100357443C (zh) 2007-12-26

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US (3) US20040005296A1 (ko)
EP (1) EP1344829B1 (ko)
JP (1) JP4212357B2 (ko)
KR (1) KR100812884B1 (ko)
CN (1) CN100357443C (ko)
AT (1) ATE393235T1 (ko)
AU (1) AU2002224113A1 (ko)
CA (1) CA2430112C (ko)
DE (1) DE60133767T2 (ko)
DK (1) DK1344829T3 (ko)
ES (1) ES2305138T3 (ko)
WO (1) WO2002042481A1 (ko)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0863202B1 (en) * 1995-11-01 2010-06-09 Dnavec Research Inc. Recombinant sendai virus
AU4395599A (en) * 1998-07-03 2000-01-24 Dnavec Research Inc. (-)-strand rna virus vector for nerve cell
US6490775B1 (en) * 1999-04-23 2002-12-10 Veri-Tek Inc. Press operation verification system
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
CN1367839A (zh) * 1999-09-06 2002-09-04 株式会社载体研究所 含有已改变的转录起始序列的副粘病毒
US7314614B1 (en) 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
US20020002143A1 (en) 2000-03-30 2002-01-03 Munehide Kano AIDS virus vaccines using sendai virus vector
KR100807016B1 (ko) * 2000-06-01 2008-02-25 가부시키가이샤 디나벡크 겐큐쇼 헤마글루티닌 활성을 갖는 막단백질을 포함하는 슈도타입레트로바이러스 벡터
AU2001266337A1 (en) * 2000-06-27 2002-01-08 Dnavec Research Inc. Virus vector for transferring gene into renal cells
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
JP4212357B2 (ja) * 2000-11-27 2009-01-21 株式会社ディナベック研究所 血管新生遺伝子をコードするパラミクソウイルスベクターおよびその利用
CN100358581C (zh) * 2002-04-30 2008-01-02 株式会社载体研究所 具有降低的血凝活性的药物载体组合物或基因载体组合物
EP1548101A4 (en) * 2002-09-04 2006-05-10 Dnavec Research Inc METHOD FOR PRODUCING A VIRAL VECTOR CONTAINING A MEMBRANE PROTEIN BINDING WITH THE NEURAMINIDASE FROM GRAM-POSITIVE BACTERIA TO SIALIC ACID AS AN INTEGRAL PART OF THE ENVELOPE
US20060104950A1 (en) * 2002-10-24 2006-05-18 Shinji Okano Methods of Tranducing genes into T cells
ATE459707T1 (de) * 2003-06-30 2010-03-15 Dnavec Research Inc Negativ-strang rna-virus-vektoren, welche ein gen mit veränderten hypermutierbaren regionen tragen
DE10333217A1 (de) * 2003-07-22 2005-03-10 Biomay Prod & Handel Polypeptide, hierfür kodierende Nucleinsäuren aus dem Schimmelpilz Cladosporium herbarum sowie deren Herstellung und Verwendung in Diagnostik und Therapie
KR20070004637A (ko) * 2004-01-22 2007-01-09 가부시키가이샤 디나벡크 겐큐쇼 바이러스 벡터의 제조방법
CN1957084A (zh) * 2004-03-23 2007-05-02 株式会社载体研究所 与组织的维持和/或修复相关联的骨髓相关细胞
KR20080068098A (ko) 2005-10-28 2008-07-22 디나벡크 가부시키가이샤 Rna 바이러스 또는 dna 바이러스의 스파이크단백질로 슈도타입화된 렌티바이러스 벡터를 사용한 기도상피 간세포로의 유전자 도입
KR101336386B1 (ko) * 2011-06-17 2013-12-04 전북대학교병원 림프관 생성 유도제
AU2014233500B2 (en) 2013-03-15 2019-06-13 Elixirgen Therapeutics, Inc. Methods of using Zscan4 for rejuvenating human cells
WO2014176514A2 (en) * 2013-04-26 2014-10-30 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
US20160312261A1 (en) * 2015-04-24 2016-10-27 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues
WO2021174121A1 (en) * 2020-02-27 2021-09-02 Icahn School Of Medicine At Mount Sinai Vegfr-3-activating agents and oncolytic viruses and uses thereof for the treatment of cancer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009610A1 (en) * 1989-12-22 1991-07-11 Farmitalia Carlo Erba S.R.L. Fibroblast growth factor for use in the prevention and treatment of viral infections
WO1995025803A1 (fr) * 1994-03-18 1995-09-28 Rhone-Poulenc Rorer S.A. ADENOVIRUS RECOMBINANTS CODANT POUR LE FACTEUR DE CROISSANCE DES FIBROBLASTES ACIDES (aFGF)
CN1407873A (zh) * 1999-12-07 2003-04-02 米卡·拉赫蒂宁 医疗装置

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5155214A (en) * 1984-03-05 1992-10-13 The Salk Institute For Biological Studies Basic fibroblast growth factor
US4994559A (en) * 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
GB8821795D0 (en) 1988-09-16 1988-10-19 Erba Carlo Spa New derivatives of human/bovine basic fibroplast growth factor
US6121246A (en) * 1995-10-20 2000-09-19 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating ischemic tissue
EP0864645B9 (en) * 1995-10-31 2006-03-22 Dnavec Research Inc. Negative-strand rna virus vector having autonomously replicating activity
EP0863202B1 (en) 1995-11-01 2010-06-09 Dnavec Research Inc. Recombinant sendai virus
US6274712B1 (en) * 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
JP3602058B2 (ja) 1999-05-18 2004-12-15 株式会社ディナベック研究所 エンベロープ遺伝子欠損パラミクソ科ウイルスベクター
ATE399206T1 (de) 1999-05-18 2008-07-15 Dnavec Research Inc Ribonukleoproteinkomplex aus paramyxovirus
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US20020169306A1 (en) * 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
US20030022376A1 (en) * 1999-05-18 2003-01-30 Kaio Kitazato Paramyxovirus-derived RNP
US7314614B1 (en) * 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
CN1252274C (zh) 1999-11-02 2006-04-19 株式会社载体研究所 用于将外源基因导入气道上皮细胞的重组仙台病毒载体
US20030170210A1 (en) * 2000-01-19 2003-09-11 Ichiro Masaki Use of paramyxovirus vector in gene transfer into blood vessel
KR100807016B1 (ko) 2000-06-01 2008-02-25 가부시키가이샤 디나벡크 겐큐쇼 헤마글루티닌 활성을 갖는 막단백질을 포함하는 슈도타입레트로바이러스 벡터
AU2001290273A1 (en) 2000-10-06 2002-04-22 Dnavec Research Inc. Paramyxovirus vector for transferring foreign gene into skeletal muscle
JP2002142770A (ja) 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
JP4212357B2 (ja) * 2000-11-27 2009-01-21 株式会社ディナベック研究所 血管新生遺伝子をコードするパラミクソウイルスベクターおよびその利用
CN1957084A (zh) * 2004-03-23 2007-05-02 株式会社载体研究所 与组织的维持和/或修复相关联的骨髓相关细胞

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009610A1 (en) * 1989-12-22 1991-07-11 Farmitalia Carlo Erba S.R.L. Fibroblast growth factor for use in the prevention and treatment of viral infections
WO1995025803A1 (fr) * 1994-03-18 1995-09-28 Rhone-Poulenc Rorer S.A. ADENOVIRUS RECOMBINANTS CODANT POUR LE FACTEUR DE CROISSANCE DES FIBROBLASTES ACIDES (aFGF)
CN1407873A (zh) * 1999-12-07 2003-04-02 米卡·拉赫蒂宁 医疗装置

Also Published As

Publication number Publication date
CN1487999A (zh) 2004-04-07
DK1344829T3 (da) 2008-09-01
US8211868B2 (en) 2012-07-03
ATE393235T1 (de) 2008-05-15
EP1344829A1 (en) 2003-09-17
CA2430112A1 (en) 2003-05-27
CA2430112C (en) 2010-07-27
ES2305138T3 (es) 2008-11-01
EP1344829A4 (en) 2005-01-05
US20110212059A1 (en) 2011-09-01
AU2002224113A1 (en) 2002-06-03
KR20030074627A (ko) 2003-09-19
JPWO2002042481A1 (ja) 2004-03-25
KR100812884B1 (ko) 2008-03-11
EP1344829B1 (en) 2008-04-23
WO2002042481A1 (fr) 2002-05-30
US20040005296A1 (en) 2004-01-08
JP4212357B2 (ja) 2009-01-21
DE60133767T2 (de) 2009-06-25
DE60133767D1 (de) 2008-06-05
US20100158867A1 (en) 2010-06-24

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