DE60133767D1 - Für fibroblasten-wachstumsfaktor 2 (fgf2) kodierender paramyxovirus-vektor und dessen verwendung - Google Patents

Für fibroblasten-wachstumsfaktor 2 (fgf2) kodierender paramyxovirus-vektor und dessen verwendung

Info

Publication number
DE60133767D1
DE60133767D1 DE60133767T DE60133767T DE60133767D1 DE 60133767 D1 DE60133767 D1 DE 60133767D1 DE 60133767 T DE60133767 T DE 60133767T DE 60133767 T DE60133767 T DE 60133767T DE 60133767 D1 DE60133767 D1 DE 60133767D1
Authority
DE
Germany
Prior art keywords
fgf2
growth factor
fibroblast growth
paramyxovirus vector
angiogenic genes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60133767T
Other languages
English (en)
Other versions
DE60133767T2 (de
Inventor
Yoshikazu Yonemitsu
Katsuo Sueishi
Masayuki Fukumura
Xiaogang Hou
Mamoru Hasegawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dnavec Research Inc
Original Assignee
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Application granted granted Critical
Publication of DE60133767D1 publication Critical patent/DE60133767D1/de
Publication of DE60133767T2 publication Critical patent/DE60133767T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18841—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60133767T 2000-11-27 2001-11-27 Für fibroblasten-wachstumsfaktor 2 (fgf2) kodierender paramyxovirus-vektor und dessen verwendung Expired - Lifetime DE60133767T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000359374 2000-11-27
JP2000359374 2000-11-27
PCT/JP2001/010323 WO2002042481A1 (fr) 2000-11-27 2001-11-27 Vecteur paramyxovirus codant pour un gene d'angiogenese et son utilisation

Publications (2)

Publication Number Publication Date
DE60133767D1 true DE60133767D1 (de) 2008-06-05
DE60133767T2 DE60133767T2 (de) 2009-06-25

Family

ID=18831146

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60133767T Expired - Lifetime DE60133767T2 (de) 2000-11-27 2001-11-27 Für fibroblasten-wachstumsfaktor 2 (fgf2) kodierender paramyxovirus-vektor und dessen verwendung

Country Status (12)

Country Link
US (3) US20040005296A1 (de)
EP (1) EP1344829B1 (de)
JP (1) JP4212357B2 (de)
KR (1) KR100812884B1 (de)
CN (1) CN100357443C (de)
AT (1) ATE393235T1 (de)
AU (1) AU2002224113A1 (de)
CA (1) CA2430112C (de)
DE (1) DE60133767T2 (de)
DK (1) DK1344829T3 (de)
ES (1) ES2305138T3 (de)
WO (1) WO2002042481A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE470704T1 (de) * 1995-11-01 2010-06-15 Dnavec Research Inc Rekombinantes sendai-virus
DE69940848D1 (de) * 1998-07-03 2009-06-18 Dnavec Research Inc (-)-strang rns virusvektor für nervenzellen
US6490775B1 (en) * 1999-04-23 2002-12-10 Veri-Tek Inc. Press operation verification system
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
JP3748535B2 (ja) * 1999-09-06 2006-02-22 株式会社ディナベック研究所 改変された転写開始配列を有するパラミクソウイルス
US7314614B1 (en) 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
KR100854917B1 (ko) 2000-03-30 2008-08-27 가부시키가이샤 디나벡크 겐큐쇼 센다이바이러스 벡터를 사용한 ａｉｄｓ 바이러스 백신
WO2001092508A1 (fr) * 2000-06-01 2001-12-06 Dnavec Research Inc. Vecteur de retrovirus de pseudo-type contenant une proteine de membrane possedant une activite d'hemagglutinine
WO2002000264A1 (fr) * 2000-06-27 2002-01-03 Dnavec Research Inc. Vecteur de virus pour transfert de gene dans des cellules renales
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
KR100812884B1 (ko) * 2000-11-27 2008-03-11 가부시키가이샤 디나벡크 겐큐쇼 혈관신생 유전자를 코드하는 파라믹소바이러스 벡터 및 그 이용
JPWO2003092738A1 (ja) * 2002-04-30 2005-09-08 株式会社ディナベック研究所 ヘマグルチニン活性を低下させた薬剤または遺伝子運搬組成物
EP1548101A4 (de) * 2002-09-04 2006-05-10 Dnavec Research Inc Verfahren zur herstellung eines viralen vektors, ein membranprotein enthaltend, welches mit hilfe von neuraminidase aus gram-positiven bakterien an sialinsäure als bestandteil des envelopes bindet
US20060104950A1 (en) * 2002-10-24 2006-05-18 Shinji Okano Methods of Tranducing genes into T cells
US20070105208A1 (en) * 2003-06-30 2007-05-10 Jun You Minus strand rna virus vector carrying gene modified in high mutation region
DE10333217A1 (de) * 2003-07-22 2005-03-10 Biomay Prod & Handel Polypeptide, hierfür kodierende Nucleinsäuren aus dem Schimmelpilz Cladosporium herbarum sowie deren Herstellung und Verwendung in Diagnostik und Therapie
US20070141705A1 (en) * 2004-01-22 2007-06-21 Makoto Inoue Method for producing viral vectors
US20080038234A1 (en) * 2004-03-23 2008-02-14 Shuji Hayashi Bone Marrow-Related Cells Associated With Tissue Maintenance And/Or Repair
EP2993235B1 (de) 2005-10-28 2019-02-13 ID Pharma Co., Ltd. Gentransfer in epithelialen stammzellen der atemwege unter verwendung von similian lentiviralen vektoren mit senadai rna-virus-spikeprotein pseudotypisierten vektoren
KR101336386B1 (ko) * 2011-06-17 2013-12-04 전북대학교병원 림프관 생성 유도제
US10335456B2 (en) 2013-03-15 2019-07-02 Elixirgen Therapeutics, Inc. Methods of using ZSCAN4 for rejuvenating human cells
EP2989113B1 (de) * 2013-04-26 2024-04-10 Genomatica, Inc. Mikroorganismen und verfahren zur herstellung von 4-hydroxybutyrat, 1,4-butandiol und verwandten verbindungen
US20160312261A1 (en) * 2015-04-24 2016-10-27 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues
EP4110803A4 (de) * 2020-02-27 2024-03-27 Icahn School of Medicine at Mount Sinai Vegfr-3-aktivierende mittel und onkolytische viren und verwendungen davon zur behandlung von krebs

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5155214A (en) * 1984-03-05 1992-10-13 The Salk Institute For Biological Studies Basic fibroblast growth factor
US4994559A (en) * 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
GB8821795D0 (en) 1988-09-16 1988-10-19 Erba Carlo Spa New derivatives of human/bovine basic fibroplast growth factor
IT1237795B (it) * 1989-12-22 1993-06-17 Erba Carlo Spa Fattori di crescita fibroblastici per l'uso nella prevenzione e nel trattamento di infezioni virali.
FR2717495B1 (fr) * 1994-03-18 1996-04-12 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
US6121246A (en) * 1995-10-20 2000-09-19 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating ischemic tissue
DE69634904T2 (de) * 1995-10-31 2006-05-18 Dnavec Research Inc., Tsukuba Negativstrand rna virus mit selbständiger replikationsaktivität
ATE470704T1 (de) * 1995-11-01 2010-06-15 Dnavec Research Inc Rekombinantes sendai-virus
US6274712B1 (en) * 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
US20030022376A1 (en) * 1999-05-18 2003-01-30 Kaio Kitazato Paramyxovirus-derived RNP
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
ATE399206T1 (de) 1999-05-18 2008-07-15 Dnavec Research Inc Ribonukleoproteinkomplex aus paramyxovirus
US20020169306A1 (en) * 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
KR20070058607A (ko) 1999-05-18 2007-06-08 가부시키가이샤 디나벡크 겐큐쇼 엔벨로프 유전자 결손 파라믹소과 바이러스 벡터
US7314614B1 (en) * 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
ATE351915T1 (de) 1999-11-02 2007-02-15 Dnavec Research Inc Rekombinanter sendaivirus-vektor für die einführung von fremdgenen ins epithel der atemwege
SE0000285D0 (sv) 1999-12-07 2000-01-31 Mika Lahtinen Medical implant
EP1251174A4 (de) * 2000-01-19 2003-05-02 Dnavec Research Inc Verwendung eines paramyxovirus-vektors für den gentransfer in blutgefässe
WO2001092508A1 (fr) * 2000-06-01 2001-12-06 Dnavec Research Inc. Vecteur de retrovirus de pseudo-type contenant une proteine de membrane possedant une activite d'hemagglutinine
US20040053877A1 (en) * 2000-10-06 2004-03-18 Masayuki Fukumura Paramyxovirus vector for transfering foreign gene into skeletal muscle
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
KR100812884B1 (ko) * 2000-11-27 2008-03-11 가부시키가이샤 디나벡크 겐큐쇼 혈관신생 유전자를 코드하는 파라믹소바이러스 벡터 및 그 이용
US20080038234A1 (en) * 2004-03-23 2008-02-14 Shuji Hayashi Bone Marrow-Related Cells Associated With Tissue Maintenance And/Or Repair

Also Published As

Publication number Publication date
KR100812884B1 (ko) 2008-03-11
US20040005296A1 (en) 2004-01-08
DE60133767T2 (de) 2009-06-25
US20100158867A1 (en) 2010-06-24
CN100357443C (zh) 2007-12-26
EP1344829A1 (de) 2003-09-17
DK1344829T3 (da) 2008-09-01
WO2002042481A1 (fr) 2002-05-30
EP1344829A4 (de) 2005-01-05
AU2002224113A1 (en) 2002-06-03
JP4212357B2 (ja) 2009-01-21
US8211868B2 (en) 2012-07-03
CA2430112A1 (en) 2003-05-27
JPWO2002042481A1 (ja) 2004-03-25
EP1344829B1 (de) 2008-04-23
CA2430112C (en) 2010-07-27
KR20030074627A (ko) 2003-09-19
US20110212059A1 (en) 2011-09-01
ES2305138T3 (es) 2008-11-01
CN1487999A (zh) 2004-04-07
ATE393235T1 (de) 2008-05-15

Similar Documents

Publication Publication Date Title
DE60133767D1 (de) Für fibroblasten-wachstumsfaktor 2 (fgf2) kodierender paramyxovirus-vektor und dessen verwendung
ATE395426T1 (de) Antisense inhibierung der ptp1b expression.
EP1315830A4 (de) Zusammensetzungen und verfahren zur zielgerichteten, in vivo einbringung von peptiden in den menschen
MX2010003606A (es) Modulacion antisentido de la expresion del receptor del factor de crecimiento fibroblastico 4.
DE69808614T2 (de) Stabilisationsschlinge zum gebrauch in der minimal-invasiven beckenchirurgie
DE69637718D1 (de) Invertierte Chimäre und Hybrid-Oligonukleotide
MY130489A (en) Substituted aryl 1, 4-pyrazine derivatives
BR0203172A (pt) Agentes terapêuticos para acondroplasia
GB2365867B (en) Vector constructs
WO2003023004A3 (en) Antisense modulation of fibroblast growth factor receptor 3 expression
ATE352639T1 (de) Antisense modulation der expression von integrin alpha 4
WO2003018600A3 (en) Antisense modulation of microsomal triglyceride transfer protein expression
WO2003105755A3 (en) ANTISENSE MODULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR C (VEGF-C) EXPRESSION
WO2003104397A3 (en) ANTISENSE MODULATION OF PROTEIN KINASE GR 6 EXPRESSION
WO2002062954A3 (en) Antisense modulation of casein kinase 2-beta expression
HUP0402327A2 (hu) Inzulinszerű növekedési faktort kötő 5-ös fehérje expressziójának antiszensz módosítása
WO2003012031A3 (en) Antisense modulation of stearoyl-coa desaturase expression
WO2002062818A3 (en) Antisense modulation of casein kinase 2-alpha expression
BRPI0209824B8 (pt) método ex vivo ou in vitro para induzir cardiomiogênese
UY25129A1 (es) Enantiomero (r) del 4-[[(cianoimino)[(1,2,2-trimetilpropil)amino] metil]amino]benzonitrilo útil para promover el crecimiento del cabello
DE69837885D1 (de) Synergistische wirkung des ob/bmp morphogens und gdnf/ngf neurotropher faktoren
WO2003070878A3 (en) Antisense modulation of hematopoietic cell protein tyrosine kinase expression
BR0209144A (pt) Composição associadas ao fator de crescimento de fibroblasto humano
IL194383A (en) Antisense oligonucleotide targeted to insulin-like growth binding protein 5
WO2002055659A3 (en) Antisense modulation of integrin beta 4 binding protein expression

Legal Events

Date Code Title Description
8364 No opposition during term of opposition