DK1344829T3 - Paramyxovirusvektor kodende for fibroblastvækstfaktor 2 (FGF2) og anvendelse deraf - Google Patents

Paramyxovirusvektor kodende for fibroblastvækstfaktor 2 (FGF2) og anvendelse deraf

Info

Publication number
DK1344829T3
DK1344829T3 DK01997561T DK01997561T DK1344829T3 DK 1344829 T3 DK1344829 T3 DK 1344829T3 DK 01997561 T DK01997561 T DK 01997561T DK 01997561 T DK01997561 T DK 01997561T DK 1344829 T3 DK1344829 T3 DK 1344829T3
Authority
DK
Denmark
Prior art keywords
fgf2
growth factor
fibroblast growth
vector encoding
paramyxovirus vector
Prior art date
Application number
DK01997561T
Other languages
English (en)
Inventor
Yoshikazu Yonemitsu
Katsuo Sueishi
Masayuki Fukumura
Xiaogang Hou
Mamoru Hasegawa
Original Assignee
Dnavec Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dnavec Research Inc filed Critical Dnavec Research Inc
Application granted granted Critical
Publication of DK1344829T3 publication Critical patent/DK1344829T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18811—Sendai virus
    • C12N2760/18841—Use of virus, viral particle or viral elements as a vector
    • C12N2760/18843—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01997561T 2000-11-27 2001-11-27 Paramyxovirusvektor kodende for fibroblastvækstfaktor 2 (FGF2) og anvendelse deraf DK1344829T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000359374 2000-11-27
PCT/JP2001/010323 WO2002042481A1 (fr) 2000-11-27 2001-11-27 Vecteur paramyxovirus codant pour un gene d'angiogenese et son utilisation

Publications (1)

Publication Number Publication Date
DK1344829T3 true DK1344829T3 (da) 2008-09-01

Family

ID=18831146

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01997561T DK1344829T3 (da) 2000-11-27 2001-11-27 Paramyxovirusvektor kodende for fibroblastvækstfaktor 2 (FGF2) og anvendelse deraf

Country Status (12)

Country Link
US (3) US20040005296A1 (da)
EP (1) EP1344829B1 (da)
JP (1) JP4212357B2 (da)
KR (1) KR100812884B1 (da)
CN (1) CN100357443C (da)
AT (1) ATE393235T1 (da)
AU (1) AU2002224113A1 (da)
CA (1) CA2430112C (da)
DE (1) DE60133767T2 (da)
DK (1) DK1344829T3 (da)
ES (1) ES2305138T3 (da)
WO (1) WO2002042481A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1143892C (zh) * 1995-11-01 2004-03-31 株式会社载体研究所 重组仙台病毒
ES2326101T3 (es) * 1998-07-03 2009-09-30 Dnavec Research Inc. Vector de virus arn cadena (-) para celulas nerviosas.
US6490775B1 (en) * 1999-04-23 2002-12-10 Veri-Tek Inc. Press operation verification system
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
DK1211318T3 (da) * 1999-09-06 2007-11-12 Dnavec Research Inc Paramyxovira omfattende en modificeret transkriptionsstartsekvens
US7314614B1 (en) 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
EP1270016A4 (en) 2000-03-30 2005-10-19 Dnavec Research Inc VACCINE AGAINST AIDS VIRUS CONTAINING A VECTOR OF SENDAI VIRUS
CA2413995C (en) * 2000-06-01 2013-08-13 Dnavec Research Inc. Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity
EP1297852A4 (en) * 2000-06-27 2004-12-29 Dnavec Research Inc VIRAL VECTOR FOR THE INTRODUCTION OF GENES IN KIDNEY CELLS (03.02.03)
JP2002142770A (ja) * 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
AU2002224113A1 (en) * 2000-11-27 2002-06-03 Dnavec Research Inc. Paramyxovirus vector encoding angiogenesis gene and utilization thereof
JPWO2003092738A1 (ja) * 2002-04-30 2005-09-08 株式会社ディナベック研究所 ヘマグルチニン活性を低下させた薬剤または遺伝子運搬組成物
AU2003261931A1 (en) * 2002-09-04 2004-03-29 Dnavec Research Inc. Process for producing virus vector containing membrane protein having sialic acid-binding activitiy in envelope with the use of gram-positive bacterium-origin neuraminidase
CA2503317A1 (en) * 2002-10-24 2004-05-06 Dnavec Research Inc. Method of transferring gene into t cells
EP1642966B1 (en) * 2003-06-30 2010-03-03 Dnavec Research Inc. Minus strand rna viral vectors carrying a gene with altered hypermutable regions
DE10333217A1 (de) * 2003-07-22 2005-03-10 Biomay Prod & Handel Polypeptide, hierfür kodierende Nucleinsäuren aus dem Schimmelpilz Cladosporium herbarum sowie deren Herstellung und Verwendung in Diagnostik und Therapie
EP1715048A4 (en) * 2004-01-22 2007-02-07 Dnavec Research Inc PROCESS FOR PRODUCING A VIRAL VECTOR
CN1957084A (zh) * 2004-03-23 2007-05-02 株式会社载体研究所 与组织的维持和/或修复相关联的骨髓相关细胞
EP2993235B1 (en) 2005-10-28 2019-02-13 ID Pharma Co., Ltd. Gene transfer into airway epithelial stem cell by using simian lentiviral vector pseudotyped with sendai rna virus spike protein
KR101336386B1 (ko) * 2011-06-17 2013-12-04 전북대학교병원 림프관 생성 유도제
CA3176712A1 (en) 2013-03-15 2014-09-18 Elixirgen Therapeutics, Inc. Methods of using zscan4 for rejunevating human cells
MY187966A (en) * 2013-04-26 2021-11-02 Genomatica Inc Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
US20160312261A1 (en) * 2015-04-24 2016-10-27 Plasmia Biotech, S.L. Enzymatic production of cytosinic nucleoside analogues
EP4110803A4 (en) * 2020-02-27 2024-03-27 Icahn School of Medicine at Mount Sinai VEGFR-3 ACTIVATING AGENTS AND ONCOLYTIC VIRUSES AND THEIR USES FOR THE TREATMENT OF CANCER

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5155214A (en) * 1984-03-05 1992-10-13 The Salk Institute For Biological Studies Basic fibroblast growth factor
US4994559A (en) * 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
GB8821795D0 (en) 1988-09-16 1988-10-19 Erba Carlo Spa New derivatives of human/bovine basic fibroplast growth factor
IT1237795B (it) * 1989-12-22 1993-06-17 Erba Carlo Spa Fattori di crescita fibroblastici per l'uso nella prevenzione e nel trattamento di infezioni virali.
FR2717495B1 (fr) * 1994-03-18 1996-04-12 Rhone Poulenc Rorer Sa Virus recombinants, préparation et utilisation en thérapie génique.
US6121246A (en) * 1995-10-20 2000-09-19 St. Elizabeth's Medical Center Of Boston, Inc. Method for treating ischemic tissue
WO1997016538A1 (fr) 1995-10-31 1997-05-09 Dnavec Research Inc. Vecteur de virus d'arn a brin negatif possedant une activite de replication autonome
CN1143892C (zh) * 1995-11-01 2004-03-31 株式会社载体研究所 重组仙台病毒
US6274712B1 (en) * 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
US7226786B2 (en) * 1999-05-18 2007-06-05 Dnavec Research Inc. Envelope gene-deficient Paramyxovirus vector
KR20070058607A (ko) 1999-05-18 2007-06-08 가부시키가이샤 디나벡크 겐큐쇼 엔벨로프 유전자 결손 파라믹소과 바이러스 벡터
WO2000070055A1 (fr) 1999-05-18 2000-11-23 Dnavec Research Inc. Ribonucleoproteine derivee d'un paramyxovirus
US20030022376A1 (en) * 1999-05-18 2003-01-30 Kaio Kitazato Paramyxovirus-derived RNP
US20030166252A1 (en) * 1999-05-18 2003-09-04 Kaio Kitazato Paramyxovirus-derived RNP
US20020169306A1 (en) * 1999-05-18 2002-11-14 Kaio Kitazato Envelope gene-deficient paramyxovirus vector
US7314614B1 (en) * 1999-11-02 2008-01-01 Dnavec Research, Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
WO2001032898A2 (en) 1999-11-02 2001-05-10 Dnavec Research Inc. Recombinant sendai virus vector for introducing exogenous genes to airway epithelia
SE0000285D0 (sv) 1999-12-07 2000-01-31 Mika Lahtinen Medical implant
CA2397903A1 (en) * 2000-01-19 2001-07-26 Dnavec Research Inc. Use of paramyxovirus vector for gene transfer into blood vessel
CA2413995C (en) * 2000-06-01 2013-08-13 Dnavec Research Inc. Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity
CN1526014A (zh) * 2000-10-06 2004-09-01 ��ʽ���������о��� 用于将外源基因导入骨骼肌的副粘病毒载体
JP2002142770A (ja) 2000-11-08 2002-05-21 Dnavec Research Inc 循環系への遺伝子送達用パラミクソウイルスベクター
AU2002224113A1 (en) * 2000-11-27 2002-06-03 Dnavec Research Inc. Paramyxovirus vector encoding angiogenesis gene and utilization thereof
CN1957084A (zh) * 2004-03-23 2007-05-02 株式会社载体研究所 与组织的维持和/或修复相关联的骨髓相关细胞

Also Published As

Publication number Publication date
US20110212059A1 (en) 2011-09-01
KR20030074627A (ko) 2003-09-19
JP4212357B2 (ja) 2009-01-21
ATE393235T1 (de) 2008-05-15
CN100357443C (zh) 2007-12-26
US20100158867A1 (en) 2010-06-24
JPWO2002042481A1 (ja) 2004-03-25
EP1344829B1 (en) 2008-04-23
ES2305138T3 (es) 2008-11-01
KR100812884B1 (ko) 2008-03-11
EP1344829A4 (en) 2005-01-05
WO2002042481A1 (fr) 2002-05-30
CA2430112A1 (en) 2003-05-27
US20040005296A1 (en) 2004-01-08
DE60133767T2 (de) 2009-06-25
US8211868B2 (en) 2012-07-03
DE60133767D1 (de) 2008-06-05
CN1487999A (zh) 2004-04-07
AU2002224113A1 (en) 2002-06-03
CA2430112C (en) 2010-07-27
EP1344829A1 (en) 2003-09-17

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