CN1407873A - 医疗装置 - Google Patents
医疗装置 Download PDFInfo
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- CN1407873A CN1407873A CN00816717.6A CN00816717A CN1407873A CN 1407873 A CN1407873 A CN 1407873A CN 00816717 A CN00816717 A CN 00816717A CN 1407873 A CN1407873 A CN 1407873A
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
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Abstract
Description
动物号,处理,观察终止时间 | 求积法(来自A和B片段) | SEM(A片段) | 组织学(B片段) |
OD1 53,600μgVEGF,1周 | 57.9% | 32.7% | 内皮细胞盖在中膜上,中等量内腔内皮细胞 |
OD155,600μgVEGF+300μgFGF-2,1周 | 57.6% | 38.9% | 内皮细胞在移植物膜壁层表面上,中等量内腔内皮细胞 |
OD156,安慰剂,1周 | 32.9% | 21.6% | 腔内血栓。观察到腔 |
内移植物表面单一内皮细胞 | |||
OD178,600μgVEGF,2周 | 55.8% | 73.4% | 几乎全部有内皮内衬 |
OD179,安慰剂,2周 | 0%,血栓形成 | 0%,血栓形成 | 血栓性阻塞 |
OD184,600μgVEGF,2周 | 62.0% | 66.5% | 内腔侧大部分内皮化 |
动物号,处理,观察终止时间 | 组织学(完全支架移植物),dx | 组织学(完全支架移植物),sin |
0D182,600μgVEGF,1周 | 极少内腔内皮细胞 | 内腔内皮细胞 |
OD191,对照,1周 | 新鲜阻塞的血栓 | 腔内血栓形成,单一内皮细胞? |
Claims (37)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE99044547 | 1999-12-07 | ||
SE9904454A SE9904454D0 (sv) | 1999-12-07 | 1999-12-07 | Medical implant |
SE99047474 | 1999-12-23 | ||
SE9904747A SE9904747D0 (sv) | 1999-12-07 | 1999-12-23 | Medical Implant |
SE0000285A SE0000285D0 (sv) | 1999-12-07 | 2000-01-31 | Medical implant |
SE00002857 | 2000-01-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1407873A true CN1407873A (zh) | 2003-04-02 |
CN1239133C CN1239133C (zh) | 2006-02-01 |
Family
ID=27354498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN00816717.6A Expired - Fee Related CN1239133C (zh) | 1999-12-07 | 2000-12-07 | 医疗装置 |
Country Status (13)
Country | Link |
---|---|
US (1) | US20030059463A1 (zh) |
EP (1) | EP1235536B1 (zh) |
JP (1) | JP2003516180A (zh) |
CN (1) | CN1239133C (zh) |
AT (1) | ATE243479T1 (zh) |
AU (1) | AU782237B2 (zh) |
CA (1) | CA2392284C (zh) |
DE (1) | DE60003580T2 (zh) |
DK (1) | DK1235536T3 (zh) |
ES (1) | ES2206342T3 (zh) |
HK (1) | HK1054858A1 (zh) |
SE (1) | SE0000285D0 (zh) |
WO (1) | WO2001041674A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100357443C (zh) * | 2000-11-27 | 2007-12-26 | 株式会社载体研究所 | 编码血管生成基因的副粘病毒载体及其应用 |
CN101474456B (zh) * | 2009-02-09 | 2012-02-22 | 乐普(北京)医疗器械股份有限公司 | 一种携载基因的医疗器械的制备方法 |
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Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030008396A1 (en) * | 1999-03-17 | 2003-01-09 | Ku David N. | Poly(vinyl alcohol) hydrogel |
US6596699B2 (en) | 1998-09-22 | 2003-07-22 | Biosurface Engineering Technologies, Inc. | Nucleic acid coating compositions and methods |
US6368658B1 (en) * | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
US7592017B2 (en) * | 2000-03-10 | 2009-09-22 | Mast Biosurgery Ag | Resorbable thin membranes |
AUPR148400A0 (en) | 2000-11-14 | 2000-12-07 | Cochlear Limited | Apparatus for delivery of pharmaceuticals to the cochlea |
US9089450B2 (en) | 2000-11-14 | 2015-07-28 | Cochlear Limited | Implantatable component having an accessible lumen and a drug release capsule for introduction into same |
AUPR879201A0 (en) | 2001-11-09 | 2001-12-06 | Cochlear Limited | Subthreshold stimulation of a cochlea |
US20030114923A1 (en) * | 2001-11-14 | 2003-06-19 | Swanick Thomas M. | Graft and method of making |
US8048444B2 (en) * | 2002-07-31 | 2011-11-01 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
DK1545389T3 (da) * | 2002-07-31 | 2020-07-20 | Mast Biosurgery Ag | Indretning til forebyggelse af adhæsioner mellem et implantat og omgivende væv |
US7704520B1 (en) * | 2002-09-10 | 2010-04-27 | Mast Biosurgery Ag | Methods of promoting enhanced healing of tissues after cardiac surgery |
US8515560B2 (en) | 2002-11-29 | 2013-08-20 | Cochlear Limited | Medical implant drug delivery device |
US7627373B2 (en) * | 2002-11-30 | 2009-12-01 | Cardiac Pacemakers, Inc. | Method and apparatus for cell and electrical therapy of living tissue |
US7044965B1 (en) * | 2002-12-13 | 2006-05-16 | Spielberg Theodore E | Therapeutic cellular stent |
US7371256B2 (en) * | 2002-12-16 | 2008-05-13 | Poly-Med, Inc | Composite vascular constructs with selectively controlled properties |
US20060083767A1 (en) * | 2003-02-27 | 2006-04-20 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
CA2517250A1 (en) * | 2003-02-28 | 2004-09-10 | Schaerer Mayfield Technologies Gmbh | Device for localizing, influencing and guiding tracking bodies, and method for operating a marking device |
US20040230298A1 (en) * | 2003-04-25 | 2004-11-18 | Medtronic Vascular, Inc. | Drug-polymer coated stent with polysulfone and styrenic block copolymer |
WO2005018683A2 (en) * | 2003-05-23 | 2005-03-03 | Angiotech International Ag | Anastomotic connector devices |
DE10328816A1 (de) * | 2003-06-21 | 2005-01-05 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Implantierbare Stimulationselektrode mit einer Beschichtung zur Erhöhung der Gewebsverträglichkeit |
US20100266663A1 (en) * | 2003-09-10 | 2010-10-21 | Calhoun Christopher J | Tissue-treating implantable compositions |
US8435285B2 (en) * | 2003-11-25 | 2013-05-07 | Boston Scientific Scimed, Inc. | Composite stent with inner and outer stent elements and method of using the same |
CA2558623C (en) | 2004-02-06 | 2013-04-16 | Georgia Tech Research Corporation | Surface directed cellular attachment |
AU2005212339B2 (en) * | 2004-02-06 | 2010-11-25 | Georgia Tech Research Corporation | Load bearing biocompatible device |
US7840263B2 (en) * | 2004-02-27 | 2010-11-23 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
US7764995B2 (en) | 2004-06-07 | 2010-07-27 | Cardiac Pacemakers, Inc. | Method and apparatus to modulate cellular regeneration post myocardial infarct |
US20050278025A1 (en) * | 2004-06-10 | 2005-12-15 | Salumedica Llc | Meniscus prosthesis |
US7556800B2 (en) * | 2004-07-09 | 2009-07-07 | Viscofan, S.A | Universal fishing bait based on filaments or strips of fibrous collagen |
US7534422B2 (en) * | 2004-07-09 | 2009-05-19 | Viscofan, S.A. | Universal fishing bait based on fibrous collagen and the procedure for its preparation |
US7729761B2 (en) * | 2004-07-14 | 2010-06-01 | Cardiac Pacemakers, Inc. | Method and apparatus for controlled gene or protein delivery |
DE602005017708D1 (de) * | 2004-07-28 | 2009-12-31 | Cordis Corp | Bifurkationsprothese zur Reparatur eines Bauchaortenaneurysmas |
JP4906723B2 (ja) * | 2004-08-13 | 2012-03-28 | マスト バイオサージェリー アクチェンゲゼルシャフト | 生分解性および非生分解性領域を有する外科用補綴物 |
US20080091277A1 (en) * | 2004-08-13 | 2008-04-17 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
WO2006026325A2 (en) * | 2004-08-26 | 2006-03-09 | Pathak Chandrashekhar P | Implantable tissue compositions and method |
US8060219B2 (en) * | 2004-12-20 | 2011-11-15 | Cardiac Pacemakers, Inc. | Epicardial patch including isolated extracellular matrix with pacing electrodes |
US7981065B2 (en) | 2004-12-20 | 2011-07-19 | Cardiac Pacemakers, Inc. | Lead electrode incorporating extracellular matrix |
US20070010741A1 (en) * | 2005-05-19 | 2007-01-11 | Biophan Technologies, Inc. | Electromagnetic resonant circuit sleeve for implantable medical device |
US20080119878A1 (en) * | 2005-08-12 | 2008-05-22 | Kai Deusch | Surgical prosthesis having biodegradable and nonbiodegradable regions |
US7774057B2 (en) | 2005-09-06 | 2010-08-10 | Cardiac Pacemakers, Inc. | Method and apparatus for device controlled gene expression for cardiac protection |
US20070134204A1 (en) * | 2005-12-09 | 2007-06-14 | Henrich Cheng | Method for treating nerve injury and vector construct for the same |
US9629626B2 (en) * | 2006-02-02 | 2017-04-25 | Covidien Lp | Mechanically tuned buttress material to assist with proper formation of surgical element in diseased tissue |
US20070190028A1 (en) * | 2006-02-13 | 2007-08-16 | Jihong Qu | Method and apparatus for heat or electromagnetic control of gene expression |
DE102006053260A1 (de) * | 2006-07-20 | 2008-01-24 | Clinical House Europe Gmbh | Implantat zur Verankerung von Zahnersatz |
US20080171972A1 (en) * | 2006-10-06 | 2008-07-17 | Stopek Joshua B | Medical device package |
US8133215B2 (en) | 2007-08-13 | 2012-03-13 | Cochlear Limited | Independently-manufactured drug delivery module and corresponding receptacle in an implantable medical device |
US8617097B2 (en) | 2010-05-24 | 2013-12-31 | Cochlear Limited | Drug-delivery accessory for an implantable medical device |
US8597948B2 (en) | 2011-03-10 | 2013-12-03 | First Principles, Inc. | Cloned biological material medical device and method thereof |
WO2012162552A1 (en) | 2011-05-26 | 2012-11-29 | Cartiva, Inc. | Tapered joint implant and related tools |
WO2016065245A1 (en) * | 2014-10-24 | 2016-04-28 | Incept, Llc | Extra luminal scaffold |
WO2016161025A1 (en) | 2015-03-31 | 2016-10-06 | Cartiva, Inc. | Hydrogel implants with porous materials and methods |
WO2016161026A1 (en) | 2015-03-31 | 2016-10-06 | Cartiva, Inc. | Carpometacarpal (cmc) implants and methods |
AU2016248062B2 (en) | 2015-04-14 | 2020-01-23 | Cartiva, Inc. | Tooling for creating tapered opening in tissue and related methods |
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US11724089B2 (en) | 2019-09-25 | 2023-08-15 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7196054B1 (en) * | 1990-11-27 | 2007-03-27 | The American National Red Cross | Methods for treating wound tissue and forming a supplemented fibrin matrix |
US5782789A (en) * | 1994-10-19 | 1998-07-21 | Atrium Medical Corporation | Macrochannel phosthetic/delivery patch |
CA2222136C (en) * | 1995-05-26 | 2005-04-05 | Bsi Corporation | Method and implantable article for promoting endothelialization |
KR100695590B1 (ko) * | 1996-11-01 | 2007-03-14 | 아크 테라퓨틱스 리미티드 | 산화질소 또는 프로스타시클린 생산을 자극하는 약제의 치료학적 용도 및 전달 기구 |
US5972027A (en) * | 1997-09-30 | 1999-10-26 | Scimed Life Systems, Inc | Porous stent drug delivery system |
GB9809082D0 (en) * | 1998-04-28 | 1998-06-24 | Eurogene Limited | Delivery device |
US6497729B1 (en) * | 1998-11-20 | 2002-12-24 | The University Of Connecticut | Implant coating for control of tissue/implant interactions |
US6398808B1 (en) * | 1999-06-15 | 2002-06-04 | Scimed Life Systems, Inc. | Localized delivery of genetic information from biostable materials |
-
2000
- 2000-01-31 SE SE0000285A patent/SE0000285D0/xx unknown
- 2000-12-07 CA CA002392284A patent/CA2392284C/en not_active Expired - Fee Related
- 2000-12-07 ES ES00986137T patent/ES2206342T3/es not_active Expired - Lifetime
- 2000-12-07 AU AU22429/01A patent/AU782237B2/en not_active Ceased
- 2000-12-07 CN CN00816717.6A patent/CN1239133C/zh not_active Expired - Fee Related
- 2000-12-07 AT AT00986137T patent/ATE243479T1/de not_active IP Right Cessation
- 2000-12-07 EP EP00986137A patent/EP1235536B1/en not_active Expired - Lifetime
- 2000-12-07 WO PCT/SE2000/002460 patent/WO2001041674A1/en active IP Right Grant
- 2000-12-07 JP JP2001542846A patent/JP2003516180A/ja not_active Withdrawn
- 2000-12-07 DE DE60003580T patent/DE60003580T2/de not_active Expired - Lifetime
- 2000-12-07 DK DK00986137T patent/DK1235536T3/da active
- 2000-12-07 US US10/149,013 patent/US20030059463A1/en not_active Abandoned
-
2003
- 2003-10-02 HK HK03107112A patent/HK1054858A1/xx not_active IP Right Cessation
Cited By (6)
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CN100357443C (zh) * | 2000-11-27 | 2007-12-26 | 株式会社载体研究所 | 编码血管生成基因的副粘病毒载体及其应用 |
US8211868B2 (en) | 2000-11-27 | 2012-07-03 | Dnavec Research Inc. | Paramyxovirus vector encoding angiogenesis gene and use thereof |
CN101474456B (zh) * | 2009-02-09 | 2012-02-22 | 乐普(北京)医疗器械股份有限公司 | 一种携载基因的医疗器械的制备方法 |
CN101502696B (zh) * | 2009-02-17 | 2012-07-11 | 乐普(北京)医疗器械股份有限公司 | 一种携载基因和/或药物的医疗器械及其制备方法 |
CN103635159A (zh) * | 2011-05-09 | 2014-03-12 | 帕尔玛兹科学公司 | 具有经增强内皮迁移特征的可植入医疗装置及其制作方法 |
CN108938143A (zh) * | 2018-08-15 | 2018-12-07 | 湖南工业大学 | 一种三层结构小口径仿生血管及其制备方法 |
Also Published As
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WO2001041674A1 (en) | 2001-06-14 |
DE60003580D1 (de) | 2003-07-31 |
ATE243479T1 (de) | 2003-07-15 |
US20030059463A1 (en) | 2003-03-27 |
CA2392284C (en) | 2009-08-18 |
CA2392284A1 (en) | 2001-06-14 |
DE60003580T2 (de) | 2004-05-27 |
EP1235536A1 (en) | 2002-09-04 |
HK1054858A1 (en) | 2003-12-19 |
AU2242901A (en) | 2001-06-18 |
CN1239133C (zh) | 2006-02-01 |
JP2003516180A (ja) | 2003-05-13 |
EP1235536B1 (en) | 2003-06-25 |
ES2206342T3 (es) | 2004-05-16 |
AU782237B2 (en) | 2005-07-14 |
DK1235536T3 (da) | 2003-10-20 |
SE0000285D0 (sv) | 2000-01-31 |
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