CN100354628C - 由偶联物非共价结合形成的表位 - Google Patents
由偶联物非共价结合形成的表位 Download PDFInfo
- Publication number
- CN100354628C CN100354628C CNB008096538A CN00809653A CN100354628C CN 100354628 C CN100354628 C CN 100354628C CN B008096538 A CNB008096538 A CN B008096538A CN 00809653 A CN00809653 A CN 00809653A CN 100354628 C CN100354628 C CN 100354628C
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- CN
- China
- Prior art keywords
- amino acid
- conjugate
- group
- head group
- microlitres
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/5432—Liposomes or microcapsules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/525—Tumor necrosis factor [TNF]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Dental Preparations (AREA)
- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
Claims (29)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9915074.0 | 1999-06-28 | ||
GBGB9915074.0A GB9915074D0 (en) | 1999-06-28 | 1999-06-28 | Ligand-binding composition |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1359469A CN1359469A (zh) | 2002-07-17 |
CN100354628C true CN100354628C (zh) | 2007-12-12 |
Family
ID=10856190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008096538A Expired - Fee Related CN100354628C (zh) | 1999-06-28 | 2000-06-27 | 由偶联物非共价结合形成的表位 |
Country Status (18)
Country | Link |
---|---|
US (2) | US7413538B1 (zh) |
EP (2) | EP1190255B1 (zh) |
JP (1) | JP4754136B2 (zh) |
KR (1) | KR100917285B1 (zh) |
CN (1) | CN100354628C (zh) |
AT (2) | ATE457460T1 (zh) |
AU (1) | AU775310B2 (zh) |
BR (1) | BR0012002A (zh) |
CA (1) | CA2377783C (zh) |
DE (2) | DE60043830D1 (zh) |
DK (1) | DK1190255T3 (zh) |
ES (1) | ES2292446T3 (zh) |
GB (1) | GB9915074D0 (zh) |
HK (1) | HK1045369A1 (zh) |
IL (2) | IL147249A0 (zh) |
PT (1) | PT1190255E (zh) |
RU (1) | RU2259194C2 (zh) |
WO (1) | WO2001001140A1 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7504364B2 (en) * | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
US7469076B2 (en) | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
EP1613737A4 (en) | 2003-03-28 | 2008-12-03 | Receptors Llc | ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS |
US7504365B2 (en) | 2004-09-03 | 2009-03-17 | Receptors Llc | Combinatorial artificial receptors including tether building blocks |
US7985715B2 (en) | 2004-09-11 | 2011-07-26 | Receptors Llc | Combinatorial artificial receptors including peptide building blocks |
ES2459020T3 (es) | 2006-09-20 | 2014-05-07 | Lexcicon Limited | Péptidos |
KR100840619B1 (ko) * | 2006-12-19 | 2008-06-24 | 한양대학교 산학협력단 | 표면개질된 리포좀, 이를 포함하는 바이오칩 및 그제조방법 |
EP2231180B1 (en) * | 2008-01-16 | 2016-08-17 | Ben-gurion University Of The Negev Research And Development Authority | Vaccine for alzheimer's disease |
WO2010086864A1 (en) | 2009-02-02 | 2010-08-05 | Galmed International Ltd. | Methods and compositions for treating alzheimer's disease |
RU2500813C1 (ru) * | 2012-10-15 | 2013-12-10 | Федеральное казенное учреждение здравоохранения Ставропольский научно-исследовательский противочумный институт Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека | Способ получения липосомально-иммунопероксидазного конъюгата |
KR101491728B1 (ko) * | 2012-12-14 | 2015-02-11 | 주식회사 휴메딕스 | 비타민 c와 비타민 b3의 컨쥬게이트 및 그를 포함하는 항산화제 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338437A2 (de) * | 1988-04-22 | 1989-10-25 | Hoechst Aktiengesellschaft | Synthetische Vakzine gegen die Maul- und Klauenseuche und Verfahren zu deren Herstellung |
CN1123185A (zh) * | 1994-09-16 | 1996-05-29 | 默克专利股份有限公司 | 免疫偶联物 |
US5580563A (en) * | 1992-05-01 | 1996-12-03 | Tam; James P. | Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof |
US5882645A (en) * | 1992-07-24 | 1999-03-16 | The School Of Pharmacy, University Of London | Peptide compounds |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3546150A1 (de) * | 1985-06-24 | 1987-01-22 | Hoechst Ag | Membrananker-wirkstoffkonjugat, seine herstellung sowie seine verwendung |
US6024964A (en) | 1985-06-24 | 2000-02-15 | Hoechst Aktiengesellschaft | Membrane anchor/active compound conjugate, its preparation and its uses |
US6074650A (en) | 1985-06-24 | 2000-06-13 | Hoechst Aktiengesellschaft | Membrane anchor/active compound conjugate, its preparation and its uses |
JP3220180B2 (ja) * | 1991-05-23 | 2001-10-22 | 三菱化学株式会社 | 薬剤含有タンパク質結合リポソーム |
DK0548024T3 (da) * | 1991-12-19 | 1997-01-27 | Ciba Geigy Ag | Aminosulfonsyrederivater samt fremgangsmåder til deres fremstilling |
JP2579730B2 (ja) * | 1993-01-22 | 1997-02-12 | 株式会社ディ・ディ・エス研究所 | ペプチド−脂質誘導体及びリポソーム |
AU696991B2 (en) * | 1993-07-16 | 1998-09-24 | Board Of Trustees Of The Leland Stanford Junior University | Regulated apoptosis |
JP3759759B2 (ja) * | 1994-03-04 | 2006-03-29 | 日本油脂株式会社 | リポソームおよび薬物運搬体 |
US6214388B1 (en) * | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
US5837544A (en) * | 1995-02-02 | 1998-11-17 | Cell Genesys, Inc. | Method of inducing a cell to proliferate using a chimeric receptor comprising janus kinase |
US5851536A (en) * | 1995-11-22 | 1998-12-22 | University Of Washington | Therapeutic delivery using compounds self-assembled into high axial ratio microstructures |
US6344436B1 (en) * | 1996-01-08 | 2002-02-05 | Baylor College Of Medicine | Lipophilic peptides for macromolecule delivery |
CA2260761C (en) * | 1996-06-25 | 2011-05-03 | Nico Johannes Christiaan Maria Beekman | Vaccine comprising antigens bound to carriers through labile bonds |
JPH10234372A (ja) * | 1997-02-27 | 1998-09-08 | Boehringer Mannheim Corp | キメラ受容体を有する細胞とその作成方法、並びに その利用 |
US6217886B1 (en) * | 1997-07-14 | 2001-04-17 | The Board Of Trustees Of The University Of Illinois | Materials and methods for making improved micelle compositions |
FR2774687B1 (fr) * | 1998-02-06 | 2002-03-22 | Inst Nat Sante Rech Med | Lipopeptides contenant un fragment de l'interferon gamma, et leur utilisation dans des compositions pharmaceutiques |
JP2002510706A (ja) * | 1998-04-07 | 2002-04-09 | ロシュ ダイアグノスティックス ゲーエムベーハー | Dnaトランスフェクションのための新規化合物 |
FR2776926B1 (fr) * | 1998-04-07 | 2003-10-24 | Inst Nat Sante Rech Med | Lipopeptides inducteurs de cytotoxicite t lymphocytaire portant au moins un epitope t auxiliaire, et leurs utilisations pour la vaccination |
EP1170018A4 (en) * | 1999-03-17 | 2002-04-17 | Mitsubishi Chem Corp | COMPLEX LINKED BY A LIGAND |
AU3673500A (en) * | 1999-04-08 | 2000-11-14 | Mitsubishi Chemical Corporation | Fine particles targeting cells and process for producing the same |
CA2370043A1 (en) * | 1999-04-23 | 2000-11-02 | Mitsubishi Chemical Corporation | Liposome bonded with antibody and polyalkylene glycol |
EP1880736A1 (en) * | 1999-04-23 | 2008-01-23 | Alza Corporation | Releasable linkage and composition containing same |
-
1999
- 1999-06-28 GB GBGB9915074.0A patent/GB9915074D0/en not_active Ceased
-
2000
- 2000-06-27 WO PCT/GB2000/002465 patent/WO2001001140A1/en active IP Right Grant
- 2000-06-27 CA CA2377783A patent/CA2377783C/en not_active Expired - Fee Related
- 2000-06-27 KR KR1020017016715A patent/KR100917285B1/ko not_active IP Right Cessation
- 2000-06-27 AT AT06012344T patent/ATE457460T1/de not_active IP Right Cessation
- 2000-06-27 EP EP00942216A patent/EP1190255B1/en not_active Expired - Lifetime
- 2000-06-27 EP EP06012344A patent/EP1722227B1/en not_active Expired - Lifetime
- 2000-06-27 PT PT00942216T patent/PT1190255E/pt unknown
- 2000-06-27 RU RU2002101927/15A patent/RU2259194C2/ru not_active IP Right Cessation
- 2000-06-27 DK DK00942216T patent/DK1190255T3/da active
- 2000-06-27 DE DE60043830T patent/DE60043830D1/de not_active Expired - Fee Related
- 2000-06-27 ES ES00942216T patent/ES2292446T3/es not_active Expired - Lifetime
- 2000-06-27 CN CNB008096538A patent/CN100354628C/zh not_active Expired - Fee Related
- 2000-06-27 DE DE60036106T patent/DE60036106T2/de not_active Expired - Lifetime
- 2000-06-27 IL IL14724900A patent/IL147249A0/xx active IP Right Grant
- 2000-06-27 AT AT00942216T patent/ATE371190T1/de not_active IP Right Cessation
- 2000-06-27 JP JP2001507094A patent/JP4754136B2/ja not_active Expired - Fee Related
- 2000-06-27 AU AU56923/00A patent/AU775310B2/en not_active Ceased
- 2000-06-27 BR BR0012002-2A patent/BR0012002A/pt not_active Application Discontinuation
- 2000-06-27 US US10/019,052 patent/US7413538B1/en not_active Expired - Fee Related
-
2001
- 2001-12-23 IL IL147249A patent/IL147249A/en not_active IP Right Cessation
-
2002
- 2002-09-13 HK HK02106716A patent/HK1045369A1/xx not_active IP Right Cessation
-
2008
- 2008-03-04 US US12/041,939 patent/US20080152703A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338437A2 (de) * | 1988-04-22 | 1989-10-25 | Hoechst Aktiengesellschaft | Synthetische Vakzine gegen die Maul- und Klauenseuche und Verfahren zu deren Herstellung |
US5580563A (en) * | 1992-05-01 | 1996-12-03 | Tam; James P. | Multiple antigen peptide system having adjuvant properties, vaccines prepared therefrom and methods of use thereof |
US5882645A (en) * | 1992-07-24 | 1999-03-16 | The School Of Pharmacy, University Of London | Peptide compounds |
CN1123185A (zh) * | 1994-09-16 | 1996-05-29 | 默克专利股份有限公司 | 免疫偶联物 |
Also Published As
Publication number | Publication date |
---|---|
JP4754136B2 (ja) | 2011-08-24 |
US7413538B1 (en) | 2008-08-19 |
DE60036106T2 (de) | 2008-05-15 |
WO2001001140A1 (en) | 2001-01-04 |
HK1045369A1 (en) | 2002-11-22 |
RU2259194C2 (ru) | 2005-08-27 |
EP1722227B1 (en) | 2010-02-10 |
AU5692300A (en) | 2001-01-31 |
DK1190255T3 (da) | 2007-12-10 |
CA2377783A1 (en) | 2001-01-04 |
EP1722227A3 (en) | 2007-02-28 |
GB9915074D0 (en) | 1999-08-25 |
DE60043830D1 (de) | 2010-03-25 |
ES2292446T3 (es) | 2008-03-16 |
JP2003503424A (ja) | 2003-01-28 |
KR20020042537A (ko) | 2002-06-05 |
IL147249A (en) | 2007-08-19 |
DE60036106D1 (de) | 2007-10-04 |
EP1190255A1 (en) | 2002-03-27 |
CA2377783C (en) | 2010-03-23 |
KR100917285B1 (ko) | 2009-09-11 |
ATE457460T1 (de) | 2010-02-15 |
EP1722227A2 (en) | 2006-11-15 |
EP1190255B1 (en) | 2007-08-22 |
AU775310B2 (en) | 2004-07-29 |
ATE371190T1 (de) | 2007-09-15 |
US20080152703A1 (en) | 2008-06-26 |
PT1190255E (pt) | 2007-09-18 |
IL147249A0 (en) | 2002-08-14 |
CN1359469A (zh) | 2002-07-17 |
BR0012002A (pt) | 2002-03-12 |
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Owner name: MOSAIC FOUND CO., LTD. Free format text: FORMER OWNER: PLOG C-MART CONCEPT CO., LTD. Free format text: FORMER OWNER: MOSAIC FOUND CO., LTD. Effective date: 20050805 |
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