CL2022003427A1 - Inhibidores de las cinasas receptoras del factor de crecimiento de fibroblastos. - Google Patents

Inhibidores de las cinasas receptoras del factor de crecimiento de fibroblastos.

Info

Publication number
CL2022003427A1
CL2022003427A1 CL2022003427A CL2022003427A CL2022003427A1 CL 2022003427 A1 CL2022003427 A1 CL 2022003427A1 CL 2022003427 A CL2022003427 A CL 2022003427A CL 2022003427 A CL2022003427 A CL 2022003427A CL 2022003427 A1 CL2022003427 A1 CL 2022003427A1
Authority
CL
Chile
Prior art keywords
inhibitors
growth factor
factor receptor
fibroblast growth
receptor kinases
Prior art date
Application number
CL2022003427A
Other languages
English (en)
Inventor
W Kaldor Stephen
Tyhonas John
A Murphy Eric
Kanouni Toufike
D Arnold Lee
Kania Robert
M Cox Jason
Original Assignee
Kinnate Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kinnate Biopharma Inc filed Critical Kinnate Biopharma Inc
Publication of CL2022003427A1 publication Critical patent/CL2022003427A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

COMPUESTOS DERIVADOS DE PIRAZOL-4-CARBOXAMIDA; COMPOSICION FARMACEUTICA Y SU USO EN EL TRATAMIENTO DEL CANCER.
CL2022003427A 2020-06-05 2022-12-02 Inhibidores de las cinasas receptoras del factor de crecimiento de fibroblastos. CL2022003427A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063035155P 2020-06-05 2020-06-05
US202063106812P 2020-10-28 2020-10-28

Publications (1)

Publication Number Publication Date
CL2022003427A1 true CL2022003427A1 (es) 2023-06-30

Family

ID=78829924

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2022003427A CL2022003427A1 (es) 2020-06-05 2022-12-02 Inhibidores de las cinasas receptoras del factor de crecimiento de fibroblastos.

Country Status (14)

Country Link
US (2) US11345681B1 (es)
EP (1) EP4161656A1 (es)
JP (1) JP2023529867A (es)
KR (1) KR20230035031A (es)
CN (1) CN116057045A (es)
AU (1) AU2021282596A1 (es)
BR (1) BR112022024729A2 (es)
CA (1) CA3181162A1 (es)
CL (1) CL2022003427A1 (es)
CO (1) CO2022018806A2 (es)
IL (1) IL298760A (es)
MX (1) MX2022015410A (es)
TW (1) TW202210472A (es)
WO (1) WO2021247969A1 (es)

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BR112022024729A2 (pt) 2020-06-05 2023-02-28 Kinnate Biopharma Inc Inibidores de quinases do receptor do fator de crescimento de fibroblastos
EP4277903A1 (en) * 2021-01-12 2023-11-22 Beijing InnoCare Pharma Tech Co., Ltd. Process for preparing (s)-1-(1-acryloylpyrrolidin-3-yl)-3-((3,5-dimethoxyphenyl) ethynyl)-5-(methylamino)-1h-pyrazole-4-carboxamide
WO2023107979A1 (en) * 2021-12-08 2023-06-15 Kinnate Biopharma Inc. Treatment of cancer with an fgfr kinase inhibitor
TW202332432A (zh) * 2021-12-08 2023-08-16 美商奇奈特生物製藥公司 Egfr抑制劑的固態形式
WO2023107870A1 (en) * 2021-12-08 2023-06-15 Kinnate Biopharma Inc. Inhibitors of fibroblast growth factor receptor kinases
CN115232074A (zh) * 2022-08-22 2022-10-25 湖南复瑞生物医药技术有限责任公司 一种1-烷基取代-2-甲基-5-溴苯并咪唑的合成方法

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