CL2021000491A1 - Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas - Google Patents
Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadasInfo
- Publication number
- CL2021000491A1 CL2021000491A1 CL2021000491A CL2021000491A CL2021000491A1 CL 2021000491 A1 CL2021000491 A1 CL 2021000491A1 CL 2021000491 A CL2021000491 A CL 2021000491A CL 2021000491 A CL2021000491 A CL 2021000491A CL 2021000491 A1 CL2021000491 A1 CL 2021000491A1
- Authority
- CL
- Chile
- Prior art keywords
- treatment
- ehgna
- ehna
- combinations
- related diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gastroenterology & Hepatology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862726172P | 2018-08-31 | 2018-08-31 | |
| US201962883860P | 2019-08-07 | 2019-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2021000491A1 true CL2021000491A1 (es) | 2021-08-20 |
Family
ID=68165623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2021000491A CL2021000491A1 (es) | 2018-08-31 | 2021-02-26 | Combinaciones para tratamiento de ehna/ehgna y enfermedades relacionadas |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US11254660B2 (https=) |
| EP (1) | EP3843740A1 (https=) |
| JP (1) | JP7161605B2 (https=) |
| KR (1) | KR102614808B1 (https=) |
| CN (1) | CN112955147A (https=) |
| AU (1) | AU2019329884B2 (https=) |
| BR (1) | BR112021003039A2 (https=) |
| CA (1) | CA3110601C (https=) |
| CL (1) | CL2021000491A1 (https=) |
| CO (1) | CO2021002230A2 (https=) |
| CR (1) | CR20210110A (https=) |
| DO (1) | DOP2021000036A (https=) |
| EC (1) | ECSP21012501A (https=) |
| IL (1) | IL281093B2 (https=) |
| MA (1) | MA53496A (https=) |
| MX (1) | MX2021002428A (https=) |
| PH (1) | PH12021550339A1 (https=) |
| PY (1) | PY1972032A (https=) |
| SG (1) | SG11202101503RA (https=) |
| TW (1) | TWI718644B (https=) |
| UY (1) | UY38351A (https=) |
| WO (1) | WO2020044266A1 (https=) |
| ZA (1) | ZA202101090B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US11590161B2 (en) | 2018-08-13 | 2023-02-28 | Viscera Labs, Inc. | Therapeutic composition and methods |
| MA54555A (fr) | 2018-11-22 | 2021-09-29 | Qilu Regor Therapeutics Inc | Agonistes de glp-1r et leurs utilisations |
| MX2021008010A (es) * | 2018-12-31 | 2021-10-13 | Coherus Biosciences Inc | Composiciones y métodos para tratar las enfermedades del hígado graso no alcohólico (nafld). |
| MX2021008661A (es) | 2019-01-18 | 2021-08-19 | Astrazeneca Ab | Inhibidores de la pcsk9 y metodos de uso de los mismos. |
| BR112021013807A2 (pt) | 2019-01-18 | 2021-11-30 | Astrazeneca Ab | Inibidores de pcsk9 e seus métodos de uso |
| EP3953344A4 (en) | 2019-04-12 | 2023-08-09 | Qilu Regor Therapeutics Inc. | GLP-IR AGONISTS AND THEIR USES |
| HRP20241159T1 (hr) | 2020-02-07 | 2024-12-06 | Gasherbrum Bio, Inc. | Heterociklički agonisti za glp-1 |
| JP2022058085A (ja) * | 2020-02-24 | 2022-04-11 | ファイザー・インク | ジアシルグリセロールアシルトランスフェラーゼ２阻害剤とアセチル－ＣｏＡカルボキシラーゼ阻害剤との組合せ |
| JP2021134211A (ja) * | 2020-02-24 | 2021-09-13 | ファイザー・インク | Ｎａｆｌｄ／ｎａｓｈおよび関連疾患の処置のための組合せ |
| CA3168474A1 (en) * | 2020-03-11 | 2021-09-16 | Mi-Kyung Kim | Pharmaceutical composition for prevention or treatment of nonalcoholic steatohepatitis |
| WO2021211959A2 (en) * | 2020-04-18 | 2021-10-21 | Inipharm, Inc. | Methods and compositions for treating drug induced steatohepatitis |
| US11478533B2 (en) | 2020-04-27 | 2022-10-25 | Novo Nordisk A/S | Semaglutide for use in medicine |
| TW202206429A (zh) | 2020-04-29 | 2022-02-16 | 美商迦舒布魯姆生物有限公司 | 雜環ｇｌｐ—１促效劑 |
| CN113816948B (zh) * | 2020-06-19 | 2023-08-11 | 江苏恒瑞医药股份有限公司 | 稠合咪唑类衍生物、其制备方法及其在医药上的应用 |
| JP2023537501A (ja) | 2020-08-06 | 2023-09-01 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環ｇｌｐ－１アゴニスト |
| CA3192601A1 (en) * | 2020-08-21 | 2022-02-24 | Terns Pharmaceuticals, Inc. | Compounds as glp-1r agonists |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| CN112635049A (zh) * | 2020-12-23 | 2021-04-09 | 无锡市第二人民医院 | 一种研究HSD17B13 rs72613567基因变异和肾功能损伤之间关系的方法 |
| PT4408840T (pt) | 2021-09-27 | 2025-10-07 | Terns Pharmaceuticals Inc | Ácidos benzimidazolocarboxílicos como agonistas de glp-1r |
| CN118401519A (zh) | 2021-10-25 | 2024-07-26 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| CN119095843A (zh) | 2022-02-23 | 2024-12-06 | 拓臻制药公司 | 作为glp-1r激动剂的化合物 |
| JP2025509281A (ja) | 2022-03-09 | 2025-04-11 | ガシャーブラム・バイオ・インコーポレイテッド | ヘテロ環式ｇｌｐ－１アゴニスト |
| US20250250269A1 (en) | 2022-04-14 | 2025-08-07 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
| TW202435857A (zh) | 2022-12-15 | 2024-09-16 | 美商迦舒布魯姆生物有限公司 | 具有glp-1促效劑活性之化合物之鹽及固體形式 |
| EP4568664B1 (en) | 2023-04-07 | 2026-04-01 | Terns Pharmaceuticals, Inc. | Combination comprising a thr-beta agonist and a glp-1r agonist for use in treating obesity |
| EP4731212A1 (en) * | 2023-06-20 | 2026-04-29 | Sagimet Biosciences Inc. | Combination therapies of fasn inhibitors with thyroid hormone receptor agonists |
| WO2025080818A1 (en) * | 2023-10-10 | 2025-04-17 | Sagimet Biosciences Inc. | Combinations of fasn inhibitors and glp-1 agonists for liver diseases |
| CN118787746B (zh) * | 2024-07-01 | 2025-09-16 | 安徽省立医院(中国科学技术大学附属第一医院) | 脂肪酸合成酶抑制剂在预防及治疗药物性肝损伤中的应用 |
| CN120698959B (zh) * | 2025-05-29 | 2026-01-23 | 河北医科大学 | 一种达格列净-依折麦布共无定形物及其制备方法和应用 |
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| EA201791258A1 (ru) | 2015-01-09 | 2017-12-29 | Джилид Аполло, Ллс | Комбинированная терапия с применением ингибитора ацетил-коа-карбоксилазы (acc) для лечения неалкогольной жировой болезни печени |
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-
2019
- 2019-08-28 US US16/553,818 patent/US11254660B2/en active Active
- 2019-08-28 WO PCT/IB2019/057259 patent/WO2020044266A1/en not_active Ceased
- 2019-08-28 JP JP2021510174A patent/JP7161605B2/ja active Active
- 2019-08-28 BR BR112021003039-5A patent/BR112021003039A2/pt unknown
- 2019-08-28 MA MA053496A patent/MA53496A/fr unknown
- 2019-08-28 SG SG11202101503RA patent/SG11202101503RA/en unknown
- 2019-08-28 AU AU2019329884A patent/AU2019329884B2/en active Active
- 2019-08-28 CR CR20210110A patent/CR20210110A/es unknown
- 2019-08-28 TW TW108130771A patent/TWI718644B/zh active
- 2019-08-28 MX MX2021002428A patent/MX2021002428A/es unknown
- 2019-08-28 CN CN201980071389.XA patent/CN112955147A/zh active Pending
- 2019-08-28 IL IL281093A patent/IL281093B2/en unknown
- 2019-08-28 CA CA3110601A patent/CA3110601C/en active Active
- 2019-08-28 KR KR1020217009415A patent/KR102614808B1/ko active Active
- 2019-08-28 EP EP19783644.8A patent/EP3843740A1/en active Pending
- 2019-08-29 UY UY0001038351A patent/UY38351A/es not_active Application Discontinuation
- 2019-08-30 PY PY201901972032A patent/PY1972032A/es unknown
-
2021
- 2021-02-17 PH PH12021550339A patent/PH12021550339A1/en unknown
- 2021-02-17 ZA ZA2021/01090A patent/ZA202101090B/en unknown
- 2021-02-23 EC ECSENADI202112501A patent/ECSP21012501A/es unknown
- 2021-02-23 CO CONC2021/0002230A patent/CO2021002230A2/es unknown
- 2021-02-25 DO DO2021000036A patent/DOP2021000036A/es unknown
- 2021-02-26 CL CL2021000491A patent/CL2021000491A1/es unknown
- 2021-10-11 US US17/498,256 patent/US12247022B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| PY1972032A (es) | 2021-06-03 |
| MA53496A (fr) | 2021-12-08 |
| US11254660B2 (en) | 2022-02-22 |
| SG11202101503RA (en) | 2021-03-30 |
| US20220023299A1 (en) | 2022-01-27 |
| JP2021535126A (ja) | 2021-12-16 |
| IL281093A (en) | 2021-04-29 |
| CR20210110A (es) | 2021-05-13 |
| AU2019329884A1 (en) | 2021-03-11 |
| BR112021003039A2 (pt) | 2021-05-18 |
| TW202026292A (zh) | 2020-07-16 |
| CA3110601C (en) | 2023-09-05 |
| CN112955147A (zh) | 2021-06-11 |
| PH12021550339A1 (en) | 2021-10-04 |
| TWI718644B (zh) | 2021-02-11 |
| JP7161605B2 (ja) | 2022-10-26 |
| WO2020044266A1 (en) | 2020-03-05 |
| CO2021002230A2 (es) | 2021-03-08 |
| CA3110601A1 (en) | 2020-03-05 |
| IL281093B1 (en) | 2025-07-01 |
| EP3843740A1 (en) | 2021-07-07 |
| ECSP21012501A (es) | 2021-03-31 |
| DOP2021000036A (es) | 2021-04-15 |
| US20200071306A1 (en) | 2020-03-05 |
| ZA202101090B (en) | 2022-06-29 |
| KR102614808B1 (ko) | 2023-12-19 |
| US12247022B2 (en) | 2025-03-11 |
| KR20210053929A (ko) | 2021-05-12 |
| UY38351A (es) | 2020-03-31 |
| MX2021002428A (es) | 2023-01-02 |
| IL281093B2 (en) | 2025-11-01 |
| AU2019329884B2 (en) | 2022-01-27 |
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