IL281093B2 - Combinations for treatment of nash/nafld and related diseases - Google Patents

Combinations for treatment of nash/nafld and related diseases

Info

Publication number
IL281093B2
IL281093B2 IL281093A IL28109321A IL281093B2 IL 281093 B2 IL281093 B2 IL 281093B2 IL 281093 A IL281093 A IL 281093A IL 28109321 A IL28109321 A IL 28109321A IL 281093 B2 IL281093 B2 IL 281093B2
Authority
IL
Israel
Prior art keywords
compound
pharmaceutically acceptable
acceptable salt
disease
nonalcoholic steatohepatitis
Prior art date
Application number
IL281093A
Other languages
English (en)
Hebrew (he)
Other versions
IL281093B1 (en
IL281093A (en
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IL281093A publication Critical patent/IL281093A/en
Publication of IL281093B1 publication Critical patent/IL281093B1/en
Publication of IL281093B2 publication Critical patent/IL281093B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
IL281093A 2018-08-31 2019-08-28 Combinations for treatment of nash/nafld and related diseases IL281093B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862726172P 2018-08-31 2018-08-31
US201962883860P 2019-08-07 2019-08-07
PCT/IB2019/057259 WO2020044266A1 (en) 2018-08-31 2019-08-28 Combinations for treatment of nash/nafld and related diseases

Publications (3)

Publication Number Publication Date
IL281093A IL281093A (en) 2021-04-29
IL281093B1 IL281093B1 (en) 2025-07-01
IL281093B2 true IL281093B2 (en) 2025-11-01

Family

ID=68165623

Family Applications (1)

Application Number Title Priority Date Filing Date
IL281093A IL281093B2 (en) 2018-08-31 2019-08-28 Combinations for treatment of nash/nafld and related diseases

Country Status (23)

Country Link
US (2) US11254660B2 (https=)
EP (1) EP3843740A1 (https=)
JP (1) JP7161605B2 (https=)
KR (1) KR102614808B1 (https=)
CN (1) CN112955147A (https=)
AU (1) AU2019329884B2 (https=)
BR (1) BR112021003039A2 (https=)
CA (1) CA3110601C (https=)
CL (1) CL2021000491A1 (https=)
CO (1) CO2021002230A2 (https=)
CR (1) CR20210110A (https=)
DO (1) DOP2021000036A (https=)
EC (1) ECSP21012501A (https=)
IL (1) IL281093B2 (https=)
MA (1) MA53496A (https=)
MX (1) MX2021002428A (https=)
PH (1) PH12021550339A1 (https=)
PY (1) PY1972032A (https=)
SG (1) SG11202101503RA (https=)
TW (1) TWI718644B (https=)
UY (1) UY38351A (https=)
WO (1) WO2020044266A1 (https=)
ZA (1) ZA202101090B (https=)

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CN115335055A (zh) * 2020-03-11 2022-11-11 东亚St株式会社 用于预防或治疗非酒精性脂肪性肝炎的药物组合物
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CN119137124A (zh) 2022-03-09 2024-12-13 加舒布鲁姆生物公司 杂环glp-1激动剂
WO2023198140A1 (en) 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists
JP2026501171A (ja) 2022-12-15 2026-01-14 ガシャーブラム・バイオ・インコーポレイテッド Ｇｌｐ－１アゴニスト活性を有する化合物の塩および固体形態
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Also Published As

Publication number Publication date
TWI718644B (zh) 2021-02-11
EP3843740A1 (en) 2021-07-07
KR102614808B1 (ko) 2023-12-19
MX2021002428A (es) 2023-01-02
AU2019329884A1 (en) 2021-03-11
CN112955147A (zh) 2021-06-11
IL281093B1 (en) 2025-07-01
CA3110601A1 (en) 2020-03-05
US20220023299A1 (en) 2022-01-27
JP7161605B2 (ja) 2022-10-26
CL2021000491A1 (es) 2021-08-20
MA53496A (fr) 2021-12-08
CO2021002230A2 (es) 2021-03-08
IL281093A (en) 2021-04-29
US11254660B2 (en) 2022-02-22
US12247022B2 (en) 2025-03-11
CR20210110A (es) 2021-05-13
SG11202101503RA (en) 2021-03-30
TW202026292A (zh) 2020-07-16
ZA202101090B (en) 2022-06-29
JP2021535126A (ja) 2021-12-16
PY1972032A (es) 2021-06-03
BR112021003039A2 (pt) 2021-05-18
AU2019329884B2 (en) 2022-01-27
KR20210053929A (ko) 2021-05-12
PH12021550339A1 (en) 2021-10-04
WO2020044266A1 (en) 2020-03-05
CA3110601C (en) 2023-09-05
US20200071306A1 (en) 2020-03-05
UY38351A (es) 2020-03-31
DOP2021000036A (es) 2021-04-15
ECSP21012501A (es) 2021-03-31

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