CL2020002253A1 - Derivados de 2,4 - diaminoquinazolina y usos médicos de los mismos. - Google Patents

Derivados de 2,4 - diaminoquinazolina y usos médicos de los mismos.

Info

Publication number
CL2020002253A1
CL2020002253A1 CL2020002253A CL2020002253A CL2020002253A1 CL 2020002253 A1 CL2020002253 A1 CL 2020002253A1 CL 2020002253 A CL2020002253 A CL 2020002253A CL 2020002253 A CL2020002253 A CL 2020002253A CL 2020002253 A1 CL2020002253 A1 CL 2020002253A1
Authority
CL
Chile
Prior art keywords
methyl
deuterium
cyclopropyl
fluoro
hydrogen
Prior art date
Application number
CL2020002253A
Other languages
English (en)
Inventor
Gowan David Craig Mc
Pierre Jean-Marie Bernard Raboisson
Werner Constant Johan Embrechts
Tim Hugo Maria Jonckers
Ludwig Paul Cooymans
Jérôme Émile Georges Guillemont
Original Assignee
Janssen Sciences Ireland Unlimited Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Sciences Ireland Unlimited Co filed Critical Janssen Sciences Ireland Unlimited Co
Publication of CL2020002253A1 publication Critical patent/CL2020002253A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Esta solicitud se refiere a derivados de quinazolina de fórmula (I), composiciones farmacéuticas que comprenden los compuestos de fórmula (I), y al uso de los compuestos de fórmual (I) en el tratamiento o la prevención de un infección vírica, de una enfermedad inducida por virus, de un cáncer o de una alergia. En la fórmula (I), R1 es alquilo C3-8, opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente entre flúor, hidroxilo, amino, nitrilo, éster, amida, alquilo C1-3 o alcoxi C1-3, el carbono de R1 unido a la amina en la posición 4 de la quinazolina se encuentra en la configuración (R), R2 es hidrógeno, deuterio, flúor, cloro, metilo, metoxi, ciclopropilo, trifluorometilo o amida carboxílica, en donde cada uno de metilo, metoxi y ciclopropilo está opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente entre flúor y nitrilo, R3 es hidrógeno o deuterio, R4 es hidrógeno, deuterio, flúor, metilo, éster carboxílico, amida carboxílica, nitrilo, ciclopropilo, heterociclo C4-7 o un grupo heteroarilo de 5 miembros, en donde cada uno de metilo, ciclopropilo, heterociclo C4-7 y grupo heteroarilo de 5 miembros está opcionalmente sustituido por uno o más sustituyentes seleccionados independientemente entre flúor, hidroxilo o metilo, R5 es hidrógeno, deuterio, flúor, cloro, metilo o metoxi, a condición de que al menos uno de R2, R3, R4 y R5 no sea hidrógeno.
CL2020002253A 2018-03-01 2020-08-31 Derivados de 2,4 - diaminoquinazolina y usos médicos de los mismos. CL2020002253A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP18159583 2018-03-01

Publications (1)

Publication Number Publication Date
CL2020002253A1 true CL2020002253A1 (es) 2021-01-15

Family

ID=61557126

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2020002253A CL2020002253A1 (es) 2018-03-01 2020-08-31 Derivados de 2,4 - diaminoquinazolina y usos médicos de los mismos.
CL2021001753A CL2021001753A1 (es) 2018-03-01 2021-06-30 Compuestos derivados de 2,4-diaminoquinazolina; composición farmacéutica; y su uso para el tratamiento de una infección vírica, cáncer, entre otras (divisional de solicitud 202002253).
CL2022000125A CL2022000125A1 (es) 2018-03-01 2022-01-18 Derivados de 2,4-diaminoquinazolina y usos médicos de los mismos. (divisional de solicitud 202002253)

Family Applications After (2)

Application Number Title Priority Date Filing Date
CL2021001753A CL2021001753A1 (es) 2018-03-01 2021-06-30 Compuestos derivados de 2,4-diaminoquinazolina; composición farmacéutica; y su uso para el tratamiento de una infección vírica, cáncer, entre otras (divisional de solicitud 202002253).
CL2022000125A CL2022000125A1 (es) 2018-03-01 2022-01-18 Derivados de 2,4-diaminoquinazolina y usos médicos de los mismos. (divisional de solicitud 202002253)

Country Status (30)

Country Link
US (2) US11597704B2 (es)
EP (2) EP3759083B1 (es)
JP (1) JP2021514981A (es)
KR (1) KR20200128394A (es)
CN (1) CN111868040A (es)
AR (1) AR114420A1 (es)
AU (1) AU2019226342B2 (es)
BR (1) BR112020017702A2 (es)
CA (1) CA3091076A1 (es)
CL (3) CL2020002253A1 (es)
DK (1) DK3759083T3 (es)
EA (1) EA202092052A1 (es)
ES (1) ES2923579T3 (es)
HR (1) HRP20220781T1 (es)
HU (1) HUE059149T2 (es)
IL (2) IL305388A (es)
JO (1) JOP20200208A1 (es)
LT (1) LT3759083T (es)
MA (1) MA52411B1 (es)
MD (1) MD3759083T2 (es)
MX (2) MX2020009071A (es)
PH (1) PH12020551345A1 (es)
PL (1) PL3759083T3 (es)
PT (1) PT3759083T (es)
RS (1) RS63401B1 (es)
SG (1) SG11202008293YA (es)
SI (1) SI3759083T1 (es)
TW (1) TW201945003A (es)
UA (1) UA127590C2 (es)
WO (1) WO2019166532A1 (es)

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WO2020255039A1 (en) * 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and quinazoline derivatives
AU2020333708C1 (en) * 2019-08-19 2024-02-22 Shanghai Zhimeng Biopharma Inc. 2-aminopyrimidine compounds and pharmaceutical compositions and uses thereof
CN114555565B (zh) * 2019-12-13 2024-03-05 四川科伦博泰生物医药股份有限公司 含氮并环化合物、其制备方法及用途
US20230058425A1 (en) * 2020-01-02 2023-02-23 Jiangsu Hengrui Medicine Co., Ltd. Crystal form of pyridopyrimidine derivative and preparation method thereof

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